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Core Facilities

Specialized Histopathology Services (Pathology)

Specialized Histopathology Services Core

Myeloperoxidase staining in mouse spleen
Myeloperoxidase staining in mouse spleen

Tissue analysis is critical to validation and evaluation of animal models of human cancer, and human cancer tissues serve as the "operating system" for translational research. The SHP Core provides professional and technical research pathology services to DF/HCC investigators working in diverse organisms, including man, non-human primates, rodents, and zebrafish. The Core also assists in experimental design and the development and interpretation of tests and their results. The Longwood site provides services in a CLIA-approved laboratory that can support clinical trial-related biomarker tests, including testing done in support of neuro-oncology trials. Both the Longwood and MGH sites also provide a comprehensive set of non-CLIA tissue-based tests and diagnostic services priced at cost for DF/HCC investigators across all disease programs, and pairs investigators with pathologists with subspecialty expertise in specific areas. The professional staff of the Longwood site includes multiple pathologists with subspecialty training in hematopathology and molecular diagnostics, whereas the MGH has several associate pathologists with subspecialty training in neuropathology (human and animal models). If projects involve cancers or pathologic states outside of the expertise of Core-associated pathologists, the Core actively seeks out pathologists with such expertise to act as collaborators.

The SHP Core provides professional and technical research pathology services to DF/HCC investigators working in diverse organisms, including man, non-human primates, rodents, and zebrafish. The Core also assists in experimental design and the development and interpretation of tests and their results.

The SHP Core provides a comprehensive set of tissue-based tests and diagnostic services priced at cost for DF/HCC investigators, and pairs investigators with pathologists with subspecialty expertise in specific areas. If projects involve cancers or pathologic states outside of the expertise of Core-associated pathologists, the Core actively seeks out pathologists with such expertise to act as collaborators.

Leadership and Staff

Longwood Site

Core Director: Jon Aster, MD, PhD

Associate Pathologist: Sabina Signoretti, MD

Associate Pathologist: Scott Rodig, MD, PhD

Junior Pathologist: Michael Kluk, MD, PhD

Junior Pathologist: Elizabeth Morgan, MD

Technical Contact: Teri Bowman, 617-525-7442

Material Drop-off / Pick-up Hours: 8 a.m. to 3 p.m., Monday through Friday

MGH Site

Core Co-Director: Anat Stemmer-Rachamimov, MD

Associate Pathologist: David Louis, MD

Associate Pathologist: Chin-Lee Wu, MD, PhD

Core Contact, Histology, IHC: Jillian Brockmann, 617-726-5510

PUBLICATION ACKNOWLEDGEMENT: If research supported by this core facility results in publication, please acknowledge this support by including the following in your publication(s):

We thank Dana-Farber/Harvard Cancer Center in Boston, MA, for the use of the Specialized Histopathology Core, which provided __________ service. Dana-Farber/Harvard Cancer Center is supported in part by an NCI Cancer Center Support Grant # NIH 5 P30 CA06516.