Photo of Aliyah R. Sohani,  MD

Aliyah R. Sohani, MD

Massachusetts General Hospital

Massachusetts General Hospital


arsohani@partners.org

Aliyah R. Sohani, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Pathology, Harvard Medical School
  • Medical Director, Hematology, Core Laboratory, Pathology Service, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research interests encompass neoplastic and non-neoplastic diseases of the blood, bone marrow, lymph nodes and other lymphoid organs. The majority of my ongoing investigations are clinicopathologic studies relating to unusual morphologic features of lymphoid neoplasms or aberrant expression of particular antigens in these neoplasms that further our understanding of the disease and that may have diagnostic, prognostic or therapeutic significance. My research effort is expanding into the field of molecular pathology in order to identify molecular and cytogenetic markers in Hodgkin and non-Hodgkin lymphoma that may help to define new clinicopathologic entities and predict tumor behavior and response to therapy.

Publications

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  • Freitag SK, Cunnane ME, Yoon MK, Barnes JA, Winkfield KM, Sohani AR. Case records of the Massachusetts General Hospital. Case 18-2015. A 41-year-old woman with decreased vision in the left eye and diplopia. N Engl J Med 2015; 372:2337-45. PubMed
  • Ok CY, Ye Q, Li L, Manyam GC, Deng L, Goswami RR, Wang X, Montes-Moreno S, Visco C, Tzankov A, Dybkaer K, Zhang L, Abramson J, Sohani AR, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Zhang S, Parsons BM, Xu M, Møller MB, Winter JN, Piris MA, Xu-Monette ZY, Medeiros LJ, Young KH. Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma - is it necessary? 2015; 6:13935-13946. PubMed
  • Jalbut MM, Sohani AR, Dal Cin P, Hasserjian RP, Moran JA, Brunner AM, Fathi AT. Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype. Leuk Res Rep 2015; 4:28-30. PubMed
  • Carey CD, Gusenleitner D, Chapuy B, Kovach AE, Kluk MJ, Sun HH, Crossland RE, Bacon CM, Rand V, Dal Cin P, Le LP, Neuberg D, Sohani AR, Shipp MA, Monti S, Rodig SJ. Molecular classification of MYC-driven B-cell lymphomas by targeted gene expression profiling of fixed biopsy specimens. J Mol Diagn 2014; 17:19-30. PubMed
  • Courville EL, Sohani AR, Hasserjian RP, Zukerberg LR, Harris NL, Ferry JA. Diverse clinicopathologic features in human herpesvirus 8-associated lymphomas lead to diagnostic problems. Am J Clin Pathol 2014; 142:816-29. PubMed
  • Petrich AM, Gandhi M, Jovanovic B, Castillo JJ, Rajguru S, Yang DT, Shah KA, Whyman JD, Lansigan F, Hernandez-Ilizaliturri FJ, Lee LX, Barta SK, Melinamani S, Karmali R, Adeimy C, Smith S, Dalal N, Nabhan C, Peace D, Vose J, Evens AM, Shah N, Fenske TS, Zelenetz AD, Landsburg DJ, Howlett C, Mato A, Jaglal M, Chavez JC, Tsai JP, Reddy N, Li S, Handler C, Flowers CR, Cohen JB, Blum KA, Song K, Sun HL, Press O, Cassaday R, Jaso J, Medeiros LJ, Sohani AR, Abramson JS. Impact of induction regimen and stem cell transplantation on outcomes in double-hit lymphoma: a multicenter retrospective analysis. Blood 2014; 124:2354-61. PubMed
