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Impact on scientific advances

The services provided by the CPRC assist DF/HCC investigators to develop research protocols and make it possible for them to conduct research within “real world” clinical settings. The CPRC staff takes DF/HCC investigators through all steps in the process from the initial contact, introducing them to key clinical and administrative staff, assessing the feasibility of their ideas, providing preliminary data, assisting them in developing their proposals, preparing budgets, to helping them work through the research administration protocols. The CPRC has been instrumental in the establishment of collaborations between DF/HCC researchers and researchers across numerous nationwide institutions.


“Multiple Risk Behavior Intervention in Health Care Settings” (also known as Health Directions 2/HD2)

  • Follow-up study to “Cancer Prevention through Health Centers, Healthy Directions.” (HD1)
  • A randomized controlled trial that is currently being conducted at two HVMA sites and is aimed at reducing cancer risk by smoking cessation, nutrition, and physical activity.    
  • The CPRC provided consultations services, preliminary data, identified collaborators at HVMA, assisted with research administration protocols, budget preparation, and contacted physicians at a number of HVMA sites to solicit participation.

The study was successfully conducted and has led to follow up projects, “Cancer Care Outcomes Research and Surveillance (CanCORS)” project.

  • The CanCORS/CRN collaboration is studying the care and outcomes of lung and colorectal cancer patients across a range of geographic regions and health-care settings.
  • A national, multi-site research study funded by NCI and the Department of Veterans Affairs, CanCORS seeks to measure the dissemination of effective interventions and examine the resulting outcomes.
  • Entailed identification of eligible patients using the automated data at each site.

The project has launched several spin-off projects and nationwide collaborations, “Predictors of Recurrence after Ductal Carcinoma in Situ (DCIS)”

  • Awarded in 2003, this NCI-funded project included investigators at Beth Israel Deaconess Medical Center, HPHC, Kaiser Permanente Northern California, and Kaiser Permanente Southern California.
  • First study to explore the link between basic and population research in our setting
  • Led to “Comparing the long-term and real world effectiveness of initial management strategies for DCIS,” funded by the AHRQ Task Order to the DeCIDE Network.  

“Ovarian Cancer Treatment Diffusion Study”

  • Identified 1,647 women with ovarian cancer diagnosed between January 1, 2004 and June 30, 2006 from the eight sites in the CRN
  • Using the CRN Virtual Data Warehouse, the investigators collected automated data on utilization, tumor registry and patient characteristics
  • The study validated the utility of automated data and was a stepping stone for several ongoing studies including a study evaluating the cardiotoxicity of chemotherapy.