Alexey Veraksa, PhD

University Of Massachusetts - Boston

University Of Massachusetts - Boston
Phone: (617) 287-6665

Alexey Veraksa, PhD

University Of Massachusetts - Boston

EDUCATIONAL TITLES

  • Assistant Professor, College of Science and Math, University Of Massachusetts - Boston

DF/HCC PROGRAM AFFILIATION

Research Abstract

My laboratory uses Drosophila as a model experimental system to address two key questions: 1) how cells control the precise quantity of signals transmitted through developmental signaling pathways, and 2) how cells integrate and interpret different signaling inputs to make an appropriate cell fate choice. We are using classic genetic and biochemical approaches, as well as advanced proteomics methods to study the regulation of developmental signaling. Current research projects in the lab are: 1. Mapping the Notch signaling network with Tandem Affinity Purification-mass spectrometry (TAP-MS) to identify in vivo protein interactions between the core components and modulators of Notch signaling. 2. Control of developmental signaling by non-visual beta-arrestin. One of the new Notch pathway interactors identified by the TAP-MS analysis is Kurtz, a Drosophila ortholog of mammalian non-visual beta-arrestins. We have shown that Kurtz forms a trimeric complex with the Notch receptor and another Notch protein modulator, Deltex. The formation of this complex leads to an increased ubiquitination of Notch and its proteasomal degradation. Current efforts are directed at studying how Kurtz regulates the activity of other signaling pathways during Drosophila development.

Publications

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  • Dent LG, Poon CL, Zhang X, Degoutin JL, Tipping M, Veraksa A, Harvey KF. The GTPase regulatory proteins Pix and Git control tissue growth via the Hippo pathway. Curr Biol 2015; 25:124-30. PubMed
  • Anjum SG, Xu W, Nikkholgh N, Basu S, Nie Y, Thomas M, Satyamurti M, Budnik BA, Ip YT, Veraksa A. Regulation of Toll signaling and inflammation by 硫-arrestin and the SUMO protease Ulp1. Genetics 2013; 195:1307-17. PubMed
  • Degoutin JL, Milton CC, Yu E, Tipping M, Bosveld F, Yang L, Bellaiche Y, Veraksa A, Harvey KF. Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous. Nat Cell Biol 2013; 15:1176-85. PubMed
  • Veraksa A. When peptides fly: Advances in Drosophila proteomics. 2010; 73:2158-70. PubMed
  • Tipping M, Kim Y, Kyriakakis P, Tong M, Shvartsman SY, Veraksa A. 硫-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development. EMBO J 2010; 29:3222-35. PubMed
  • Lake RJ, Grimm LM, Veraksa A, Banos A, Artavanis-Tsakonas S. In vivo analysis of the Notch receptor S1 cleavage. PLoS ONE 2009; 4:e6728. PubMed
  • Omori Y, Zhao C, Saras A, Mukhopadhyay S, Kim W, Furukawa T, Sengupta P, Veraksa A, Malicki J. Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8. Nat Cell Biol 2008; 10:437-44. PubMed
  • Mukherjee A, Veraksa A, Bauer A, Rosse C, Camonis J, Artavanis-Tsakonas S. Regulation of Notch signalling by non-visual beta-arrestin. Nat Cell Biol 2005; 7:1091-101. PubMed
  • Veraksa A, Bauer A, Artavanis-Tsakonas S. Analyzing protein complexes in Drosophila with tandem affinity purification-mass spectrometry. Dev Dyn 2005; 232:827-34. PubMed
  • Moberg KH, Mukherjee A, Veraksa A, Artavanis-Tsakonas S, Hariharan IK. The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr Biol 2004; 14:965-74. PubMed
  • Veraksa A, Kennison J, McGinnis W. DEAF-1 function is essential for the early embryonic development of Drosophila. Genesis 2002; 33:67-76. PubMed
  • Pederson JA, LaFollette JW, Gross C, Veraksa A, McGinnis W, Mahaffey JW. Regulation by homeoproteins: a comparison of deformed-responsive elements. Genetics 2000; 156:677-86. PubMed
  • Veraksa A, McGinnis N, Li X, Mohler J, McGinnis W. Cap 'n' collar B cooperates with a small Maf subunit to specify pharyngeal development and suppress deformed homeotic function in the Drosophila head. Development 2000; 127:4023-37. PubMed
  • Veraksa A, Del Campo M, McGinnis W. Developmental patterning genes and their conserved functions: from model organisms to humans. Mol Genet Metab 2000; 69:85-100. PubMed
  • Veraksa A. Regulation of developmental processes: insights from mass spectrometry-based proteomics. Wiley Interdiscip Rev Dev Biol 2013; 2:723-34. PubMed
  • Kyriakakis P,Tipping M,Abed L,Veraksa A. Tandem affinity purification in Drosophila: The advantages of the GS-TAP system. Fly (Austin) 2010; 2:229-35. PubMed
  • Li X, Veraksa A, McGinnis W. A sequence motif distinct from Hox binding sites controls the specificity of a Hox response element. Development 1999; 126:5581-9. PubMed
  • Del Campo M, Jones MC, Veraksa AN, Curry CJ, Jones KL, Mascarello JT, Ali-Kahn-Catts Z, Drumheller T, McGinnis W. Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. Am J Hum Genet 1999; 65:104-10. PubMed
  • McGinnis N, Ragnhildstveit E, Veraksa A, McGinnis W. A cap 'n' collar protein isoform contains a selective Hox repressor function. Development 1998; 125:4553-64. PubMed
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