Photo of A. Lindsay Frazier,  MD

A. Lindsay Frazier, MD

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute
Phone: (617) 632-2273
Fax: (617) 632-4850


Lindsay_Frazier@dfci.harvard.edu

A. Lindsay Frazier, MD

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Associate Professor, Pediatrics, Harvard Medical School
  • Associate Professor, Pediatric Oncology, Dana-Farber Cancer Institute
  • Research Associate, Nutrition, Harvard T.H. Chan School Of Public Health

DF/HCC PROGRAM AFFILIATION

DF/HCC ASSOCIATIONS

  • Member, Center Scientific Council

Research Abstract

My research is focused in three main areas: (1) adolescent exposures that predispose to adult malignancy (tobacco, diet, alcohol, physical activity), (2) cancer prevention policy-both primary and secondary prevention, (3) treatment of germ cell tumors in pediatric patients. Three cohort studies: Nurses' Health Study (NHS), Nurses' Health Study II (NHSII), and the Growing Up Today Study (GUTS) serve as the basis for my epidemiologic research; the National Consortium of Pediatric Oncologists, the Pediatric Oncology Group, is the basis for the clinical trials that I co-chair.

Publications

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  • Cornejo KM, Frazier L, Lee RS, Kozakewich HP, Young RH. Yolk Sac Tumor of the Testis in Infants and Children: A Clinicopathologic Analysis of 33 Cases. Am J Surg Pathol 2015. PubMed
  • Rescorla FJ, Ross JH, Billmire DF, Dicken BJ, Villaluna D, Davis MM, Krailo M, Cullen JW, Olson TA, Egler RA, Amatruda JF, Rodrigues-Galindo C, Frazier AL. Surveillance after initial surgery for Stage I pediatric and adolescent boys with malignant testicular germ cell tumors: Report from the Children's Oncology Group. J Pediatr Surg 2015. PubMed
  • Frazier AL, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray MJ, Amatruda JF, Thornton C, Arul GS, Billmire D, Shaikh F, Pashankar F, Stoneham S, Krailo M, Nicholson JC. Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United Kingdom and United States. J Clin Oncol 2015; 33:195-201. PubMed
  • Billmire DF, Rescorla FJ, Ross JH, Schlatter MG, Dicken BJ, Krailo MD, Rodriguez-Galindo C, Olson TA, Cullen JW, Frazier AL. Impact of central surgical review in a study of malignant germ cell tumors. J Pediatr Surg 2015. PubMed
  • Roberts AL, Rosario M, Calzo JP, Corliss HL, Frazier L, Austin SB. Masculine boys, feminine girls, and cancer risk behaviors: an 11-year longitudinal study. J Adolesc Health 2014. PubMed
  • Stoneham SJ, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray M, Amatruda JF, Thornton C, Arul GS, Billmire D, Krailo M, Stark D, Covens A, Hurteau J, Stenning S, Nicholson JC, Gershenson D, Frazier AL. Adolescents and Young Adults With a "Rare" Cancer: Getting Past Semantics to Optimal Care for Patients With Germ Cell Tumors. Oncologist 2014. PubMed
  • Banerjee SC, Hay JL, Geller AC, Gagne JJ, Frazier AL. Quitting the "Cancer Tube": a qualitative examination of the process of indoor tanning cessation. Transl Behav Med 2014; 4:209-19. PubMed
  • Schultz KA, Harris A, Williams GM, Baldinger S, Doros L, Valusek P, Frazier AL, Dehner LP, Messinger Y, Hill DA. Judicious DICER1 testing and surveillance imaging facilitates early diagnosis and cure of pleuropulmonary blastoma. Pediatr Blood Cancer 2014. PubMed
