Photo of Allon M Klein,  PhD

Allon M Klein, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 432-4996


allon_klein@hms.harvard.edu

Allon M Klein, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • Assistant Professor, Systems Biology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Publications

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  • Briggs JA, Li VC, Lee S, Woolf CJ, Klein A, Kirschner MW. Mouse embryonic stem cells can differentiate via multiple paths to the same state. Elife 2017. PubMed
  • Klein AM, Macosko E. InDrops and Drop-seq technologies for single-cell sequencing. Lab Chip 2017; 17:2540-2541. PubMed
  • Wagner DE, Klein AM. Genetic screening enters the single-cell era. Nat Methods 2017; 14:237-238. PubMed
  • Zilionis R, Nainys J, Veres A, Savova V, Zemmour D, Klein AM, Mazutis L. Single-cell barcoding and sequencing using droplet microfluidics. Nat Protoc 2016; 12:44-73. PubMed
  • Baron M, Veres A, Wolock SL, Faust AL, Gaujoux R, Vetere A, Ryu JH, Wagner BK, Shen-Orr SS, Klein AM, Melton DA, Yanai I. A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure. Cell Syst 2016; 3:346-360.e4. PubMed
  • Rompolas P, Mesa KR, Kawaguchi K, Park S, Gonzalez D, Brown S, Boucher J, Klein AM, Greco V. Spatiotemporal coordination of stem cell commitment during epidermal homeostasis. Science 2016; 352:1471-4. PubMed
  • Klein AM, Mazutis L, Akartuna I, Tallapragada N, Veres A, Li V, Peshkin L, Weitz DA, Kirschner MW. Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell 2015; 161:1187-201. PubMed
  • Kronen MR, Schoenfelder KP, Klein AM, Nystul TG. Basolateral junction proteins regulate competition for the follicle stem cell niche in the Drosophila ovary. PLoS ONE 2014; 9:e101085. PubMed
  • Hernández AR, Klein AM, Kirschner MW. Kinetic responses of β-catenin specify the sites of Wnt control. Science 2012; 338:1337-40. PubMed
  • Klein AM, Nikolaidou-Neokosmidou V, Doupé DP, Jones PH, Simons BD. Patterning as a signature of human epidermal stem cell regulation. J R Soc Interface 2011; 8:1815-24. PubMed
  • Klein AM, Simons BD. Universal patterns of stem cell fate in cycling adult tissues. Development 2011; 138:3103-11. PubMed
  • Waks Z, Klein AM, Silver PA. Cell-to-cell variability of alternative RNA splicing. Mol Syst Biol 2011; 7:506. PubMed
  • Lopez-Garcia C, Klein AM, Simons BD, Winton DJ. Intestinal stem cell replacement follows a pattern of neutral drift. Science 2010; 330:822-5. PubMed
  • Klein AM, Nakagawa T, Ichikawa R, Yoshida S, Simons BD. Mouse germ line stem cells undergo rapid and stochastic turnover. Cell Stem Cell 2010; 7:214-24. PubMed
  • Klein AM, Brash DE, Jones PH, Simons BD. Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia. Proc Natl Acad Sci U S A 2010; 107:270-5. PubMed
  • Klein AM, Doupé DP, Jones PH, Simons BD. Kinetics of cell division in epidermal maintenance. Phys Rev E Stat Nonlin Soft Matter Phys 2007; 76:021910. PubMed
  • Clayton E, Doupé DP, Klein AM, Winton DJ, Simons BD, Jones PH. A single type of progenitor cell maintains normal epidermis. Nature 2007; 446:185-9. PubMed
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