Photo of Alexandra E. Shields,  PhD

Alexandra E. Shields, PhD

Massachusetts General Hospital

Massachusetts General Hospital


ashields@partners.org

Alexandra E. Shields, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Medicine, Harvard Medical School
  • Associate Professor, Medicine (Institute for Health Policy), Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Shields' principal research interests include issues related to the quality of care provided to underserved populations, health disparities, and challenges associated with clinical integration of new genetic technologies. Dr. Shields is the Director of the Harvard/MGH Center on Genomics, Vulnerable Populations, and Health Disparities, which examines the complex intersection of emerging genetic research and the persistent problem of health disparities. This initiative includes analyses of current issues of pharmacogenetic treatment for cancer and developing the capacity to monitor the equitable diffusion of emergent genetic-based treatments across racial/ethnic subpopulations and by insurance status in the U.S.

Publications

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  • Levy DE, Byfield SD, Comstock CB, Garber JE, Syngal S, Crown WH, Shields AE. Underutilization of BRCA1/2 testing to guide breast cancer treatment: Black and Hispanic women particularly at risk. Genet Med 2011; 13:349-355. PubMed
  • Park ER, Kleimann S, Youatt EJ, Lockhart A, Campbell EG, Levy DE, Halbert CH, Schmieder E, Krishna R, Shields AE. Black and White adults' perspectives on the genetics of nicotine addiction susceptibility. Addict Behav 2011. PubMed
  • Schnoll RA, Patterson F, Wileyto EP, Heitjan DF, Shields AE, Asch DA, Lerman C. Effectiveness of extended-duration transdermal nicotine therapy: a randomized trial. Ann Intern Med 2010; 152:144-51. PubMed
  • Levy DE,Garber JE,Shields AE. Guidelines for Genetic Risk Assessment of Hereditary Breast and Ovarian Cancer: Early Disagreements and Low Utilization. J Gen Intern Med 2009; 24:822-8. PubMed
  • Shields AE,Levy DE,Blumenthal D,Currivan D,McGinn-Shapiro M,Weiss KB,Yucel R,Lerman C. Primary care physicians' willingness to offer a new genetic test to tailor smoking treatment, according to test characteristics. Nicotine Tob Res 2008; 10:1037-45. PubMed
  • Shields AE,Burke W,Levy DE. Differential use of available genetic tests among primary care physicians in the United States: results of a national survey. Genet Med 2008; 10:404-14. PubMed
  • Shields AE, Lerman C. Anticipating clinical integration of pharmacogenetic treatment strategies for addiction: are primary care physicians ready? Clin Pharmacol Ther 2008; 83:635-9. PubMed
  • Shields AE,McGinn-Shapiro M,Fronstin P. Trends in private insurance, Medicaid/State Children's Health Insurance Program, and the Healthcare Safety Net: implications for vulnerable populations and health disparities. Ann N Y Acad Sci 2008; 1136:137-48. PubMed
  • Vogeli C, Shields AE, Lee TA, Gibson TB, Marder WD, Weiss KB, Blumenthal D. Multiple chronic conditions: prevalence, health consequences, and implications for quality, care management, and costs. J Gen Intern Med 2007; 22 Suppl 3:391-5. PubMed
  • Lee TA, Shields AE, Vogeli C, Gibson TB, Woong-Sohn M, Marder WD, Blumenthal D, Weiss KB. Mortality rate in veterans with multiple chronic conditions. J Gen Intern Med 2007; 22 Suppl 3:403-7. PubMed
  • Levy DE, Youatt EJ, Shields AE. Primary care physicians' concerns about offering a genetic test to tailor smoking cessation treatment. Genet Med 2007; 9:842-9. PubMed
  • Phillips JM,Siegel SJ,Shields AE,Patterson F,Gould TJ,Strasser AA,Ray R,Pinto A,Audrain-McGovern J,Rukstalis M,Perkins KA,Blendy JA,Lerman C. Translating basic science to improve pharmacotherapy for nicotine dependence. Nicotine Tob Res 2008; 9 Suppl 4:S583-98. PubMed