  • Soumerai JD, Sohani AR, Abramson JS. Diagnosis and management of castleman disease. Cancer Control 2014; 21:266-78. PubMed
  • Kovach AE, DeLelys ME, Kelliher AS, Dillon LJ, Hasserjian RP, Ferry JA, Preffer FI, Sohani AR. Diagnostic utility of cerebrospinal fluid flow cytometry in patients with and without prior hematologic malignancy. Am J Hematol 2014; 89:978-84. PubMed
  • Movassaghian M, Sohani AR, McAfee SL, Perry AM, Dal Cin P, McLaughlin C, Fathi AT. Chromosome 17p deletion in a case of T-cell acute lymphoblastic lymphoma. Am J Hematol 2014. PubMed
  • Branda JA, Dighe AS, Dzik W, Ferraro MJ, Flood J, Lee-Lewandrowski E, Makar R, Mandokolathur M, Rosenberg ES, Saidman S, Sluss P, Sohani AR, Stowell C, Van Cott EM, Lewandrowski KB. The practice of clinical pathology: a quantitative description of laboratory director activities at a large academic medical center. Am J Clin Pathol 2014; 142:144-9. PubMed
  • Hamadeh F, MacNamara S, Bacon CM, Sohani AR, Swerdlow SH, Cook JR. Gamma heavy chain disease lacks the MYD88 l265p mutation associated with lymphoplasmacytic lymphoma. Haematologica 2014. PubMed
  • Soumerai JD, Hellmann MD, Feng Y, Sohani AR, Toomey CE, Barnes JA, Takvorian RW, Neuberg D, Hochberg EP, Abramson JS. Treatment of primary mediastinal B-cell lymphoma with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone is associated with a high rate of primary refractory disease. Leuk Lymphoma 2014; 55:538-43. PubMed
  • Laviv A, Sohani AR, Troulis MJ. Lymphoma Mimics Obstructive Sialadenitis: Three Cases. J Oral Maxillofac Surg 2014. PubMed
  • Bianchi G, Anderson KC, Harris NL, Sohani AR. The heavy chain diseases: clinical and pathologic features. Oncology (Huntingt) 2014; 28:45-53. PubMed
  • Aboutalebi A, Korman JB, Sohani AR, Hasserjian RP, Louissaint A, Le L, Kraft S, Duncan LM, Nazarian RM. Aleukemic cutaneous myeloid sarcoma. J Cutan Pathol 2013; 40:996-1005. PubMed
  • Platt MY, Delelys ME, Preffer FI, Sohani AR. Flow cytometry is of limited utility in the early identification of "Double-hit" B-cell lymphomas. 2013; 84:143-8. PubMed
  • Saini N, Hochberg EP, Linden EA, Jha S, Grohs HK, Sohani AR. HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature. Case Rep Oncol Med 2013; 2013:292301. PubMed
  • Bogusz AM, Baxter RH, Currie T, Sinha P, Sohani AR, Kutok JL, Rodig SJ. Quantitative Immunofluorescence Reveals the Signature of Active B-cell Receptor Signaling in Diffuse Large B-cell Lymphoma. Clin Cancer Res 2012; 18:6122-35. PubMed
  • Barnes J, Jacobsen E, Feng Y, Freedman A, Hochberg E, Lacasce A, Armand P, Joyce R, Sohani A, Rodig S, Neuberg D, Fisher D, Abramson J. Everolimus in combination with rituximab induces complete responses in heavily pretreated diffuse large B-cell lymphoma. Haematologica 2012. PubMed
  • Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y, Sheehy P, Manning RJ, Patterson CJ, Tripsas C, Arcaini L, Pinkus GS, Rodig SJ, Sohani AR, Harris NL, Laramie JM, Skifter DA, Lincoln SE, Hunter ZR. MYD88 L265P somatic mutation in Waldenstr旦m's macroglobulinemia. N Engl J Med 2012; 367:826-33. PubMed
