The Recombinant Protein Expression and Purification (RPrEP) Core was established in 2009 to provide a cost-effective resource to the MGH and DF/HCC community for expression and purification of recombinant proteins necessary for pre-clinical studies as well as for basic mechanistic studies by immunologists and cancer biologists.

Recombinant Proteins can be manufactured by this Core for a variety of applications according to MGH-DF/HCC investigator needs. In addition to large-scale production of recombinant proteins in yeast Pichia pastoris, a cost effective small-scale production service will be provided using E.coli or yeast Pichia pastoris expression system (e.g. for small animal studies, use as immunogens, ELISAs, or high throughput microarray platforms).

Leadership and Staff

Scientific Director: David Sachs, MD
Scientific Co-director: Christene Huang, PhD
Technical Director: Zhirui Wang
Accounts Manager: Pat Kiszkiss