Photo of Alan B. Packard,  PhD

Alan B. Packard, PhD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 355-7539
Fax: (617) 730-0619


alan.packard@childrens.harvard.edu

Alan B. Packard, PhD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Radiology, Harvard Medical School
  • Senior Research Associate, Nuclear Medicine, Boston Children's Hospital

Research Abstract

Our laboratory is engaged in the development of radiolabeled proteins and small molecules for multiple applications including cancer imaging and therapy and F-18-labeled small molecules for myocardial perfusion imaging. The focus of the cancer program is on the development of Cu-64- and Zr-89-labeled antibodies that can be used to noninvasively evaluate disease status as well as target status for therapy with the unlabeled antibody. We are also developing antibodies labeled with therapeutic radionuclides such as Lu-177 than can be used to treat small metastatic lesions before than develop become problemmatic.

 

Publications

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  • O'Neill AF, Dearling JL, Wang Y, Tupper T, Sun Y, Aster JC, Calicchio ML, Perez-Atayde AR, Packard AB, Kung AL. Targeted imaging of Ewing sarcoma in preclinical models using a 64Cu-labeled anti-CD99 antibody. Clin Cancer Res 2014; 20:678-87. PubMed
  • Dearling JL, Barnes JW, Panigrahy D, Zimmerman RE, Fahey F, Treves ST, Morrison MS, Kieran MW, Packard AB. Specific uptake of 99mTc-NC100692, an 留v硫3-targeted imaging probe, in subcutaneous and orthotopic tumors. Nucl Med Biol 2013; 40:788-94. PubMed
  • Vavere AL, Butch ER, Dearling JL, Packard AB, Navid F, Shulkin BL, Barfield RC, Snyder SE. 64Cu-p-NH2-Bn-DOTA-hu14.18K322A, a PET Radiotracer Targeting Neuroblastoma and Melanoma. J Nucl Med 2012; 53:1772-8. PubMed
  • Dearling JL, Voss SD, Dunning P, Snay E, Fahey F, Smith SV, Huston JS, Meares CF, Treves ST, Packard AB. Imaging cancer using PET--the effect of the bifunctional chelator on the biodistribution of a (64)Cu-labeled antibody. Nucl Med Biol 2011; 38:29-38. PubMed
  • Grant FD, Fahey FH, Packard AB, Davis RT, Alavi A, Treves ST. Skeletal PET with 18F-fluoride: applying new technology to an old tracer. J Nucl Med 2007; 49:68-78. PubMed
  • Voss SD, Smith SV, DiBartolo N, McIntosh LJ, Cyr EM, Bonab AA, Dearling JL, Carter EA, Fischman AJ, Treves ST, Gillies SD, Sargeson AM, Huston JS, Packard AB. Positron emission tomography (PET) imaging of neuroblastoma and melanoma with 64Cu-SarAr immunoconjugates. Proc Natl Acad Sci U S A 2007; 104:17489-93. PubMed
  • Treves ST, Packard AB, Fung LC. Assessment of rapid changes in renal blood flow with (191m)ir, an ultra-short-lived radionuclide. J Nucl Med 2004; 45:508-11. PubMed
  • Kiani S, Staples RJ, Packard AB. A lariat-functionalized copper(II) diimine-dioxime complex. Acta Crystallogr C 2002; 58:m593-5. PubMed
  • Packard AB, Kronauge JF, Barbarics E, Kiani S, Treves ST. Synthesis and biodistribution of a Lipophilic 64Cu-labeled monocationic Copper(II) complex. Nucl Med Biol 2002; 29:289-94. PubMed
  • Inouye H, Nguyen JT, Fraser PE, Shinchuk LM, Packard AB, Kirschner DA. Histidine residues underlie Congo red binding to A beta analogs. Amyloid 2000; 7:179-88. PubMed
  • Pandey MK, Byrne JF, Jiang H, Packard AB, DeGrado TR. Cyclotron production of (68)Ga via the (68)Zn(p,n)(68)Ga reaction in aqueous solution Am J Nucl Med Mol Imaging 2014; 4:303-10.
  • Treves ST, Fung L, Packard AB. Rapid renal single-photon emission tomography by continuous infusion of iridium-191m. Eur J Nucl Med 1999; 26:489-93. PubMed
  • Packard AB, Kronauge JF, Day PJ, Treves ST. Synthesis and biodistribution of 64Cu-labeled monocationic diiminedioxime copper(II) complexes. Nucl Med Biol 1998; 25:531-7. PubMed
  • Packard AB, Barbarics E, Kronauge JF, Wen PY, Day PJ, Jones AG. Comparison of uptake of 99mTc-alkylisonitriles in the rat 9L gliosarcoma tumor model. Nucl Med Biol 1997; 24:21-5. PubMed
  • Packard AB, Roach PJ, Davis RT, Carmant L, Davis R, Riviello J, Holmes G, Barnes PD, O'Tuama LA, Bjornson B, Treves ST. Ictal and interictal technetium-99m-bicisate brain SPECT in children with refractory epilepsy. J Nucl Med 1996; 37:1101-6. PubMed
  • Packard AB, Day PJ, Treves ST. An improved 191Os/191mIr generator using a hybrid anion exchanger. Nucl Med Biol 1995; 22:887-91. PubMed
  • Packard AB, Kronauge JF, Limpa-Amara N, Lampson L, O'Tuama LA, Jones AG. Tumor uptake of 99mTc-MIBI and 201Tl by a 9L gliosarcoma brain tumor model in rats. Nucl Med Biol 1993; 20:773-6. PubMed
  • O'Tuama LA, Treves ST, Larar JN, Packard AB, Kwan AJ, Barnes PD, Scott RM, Black PM, Madsen JR, Goumnerova LC. Thallium-201 versus technetium-99m-MIBI SPECT in evaluation of childhood brain tumors: a within-subject comparison. J Nucl Med 1993; 34:1045-51. PubMed
  • Packard AB, Lambert C. Evaluation of osmium(II)-nitrosyl complexes as a method to increase the yield of the 191Os-191mIr generator. Int J Rad Appl Instrum B 1992; 19:357-62. PubMed
  • O'Tuama LA, Packard AB, Treves ST. SPECT imaging of pediatric brain tumor with hexakis (methoxyisobutylisonitrile) technetium (I). J Nucl Med 1990; 31:2040-1. PubMed
  • Packard AB, Srivastava SC, Richards P, Meinken GE, Ford L, Benson WR. Synthesis and biological properties of the lipophilic technetium-99m complex 99mTc(acac)3. Int J Rad Appl Instrum B 1988; 16:291-4. PubMed
  • Heller GV, Treves ST, Parker JA, Duke LA, O'Brien GM, Davis RT, Fitzgibbon C, Packard AB. Comparison of ultrashort-lived iridium-191m with technetium-99m for first pass radionuclide angiocardiographic evaluation of right and left ventricular function in adults. J Am Coll Cardiol 1986; 7:1295-302. PubMed
  • Packard AB, O'Brien GM, Treves S. The development of an 191Os----191mIr generator using an osmium chelate parent complex--I. Trans-dioxobismalonatoosmate(VI). Int J Rad Appl Instrum B 1985; 13:519-22. PubMed
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