Project 1: Molecular signatures of lethal and indolent prostate cancer
Co-Principal Investigators: Philip Kantoff, MD (DFCI) and Mark Rubin, MD, PhD (Cornell)
Co-Investigator: Hans-Olov Adami, MD (HSPH)

Project 1: Supplement IPBS Supplement Project 1
Principal Investigator: Massimo Loda, MD (DFCI)

Project 2: Genetic and clinical characterization of the 8q24 prostate cancer risk locus
Co-Principal Investigators: Matthew Freedman, MD (MGH) and Oliver Sartor, MD (MIT/Broad)

Project 2: Supplement IPBS Supplement Project 2
Principal Investigator: Massimo Loda, MD (DFCI)

Project 3: Development of kinase inhibitor combination therapy in prostate cancer
Co-Principal Investigators: William Hahn, MD, PhD (DFCI) and Glenn Bubley, MD (BIDMC)

Project 4: Modulating transcription factor targets via chemical genomics
Co-Principal Investigators: Todd Golub, MD (DFCI/Broad) and William Oh, MD (DFCI)

Project 5: The androgen receptor in hormone refractory disease
Co-Principal Investigators: Steven Balk, MD, PhD (BIDMC) and Myles Brown, MD (DFCI)