David A. Sinclair, Ph.D.

Associate Professor, Department of Pathology, Harvard Medical School

Contact Info

David Sinclair
Harvard Medical School
77 Avenue Louis Pasteur
Boston, MA, 02115
Mailstop: NRB, 954
Phone: 617-432-3931
Fax: 617-432-6225
david_sinclair@hms.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Research Abstract

Publications

• Lamming DW, Wood JG, Sinclair DA.Small molecules that regulate lifespan: evidence for xenohormesis.Mol Microbiol 2004 Aug;53(4):1003-9.
  15306006
• Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D.Sirtuin activators mimic caloric restriction and delay ageing in metazoans.Nature 2004 Aug 5;430(7000):686-9.
  15254550
• Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA.Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.Science 2004 Jul 16;305(5682):390-2.
  15205477
• Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, Frye R, Ploegh H, Kessler BM, Sinclair DA.Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.Mol Cell 2004 Mar 12;13(5):627-38.
  15023334
• Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.Stress-dependent regulation of FOXO transcription factors by the SIRT1 dea
  14976264
• Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H, Sinclair DA.Yeast life-span extension by calorie restriction is independent of NAD fluctuation.Science 2003 Dec 19;302(5653):2124-6.
  14605207
• Sinclair DA.Cell biology. An age of instability.Science 2003 Sep 26;301(5641):1859-60.
  14512612
• Bitterman KJ, Medvedik O, Sinclair DA.Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin.Microbiol Mol Biol Rev 2003 Sep;67(3):376-99, table of contents.
  12966141
• Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA.Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.Nature 2003 Sep 11;425(6954):191-6.
  12939617
• Sinclair D.Is DNA cut out for a long life?.Sci Aging Knowledge Environ 2003 Apr 23;2003(16):PE8.
  12844521
• Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA.Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.Nature 2003 May 8;423(6936):181-5.
  12736687
• Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA.Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.J Biol Chem 2002 Nov 22;277(47):45099-107.
  12297502
• Sinclair DA.Paradigms and pitfalls of yeast longevity research.Mech Ageing Dev 2002 Apr 30;123(8):857-67.
  12044934
• Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA.Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels.J Biol Chem 2002 May 24;277(21):18881-90.
  11884393
• Mills KD, Sinclair DA, Guarente L.MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks.Cell 1999 May 28;97(5):609-20.
  10367890
• Johnson FB, Sinclair DA, Guarente L.Molecular biology of aging.Cell 1999 Jan 22;96(2):291-302.
  9988222
• Sinclair D, Mills K, Guarente L.Aging in Saccharomyces cerevisiae.Annu Rev Microbiol 1998;52:533-60.
  9891807
• Sinclair DA, Mills K, Guarente L.Molecular mechanisms of yeast aging.Trends Biochem Sci 1998 Apr;23(4):131-4.
  9584615
• Sinclair DA, Guarente L.Extrachromosomal rDNA circles--a cause of aging in yeast.Cell 1997 Dec 26;91(7):1033-42.
  9428525
• Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, Pak SM, Laroche T, Gasser SM, Guarente L.Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.Cell 1997 May 2;89(3):
  9150138