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Specialized Histopathology Services (Pathology)



Agace WW, Parker CM. Human intestinal lamina propria and intraepithelial lymphocytes express receptor specific for chemokines induced by inflammation. Eur J Immunol 2000;30:819-26

Amatruda JF, Shepard JL, Stern HM, Zon LI. Zebrafish as a cancer model system. Cancer Cell 2002;1:229-231

Bardeesy N, Morgan J, Sinha M, Signoretti S, Srivastava S, et al. Obligate roles for p16 Ink4a and p19 Arf-p53 in the suppression of murine pancreatic neoplasia. Mol Cell Biol 2002;22:635-43.

Bennett CM, Kanki JP, Rhodes J, Paw BH, Kieran MW, et al. Myelopoiesis in the zebrafish, Danio rerio. Blood 2001:98;643-51.

Boyartchuk, VL, Broman KW, Mosher RE, D'Orazio SEF, Starnbach MN, Dietrich WF. Multigenic control of Listeria monocytogenes susceptibility in mice. Nature Genet 2001;27:259-60.

Casola S, Humme S, Alimzhanov M, Uyttersprot N, Kutok JL, et al. B cell subset and germinal center differentiation promoted by EBV protein LMP2A. Nature Immunol 2004;5;317-27.

Chan IT, Kutok JL, Williams IR, Cohen S, Kelly L, et al. Conditional expression of oncogneic K-ras from its endogenous promoter is sufficient to induce a myeloproliferative disease. JCI 2004;113:528-38

Chen J, Deangelo DJ, Kutok JL, Williams IR, Lee BH, et al. PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder. Proc Natl Acad Sci USA 2004:101;14479-84.

Chen J, Williams IR, Kutok JL, Duclos N, Anastasiadou E, Masters SC, Fu H, Gilliland DG. Positive and negative regulatory roles of the WW-like domain in TEL/PDGFR transformation. Blood 2004:104;535-42.

Cho Y, Ramer J, Rivailler P, Quink C, Garber RL, et al. An Epstein-Barr related herpes virus from marmoset lymphomas. Proc Natl Acad Sci 2001;98:1224-29.

Cools J, DeAngelo D, Gotlib J, Stover EH, Legare RD, et al. A novel tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes represents the therapeutic target of imatinib in idiopathic hypereosinophilic syndromes. New Engl J Med 2003;348:1201-14.

Cools J, Stover EH, Boulton CL, Gotlib J, Legare RD, et al. PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRalpha-induced myeloproliferative disease. Cancer Cell 2003;3:459-469.

Dash AB, Williams IR, Kutok JL, Tomasson MH, Anastasiadou E, et al. A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. Proc Natl Acad Sci U S A 2002;99:7622-27.

Deguchi K, Ayton PM, Carapeti M, Kutok JL, Snyder CS, et al. MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. Cancer Cell 2003;3:259-271.

DeSalle LM, Latres E, Lin D, Graner E, Montagnoli A, et al. The de-ubiquitinating enzyme Unp interacts with the Retinoblastoma protein. Oncogene 2001;20:5538-42

Dimitroff CJ, Lechpammer M, Long-Woodward D, KutokJL. Rolling of human bone-metastatic prostate tumor cells on human bone marrow endothelium under shear flow is mediated by E-selectin. Cancer Res 2004:63;5261-9.

Donato JL, Ko J, Kutok JL, Cheng T, Shirakawa T, et al. Human HTM4 is a hematopoietic cell cycle regulator. J Clin Invest 2002;109:51-8.

Ellis FH Jr, Xu X, Kulke MH, LoCicero J, Loda M. Malignant transformation of the esophageal mucosa is enhanced in p27 knock-out mice. J Thor Cardiov Surg2001, 122: 809-11

Enerback C, Porter DA, Seth P, Sgroi D, Gaudet J, et al. Psoriasin expression in mammary epithelial cells in vitro and in vivo. Cancer Res 2002;62:43-47.

Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S. Insulin-degrading enzyme regulates the levels of insulin, amyloid {beta}-protein, and the {beta}-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci USA 2003:100;4162-7.

Fierro IM, Kutok JL, Serhan CN. A novel inhibitor of angiogenesis. Aspirin-triggered-15R lipoxin A4. J Pharmacol Exp Ther. 2002;300:385-92.

