DF/HCC Program Affiliation

Cancer Immunology
Cancer Cell Biology

Research Abstract

Cell migration into inflamed sites is the result of a complex set of molecularly distinguishable signals. A family of chemoattractant cytokines, termed chemokines, released at the focus of tissue injury attract circulating leukocytes. Chemokines induce leukocyte migration and activation by binding to a family of G protein-coupled receptors that are differentiallyexpressed on various target cells. The expression of most chemokine receptors is restricted to leukocytes. In addition, some chemokine receptors are constitutively expressed while products of the inflammatory response regulate the expression of others. This laboratory has cloned and characterized several murine chemokines and chemokine receptors involved in physiologic and pathologic responses. Particular attention is focused on those chemokines that are expressed in the central nervous system, including those associated with chronic inflammatory diseases or cell survival. We have also used chemokines as a cancer therapeutic.

Publications

• Abromson-Leeman S, Ladell DS, Bronson RT, Dorf ME.Heterogeneity of EAE mediated by multiple distinct T-effector subsets.J Neuroimmunol 2007 Dec;192(1-2):3-12.
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• Li S, Wang L, Berman MA, Zhang Y, Dorf ME.RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling.Mol Cell 2006 Nov 17;24(4):497-509.
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