Alexey Veraksa, PhD

University Of Massachusetts - Boston

University Of Massachusetts - Boston
Phone: (617) 287-6665

Alexey Veraksa, PhD

University Of Massachusetts - Boston

EDUCATIONAL TITLES

  • Assistant Professor, College of Science and Math, University Of Massachusetts - Boston

DF/HCC PROGRAM AFFILIATION

Research Abstract

My laboratory uses Drosophila as a model experimental system to address two key questions: 1) how cells control the precise quantity of signals transmitted through developmental signaling pathways, and 2) how cells integrate and interpret different signaling inputs to make an appropriate cell fate choice. We are using classic genetic and biochemical approaches, as well as advanced proteomics methods to study the regulation of developmental signaling. Current research projects in the lab are: 1. Mapping the Notch signaling network with Tandem Affinity Purification-mass spectrometry (TAP-MS) to identify in vivo protein interactions between the core components and modulators of Notch signaling. 2. Control of developmental signaling by non-visual beta-arrestin. One of the new Notch pathway interactors identified by the TAP-MS analysis is Kurtz, a Drosophila ortholog of mammalian non-visual beta-arrestins. We have shown that Kurtz forms a trimeric complex with the Notch receptor and another Notch protein modulator, Deltex. The formation of this complex leads to an increased ubiquitination of Notch and its proteasomal degradation. Current efforts are directed at studying how Kurtz regulates the activity of other signaling pathways during Drosophila development.

Publications

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  • Nie Y, Li Q, Amcheslavsky A, Duhart JC, Veraksa A, Stocker H, Raftery LA, Ip YT. Bunched and Madm Function Downstream of Tuberous Sclerosis Complex to Regulate the Growth of Intestinal Stem Cells in Drosophila. Stem Cell Rev 2015. PubMed
  • Zhang C, Robinson BS, Xu W, Yang L, Yao B, Zhao H, Byun PK, Jin P, Veraksa A, Moberg KH. The ecdysone receptor coactivator Taiman links Yorkie to transcriptional control of germline stem cell factors in somatic tissue. Dev Cell 2015. PubMed
  • Dent LG, Poon CL, Zhang X, Degoutin JL, Tipping M, Veraksa A, Harvey KF. The GTPase regulatory proteins Pix and Git control tissue growth via the Hippo pathway. Curr Biol 2015; 25:124-30. PubMed
  • Anjum SG, Xu W, Nikkholgh N, Basu S, Nie Y, Thomas M, Satyamurti M, Budnik BA, Ip YT, Veraksa A. Regulation of Toll signaling and inflammation by β-arrestin and the SUMO protease Ulp1. Genetics 2013; 195:1307-17. PubMed
  • Degoutin JL, Milton CC, Yu E, Tipping M, Bosveld F, Yang L, Bellaiche Y, Veraksa A, Harvey KF. Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous. Nat Cell Biol 2013; 15:1176-85. PubMed
  • Veraksa A. When peptides fly: Advances in Drosophila proteomics. 2010; 73:2158-70. PubMed
  • Tipping M, Kim Y, Kyriakakis P, Tong M, Shvartsman SY, Veraksa A. 硫-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development. EMBO J 2010; 29:3222-35. PubMed
  • Lake RJ, Grimm LM, Veraksa A, Banos A, Artavanis-Tsakonas S. In vivo analysis of the Notch receptor S1 cleavage. PLoS ONE 2009; 4:e6728. PubMed
  • Omori Y, Zhao C, Saras A, Mukhopadhyay S, Kim W, Furukawa T, Sengupta P, Veraksa A, Malicki J. Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8. Nat Cell Biol 2008; 10:437-44. PubMed
  • Veraksa A. Regulation of developmental processes: insights from mass spectrometry-based proteomics. Wiley Interdiscip Rev Dev Biol 2013; 2:723-34. PubMed
  • Kyriakakis P,Tipping M,Abed L,Veraksa A. Tandem affinity purification in Drosophila: The advantages of the GS-TAP system. Fly (Austin) 2010; 2:229-35. PubMed