Photo of Alexandra J. Golby,  MD

Alexandra J. Golby, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-7373
Fax: (617) 713-3050


agolby@partners.org

Alexandra J. Golby, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Radiology, Harvard Medical School
  • Associate Professor, Neurosurgery, Harvard Medical School
  • Associate Neurosurgeon, Neurosurgery, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research involves the application of brain mapping techniques to brain tumor patients. We use multiple functional brain mapping techniques (functional MRI and intracranial EEG) to better understand the brain basis of behavior. The goals are: 1) to use these techniques to define individual functional anatomy in patients with brain tumors, 2) to cross validate information acquired through different techniques and to gain a better understanding of the relationship between these different brain signals, 3) to demonstrate the ways in which the functional anatomy is altered by disease and recovery, and 4) to use this information to improve surgical therapy for patients with brain tumors. In order to accomplish this, our program includes the following: 1) direct cortical electrophysiologic recording and analysis techniques; 2) advanced functional MR (fMRI) imaging; 3) research methods including data analysis, interpretation, and presentation; and 4) the theoretical underpinnings and investigative tools of current cognitive neuroscience. We perform multi-modality studies of memory-associated cognitive processes in healthy people and patients with brain tumors. This research benefits from numerous collaborators from radiology, engineering, HMS, Brandeis, and MIT.