  • Sohani AR, Jaffe ES, Harris NL, Ferry JA, Pittaluga S, Hasserjian RP. Nodular lymphocyte-predominant hodgkin lymphoma with atypical T cells: a morphologic variant mimicking peripheral T-cell lymphoma. Am J Surg Pathol 2011; 35:1666-78. PubMed
  • El Saleeby CM, Grottkau BE, Friedmann AM, Westra SJ, Sohani AR. Case records of the Massachusetts General Hospital. Case 4-2011. A 4-year-old boy with back pain and hypercalcemia. N Engl J Med 2011; 364:552-62. PubMed
  • Cannizzo E, Bellio E, Sohani AR, Hasserjian RP, Ferry JA, Dorn ME, Sadowski C, Bucci JJ, Carulli G, Preffer F. Multiparameter immunophenotyping by flow cytometry in multiple myeloma: The diagnostic utility of defining ranges of normal antigenic expression in comparison to histology. 2010; 78:231-8. PubMed
  • Vallet S, Mukherjee S, Vaghela N, Hideshima T, Fulciniti M, Pozzi S, Santo L, Cirstea D, Patel K, Sohani AR, Guimaraes A, Xie W, Chauhan D, Schoonmaker JA, Attar E, Churchill M, Weller E, Munshi N, Seehra JS, Weissleder R, Anderson KC, Scadden DT, Raje N. Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease. Proc Natl Acad Sci U S A 2010; 107:5124-9. PubMed
  • Ropper AH, Raje NS, Lawrimore TM, Camelo-Piragua S, Sohani AR. Case records of the Massachusetts General Hospital. Case 7-2010. A 49-year-old man with peripheral neuropathy and ascites. N Engl J Med 2010; 362:929-40. PubMed
  • Snuderl M, Kolman OK, Chen YB, Hsu JJ, Ackerman AM, Cin PD, Ferry JA, Harris NL, Hasserjian RP, Zukerberg LR, Abramson JS, Hochberg EP, Lee H, Lee AI, Toomey CE, Sohani AR. B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma. Am J Surg Pathol 2010; 34:327-40. PubMed
  • Sohani AR, Ferry JA, Chang PS, Abramson JS. Epstein-barr virus-positive diffuse large B-cell lymphoma during therapy with alemtuzumab for T-cell prolymphocytic leukemia. J Clin Oncol 2010; 28:e69-72. PubMed
  • Bender Ignacio RA, Liu AY, Sohani AR, Vyas JM. Hodgkin's lymphoma masquerading as vertebral osteomyelitis in a man with diabetes: a case report. J Med Case Reports 2010; 4:102. PubMed
  • O'Gara PT, Shepard JA, Yared K, Sohani AR. Case records of the Massachusetts General Hospital: Case 39-2009--a 28-year-old pregnant woman with acute cardiac failure. N Engl J Med 2009; 361:2462-73. PubMed
  • Wilbur DC, Madi K, Colvin RB, Duncan LM, Faquin WC, Ferry JA, Frosch MP, Houser SL, Kradin RL, Lauwers GY, Louis DN, Mark EJ, Mino-Kenudson M, Misdraji J, Nielsen GP, Pitman MB, Rosenberg AE, Smith RN, Sohani AR, Stone JR, Tambouret RH, Wu CL, Young RH, Zembowicz A, Klietmann W. Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations. Arch Pathol Lab Med 2009; 133:1949-53. PubMed
  • Slack GW,Ferry JA,Hasserjian RP,Sohani AR,Longtine JA,Harris NL,Zukerberg LR. Lymphocyte depleted Hodgkin lymphoma: an evaluation with immunophenotyping and genetic analysis. Leuk Lymphoma 2009. PubMed
  • Ferry JA,Sohani AR,Longtine JA,Schwartz RA,Harris NL. HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma. Mod Pathol 2009; 22:618-26. PubMed
  • Cannizzo E, Sohani AR, Ferry JA, Hochberg EP, Kluk MJ, Dorn ME, Sadowski C, Bucci JJ, Ackerman AM, Longtine JA, Carulli G, Preffer FI. Carcinoma and multiple lymphomas in one patient: establishing the diagnoses and analyzing risk factors. J Hematop 2010; 2:163-70. PubMed