  • Boeke CE, Tamimi RM, Berkey CS, Colditz GA, Eliassen AH, Malspeis S, Willett WC, Frazier AL. Adolescent Carotenoid Intake and Benign Breast Disease. Pediatrics 2014. PubMed
  • Vergamini LB, Frazier AL, Abrantes FL, Ribeiro KB, Rodriguez-Galindo C. Increase in the Incidence of Differentiated Thyroid Carcinoma in Children, Adolescents, and Young Adults: A Population-Based Study. J Pediatr 2014. PubMed
  • Denburg AE, Knaul FM, Atun R, Frazier LA, Barr RD. Beyond the bench and the bedside: economic and health systems dimensions of global childhood cancer outcomes. Pediatr Blood Cancer 2014; 61:572-6. PubMed
  • Billmire DF, Cullen JW, Rescorla FJ, Davis M, Schlatter MG, Olson TA, Malogolowkin MH, Pashankar F, Villaluna D, Krailo M, Egler RA, Rodriguez-Galindo C, Frazier AL. Surveillance after initial surgery for pediatric and adolescent girls with stage I ovarian germ cell tumors: report from the Children's Oncology Group. J Clin Oncol 2014; 32:465-70. PubMed
  • Charlton BM, Corliss HL, Missmer SA, Frazier AL, Rosario M, Kahn JA, Austin SB. Influence of hormonal contraceptive use and health beliefs on sexual orientation disparities in Papanicolaou test use. Am J Public Health 2014; 104:319-25. PubMed
  • Coccia PF, Pappo AS, Altman J, Bhatia S, Borinstein SC, Flynn J, Frazier AL, George S, Goldsby R, Hayashi R, Huang MS, Johnson RH, Beaupin LK, Link MP, Oeffinger KC, Orr KM, Reed D, Spraker HL, Thomas DA, von Mehren M, Wechsler DS, Whelan KF, Zebrack B, Shead DA, Sundar H. Adolescent and young adult oncology, version 2.2014. J Natl Compr Canc Netw 2014; 12:21-32; quiz 32. PubMed
  • Malogolowkin MH, Krailo M, Marina N, Olson T, Frazier AL. Pilot study of cisplatin, etoposide, bleomycin, and escalating dose cyclophosphamide therapy for children with high risk germ cell tumors: a report of the children's oncology group (COG). Pediatr Blood Cancer 2013; 60:1602-5. PubMed
  • Berkey CS, Willett WC, Tamimi RM, Rosner B, Frazier AL, Colditz GA. Vegetable protein and vegetable fat intakes in pre-adolescent and adolescent girls, and risk for benign breast disease in young women. Breast Cancer Res Treat 2013; 141:299-306. PubMed
  • Rodriguez-Galindo C, Krailo M, Frazier L, Chintagumpala M, Amatruda J, Katzenstein H, Malogolowkin M, Spector L, Pashankar F, Meyers R, Tomlinson G, . Children's Oncology Group's 2013 blueprint for research: Rare tumors. Pediatr Blood Cancer 2013; 60:1016-21. PubMed
  • Frazier AL, Rosenberg SM. Preadolescent and adolescent risk factors for benign breast disease. J Adolesc Health 2013; 52:S36-40. PubMed
  • Berkey CS, Willett WC, Tamimi RM, Rosner B, Frazier AL, Colditz GA. Dairy intakes in older girls and risk of benign breast disease in young women. Cancer Epidemiol Biomarkers Prev 2013; 22:670-4. PubMed
  • Rodriguez-Galindo C, Friedrich P, Morrissey L, Frazier L. Global challenges in pediatric oncology. Curr Opin Pediatr 2013; 25:3-15. PubMed
  • Amatruda JF, Ross JA, Christensen B, Fustino NJ, Chen KS, Hooten AJ, Nelson H, Kuriger JK, Rakheja D, Frazier AL, Poynter JN. DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors. BMC Cancer 2013; 13:313. PubMed
