Services provided by the Core include:
- Biostatistical consulting in the planning, conduct, analysis and reporting of
Advice and support in the preparation of grant applications of DF/HCC members Scientific computing for data analysis and scientific graphics necessary for analyses of epidemiological, clinical, basic science, and genomic studies.Advice and consultation to the Quality Assurance Office for Clinical Trials (QACT) on efficient and accurate database design and management of clinical research data.Computer support for the clinical research database, using the Ingres system on the Department of Biostatistics and Computational Biology (DFCI) network. Advice and consultation to the Office for the Protection of Research Risks (OPRS) in the scientific and human protection reviews of clinical trials through membership on the DF/HCC Scientific Review Committees and the DFCI IRB, which serves as the central IRB for the DF/HCC. Education for members of the DF/HCC in the areas of study design, data collection, computerization, and statistical methods for laboratory, clinical and population based studies.
- Clinical trials. The Biostatistics Core consults on and reviews all clinical protocols activated by the DF/HCC.
- Epidemiologic and population based studies and studies in somatic genetics and the risk of cancer
- Experiments in the biology of cancer, including genomic experiments and laboratory and animal studies.
- Translational research studies with combined measurements on clinical and biological parameters.
Below are some of the Biostatistics Core Policies (approved by the DF/HCC Center Scientific Council) that have an impact on users.
- In general, the priorities for statistical work (from highest to lowest) are:
- Grant preparation
- Abstracts for national meetings, and other reports with fixed deadlines
- Protocol design and review
- Laboratory, animal, and epidemiology study design and review
- Short term consults
- Study monitoring, analysis, manuscript preparation, and replies to manuscript reviews
- Education of users
- In order to better manage statistical work on projects with external deadlines, the Biostatistics Core requires that the Core:
- Be informed of new P01 and SPORE grant submissions at least 6 months before the deadline
- Be informed of new R01 and K series grant submissions at least 1 month before the deadline
- Be provided with data sets for an analysis for an abstract submission (e.g., for ASCO, AACR, ASH, ASTRO) at least 1 month before the deadline
- Will only work on analysis and reporting for abstract presentations (e.g., for ASCO, AACR, ASH, ASTRO meetings) if the Core was notified at the time of abstract submission and the relevant statistician was given enough time to comment on the abstract at the time of submission.