Publications

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  • Curry WT, Gorrepati R, Piesche M, Sasada T, Agarwalla PK, Jones PS, Gerstner ER, Golby AJ, Batchelor T, Wen PY, Mihm MC, Dranoff G. Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Anti-tumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma. Clin Cancer Res 2016. PubMed
  • Ahmadi E, Katnani HA, Daftari Besheli L, Gu Q, Atefi R, Villeneuve MY, Eskandar E, Lev MH, Golby AJ, Gupta R, Bonmassar G. An Electrocorticography Grid with Conductive Nanoparticles in a Polymer Thick Film on an Organic Substrate Improves CT and MR Imaging. Radiology 2016. PubMed
  • Chen Z, Tie Y, Olubiyi O, Zhang F, Mehrtash A, Rigolo L, Kahali P, Norton I, Pasternak O, Rathi Y, Golby AJ, O'Donnell LJ. Corticospinal tract modeling for neurosurgical planning by tracking through regions of peritumoral edema and crossing fibers using two-tensor unscented Kalman filter tractography. 2016. PubMed
  • Torcuator RG, Hulou MM, Chavakula V, Jolesz FA, Golby AJ. Intraoperative real-time MRI-guided stereotactic biopsy followed by laser thermal ablation for progressive brain metastases after radiosurgery. J Clin Neurosci 2015. PubMed
  • Ramkissoon SH, Bi WL, Schumacher SE, Ramkissoon LA, Haidar S, Knoff D, Dubuc A, Brown L, Burns M, Cryan JB, Abedalthagafi M, Kang YJ, Schultz N, Reardon DA, Lee EQ, Rinne ML, Norden AD, Nayak L, Ruland S, Doherty LM, LaFrankie DC, Horvath M, Aizer AA, Russo A, Arvold ND, Claus EB, Al-Mefty O, Johnson MD, Golby AJ, Dunn IF, Chiocca EA, Trippa L, Santagata S, Folkerth RD, Kantoff P, Rollins BJ, Lindeman NI, Wen PY, Ligon AH, Beroukhim R, Alexander BM, Ligon KL. Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. 2015. PubMed
  • Liu Y, Alexander BM, Chen YH, Horvath MC, Aizer AA, Claus EB, Dunn IF, Golby AJ, Johnson MD, Friesen S, Mannarino EG, Wagar M, Hacker FL, Arvold ND. Salvage whole brain radiotherapy or stereotactic radiosurgery after initial stereotactic radiosurgery for 1-4 brain metastases. J. Neurooncol. 2015. PubMed
  • Shankar GM, Francis JM, Rinne ML, Ramkissoon SH, Huang FW, Venteicher AS, Akama-Garren EH, Kang YJ, Lelic N, Kim JC, Brown LE, Charbonneau SK, Golby AJ, Sekhar Pedamallu C, Hoang MP, Sullivan RJ, Cherniack AD, Garraway LA, Stemmer-Rachamimov A, Reardon DA, Wen PY, Brastianos PK, Curry WT, Barker FG, Hahn WC, Nahed BV, Ligon KL, Louis DN, Cahill DP, Meyerson M. Rapid Intraoperative Molecular Characterization of Glioma. JAMA Oncol 2015. PubMed
  • Olubiyi OI, Ozdemir A, Incekara F, Tie Y, Dolati P, Hsu L, Santagata S, Chen Z, Rigolo L, Golby AJ. Intraoperative Magnetic Resonance Imaging in Intracranial Glioma Resection: A Single-Center, Retrospective Blinded Volumetric Study. World Neurosurg 2015. PubMed
  • Rahman R, Catalano PJ, Reardon DA, Norden AD, Wen PY, Lee EQ, Nayak L, Beroukhim R, Dunn IF, Golby AJ, Johnson MD, Chiocca EA, Claus EB, Alexander BM, Arvold ND. Incidence, risk factors, and reasons for hospitalization among glioblastoma patients receiving chemoradiation. J. Neurooncol. 2015; 124:137-46. PubMed
  • Abd-El-Barr MM, Santos SM, Aglio LS, Young GS, Mukundan S, Golby AJ, Gormley WB, Dunn IF. "Extraoperative" MRI (eoMRI) for Brain Tumor Surgery: Initial Results at a Single Institution. World Neurosurg 2015. PubMed
  • Arvold ND, Tanguturi SK, Aizer AA, Wen PY, Reardon DA, Lee EQ, Nayak L, Christianson LW, Horvath MC, Dunn IF, Golby AJ, Johnson MD, Claus EB, Chiocca EA, Ligon KL, Alexander BM. Hypofractionated versus standard radiation therapy with or without temozolomide for older glioblastoma patients. Int J Radiat Oncol Biol Phys 2015. PubMed
  • Tempany CM, Jayender J, Kapur T, Bueno R, Golby A, Agar N, Jolesz FA. Multimodal imaging for improved diagnosis and treatment of cancers. Cancer 2015. PubMed
  • Chen Z, Tie Y, Olubiyi O, Rigolo L, Mehrtash A, Norton I, Pasternak O, Rathi Y, Golby AJ, O'Donnell LJ. Reconstruction of the arcuate fasciculus for surgical planning in the setting of peritumoral edema using two-tensor unscented Kalman filter tractography. Neuroimage Clin 2015; 7:815-22. PubMed
  • Aizer AA, Arvold ND, Catalano P, Claus EB, Golby AJ, Johnson MD, Al-Mefty O, Wen PY, Reardon DA, Lee EQ, Nayak L, Rinne ML, Beroukhim R, Weiss SE, Ramkissoon SH, Abedalthagafi M, Santagata S, Dunn IF, Alexander BM. Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma. 2014. PubMed
  • Rajakesari S, Arvold ND, Jimenez RB, Christianson LW, Horvath MC, Claus EB, Golby AJ, Johnson MD, Dunn IF, Lee EQ, Lin NU, Friesen S, Mannarino EG, Wagar M, Hacker FL, Weiss SE, Alexander BM. Local control after fractionated stereotactic radiation therapy for brain metastases. J. Neurooncol. 2014; 120:339-46. PubMed
  • Santagata S, Eberlin LS, Norton I, Calligaris D, Feldman DR, Ide JL, Liu X, Wiley JS, Vestal ML, Ramkissoon SH, Orringer DA, Gill KK, Dunn IF, Dias-Santagata D, Ligon KL, Jolesz FA, Golby AJ, Cooks RG, Agar NY. Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery. Proc Natl Acad Sci U S A 2014; 111:11121-6. PubMed
  • Lee JW, Norden AD, Ligon KL, Golby AJ, Beroukhim R, Quackenbush J, Wells W, Oelschlager K, Maetzold D, Wen PY. Tumor associated seizures in glioblastomas are influenced by survival gene expression in a region-specific manner: a gene expression imaging study. Epilepsy Res 2014. PubMed
  • Calligaris D, Norton I, Feldman DR, Ide JL, Dunn IF, Eberlin LS, Cooks RG, Jolesz FA, Golby AJ, Santagata S, Agar NY. Mass spectrometry imaging as a tool for surgical decision-making. J Mass Spectrom 2013; 48:1178-87. PubMed