  • Shields AE. Trends in private insurance, Medicaid/State Children's Health Insurance Program, and the health-care safety net: implications for asthma disparities. Chest 2007; 132:818S-830S. PubMed
  • Shields AE, Shin P, Leu MG, Levy DE, Betancourt RM, Hawkins D, Proser M. Adoption of health information technology in community health centers: results of a national survey. Health Aff (Millwood) 2007; 26:1373-83. PubMed
  • Braun L, Fausto-Sterling A, Fullwiley D, Hammonds EM, Nelson A, Quivers W, Reverby SM, Shields AE. Racial categories in medical practice: how useful are they? PLoS Med 2007; 4:e271. PubMed
  • Park ER, Kleimann S, Pelan JA, Shields AE. Anticipating clinical integration of genetically tailored tobacco dependence treatment: perspectives of primary care physicians. Nicotine Tob Res 2007; 9:271-9. PubMed
  • Munaf. Smoking cessation treatment: pharmacogenetic assessment. Curr Opin Mol Ther 2005; 7:202-8. PubMed
  • Munaf. Pharmacogenetics and nicotine addiction treatment. Pharmacogenomics 2005; 6:211-223. PubMed
  • Shields AE, Blumenthal D, Weiss KB, Comstock CB, Currivan D, Lerman C. Barriers to translating emerging genetic research on smoking into clinical practice. Perspectives of primary care physicians. J Gen Intern Med 2005; 20:131-8. PubMed
  • Shields AE, Fortun M, Hammonds EM, King PA, Lerman C, Rapp R, Sullivan PF. The use of race variables in genetic studies of complex traits and the goal of reducing health disparities: a transdisciplinary perspective. Am Psychol 2005; 60:77-103. PubMed
  • Shields A, Lerman C, Sullivan P. Translating emerging research on the genetics of smoking into clinical practice: ethical and social considerations. Nicotine Tob Res 2004; 6:675-88. PubMed
  • Lerman C, Shields AE. Genetic testing for cancer susceptibility: the promise and the pitfalls. Nat Rev Cancer 2004; 4:235-41. PubMed
  • Shields AE, Comstock C, Weiss KB. Variations in asthma care by race/ethnicity among children enrolled in a state Medicaid program. Pediatrics 2004; 113:496-504. PubMed
  • Unger JB, Cruz T, Shakib S, Mock J, Shields A, Baezconde-Garbanati L, Palmer P, Cruz JD, Edsall E, Gritz ER, Glynn T, Johnson CA. Exploring the cultural context of tobacco use: a transdisciplinary framework. Nicotine Tob Res 2003; 5 Suppl 1:S101-17. PubMed
  • Baker TB, Hatsukami DK, Lerman C, O'Malley SS, Shields AE, Fiore MC. Transdisciplinary science applied to the evaluation of treatments for tobacco use. Nicotine Tob Res 2003; 5 Suppl 1:S89-99. PubMed
  • Shields AE, Comstock C, Finkelstein JA, Weiss KB. Comparing asthma care provided to Medicaid-enrolled children in a Primary Care Case Manager plan and a staff model HMO. Ambul Pediatr 2003; 3:253-62. PubMed
  • Audrain-McGovern J, Tercyak KP, Shields AE, Bush A, Espinel CF, Lerman C. Which adolescents are most receptive to tobacco industry marketing? implications for counter-advertising campaigns. Health Commun 2003; 15:499-513. PubMed
  • Shields AE, Finkelstein JA, Comstock C, Weiss KB. Process of care for Medicaid-enrolled children with asthma: served by community health centers and other providers. Med Care 2002; 40:303-14. PubMed
  • Wilfond BS, Geller G, Lerman C, Audrain-McGovern J, Shields AE. Ethical issues in conducting behavioral genetics research: the case of smoking prevention trials among adolescents. J Health Care Law Policy 2004; 6:73-88. PubMed
  • Jha AK, DesRoches CM, Shields AE, Miralles PD, Zheng J, Rosenbaum S, Campbell EG. Evidence of an emerging digital divide among hospitals that care for the poor. Health Aff (Millwood) 2009; 28:w1160-70. PubMed
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