  • Farkash EA, Ferry JA, Harris NL, Hochberg EP, Takvorian RW, Zuckerman DS, Sohani AR. Rare lymphoid malignancies of the breast: a report of two cases illustrating potential diagnostic pitfalls. J Hematop 2010; 2:237-44. PubMed
  • Abramson JS,Chatterji M,Rahemtullah A. Case records of the Massachusetts General Hospital. Case 39-2008. A 51-year-old woman with splenomegaly and anemia. N Engl J Med 2008; 359:2707-18. PubMed
  • Rahemtullah A,Longtine JA,Harris NL,Dorn M,Zembowicz A,Quintanilla-Fend L,Preffer FI,Ferry JA. CD20+ T-cell lymphoma: clinicopathologic analysis of 9 cases and a review of the literature. Am J Surg Pathol 2008; 32:1593-607. PubMed
  • Rahemtullah A,Harris NL,Dorn ME,Preffer FI,Hasserjian RP. Beyond the lymphocyte predominant cell: CD4+CD8+ T-cells in nodular lymphocyte predominant Hodgkin lymphoma. Leuk Lymphoma 2008; 49:1870-8. PubMed
  • Munshi NC,Digumarthy S,Rahemtullah A. Case records of the Massachusetts General Hospital. Case 13-2008. A 46-year-old man with rheumatoid arthritis and lymphadenopathy. N Engl J Med 2008; 358:1838-48. PubMed
  • Rahemtullah A, Van Cott EM. Hypercoagulation testing in ischemic stroke. Arch Pathol Lab Med 2007; 131:890-901. PubMed
  • Chen YB, Rahemtullah A, Hochberg E. Primary effusion lymphoma. Oncologist 2007; 12:569-76. PubMed
  • Chen YB, Rahemtullah A, Breeden E, Hochberg EP. Bleomycin-induced flagellate erythema. J Clin Oncol 2007; 25:898-900. PubMed
  • Rahemtullah A, Reichard KK, Preffer FI, Harris NL, Hasserjian RP. A double-positive CD4+CD8+ T-cell population is commonly found in nodular lymphocyte predominant Hodgkin lymphoma. Am J Clin Pathol 2006; 126:805-14. PubMed
  • Rahemtullah A, Oliva E. Nephrogenic adenoma: an update on an innocuous but troublesome entity. Adv Anat Pathol 2006; 13:247-55. PubMed
  • Williams WW, Ecker JL, Thadhani RI, Rahemtullah A. Case records of the Massachusetts General Hospital. Case 38-2005. A 29-year-old pregnant woman with the nephrotic syndrome and hypertension. N Engl J Med 2005; 353:2590-600. PubMed
  • Wang SA, Rahemtullah A, Faquin WC, Roepke J, Harris NL, Hasserjian RP. Hodgkin's lymphoma of the thyroid: a clinicopathologic study of five cases and review of the literature. Mod Pathol 2005; 18:1577-84. PubMed
  • Rahemtullah A, Szyfelbein K, Zembowicz A. Glomus coccygeum: report of a case and review of the literature. Am J Dermatopathol 2005; 27:497-9. PubMed
  • Rahemtullah A, Misdraji J, Pitman MB. Adenosquamous carcinoma of the pancreas: cytologic features in 14 cases. Cancer 2003; 99:372-8. PubMed
  • Weber AL, Rahemtullah A, Ferry JA. Hodgkin and non-Hodgkin lymphoma of the head and neck: clinical, pathologic, and imaging evaluation. Neuroimaging Clin N Am 2003; 13:371-92. PubMed
  • Rahemtullah A, Lieberman E, Benson C, Norton ME. Outcome of pregnancy after prenatal diagnosis of umbilical vein varix. J Ultrasound Med 2001; 20:135-9. PubMed
  • Rahemtullah A, McGillivray B, Wilson RD. Suspected skeletal dysplasias: femur length to abdominal circumference ratio can be used in ultrasonographic prediction of fetal outcome. Am J Obstet Gynecol 1997; 177:864-9. PubMed
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