The A. David Mazzone Research Awards Program will fund a series of collaborative and innovative cancer research, career development, community outreach, and training projects to address a range of needs in prostate cancer and Lupron-treatable diseases.

Funding Agency: The funding agency for the A. David Mazzone Research Awards Program is a non-federal grant from the U.S. District Court for the District of Massachusetts. Funding was derived from a pool of unclaimed funds from the settlement in 2004 of a class action suit against TAP Pharmaceuticals. The class action suit was related to marketing and sales practices for the prostate cancer drug Lupron.

2013 Opportunities

High Impact Awards are large-scale, team-driven prostate cancer research projects intended to accelerate the discovery, development and application of new agents to treat prostate cancer and/or to address significant problems in prostate cancer research.
Award amount: Up to $250,000 per year for two years for direct costs only ($500,000 total).
Submission Deadline for 2013 Awards: 04:59:59 PM EST, Friday, April 5, 2013.

High Impact Trial Awards are large-scale, prostate cancer research projects for multi-institutional teams of investigators (at least four institutions).  This award is designed to harness medical discoveries to test new compounds and therapies which inhibit putative targets and to study responses and prolongation of survival in Castration Resistant Prostate Cancer (CRPC).
Award amount: Up to $250,000 per year for two years for direct costs only ($500,000 total).
Submission Deadline for 2013 Awards: 04:59:59 PM EST, Friday, April 5, 2013.

Project Development Awards will support investigators conducting innovative pilot projects in prostate cancer translational research spanning the disciplines of basic biology, population studies, outcomes, or social science.
Award amount: Up to $50,000 per year for two years for direct costs only ($100,000 total).
Submission Deadline for 2013 Awards: 04:59:59 PM EST, Friday, April 5, 2013.

Disparity Research Awards provide support for research projects aimed at understanding and eliminating racial, ethnic, and socioeconomic disparities in prostate cancer.
Award amount: Up to $50,000 per year for two years for direct costs only ($100,000 total).
Submission Deadline for 2013 Awards: 04:59:59 PM EST, Friday, April 5, 2013.

Community Outreach Research Awards are designed to help the Cancer Center play a greater role in facilitating engaged research participation or outreach activities among communities which are predominantly lower income and/or racially/ethnically diverse.
Award amount: Up to $50,000 per year for two years for direct costs only ($100,000 total).
Submission Deadline for 2013 Awards: 04:59:59 PM EST, Friday, April 5, 2013.

(Exclusively for DF/HCC partner institutions members) Career Development Awards will support junior investigators transitioning from training to independent investigators. Research may focus on any aspect of prostate cancer prevention, health services and health policy research, treatment, and survivorship.
Award amount: Up to $50,000 per year for two years for direct costs only ($100,000 total).
Submission Deadline for 2013 Awards: 04:59:59 PM EST, Friday, April 5, 2013.

Student Training Awards will support students for participation in the CURE Program. Through involvement in a research project, students acquire scientific knowledge and technical skills, and increase their understanding of cancer and how to conduct cancer research.
Award amount: multiple awards up to a total program funding amount of $160,000.
Visit Program Web Site: http://www.dfhcc.harvard.edu/cancer-disparities/for-students/cure-program/

Prostate Cancer Foundation Challenge Awards will support large-scale research projects. Proposals must be from teams of at least 3 highly experienced investigators capable of providing unique scientific expertise to the solution of a significant problem in prostate cancer research. A team may be assembled from one institution, or several institutions, from across the globe.
Award amount: one award remaining for a two-year award of up to $1,000,000  for direct cost only.
Visit Program Web Site: http://www.pcf.org/site/c.leJRIROrEpH/b.5849007/k.F70A/Open_RFAs.htm

Mazzone Awards Program 2012

Projects Recommended for Funding for Period 2012–2014

High Impact

Levi Garraway (DFCI)
Defining the spectrum of resistance to androgen ablation therapy in prostate cancer

Steven Balk (BIDMC)
Molecular Characterization of Gleason 3 Tumors That Progress to Gleason 4

Career Development

Julie Kasperzyk (BWH)
Within-Person Molecular Differences in Primary Versus Metastatic Prostate Cancer

Jennifer Rider (HSPH)
Inflammation and tissue microenvironment as predictors of prostate cancer risk, mortality and therapy response among men with an initially benign TURP

Project Development

Zhe Li (BWH)
Castration-Resistant Luminal Cells in the Prostate

Massimo Loda (DFCI)
Developing a Blood-based Metabolomic Signature of Gleason Score

Robert Cormack (DFCI)
Nanoplatforms for Localized Chemo Radiation Therapy for Prostate Cancer

Lupron-Treatable Diseases and Conditions

Jose Teixeira (MGH)
Pre-clinical in vivo studies investigating the efficacy of mTOR inhibitors for uterine fibroids

Elizabeth Henske (BWH)
Targeting estrogen-dependent mechanisms in lymphangioleiomyomatosis (LAM)

Disparities Research

Lorelei Mucci (HSPH)
Estimating the prostate cancer burden attributed to lifestyle and genetic factors among African-American and White men

Karen Emmons (DFCI)
Factors Influencing Willingness to Participate in Biobanking Among Black Men With and At-Risk for Prostate Cancer

Community Outreach

Jennifer Allen (DFCI)
Engaging African American Faith Communities in Prostate Cancer Education

Glenn Bubley (BIDMC)
Enhancing the effectiveness, mission, and outreach of an ongoing community prostate cancer support group