  • Fligor BJ, Krasker JD, Villaluna D, Krailo M, Frazier AL. "Accelerated ear-age": a new measure of chemotherapy-induced ototoxicity. Pediatr Blood Cancer 2012; 59:947-9. PubMed
  • Shaikh F, Nathan PC, Hale J, Uleryk E, Frazier L. Is there a role for carboplatin in the treatment of malignant germ cell tumors? A systematic review of adult and pediatric trials. Pediatr Blood Cancer 2012. PubMed
  • Pérez-Cuevas R, Doubova SV, Zapata-Tarres M, Flores-Hernández S, Frazier L, Rodríguez-Galindo C, Cortes-Gallo G, Chertorivski-Woldenberg S, Muñoz-Hernández O. Scaling up cancer care for children without medical insurance in developing countries: The case of Mexico. Pediatr Blood Cancer 2012. PubMed
  • Troisi R, Altantsetseg D, Davaasambuu G, Rich-Edwards J, Davaalkham D, Tretli S, Hoover RN, Frazier AL. Breast cancer incidence in Mongolia. Cancer Causes Control 2012; 23:1047-53. PubMed
  • Berkey CS, Willett WC, Frazier AL, Rosner B, Tamimi RM, Colditz GA. Prospective study of growth and development in older girls and risk of benign breast disease in young women. Cancer 2011. PubMed
  • Frazier AL, Shamberger RC, Henderson TO, Diller L. Decision analysis to compare treatment strategies for Stage I/favorable histology Wilms tumor. Pediatr Blood Cancer 2010; 54:879-84. PubMed
  • Berkey CS, Willett WC, Frazier AL, Rosner B, Tamimi RM, Rockett HR, Colditz GA. Prospective Study of Adolescent Alcohol Consumption and Risk of Benign Breast Disease in Young Women. Pediatrics 2010; 125:e1081-7. PubMed
  • Linos E, Willett WC, Cho E, Frazier L. Adolescent diet in relation to breast cancer risk among premenopausal women. Cancer Epidemiol Biomarkers Prev 2010; 19:689-96. PubMed
  • Ayyanar K, Blackman SC, Chordas C, Frazier L, Kieran MW. Metachronous mediastinal seminoma occurring after intracranial germinoma in an adolescent. J Pediatr Hematol Oncol 2009; 31:861-4. PubMed
  • West JA, Viswanathan SR, Yabuuchi A, Cunniff K, Takeuchi A, Park IH, Sero JE, Zhu H, Perez-Atayde A, Frazier AL, Surani MA, Daley GQ. A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature 2009; 460:909-13. PubMed
  • Kahn JA,Ding L,Huang B,Zimet GD,Rosenthal SL,Frazier AL. Mothers' intention for their daughters and themselves to receive the human papillomavirus vaccine: a national study of nurses. Pediatrics 2009; 123:1439-45. PubMed
  • Linos E,Willett WC,Cho E,Colditz G,Frazier LA. Red meat consumption during adolescence among premenopausal women and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2008; 17:2146-51. PubMed
  • Kahn JA, Huang B, Gillman MW, Field AE, Austin SB, Colditz GA, Frazier AL. Patterns and determinants of physical activity in U.S. adolescents. J Adolesc Health 2008; 42:369-77. PubMed
  • Frazier AL, Rumcheva P, Olson T, Giller R, Cushing B, Cullen J, Marina N, London WB. Application of the adult international germ cell classification system to pediatric malignant non-seminomatous germ cell tumors: a report from the Children's Oncology Group. Pediatr Blood Cancer 2007; 50:746-51. PubMed
  • Fisher LB, Winickoff JP, Camargo CA Jr, Colditz GA, Frazier AL. Household smoking restrictions and adolescent smoking. Am J Health Promot 2007; 22:15-21. PubMed
  • Taveras EM, Field AE, Berkey CS, Rifas-Shiman SL, Frazier AL, Colditz GA, Gillman MW. Longitudinal relationship between television viewing and leisure-time physical activity during adolescence. Pediatrics 2007; 119:e314-9. PubMed