  • Ji M, Orringer DA, Freudiger CW, Ramkissoon S, Liu X, Lau D, Golby AJ, Norton I, Hayashi M, Agar NY, Young GS, Spino C, Santagata S, Camelo-Piragua S, Ligon KL, Sagher O, Xie XS. Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. Sci Transl Med 2013; 5:201ra119. PubMed
  • Abd-El-Barr MM, Saleh E, Huang RY, Golby AJ. Effect of disease and recovery on functional anatomy in brain tumor patients: insights from functional MRI and diffusion tensor imaging. Imaging Med 2014; 5:333-346. PubMed
  • Monje M, Thomason ME, Rigolo L, Wang Y, Waber DP, Sallan SE, Golby AJ. Functional and structural differences in the hippocampus associated with memory deficits in adult survivors of acute lymphoblastic leukemia. Pediatr Blood Cancer 2012. PubMed
  • Eberlin LS, Norton I, Orringer D, Dunn IF, Liu X, Ide JL, Jarmusch AK, Ligon KL, Jolesz FA, Golby AJ, Santagata S, Agar NY, Cooks RG. Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors. Proc Natl Acad Sci U S A 2013; 110:1611-6. PubMed
  • Pohl KM, Konukoglu E, Novellas S, Ayache N, Fedorov A, Talos IF, Golby A, Wells WM, Kikinis R, Black PM. A new metric for detecting change in slowly evolving brain tumors: validation in meningioma patients. Neurosurgery 2011; 68:225-33. PubMed
  • Elhawary H, Liu H, Patel P, Norton I, Rigolo L, Papademetris X, Hata N, Golby AJ. Intraoperative real-time querying of white matter tracts during frameless stereotactic neuronavigation. Neurosurgery 2011. PubMed
  • Agar NY, Golby AJ, Ligon KL, Norton I, Mohan V, Wiseman JM, Tannenbaum A, Jolesz FA. Development of stereotactic mass spectrometry for brain tumor surgery. Neurosurgery 2011. PubMed
  • Eberlin LS, Dill AL, Golby AJ, Ligon KL, Wiseman JM, Cooks RG, Agar NY. Discrimination of human astrocytoma subtypes by lipid analysis using desorption electrospray ionization imaging mass spectrometry. Angew Chem Int Ed Engl 2010; 49:5953-6. PubMed
  • Lee JW, Wen PY, Hurwitz S, Black P, Kesari S, Drappatz J, Golby AJ, Wells WM, Warfield SK, Kikinis R, Bromfield EB. Morphological characteristics of brain tumors causing seizures. Arch Neurol 2010; 67:336-42. PubMed
  • Mislow JM, Golby AJ, Black PM. Origins of intraoperative MRI. Magn Reson Imaging Clin N Am 2009; 18:1-10. PubMed
  • Tokuda J, Fischer GS, Papademetris X, Yaniv Z, Ibanez L, Cheng P, Liu H, Blevins J, Arata J, Golby AJ, Kapur T, Pieper S, Burdette EC, Fichtinger G, Tempany CM, Hata N. OpenIGTLink: an open network protocol for image-guided therapy environment. Int J Med Robot 2009; 5:423-34. PubMed
  • Qazi AA,Radmanesh A,O'Donnell L,Kindlmann G,Peled S,Whalen S,Westin CF,Golby AJ. Resolving crossings in the corticospinal tract by two-tensor streamline tractography: Method and clinical assessment using fMRI. Neuroimage 2009; 47 Suppl 2:T98-106. PubMed
  • Tie Y,Suarez RO,Whalen S,Radmanesh A,Norton IH,Golby AJ. Comparison of blocked and event-related fMRI designs for pre-surgical language mapping. Neuroimage 2009; 47 Suppl 2:T107-15. PubMed
  • Peled S, Whalen S, Jolesz FA, Golby AJ. High b-value apparent diffusion-weighted images from CURVE-ball DTI. J Magn Reson Imaging 2009; 30:243-8. PubMed
  • O'Donnell LJ,Westin CF,Golby AJ. Tract-based morphometry for white matter group analysis. Neuroimage 2009; 45:832-44. PubMed
  • Mislow JM, Golby AJ, Black PM. Origins of intraoperative MRI. Neurosurg Clin N Am 2009; 20:137-46. PubMed
  • White PJ,Whalen S,Tang SC,Clement GT,Jolesz F,Golby AJ. An intraoperative brain shift monitor using shear mode transcranial ultrasound: preliminary results. J Ultrasound Med 2009; 28:191-203. PubMed
  • Tie Y,Whalen S,Suarez RO,Golby AJ. Group independent component analysis of language fMRI from word generation tasks. Neuroimage 2008; 42:1214-25. PubMed
  • Archip N, Clatz O, Whalen S, Dimaio SP, Black PM, Jolesz FA, Golby A, Warfield SK. Compensation of geometric distortion effects on intraoperative magnetic resonance imaging for enhanced visualization in image-guided neurosurgery. Neurosurgery 2008; 62:209-15; discussion 215-6. PubMed
  • Upadhyay UM, Golby AJ. Role of pre- and intraoperative imaging and neuronavigation in neurosurgery. Expert Rev Med Devices 2007; 5:65-73. PubMed
  • Larsen S, Kikinis R, Talos IF, Weinstein D, Wells W, Golby A. Quantitative comparison of functional MRI and direct electrocortical stimulation for functional mapping. Int J Med Robot 2007; 3:262-70. PubMed
  • Archip N, Clatz O, Whalen S, Kacher D, Fedorov A, Kot A, Chrisochoides N, Jolesz F, Golby A, Black PM, Warfield SK. Non-rigid alignment of pre-operative MRI, fMRI, and DT-MRI with intra-operative MRI for enhanced visualization and navigation in image-guided neurosurgery. Neuroimage 2007; 35:609-24. PubMed
  • Rolls HK, Yoo SS, Zou KH, Golby AJ, Panych LP. Rater-dependent accuracy in predicting the spatial location of functional centers on anatomical MR images. Clin Neurol Neurosurg 2006; 109:225-35. PubMed
  • Dimaio SP, Archip N, Hata N, Talos IF, Warfield SK, Majumdar A, Mcdannold N, Hynynen K, Morrison PR, Wells WM, Kacher DF, Ellis RE, Golby AJ, Black PM, Jolesz FA, Kikinis R. Image-guided neurosurgery at Brigham and Women's Hospital. IEEE Eng Med Biol Mag 2006; 25:67-73. PubMed
  • Branco DM, Suarez RO, Whalen S, O'shea JP, Nelson AP, da Costa JC, Golby AJ. Functional MRI of memory in the hippocampus: Laterality indices may be more meaningful if calculated from whole voxel distributions. Neuroimage 2006; 32:592-602. PubMed
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