Alex, Shu-Wing Ng, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 278-0072
Fax: (617) 975-0856


sng@rics.bwh.harvard.edu

Alex, Shu-Wing Ng, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School
  • Associate Director of Research, Gynecologic Oncology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

We employed multidisciplinary genomics and proteomics methods to screen for potential ovarian cancer biomarkers and novel therapeutic targets. Ongoing projects include microRNA, activity-based profiling of deregulated enzymes and metabolomics, cancer signaling pathways, functions of transcription factors and chromatin modifiers in cancer stem cells and ovarian pathogenesis, tumor heterogeneity and identification of tumor type-specific molecular signatures for potential application to precision medicine.

Publications

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  • Worley MJ, Liu S, Hua Y, Kwok JS, Samuel A, Hou L, Shoni M, Lu S, Sandberg EM, Keryan A, Wu D, Ng SK, Kuo WP, Parra-Herran CE, Tsui SK, Welch W, Crum C, Berkowitz RS, Ng SW. Molecular changes in endometriosis-associated ovarian clear cell carcinoma. Eur J Cancer 2015. PubMed
  • Ng SK, McLachlan GJ, Wang K, Nagymanyoki Z, Liu S, Ng SW. Inference on differences between classes using cluster-specific contrasts of mixed effects. Biostatistics 2014. PubMed
  • Benjamin DI, Louie SM, Mulvihill MM, Kohnz RA, Li DS, Chan LG, Sorrentino A, Bandyopadhyay S, Cozzo A, Ohiri A, Goga A, Ng SW, Nomura DK. Inositol Phosphate Recycling Regulates Glycolytic and Lipid Metabolism That Drives Cancer Aggressiveness. ACS Chem Biol 2014. PubMed
  • Esselen KM, Ng SK, Hua Y, White M, Jimenez CA, Welch WR, Drapkin R, Berkowitz RS, Ng SW. Endosalpingiosis as it relates to tubal, ovarian and serous neoplastic tissues: an immunohistochemical study of tubal and M端llerian antigens. Gynecol Oncol 2014; 132:316-21. PubMed
  • Lui KO, Howie D, Ng SW, Liu S, Chien KR, Waldmann H. Tolerance induction to human stem cell transplants with extension to their differentiated progeny. Nat Commun 2014; 5:5629. PubMed
  • Shoni M, Lui KO, Vavvas DG, Muto MG, Berkowitz RS, Vlahos N, Ng SW. Protein kinases and associated pathways in pluripotent state and lineage differentiation. Curr Stem Cell Res Ther 2014; 9:366-87. PubMed
  • Greer AH, Yong T, Fennell K, Moustafa YW, Fowler M, Galiano F, Ng SW, Berkowitz RS, Cardelli J, Meyers S, Davis JN. Knockdown of core binding factor硫 alters sphingolipid metabolism. J Cell Physiol 2013; 228:2350-64. PubMed
  • Shoni M, Nagymanyoki Z, Vitonis AF, Jimenez C, Ng SW, Quade BJ, Berkowitz RS. p-21-Activated kinase-1, -4 and -6 and estrogen receptor expression pattern in normal placenta and gestational trophoblastic diseases. Gynecol Oncol 2013; 131:759-63. PubMed
  • Zhou S, Tang L, Wang H, Dai J, Zhang J, Shen L, Ng SW, Berkowitz RS. Overexpression of c-Abl predicts unfavorable outcome in epithelial ovarian cancer. Gynecol Oncol 2013; 131:69-76. PubMed
  • Barroilhet L, Yang J, Hasselblatt K, Paranal RM, Ng SK, Rauh-Hain JA, Welch WR, Bradner JE, Berkowitz RS, Ng SW. C-terminal binding protein-2 regulates response of epithelial ovarian cancer cells to histone deacetylase inhibitors. Oncogene 2013; 32:3896-903. PubMed