  • O'Riordan DL, Field AE, Geller AC, Brooks DR, Aweh G, Colditz GA, Frazier AL. Frequent tanning bed use, weight concerns, and other health risk behaviors in adolescent females (United States). Cancer Causes Control 2006; 17:679-86. PubMed
  • Marina N, London WB, Frazier AL, Lauer S, Rescorla F, Cushing B, Malogolowkin MH, Castleberry RP, Womer RB, Olson T. Prognostic factors in children with extragonadal malignant germ cell tumors: a pediatric intergroup study. J Clin Oncol 2006; 24:2544-8. PubMed
  • Geller AC, Brooks DR, Colditz GA, Koh HK, Frazier AL. Sun protection practices among offspring of women with personal or family history of skin cancer. Pediatrics 2006; 117:e688-94. PubMed
  • Barbeau EM, Li Y, Calderon P, Hartman C, Quinn M, Markkanen P, Roelofs C, Frazier L, Levenstein C. Results of a union-based smoking cessation intervention for apprentice iron workers (United States). Cancer Causes Control 2006; 17:53-61. PubMed
  • Gillman MW, Rifas-Shiman SL, Berkey CS, Frazier AL, Rockett HR, Camargo CA, Field AE, Colditz GA. Breast-feeding and overweight in adolescence. Epidemiology 2005; 17:112-4. PubMed
  • Stoddard AM, Fagan P, Sorensen G, Hunt MK, Frazier L, Girod K. Reducing cigarette smoking among working adolescents: results from the SMART study. Cancer Causes Control 2005; 16:1159-64. PubMed
  • Marina N, Chang KW, Malogolowkin M, London WB, Frazier AL, Womer RB, Rescorla F, Billmire DF, Davis MM, Perlman EJ, Giller R, Lauer SJ, Olson TA,. Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors: a Children's Oncology Group study. Cancer 2005; 104:841-7. PubMed
  • Taveras EM, Rifas-Shiman SL, Berkey CS, Rockett HR, Field AE, Frazier AL, Colditz GA, Gillman MW. Family dinner and adolescent overweight. Obes Res 2005; 13:900-6. PubMed
  • Thomson CC, Fisher LB, Winickoff JP, Colditz GA, Camargo CA, King C, Frazier AL. State tobacco excise taxes and adolescent smoking behaviors in the United States. J Public Health Manag Pract 2005; 10:490-6. PubMed
  • Austin SB, Ziyadeh N, Kahn JA, Camargo CA, Colditz GA, Field AE. Sexual Orientation, Weight Concerns, and Eating-Disordered Behaviors in Adolescent Girls and Boys. J Am Acad Child Adolesc Psychiatry 2004; 43:1115-1123. PubMed
  • Austin SB, Ziyadeh N, Fisher LB, Kahn JA, Colditz GA, Frazier AL. Sexual orientation and tobacco use in a cohort study of US adolescent girls and boys. Arch Pediatr Adolesc Med 2004; 158:317-22. PubMed
  • Frazier AL, Li L, Cho E, Willett WC, Colditz GA. Adolescent diet and risk of breast cancer. Cancer Causes Control 2004; 15:73-82. PubMed
  • Hunt MK, Fagan P, Lederman R, Stoddard A, Frazier L, Girod K, Sorensen G. Feasibility of implementing intervention methods in an adolescent worksite tobacco control study. Tob Control 2003; 12 Suppl 4:IV40-IV45. PubMed
  • Fagan P, Stoddard AM, Hunt MK, Frazier L, Girod K, Sorensen G. The feasibility of evaluating a tobacco control intervention for working youth. Tob Control 2003; 12 Suppl 4:IV34-IV39. PubMed
  • Fagan P, Eisenberg M, Frazier L, Stoddard AM, Avrunin JS, Sorensen G. Employed adolescents and beliefs about self-efficacy to avoid smoking. Addict Behav 2003; 28:613-26. PubMed
