The Office for Human Research Studies (OHRS) is responsible for the scientific and Institutional Review Board review processes for all cancer relevant research conducted by the five Harvard clinical institutions under the umbrella of Dana-Farber/Harvard Cancer Center. These institutions are: Beth Israel Deaconess Medical Center; Brigham and Women's Hospital; Children's Hospital Boston; Dana-Farber Cancer Institute; and Massachusetts General Hospital. OHRS is responsible for ensuring the administrative and regulatory management, implementation, and operation of the (1) Protocol Review and Monitoring System under the Cancer Center Grant; (2) the system for the institutional review board review of research; (3) the Health Improvement Portability and Accountability Act as it relates to research; and (4) Activation of Research Protocols.