Photo of Alan B Cantor,  MD, PhD

Alan B Cantor, MD, PhD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 919-2026
Fax: (617) 730-0222


alan.cantor@childrens.harvard.edu

Alan B Cantor, MD, PhD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Pediatrics, Harvard Medical School
  • Assistant in Medicine, Medicine, Boston Children's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

The Cantor laboratory is interested in further elucidating how dysregulation of normal hematopoietic transcriptional mechanisms contributes to human leukemogenesis. We have a particular interest in early initiating events events in leukemogenesis. This includes proteomic, genomic, epigenetic, and biochemical studies of members of the GATA and RUNX transcription factor families, which are frequently mutated in human leukemias. We have also applied genetic studies of familial leukemia/myelodysplastic predisposition syndromes, such as Familial Platelet Disorder with Propensity to Develop Leukemia (FPD/AML) to identify novel genes involved in human leukemogenesis. Our studies also examine the molecular basis of Down Syndrome Transient Myeloproliferative Disorder (DS-TMD) and Acute Megakaryoblastic Leukemia (DS-AMKL), as well as Juvenile Myelomonocytic Leukemia.

Publications

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  • Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Schultz IJ, Dalton AJ, Wittig JG, Palis J, Orkin SH, Lodish HF, Eisenstein RS, Cantor AB, Paw BH. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal 2015; 8:ra34. PubMed
  • Woo AJ, Wieland K, Huang H, Akie TE, Piers T, Kim J, Cantor AB. Developmental differences in IFN signaling affect GATA1s-induced megakaryocyte hyperproliferation. J Clin Invest 2013. PubMed
  • Huang H, Woo AJ, Waldon Z, Schindler Y, Moran TB, Zhu HH, Feng GS, Steen H, Cantor AB. A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev 2012; 26:1587-601. PubMed
  • Yu M, Mazor T, Huang H, Huang HT, Kathrein KL, Woo AJ, Chouinard CR, Labadorf A, Akie TE, Moran TB, Xie H, Zacharek S, Taniuchi I, Roeder RG, Kim CF, Zon LI, Fraenkel E, Cantor AB. Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell 2012; 45:330-43. PubMed
  • Woo AJ, Kim J, Xu J, Huang H, Cantor AB. Role of ZBP-89 in human globin gene regulation and erythroid differentiation. Blood 2011; 118:3684-93. PubMed
  • Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 2010; 143:313-24. PubMed
  • Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell 2010; 142:133-43. PubMed
  • Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, Yu D, Hardison R, Weiss MJ, Orkin SH, Bernstein BE, Fraenkel E, Cantor AB. Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell 2009; 36:682-95. PubMed
  • Huang H, Cantor AB. Common features of megakaryocytes and hematopoietic stem cells: what's the connection? J Cell Biochem 2009; 107:857-64. PubMed
  • Huang H, Yu M, Akie TE, Moran TB, Woo AJ, Tu N, Waldon Z, Lin YY, Steen H, Cantor AB. Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development. Mol Cell Biol 2009; 29:4103-15. PubMed
  • Wang J,Cantor AB,Orkin SH. Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation. Curr Protoc Stem Cell Biol 2009; Chapter 1:Unit1B.5. PubMed
  • Kim J,Cantor AB,Orkin SH,Wang J. Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nat Protoc 2009; 4:506-17. PubMed
  • Sankaran VG,Menne TF,Xu J,Akie TE,Lettre G,Van Handel B,Mikkola HK,Hirschhorn JN,Cantor AB,Orkin SH. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science 2008; 322:1839-42. PubMed
  • Hawley RG, Hawley TS, Cantor AB. TLX1 (HOX11) immortalization of embryonic stem cell-derived and primary murine hematopoietic progenitors. Curr Protoc Stem Cell Biol 2008; Chapter 1:Unit 1F.7. PubMed
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