Fleming MD, Pinkus JL, Alexander SW, Tam C, Loda M, et al. Coincident expression of the chemokine receptors CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis. Blood 2003;101: 2473-5.

Frantsve J, Schwaller J, Sternberg DW, Kutok J, Gilliland DG. Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol Cell Biol 2001:21;3547-57.

Gu L., Tseng S, Rollins B. Control of Th2 lymphocyte polarization by the chemokine monocyte chemoattractant protein-1. Nature 2000;404: 407-11

Hsu K, Traver D, Kutok JL, Hagen A, Liu TX, et al.: The pu.1 promoter drives myeloid gene expression in zebrafish. Blood 2004;104:1291-7.

Husson H, Freedman A, Cardoso A, Schultze J, Munoz O, et al. CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells. Br J Haematol 2002;119:492-5.

Karuman P, Gozani O, Odze RD, Zhou XL, Zhu H, et al. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.Molecular Cell 2001:7;1307-19

Kelly LM, Kutok JL, Williams IR, Boulton CL, Amaral SM, et al. PML/RARa and FLT3/ITD induce an APL-like disease in a mouse model. Proc Natl Acad Sci USA 2002;99:8283-8.

Kelly LM, Liu Q, Kutok JL, Williams IR, Boulton CL, Gilliland DG. FLT3-ITD mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. Blood 2002;99:310-318.

Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Jr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002:1;237-46.

Krop IE, Sgroi D, Porter DA, Lunetta KL, LeVangie R, et al. HIN-1, a cytokine silenced in early breast cancers. Proc Natl Acad Sci U S A 2001;98:9796-801.

Kutok JL, Klumpp S, Simon M, MacKey JJ, Nguyen V, Middeldorp JM, et al. Molecular evidence for rhesus lymphocryptovirus infection of epithelial cells in immunosuppressed rhesus macaques. J Virol 2004;78:3455-61.

Langenau DM, Ferrando AA, Traver D, Kutok JL, Hezel JP, et al. In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci USA 2004:101;7369-7374.

Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, et al. Myc-induced T-cell Leukemia in Transgenic Zebrafish. Science 2003;299:887-90.

Lindeman N, Waltregny D, Signoretti S, Loda M. Gene transcript quantitation by real-time rt-PCR in cells selected by immunohistochemistry-laser capture microdissection. Diagn Mol Pathol 2000;11:187-92.

Liou Y-C, Ryo A, Huang H-K, Lu PJ, Fujimori F, et al. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc Natl Acad Sci USA 2002;99:1335-40.

Liu Q, Schwaller J, Kutok J, Cain D, Aster JC, et al. Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia. Embo J 2000;19:1827-1838.

Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, et al. Specific activating mutations in the epidermal growth factor receptor determine responsiveness of non-small cell lung cancer to Gefitinib. New Eng J Med 2004:350;2129-2139.

Majumder PK, Yeh JJ, Que X, Kum J, Ma H, et al. Prostate intraepithelial neoplasia induced by prostate restricted Akt activation the MPAKT model. Proc Natl Acad Sci USA 2003;100:7841-6.

Manis JP, Morales JC, Xia Z, Kutok JL, Alt FW, Carpenter PB. 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol 2004;5:481-7.

Mutter GL, Ince TA, Baak JPA, Kust G, Zhou X, Eng C. Molecular identification of latent pre-cancers in histologically normal endometrium. Cancer Res 2001:61;4311-4.

Palmer RE, Lee SB, Wong JC, Reynolds PA, Zhang H, et al. Induction of BAIAP3 by the EWS-WT1 chimeric fusion implicates exocytosis in tumorigenesis. Cancer Cell 2002:2;497-505.

Pankaj Seth, Ian Krop, Dale Porter, Yan Geng, Andrea Richardson and Kornelia Polyak. EIT-6, an estrogen responsive growth promoting gene. Oncogene 2002:21;836-43.

Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, et al. BRAF mutations are sufficient to promote nevi formation, and cooperate with p53 in the genesis of melanoma. Curr Biol: in press.

Porter D, Lahti-Domenici J, Keshaviah A, Bae YK, Argani P, et al. Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res 2003;1:362-5

Ranger AM, Zha J, Harada H, Datta SR, Danial NN, et al. Bad-Deficient Mice Develop Diffuse Large B Cell Lymphoma. Proc Natl Acad Sci USA 2003;100(16):9324-9.

