S. J. Adelstein, M.D. Ph.D.
'Paul C. Cabot Distinguished Professor of Medical Biophysics, Department of Pathology, Harvard Medical School
Professor, Department of Radiology, Harvard Medical School
Professor, Nuclear Medicine, Brigham And Women's Hospital
Senior Radiologist, Nuclear Medicine, Brigham And Women's Hospital
DF/HCC Program Affiliation
Cancer Imaging
Research Abstract
Our laboratory studies the biophysical effects of densely ionizing radiation and its application to experimental cancer therapy. The interaction of alpha particles as well as Auger and Koster-Cronig electrons wtih chromosal DNA and its consituents is a central focus. Biological endpoints include double strand breaks, clonal survival, transformation and mutagenesis. The information obtained from these studies is used in the development of agents for targeted radionuclide therapy.We are also interested in cell surface enzymes and mitochondrial membranes as targets for radio-labeled imaging and therapeutic probes.
Publications
- Pospisil P, Wang K, Al Aowad AF, Iyer LK, Adelstein SJ, Kassis AI.Computational modeling and experimental evaluation of a novel prodrug for targeting the extracellular space of prostate tumors.Cancer Res 2007 Mar 1;67(5):2197-205.
17332350 - Balagurumoorthy P, Chen K, Bash RC, Adelstein SJ, Kassis AI.Mechanisms underlying production of double-strand breaks in plasmid DNA after decay of 125I-Hoechst.Radiat Res 2006 Aug;166(2):333-44.
16881734 - Kishikawa H, Wang K, Adelstein SJ, Kassis AI.Inhibitory and stimulatory bystander effects are differentially induced by Iodine-125 and Iodine-123.Radiat Res 2006 Jun;165(6):688-94.
16802869 - Adelstein SJ, Kassis AI, Bodei L, Mariani G.Radiotoxicity of iodine-125 and other auger-electron-emitting radionuclides: background to therapy.Cancer Biother Radiopharm 2003 Jun;18(3):301-16.
12954118 - Kassis AI, Wen PY, Van den Abbeele AD, Baranowska-Kortylewicz J, Makrigiorgos GM, Metz KR, Matalka KZ, Cook CU, Sahu SK, Black PM, Adelstein SJ.5-[125I]iodo-2'-deoxyuridine in the radiotherapy of brain tumors in rats.J Nucl Med 1998 Jul;39(7):1148-54.
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