DF/HCC Program Affiliation

Prostate Cancer
Angiogenesis, Invasion, and Metastasis

Research Abstract

We are currently focusing on the biological function of angiogenin, an angiogenic ribonuclease that undergoes nuclear translocation in proliferating endothelial cells and in various cancer cells. Angiogenin binds at the promoter region of the ribosomal RNA gene and induces rRNA transcription thereby playing a role in ribosome biogenesis, protein translation and therefore, cell proliferation. Silencing of angiogenin expression in cancer cells resulted in reduced cell growth rate and a reversal of the malignant phenotype. In endothelial cells, inhibition of angiogenin expression decreased cell proliferation induced by other growth stimuli. Thus, angiogenin-stimulated rRNA transcription may play a dual role in cancer progression.

Publications

No representative citations available.