  • Frazier AL, Ryan CT, Rockett H, Willett WC, Colditz GA. Adolescent diet and risk of breast cancer. Breast Cancer Res 2003; 5:R59-64. PubMed
  • Geller AC, Colditz G, Oliveria S, Emmons K, Jorgensen C, Aweh GN, Frazier AL. Use of sunscreen, sunburning rates, and tanning bed use among more than 10 000 US children and adolescents. Pediatrics 2002; 109:1009-14. PubMed
  • Kahn JA, Colditz G, Aweh GN, Frazier AL. Prevalence and correlates of pelvic examinations in sexually active female adolescents. Ambul Pediatr 2002; 2:212-7. PubMed
  • Fagan P, Eisenberg M, Stoddard AM, Frazier L, Sorensen G. Social influences, social norms, social support, and smoking behavior among adolescent workers. Am J Health Promot 2001; 15:414-21. PubMed
  • Frazier AL, Colditz GA, Fuchs CS, Kuntz KM. Cost-effectiveness of screening for colorectal cancer in the general population. JAMA 2000; 284:1954-61. PubMed
  • Berkey CS, Gardner JD, Frazier AL, Colditz GA. Relation of childhood diet and body size to menarche and adolescent growth in girls. Am J Epidemiol 2000; 152:446-52. PubMed
  • Gillman MW, Rifas-Shiman SL, Frazier AL, Rockett HR, Camargo CA, Field AE, Berkey CS, Colditz GA. Family dinner and diet quality among older children and adolescents. Arch Fam Med 2000; 9:235-40. PubMed
  • Tomeo CA, Rich-Edwards JW, Michels KB, Berkey CS, Hunter DJ, Frazier AL, Willett WC, Buka SL. Reproducibility and validity of maternal recall of pregnancy-related events. Epidemiology 1999; 10:774-7. PubMed
  • Tomeo CA, Field AE, Berkey CS, Colditz GA, Frazier AL. Weight concerns, weight control behaviors, and smoking initiation. Pediatrics 1999; 104:918-24. PubMed
  • Field AE, Camargo CA, Taylor CB, Berkey CS, Frazier AL, Gillman MW, Colditz GA. Overweight, weight concerns, and bulimic behaviors among girls and boys. J Am Acad Child Adolesc Psychiatry 1999; 38:754-60. PubMed
  • Berkey CS, Frazier AL, Gardner JD, Colditz GA. Adolescence and breast carcinoma risk. Cancer 1999; 85:2400-9. PubMed
  • Rockett HR, Breitenbach M, Frazier AL, Witschi J, Wolf AM, Field AE, Colditz GA. Validation of a youth/adolescent food frequency questionnaire. Prev Med 1997; 26:808-16. PubMed
  • Colditz GA, Cannuscio CC, Frazier AL. Physical activity and reduced risk of colon cancer: implications for prevention. Cancer Causes Control 1997; 8:649-67. PubMed
  • Frazier AL, Grier HE, Green DM. Treatment of endodermal sinus tumor in children using a regimen that lacks bleomycin. Med Pediatr Oncol 1996; 27:69-73. PubMed
  • Frazier AL, Willett WC, Colditz GA. Reproducibility of recall of adolescent diet: Nurses' Health Study (United States). Cancer Causes Control 1995; 6:499-506. PubMed
  • Colditz GA, Frazier AL. Models of breast cancer show that risk is set by events of early life: prevention efforts must shift focus. Cancer Epidemiol Biomarkers Prev 1995; 4:567-71. PubMed
  • Tsuzaki S, Cone RD, Frazier AL, Moses AC. The interaction of signal transduction pathways in FRTL5 thyroid follicular cells: studies with stable expression of beta 2-adrenergic receptors. Endocrinology 1991; 128:1359-68. PubMed
  • Frazier AL, Robbins LS, Stork PJ, Sprengel R, Segaloff DL, Cone RD. Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing. Mol Endocrinol 1990; 4:1264-76. PubMed
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