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Core Facilities

Collaborative RNAi

The DF/HCC Collaborative RNAi Core brings together a number of local experts, resources, and centers working in the field of RNAi screening. Our primary mission is to help researchers design, perform, and analyze the results of RNAi screens relevant to cancer study.

We feel that RNAi screening and related approaches have rich potential to reveal insights into the underlying biology of cancer, as well as to point to appropriate targets for development of therapeutic treatments.

RNAi screening may contribute to our understanding of cancer by:

  • Identifying genes, pathways, and networks involved in cancer-related processes such as cell death, cell division, metabolism, and differentiation
  • Identifying potential drug targets
  • Identifying genes involved in drug resistance
  • Identifying genes that interact with known cancer-associated factors

The participating groups include the DFCI RNAi Facility, the Drosophila RNAi Screening Center, the ICCB Longwood Screening Facility, the Laboratory of Steve Elledge, and the Genetic Perturbation Platform of the Broad Institute. We welcome participation from additional area experts and centers.

By coming together, we feel that we can provide an exceptionally broad spectrum of expert support, reagents, equipment and services relevant to RNAi screening. Writing a grant that proposes a screen? We can also help with grant writing, budgets, and letters of support.

Please be aware that the hands-on involvement of a researcher from your lab is essential to the process and helps to ensure success. No one will be able to perform the screen better, or more quickly and accurately gauge how things are going, than the research group that designed and will later analyze the results of the screen.

DF/HCC Collaborative RNAi Core Director (Contact Person):
Stephanie Mohr, PhD
Email: smohr@hms.harvard.edu
Phone: 617-432-5626

Core Scientific Leadership:
Steve Elledge, PhD
William Hahn, MD, PhD
Norbert Perrimon, PhD
Caroline Shamu, PhD
David Root, PhD

Screening Center Contacts:
Stephanie Mohr, PhD (Drosophila RNAi Screening Center)
John Doench, PhD (Genetic Perturbation Platform of the Broad)
Caroline Shamu, PhD (ICCB Longwood Screening Facility)

PUBLICATION ACKNOWLEDGEMENT: If research supported by this core facility results in publication, please acknowledge this support by including the following in your publication(s):

We thank Dana-Farber/Harvard Cancer Center in Boston, MA, for the use of the Collaborative RNAi Core, which provided __________ service. Dana-Farber/Harvard Cancer Center is supported in part by a NCI Cancer Center Support Grant # NIH 5 P30 CA06516.