Rivailler P, Carville A, Kaur A, Rao P, Quink C, Kutok JL, et al. Experimental rhesus lymphocryptovirus infection in immunosuppressed macaques: an animal model for Epstein-Barr virus pathogenesis in the immunosuppressed host. Blood 2004:104;1482-9.

Rosen ED, Spiegelman BM, Mortensen RM. PPARg is required for the differentiation of adipose tissue in vivo and in vitro. Molecular Cell 1999;4:611-17.

Rosenbauer F, Wagner K, Kutok JL, Iwasaki H, Le Beau MM, et al. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet 2004, 36:624-30.

Savage KJ, Monti S, Kutok JL, Cattoretti G, Neuberg D, et al. Mediastinal large B-Cell lymphoma: a unique subset of diffuse large B-cell lymphoma with an expression signature resembling that of Hodgkins Reed-Sternberg Cells Blood. 2003:102;3871-9.

Schmollinger JC, Vonderheide RH, Hoar KM, Maecker B, Schultze JL, et al. The inhibitor of apoptosis protein ML-IAP is a target for immune mediated tumor destruction. Proc Natl Acad Sci USA 2003;100:3398-403.

Shepard JL, Stern HM, Pfaff KL, Amatruda JF. Analysis of the cell cycle in zebrafish embryos. Methods Cell Biol 2004:76;109-25

Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, et al. Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med 2002;8:68-74.

Singh D, Febbo PG, Ross K, Jackson DG, Manola J, et al. Molecular determinants of prostate cancer behavior. Cancer Cell (In press).

Stemmer-Rachamimov AO, Louis DN, Nielsen PG, Antonescu CR, et al. Comparative pathology of nerve sheath tumors in mouse models and humans. Cancer Res 2004:64;3718-24.

Stern HM, Zon LI. Cancer genetics and drug discovery in the zebrafish. Nat Rev Cancer 2003,3:533-539.

Syngal S, Fox EA, Eng C, Kolodner RD, Garber JE. Sensitivity and specificity of clinical criteria for hereditary nonpolyposis colorectal cancer-associated mutations in MSH2 and MLH1. J Med Genet 2000;37:641-5.

Syngal S, Schrag D, Falchuk M, Tung N, Farraye FA, et al. Phenotypic characteristics associated with the APC Gene I1307K mutation in Ashkenazi Jewish Patients with colorectal polyps. JAMA 2000;284:857-860

Tomasson MH, Williams IR, Li S, Kutok J, Cain D, et al. Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony- stimulating factor or interleukin-3. Blood 2001:97;1435-41.

Traver D, Winzeler A, Stern HM, Mayhall EA, Langenau DM, et al. Biological effects of lethal irradiation and rescue by hematopoietic cell transplantation in the zebrafish. Blood 2004:104;1298-305.

Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 2002:100;3776-81.

Wohlschlegel JA, Kutok JL, Weng AP, Dutta A. Expression of geminin as a marker of cell proliferation in normal tissues and malignancies. Am J Pathol 2002;161:267-273.

Wong G, Li W, Madhusudhan MS, Krilis SA, Gurish MF, et al. Tryptase 4: A new member of the chromosome 17 family of mouse serine proteases. J Biol Chem 2001:276;20648-58.

Wu CJ, Hochberg EP, Rogers SA, Kutok JL, Biernacki M, et al. Molecular assessment of erythroid lineage chimerism following nonmyeloablative allogeneic stem cell transplantation. Exp Hematol 2003;31:924-933.2003;31:924-933.

Yang C, Ionescu-Tiba V, Burns K, Gadd M, Zukerberg LR, Louis DN, Sgroi D, Schmidt EV. The role of the cyclin D1-dependent kinases erbB2-mediated breast cancer. Am J Pathol 2004:164;1031-1038.

Zhang H, Palmer R, Gao X, Kreidberg J, Gerald W, et al. Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1. Curr Biol 2003:13;1625-9.

Zinkel SS, Ong CC, Ferguson DO, Iwasaki H, Akashi K, Bronson RT, et al. Pro-apoptotic BID is required for myeloid homeostsis and tumor suppression. Genes Dev 2003;17:229-39.