Photo of Adrian Salic,  PhD

Adrian Salic, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 432-6341
Fax: (617) 432-6339


asalic@hms.harvard.edu

Adrian Salic, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • Associate Professor, Cell Biology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Publications

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  • Tukachinsky H, Petrov K, Watanabe M, Salic A. Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog. Proc Natl Acad Sci U S A 2016; 113:E5866-E5875. PubMed
  • Huang P, Nedelcu D, Watanabe M, Jao C, Kim Y, Liu J, Salic A. Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling. Cell 2016; 166:1176-1187.e14. PubMed
  • Broadus MR, Chen TW, Neitzel LR, Ng VH, Jodoin JN, Lee LA, Salic A, Robbins DJ, Capobianco AJ, Patton JG, Huppert SS, Lee E. Identification of a Paralog-Specific Notch1 Intracellular Domain Degron. Cell Rep 2016; 15:1920-9. PubMed
  • Jao CY, Nedelcu D, Lopez LV, Samarakoon TN, Welti R, Salic A. Bioorthogonal probes for imaging sterols in cells. Chembiochem 2015; 16:611-7. PubMed
  • Jao CY, Roth M, Welti R, Salic A. Biosynthetic labeling and two-color imaging of phospholipids in cells. Chembiochem 2015; 16:472-6. PubMed
  • Iyoshi S, Cheng J, Tatematsu T, Takatori S, Taki M, Yamamoto Y, Salic A, Fujimoto T. Asymmetrical distribution of choline phospholipids revealed by click chemistry and freeze-fracture electron microscopy. ACS Chem Biol 2014; 9:2217-22. PubMed
  • Signer RA, Magee JA, Salic A, Morrison SJ. Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature 2014; 509:49-54. PubMed
  • Nedelcu D, Liu J, Xu Y, Jao C, Salic A. Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat Chem Biol 2013; 9:557-64. PubMed
  • Tukachinsky H, Kuzmickas RP, Jao CY, Liu J, Salic A. Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand. Cell Rep 2012; 2:308-20. PubMed
  • Liu J, Xu Y, Stoleru D, Salic A. Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin. Proc Natl Acad Sci U S A 2012; 109:413-8. PubMed
  • Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA, Salic A. Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol 2011; 192:825-38. PubMed
  • Tukachinsky H, Lopez LV, Salic A. A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J Cell Biol 2010; 191:415-28. PubMed
  • Jao CY, Roth M, Welti R, Salic A. Metabolic labeling and direct imaging of choline phospholipids in vivo. Proc Natl Acad Sci U S A 2009; 106:15332-7. PubMed
  • Jao CY, Salic A. Exploring RNA transcription and turnover in vivo by using click chemistry. Proc Natl Acad Sci U S A 2008; 105:15779-84. PubMed
  • Buck SB, Bradford J, Gee KR, Agnew BJ, Clarke ST, Salic A. Detection of S-phase cell cycle progression using 5-ethynyl-2'-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2'-deoxyuridine antibodies. BioTechniques 2008; 44:927-9. PubMed
  • Salic A, Mitchison TJ. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A 2008; 105:2415-20. PubMed
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