Photo of Alex,  Shu-Wing Ng, PhD

Alex, Shu-Wing Ng, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 278-0072
Fax: (617) 975-0856


sng@rics.bwh.harvard.edu

Alex, Shu-Wing Ng, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School
  • Associate Director of Research, Gynecologic Oncology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

We employed multidisciplinary genomics and proteomics methods to screen for potential ovarian cancer biomarkers and novel therapeutic targets. Ongoing projects include microRNA, activity-based profiling of deregulated enzymes and metabolomics, cancer signaling pathways, functions of transcription factors and chromatin modifiers in cancer stem cells and ovarian pathogenesis, tumor heterogeneity and identification of tumor type-specific molecular signatures for potential application to precision medicine.

Publications

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  • Zhang Y, Kwok JS, Choi PW, Liu M, Yang J, Singh M, Ng SK, Welch WR, Muto MG, Tsui SK, Sugrue SP, Berkowitz RS, Ng SW. Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells. 2016; 7:11397-411. PubMed
  • Choi PW, Yang J, Ng SK, Feltmate C, Muto MG, Hasselblatt K, Lafferty-Whyte K, JeBailey L, MacConaill L, Welch WR, Fong WP, Berkowitz RS, Ng SW. Loss of E-cadherin disrupts ovarian epithelial inclusion cyst formation and collective cell movement in ovarian cancer cells. 2016; 7:4110-21. PubMed
  • Worley MJ, Liu S, Hua Y, Kwok JS, Samuel A, Hou L, Shoni M, Lu S, Sandberg EM, Keryan A, Wu D, Ng SK, Kuo WP, Parra-Herran CE, Tsui SK, Welch W, Crum C, Berkowitz RS, Ng SW. Molecular changes in endometriosis-associated ovarian clear cell carcinoma. Eur J Cancer 2015. PubMed
  • Ng SK, McLachlan GJ, Wang K, Nagymanyoki Z, Liu S, Ng SW. Inference on differences between classes using cluster-specific contrasts of mixed effects. Biostatistics 2014. PubMed
  • Benjamin DI, Louie SM, Mulvihill MM, Kohnz RA, Li DS, Chan LG, Sorrentino A, Bandyopadhyay S, Cozzo A, Ohiri A, Goga A, Ng SW, Nomura DK. Inositol phosphate recycling regulates glycolytic and lipid metabolism that drives cancer aggressiveness. ACS Chem Biol 2014. PubMed
  • Esselen KM, Ng SK, Hua Y, White M, Jimenez CA, Welch WR, Drapkin R, Berkowitz RS, Ng SW. Endosalpingiosis as it relates to tubal, ovarian and serous neoplastic tissues: an immunohistochemical study of tubal and M├╝llerian antigens. Gynecol Oncol 2014; 132:316-21. PubMed
  • Lui KO, Howie D, Ng SW, Liu S, Chien KR, Waldmann H. Tolerance induction to human stem cell transplants with extension to their differentiated progeny. Nat Commun 2014; 5:5629. PubMed
  • Shoni M, Lui KO, Vavvas DG, Muto MG, Berkowitz RS, Vlahos N, Ng SW. Protein kinases and associated pathways in pluripotent state and lineage differentiation. Curr Stem Cell Res Ther 2014; 9:366-87. PubMed
  • Greer AH, Yong T, Fennell K, Moustafa YW, Fowler M, Galiano F, Ng SW, Berkowitz RS, Cardelli J, Meyers S, Davis JN. Knockdown of core binding factor╬▓ alters sphingolipid metabolism. J Cell Physiol 2013; 228:2350-64. PubMed
  • Shoni M, Nagymanyoki Z, Vitonis AF, Jimenez C, Ng SW, Quade BJ, Berkowitz RS. p-21-Activated kinase-1, -4 and -6 and estrogen receptor expression pattern in normal placenta and gestational trophoblastic diseases. Gynecol Oncol 2013; 131:759-63. PubMed
  • Zhou S, Tang L, Wang H, Dai J, Zhang J, Shen L, Ng SW, Berkowitz RS. Overexpression of c-Abl predicts unfavorable outcome in epithelial ovarian cancer. Gynecol Oncol 2013; 131:69-76. PubMed
  • Barroilhet L, Yang J, Hasselblatt K, Paranal RM, Ng SK, Rauh-Hain JA, Welch WR, Bradner JE, Berkowitz RS, Ng SW. C-terminal binding protein-2 regulates response of epithelial ovarian cancer cells to histone deacetylase inhibitors. Oncogene 2013; 32:3896-903. PubMed
  • May T, Yang J, Shoni M, Liu S, He H, Gali R, Ng SK, Crum C, Berkowitz RS, Ng SW. BRCA1 expression is epigenetically repressed in sporadic ovarian cancer cells by overexpression of C-terminal binding protein 2. Neoplasia 2013; 15:600-8. PubMed
  • Worley MJ, Welch WR, Berkowitz RS, Ng SW. Endometriosis-associated ovarian cancer: a review of pathogenesis. Int J Mol Sci 2013; 14:5367-79. PubMed
  • Rodriguez N, Yang J, Hasselblatt K, Liu S, Zhou Y, Rauh-Hain JA, Ng SK, Choi PW, Fong WP, Agar NY, Welch WR, Berkowitz RS, Ng SW. Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells. EMBO Mol Med 2012; 4:952-63. PubMed
  • Saw YT, Yang J, Ng SK, Liu S, Singh S, Singh M, Welch WR, Tsuda H, Fong WP, Thompson D, Vasiliou V, Berkowitz RS, Ng SW. Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures. BMC Cancer 2012; 12:329. PubMed
  • Ifediba MA, Medarova Z, Ng SW, Yang J, Moore A. siRNA delivery to CNS cells using a membrane translocation peptide. Bioconjug Chem 2010; 21:803-6. PubMed
  • Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell 2010; 140:49-61. PubMed
  • Tang L, Yang J, Ng SK, Rodriguez N, Choi PW, Vitonis A, Wang K, McLachlan GJ, Caiazzo RJ, Liu BC, Welch WR, Cramer DW, Berkowitz RS, Ng SW. Autoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian cancer. Eur J Cancer 2009; 46:170-9. PubMed
  • Medarova Z,Kumar M,Ng SW,Yang J,Barteneva N,Evgenov NV,Petkova V,Moore A. Multifunctional magnetic nanocarriers for image-tagged SiRNA delivery to intact pancreatic islets. Transplantation 2008; 86:1170-7. PubMed
  • Ehrlich JR, Tang L, Caiazzo RJ Jr, Cramer DW, Ng SK, Ng SW, Liu BC. The "reverse capture" autoantibody microarray : an innovative approach to profiling the autoantibody response to tissue-derived native antigens. Methods Mol Biol 2008; 441:175-92. PubMed
  • Ng SK, McLachlan GJ, Wang K, Ben-Tovim Jones L, Ng SW. A mixture model with random-effects components for clustering correlated gene-expression profiles. Bioinformatics 2006; 22:1745-52. PubMed
  • Singh M, Kindelberger D, Nagymanyoki Z, Ng SW, Quick CM, Yamamoto H, Fichorova R, Fulop V, Berkowitz RS. Vascular endothelial growth factors and their receptors and regulators in gestational trophoblastic diseases and normal placenta. J Reprod Med 2012; 57:197-203. PubMed
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