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Steven P. Balk, MD, PhD

Professor, Department of Medicine, Harvard Medical School

Staff Physician, Hematology/Oncology, Beth Israel Deaconess Medical Center

Contact Info

Steven Balk
Beth Israel Deaconess Medical Center
330 Brookline Avenue
Boston, MA, 02215
Mailstop: HIM Bldg, Room 1047
Phone: 617-735-2065
Fax: 617-667-0610
sbalk@bidmc.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Prostate Cancer, Co-Leader
Cancer Immunology

DF/HCC Associations

Member, Center Scientific Council

Research Abstract

The major focus of the lab is on the molecular basis of prostate cancer development and progression. The androgen receptor, which is a member of the steroid hormone receptor superfamily, plays a major role in prostate cancer. We have identified mutations in the androgen receptor that contribute to prostate cancer progression and are characterizing androgen receptor interacting proteins. We have also determined that the platelet derived growth factor receptor contributes to prostate cancer and are attempting to define other important growth factor-receptor interactions that may be useful therapeutic targets. Finally, efforts are underway to develop murine transgenic and gene knockout models of PCa. A second interest in the lab is a novel T cell population termed NK T cells and the MHC class I-like CD1d protein they recognize. These cells appear to have an important immunoregulatory function and we are determining the role they play in viral infections and anti-tumor
responses.

Publications

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