  • May T, Yang J, Shoni M, Liu S, He H, Gali R, Ng SK, Crum C, Berkowitz RS, Ng SW. BRCA1 expression is epigenetically repressed in sporadic ovarian cancer cells by overexpression of C-terminal binding protein 2. Neoplasia 2013; 15:600-8. PubMed
  • Worley MJ, Welch WR, Berkowitz RS, Ng SW. Endometriosis-associated ovarian cancer: a review of pathogenesis. Int J Mol Sci 2013; 14:5367-79. PubMed
  • Rodriguez N, Yang J, Hasselblatt K, Liu S, Zhou Y, Rauh-Hain JA, Ng SK, Choi PW, Fong WP, Agar NY, Welch WR, Berkowitz RS, Ng SW. Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells. EMBO Mol Med 2012; 4:952-63. PubMed
  • Saw YT, Yang J, Ng SK, Liu S, Singh S, Singh M, Welch WR, Tsuda H, Fong WP, Thompson D, Vasiliou V, Berkowitz RS, Ng SW. Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures. BMC Cancer 2012; 12:329. PubMed
  • Ifediba MA, Medarova Z, Ng SW, Yang J, Moore A. siRNA delivery to CNS cells using a membrane translocation peptide. Bioconjug Chem 2010; 21:803-6. PubMed
  • Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell 2010; 140:49-61. PubMed
  • Tang L, Yang J, Ng SK, Rodriguez N, Choi PW, Vitonis A, Wang K, McLachlan GJ, Caiazzo RJ, Liu BC, Welch WR, Cramer DW, Berkowitz RS, Ng SW. Autoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian cancer. Eur J Cancer 2009; 46:170-9. PubMed
  • Medarova Z,Kumar M,Ng SW,Yang J,Barteneva N,Evgenov NV,Petkova V,Moore A. Multifunctional magnetic nanocarriers for image-tagged SiRNA delivery to intact pancreatic islets. Transplantation 2008; 86:1170-7. PubMed
  • Ehrlich JR, Tang L, Caiazzo RJ Jr, Cramer DW, Ng SK, Ng SW, Liu BC. The "reverse capture" autoantibody microarray : an innovative approach to profiling the autoantibody response to tissue-derived native antigens. Methods Mol Biol 2008; 441:175-92. PubMed
  • Ng SK, McLachlan GJ, Wang K, Ben-Tovim Jones L, Ng SW. A mixture model with random-effects components for clustering correlated gene-expression profiles. Bioinformatics 2006; 22:1745-52. PubMed
  • Huang KC, Park DC, Ng SK, Lee JY, Ni X, Ng WC, Bandera CA, Welch WR, Berkowitz RS, Mok SC, Ng SW. Selenium binding protein 1 in ovarian cancer. Int J Cancer 2005; 118:2433-40. PubMed
  • Jiao W,Lin HM,Timmons J,Nagaich AK,Ng SW,Misteli T,Rane SG. E2F-dependent repression of topoisomerase II regulates heterochromatin formation and apoptosis in cells with melanoma-prone mutation. Cancer Res 2005; 65:4067-77. PubMed
  • Saxena D,Yiu GK,Ni X,Huang KC,Mantovani R,Jacquemin-Sablon AG,Ng SW. Characterization of promoter elements involved in the down-regulation of topoisomerase IIalpha expression in a drug-resistant cell line. Gene 2004; 342:145-55. PubMed
  • Ni X,Zhang W,Huang KC,Wang Y,Ng SK,Mok SC,Berkowitz RS,Ng SW. Characterisation of human kallikrein 6/protease M expression in ovarian cancer. Br J Cancer 2004; 91:725-31. PubMed
  • Huang KC, Rao PH, Lau CC, Heard E, Ng SK, Brown C, Mok SC, Berkowitz RS, Ng SW. Relationship of XIST expression and responses of ovarian cancer to chemotherapy. Mol Cancer Ther 2002; 1:769-76. PubMed
  • Wei SH, Chen CM, Strathdee G, Harnsomburana J, Shyu CR, Rahmatpanah F, Shi H, Ng SW, Yan PS, Nephew KP, Brown R, Huang TH. Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers. Clin Cancer Res 2002; 8:2246-52. PubMed
