RFA: Clinical Research Career Development Program - K12 (Due 5/27/16)

April 22, 2016

AWARD AMOUNT: $100,000 in salary support, plus additional funds (restrictions apply, see details below)
APPLICATION DEADLINE: Friday, May 27, 2016

The DF/HCC K-12 Fellowship Advisory Committee is currently seeking applicants (physician/researchers who have completed their required clinical training in an oncology subspecialty) for the K12 Paul Calabresi Award for Clinical Oncology (PCACO) entitled “Clinical Research Career Development Program.” Funding for one new awardee will be available, retroactive to May 1, 2016.  At this time we are also seeking applicants for 2 additional slots that will become available October 1, 2016.  Senior fellows and junior faculty, within five years of their first appointment, are eligible, provided they do not hold R-01 or equivalent funding. The deadline for applications is Friday, May 27, 2016.

The recipient will receive $100,000 towards salary support and additional funds for the following: (a) research expenses such as supplies, equipment, and technical personnel; (b) tuition, fees and books related to career development; (c) travel to research meetings or training; and (d) statistical services including personnel and computer time.  The recipient must devote a minimum of 75% effort to the Clinical Research Career Development Program. The program is funded through March 31, 2018 providing awardees up to 5 years of support.  Support beyond 3/31/18 is contingent upon a successful renewal of the grant. 

Selection Process:

The DF/HCC K12 Advisory Committee will review all applications and make a final selection of the K12 awardee in May of 2016.  Candidates will be chosen for participation in this program based on the following:

  1. A record of outstanding scholarship in medicine or nursing and in related post-graduate work.
  2. Training in a clinical subspecialty of cancer medicine, including radiation therapy, surgical oncology, medical or pediatric oncology or nursing, and excellence in the practice of his/her specialty.
  3. Demonstrated commitment to, and proficiency in cancer research, as evidenced by an initial successful completion of high quality research project(s), and a preliminary record of high quality publication.
  4. A proposal for a multi-year research program in translational research that, if successful, will include performance of a prospective clinical trial, and an independent career in clinical investigation
  5. A plan for mentorship and formal training in laboratory (or “dry lab”) and clinical aspects of translational research.  The training experience should be designed to enhance the candidate’s research capabilities.  Mentors will ordinarily include both laboratory and clinical faculty members; however, it will be required that at least one of the mentors have a broad background in clinical trials design and evaluation.  The candidate will actively participate in a clinical subspecialty as a basic component of the research plan.  Formal training should include course work in clinical trial design, responsible conduct of research, biostatistics, and regulatory medicine, unless those courses have already been completed as part of the candidate’s fellowship or post-graduate training.  Additional courses relevant to the candidate’s research interests, including hands-on training in laboratory methods and translational research, may be included in the candidate’s research plan. 
  6. Special attention will be given to recruitment of candidates representing diverse background and underserved groups, including minorities and women.


  1. All candidates must be U.S. citizens, naturalized citizens, or permanent residents. Individuals on temporary or student visas are not eligible.
  2. Candidates must be able to spend a minimum of 75 percent effort conducting research and research career development including courses during the period of the award.
  3. Eligible appointees must be physicians in a cancer related specialty and must hold the HMS title of Instructor as of the time of appointment.
  4. Individuals who may have been or currently are a PI of an NIH R03 or R21 grant or a PHS or non-Federal award that duplicates the provisions of an R03 or R21 grant remain eligible for an NCI K12 appointment
  5. Individuals are NOT eligible for an appointment if they:
  • Have been or are currently PIs on an NCI or NIH individual mentored career development career, e.g., K01, K07, K08, K23 award;  an NCI Transition Career Award (K22);  the Pathway to Independence (K99/R00) award; or non-PHS equivalents;
  • Have been or are currently a PI on NIH research grants (such as R01, Program Project (P01) or Cancer Center (P50) grants or subprojects of such grants); and
  • Have been or are currently a PI on peer-reviewed non-NIH research grants over $100,000 in direct costs per year intended for faculty independent investigators.      

Application Format:

A formal application will be required, in which the candidate will present:

  1. K12 Application Cover Sheet. (Please use the coversheet listed under "related files" below)
  2. A complete curriculum vitae and bibliography
  3. A proposal for a multiyear research project in clinical or translational cancer research. This should be organized as follows (maximum length: 5 pages): Introduction, Specific Aims, Background and Rationale, Preliminary Findings, Experimental Plan, Timetable for completion of project and references. References are not included within the 5-page limit.
  4. A plan for didactic coursework (maximum length: one page).  The plan should include training in the responsible conduct of research and service on a DFHCC scientific Review committee for at least one year.  The candidates training plan should include taking the year long course in Translational Research offered by Harold Burstein, MD, PhD at the DFCI.
  5. A plan for mentorship (maximum length: one page)
  6. Attestation of support from both the institution and the proposed mentor(s), in letter format.  A total of three letters of recommendation must accompany applications.  This includes a letter from the candidate’s Chief of Service, in which the institution’s commitment to the long-term development of the candidate’s career is stated.  If the candidate is not already in a faculty position, the institution should provide evidence of intent to support promotion of the candidate to faculty status in a clinical oncology department (Radiation Therapy, Surgery, Medical, Pediatric or Nursing Oncology).

If you wish to apply for this award, please email your application by Friday, May 27, 2016 to Lee Jaffe at LBJAFFE@PARTNERS.ORG

Please do not include copies of IRB protocols. All files must be in PDF format and the reference letters must include signatures.  If you submit more than one PDF file, please label each file “Applicant’s Last Name # of #”.  For example, if the applicant’s last name is John Anderson, the files should be named as follows:

Anderson 1 of 6.pdf
Anderson 2 of 6.pdf
Anderson 3 of 6.pdf