Photo of Alison M. Friedmann,

Alison M. Friedmann

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-2737
Fax: (617) 724-0702


afriedmann@partners.org

Alison M. Friedmann

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Pediatrics, Harvard Medical School
  • Assistant Pediatrician, Pediatrics, Massachusetts General Hospital

Research Abstract

My research interests are clinical in the field of supportive care for children with cancer. In particular, I am interested in such aspects as management of fever and neutropenia, use of growth factors, and transfusion support, with an emphasis on outcomes research including quality of life outcomes. I am currently the PI on a pilot study of early discharge to home-based intravenous antibiotics for children with low-risk fever and neutropenia which looks at traditional medical outcomes as well as quality of life and economic measures. Also, I am designing a study which will look at genetic polymorphisms of immune response modifiers which may play a role in the individual's "innate" risk of fever and neutropenia or significant infections/complications. I am a "young investigator" on the Epidemiology Committee of the Children's Oncology Group, an active participant in the Pediatric Hodgkin's Disease Consortium, which conducts multi-center clinical trials, and a subcommittee leader (psychosocial/outcomes research) for the Childhood Cancer Survivor Program in Development.

Publications

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  • Ladra MM, Mandeville HC, Niemierko A, Padera TP, Friedmann AM, MacDonald SM, Ebb D, Chen YL, Tarbell NJ, Yock TI. Local failure in parameningeal rhabdomyosarcoma correlates with poor response to induction chemotherapy. Int J Radiat Oncol Biol Phys 2015; 92:358-67. PubMed
  • Lucas JT, Ladra MM, MacDonald SM, Busse PM, Friedmann AM, Ebb DH, Marcus KJ, Tarbell NJ, Yock TI. Proton therapy for pediatric and adolescent esthesioneuroblastoma. Pediatr Blood Cancer 2015. PubMed
  • Ladra MM, Szymonifka JD, Mahajan A, Friedmann AM, Yong Yeap B, Goebel CP, MacDonald SM, Grosshans DR, Rodriguez-Galindo C, Marcus KJ, Tarbell NJ, Yock TI. Preliminary Results of a Phase II Trial of Proton Radiotherapy for Pediatric Rhabdomyosarcoma. J Clin Oncol 2014. PubMed
  • Ladra MM, Edgington SK, Mahajan A, Grosshans D, Szymonifka J, Khan F, Moteabbed M, Friedmann AM, MacDonald SM, Tarbell NJ, Yock TI. A dosimetric comparison of proton and intensity modulated radiation therapy in pediatric rhabdomyosarcoma patients enrolled on a prospective phase II proton study. Radiother Oncol 2014; 113:77-83. PubMed
  • Friedmann AM, Wolfson JA, Hudson MM, Weinstein HJ, Link MP, Billett A, Larsen EC, Yock T, Donaldson SS, Marcus K, Krasin MJ, Howard SC, Metzger ML. Relapse after treatment of pediatric Hodgkin lymphoma: outcome and role of surveillance after end of therapy. Pediatr Blood Cancer 2013; 60:1458-63. PubMed
  • Siegel MJ, Acharyya S, Hoffer FA, Wyly JB, Friedmann AM, Snyder BS, Babyn PS, Khanna G, Siegel BA. Whole-body MR imaging for staging of malignant tumors in pediatric patients: results of the American College of Radiology Imaging Network 6660 Trial. Radiology 2013; 266:599-609. PubMed
  • Childs SK, Kozak KR, Friedmann AM, Yeap BY, Adams J, Macdonald SM, Liebsch NJ, Tarbell NJ, Yock TI. Proton Radiotherapy for Parameningeal Rhabdomyosarcoma: Clinical Outcomes and Late Effects. Int J Radiat Oncol Biol Phys 2011. PubMed
  • El Saleeby CM, Grottkau BE, Friedmann AM, Westra SJ, Sohani AR. Case records of the Massachusetts General Hospital. Case 4-2011. A 4-year-old boy with back pain and hypercalcemia. N Engl J Med 2011; 364:552-62. PubMed
  • Aftandilian CC, Friedmann AM. Burkitt lymphoma with pancreatic involvement. J Pediatr Hematol Oncol 2010; 32:e338-40. PubMed
  • Cotter SE, Herrup DA, Friedmann A, Macdonald SM, Pieretti RV, Robinson G, Adams J, Tarbell NJ, Yock TI. Proton Radiotherapy for Pediatric Bladder/Prostate Rhabdomyosarcoma: Clinical Outcomes and Dosimetry Compared to Intensity-Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys 2010. PubMed
  • Friedmann A, Dehnhardt J, Kleber BM, Bernimoulin JP. Cytobiocompatibility of collagen and ePTFE membranes on osteoblast-like cells in vitro. J Biomed Mater Res A 2008; 86:935-41. PubMed
  • Lipkin E, Tal-Stein R, Friedmann A, Soller M. Effect of quantitative trait loci for milk protein percentage on milk protein yield and milk yield in Israeli Holstein dairy cattle. J Dairy Sci 2008; 91:1614-27. PubMed
  • Friedmann AM, Weinstein HJ. The evolving standard of care for hodgkin lymphoma. J Pediatr Hematol Oncol 2008; 30:121-3. PubMed
  • Friedmann AM. Evaluation and management of lymphadenopathy in children. Pediatr Rev 2008; 29:53-60. PubMed
  • Bagnato A, Schiavini F, Rossoni A, Maltecca C, Dolezal M, Medugorac I, Solkner J, Russo V, Fontanesi L, Friedmann A, Soller M, Lipkin E. Quantitative trait loci affecting milk yield and protein percentage in a three-country Brown Swiss population. J Dairy Sci 2008; 91:767-83. PubMed
  • Kaner D, Bernimoulin JP, Hopfenmuller W, Kleber BM, Friedmann A. Controlled-delivery chlorhexidine chip versus amoxicillin/metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis: a randomized controlled clinical trial. J Clin Periodontol 2007; 34:880-91. PubMed
  • Kaner D, Christan C, Dietrich T, Bernimoulin JP, Kleber BM, Friedmann A. Timing affects the clinical outcome of adjunctive systemic antibiotic therapy for generalized aggressive periodontitis. J Periodontol 2007; 78:1201-8. PubMed
  • Friedmann AC, Ameen M, Swale VJ. Familial pityriasis rotunda in black-skinned patients; a first report. Br J Dermatol 2007; 156:1365-7. PubMed
  • Borges E, Ferry JA, Friedmann AM. Epstein-Barr virus-negative precursor B cell lymphoblastic lymphoma after liver transplantation: a unique form of posttransplant lymphoproliferative disease. Transplantation 2002; 73:541-3. PubMed
  • Friedmann AM, Weinstein HJ. The role of prognostic features in the treatment of childhood acute lymphoblastic leukemia. Oncologist 2000; 5:321-8. PubMed
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