  • Seiden MV, Ng SW, Supko JG, Ryan DP, Clark JW, Lynch T, Huang KC, Kwiatkowski D, Skarin A, Eder JP. A phase I clinical trial of sequentially administered doxorubicin and topotecan in refractory solid tumors. Clin Cancer Res 2002; 8:691-7. PubMed
  • Yiu GK, Chan WY, Ng SW, Chan PS, Cheung KK, Berkowitz RS, Mok SC. SPARC (secreted protein acidic and rich in cysteine) induces apoptosis in ovarian cancer cells. Am J Pathol 2001; 159:609-22. PubMed
  • Lodge AJ, Anderson JJ, Ng SW, Fenwick F, Steward M, Haugk B, Horne CH, Angus B. Expression of topoisomerase IIIalpha in normal and neoplastic tissues determined by immunohistochemistry using a novel monoclonal antibody. Br J Cancer 2000; 83:498-505. PubMed
  • Ng SW, Yiu GK, Liu Y, Huang LW, Palnati M, Jun SH, Berkowitz RS, Mok SC. Analysis of p73 in human borderline and invasive ovarian tumor. Oncogene 2000; 19:1885-90. PubMed
  • Garrett AP, Ng SW, Muto MG, Welch WR, Bell DA, Berkowitz RS, Mok SC. ras gene activation and infrequent mutation in papillary serous carcinoma of the peritoneum. Gynecol Oncol 2000; 77:105-11. PubMed
  • Singh M, Kindelberger D, Nagymanyoki Z, Ng SW, Quick CM, Yamamoto H, Fichorova R, Fulop V, Berkowitz RS. Vascular endothelial growth factors and their receptors and regulators in gestational trophoblastic diseases and normal placenta. J Reprod Med 2012; 57:197-203. PubMed
  • Vegh GL,Fulop V,Liu Y,Ng SW,Tuncer ZS,Genest DR,Paldi-Haris P,Foldi J,Mok SC,Berkowitz RS. Differential gene expression pattern between normal human trophoblast and choriocarcinoma cell lines: downregulation of heat shock protein-27 in choriocarcinoma in vitro and in vivo. Gynecol Oncol 1999; 75:391-6. PubMed
  • Ng SW,Liu Y,Hasselblatt KT,Mok SC,Berkowitz RS. A new human topoisomerase III that interacts with SGS1 protein. Nucleic Acids Res 1999; 27:993-1000. PubMed
  • Fulop V,Colitti CV,Genest D,Berkowitz RS,Yiu GK,Ng SW,Szepesi J,Mok SC. DOC-2/hDab2, a candidate tumor suppressor gene involved in the development of gestational trophoblastic diseases. Oncogene 1998; 17:419-24. PubMed
  • Mok SC,Chan WY,Wong KK,Cheung KK,Lau CC,Ng SW,Baldini A,Colitti CV,Rock CO,Berkowitz RS. DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer. Oncogene 1998; 16:2381-7. PubMed
  • Ng SW, Liu Y, Schnipper LE. Cloning and characterization of the 5'-flanking sequence for the human DNA topoisomerase II beta gene. Gene 1998; 203:113-9. PubMed
  • Eder JP, Chan VT, Ng SW, Rizvi NA, Zacharoulis S, Teicher BA, Schnipper LE. DNA topoisomerase II alpha expression is associated with alkylating agent resistance. Cancer Res 1995; 55:6109-16. PubMed
  • Ng SW, Eder JP, Schnipper LE, Chan VT. Molecular cloning and characterization of the promoter for the Chinese hamster DNA topoisomerase II alpha gene. J Biol Chem 1995; 270:25850-8. PubMed
  • Chan VT, Ng SW, Eder JP, Schnipper LE. Molecular cloning and identification of a point mutation in the topoisomerase II cDNA from an etoposide-resistant Chinese hamster ovary cell line. J Biol Chem 1993; 268:2160-5. PubMed
  • Ng SW,Wiedemann M,Kontermann R,Petersen G. Molecular characterization of a putative peroxidase gene of Drosophila melanogaster. Biochim Biophys Acta 1992; 1171:224-8. PubMed
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