Photo of Alphonse G. Taghian,  MD, PhD

Alphonse G. Taghian, MD, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-7559
Fax: (617) 726-3603


ataghian@partners.org

Alphonse G. Taghian, MD, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Radiation Oncology, Harvard Medical School
  • Diector Breast Radiation Oncology, Radiation Oncology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

The foundation of my clinical, research and academic practice is in advancing all aspects of a patient’s care. I have dedicated my academic and research career to the investigation, development and clinical implementation of innovative approaches to improving the delivery and quality of breast cancer radiation treatment. The focal point of my work concerns the minimization of treatment related side effects and complications to improve the quality of life for patients while not compromising the expected benefit of the cancer therapy. This approach serves as the basis of my clinical practice and is an ideology that I stress to those individuals which I mentor. My current and future research protocols will be a continuation of these efforts with projects focusing in using techniques to decrease cardiac and pulmonary toxicity from radiation in patients treated with Herceptin-based chemotherapy, once and twice daily external beam partial breast irradiation (PBI) to complete breast radiation in one or two weeks, and investigation of symptoms, impact on quality of life and early detection and intervention of breast cancer related lymphedema.

 

Publications

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  • Swaroop MN, Ferguson CM, Horick NK, Skolny MN, Miller CL, Jammallo LS, Brunelle CL, O'Toole JA, Isakoff SJ, Specht MC, Taghian AG. Impact of adjuvant taxane-based chemotherapy on development of breast cancer-related lymphedema: results from a large prospective cohort. Breast Cancer Res Treat 2015; 151:393-403. PubMed
  • Braunstein LZ, Taghian AG. Hypofractionated whole breast irradiation for early-stage breast cancer. JAMA 2015; 313:1370-1. PubMed
  • O'Toole JA, Ferguson CM, Swaroop MN, Horick N, Skolny MN, Brunelle CL, Miller CL, Jammallo LS, Specht MC, Taghian AG. The impact of breast cancer-related lymphedema on the ability to perform upper extremity activities of daily living. Breast Cancer Res Treat 2015; 150:381-8. PubMed
  • Chandra RA, Miller CL, Skolny MN, Warren LE, Horick N, Jammallo LS, Sadek BT, Shenouda MN, O'Toole J, Specht MC, Taghian AG. Radiation therapy risk factors for development of lymphedema in patients treated with regional lymph node irradiation for breast cancer. Int J Radiat Oncol Biol Phys 2015; 91:760-4. PubMed
  • Braunstein LZ, Niemierko A, Shenouda MN, Truong L, Sadek BT, Abi Raad R, Wong JS, Punglia RS, Taghian AG, Bellon JR. Outcome following local-regional recurrence in women with early-stage breast cancer: impact of biologic subtype. Breast J 2015; 21:161-7. PubMed
  • Miller CL, Colwell AS, Horick N, Skolny MN, Jammallo LS, OʼToole JA, Shenouda MN, Sadek BT, Swaroop MN, Ferguson CM, Smith BL, Specht MC, Taghian AG. Immediate Implant Reconstruction Is Associated With a Reduced Risk of Lymphedema Compared to Mastectomy Alone: A Prospective Cohort Study. Ann Surg 2015. PubMed
  • Brunelle C, Skolny M, Ferguson C, Swaroop M, O'Toole J, Taghian AG. Establishing and sustaining a prospective screening program for breast cancer-related lymphedema at the massachusetts general hospital: lessons learned. J Pers Med 2015; 5:153-64. PubMed
  • Rochet N, Drake JI, Harrington K, Wolfgang JA, Napolitano B, Sadek BT, Shenouda MN, Keruakous AR, Niemierko A, Taghian AG. Deep inspiration breath-hold technique in left-sided breast cancer radiation therapy: Evaluating cardiac contact distance as a predictor of cardiac exposure for patient selection. 2014. PubMed
  • Jammallo LS, Miller CL, Horick NK, Skolny MN, O'Toole J, Specht MC, Taghian AG. Factors associated with fear of lymphedema after treatment for breast cancer. Oncol Nurs Forum 2014; 41:473-83. PubMed
  • Keruakous AR, Sadek BT, Shenouda MN, Niemierko A, Abi Raad RF, Specht M, Smith BL, Taghian AG. The impact of isolated tumor cells on loco-regional recurrence in breast cancer patients treated with breast-conserving treatment or mastectomy without post-mastectomy radiation therapy. Breast Cancer Res Treat 2014; 146:365-70. PubMed
  • Wang Y, Li W, Patel SS, Cong J, Zhang N, Sabbatino F, Liu X, Qi Y, Huang P, Lee H, Taghian A, Li JJ, DeLeo AB, Ferrone S, Epperly MW, Ferrone CR, Ly A, Brachtel EF, Wang X. Blocking the formation of radiation-induced breast cancer stem cells. 2014; 5:3743-55. PubMed
  • Galland-Girodet S, Pashtan I, MacDonald SM, Ancukiewicz M, Hirsch AE, Kachnic LA, Specht M, Gadd M, Smith BL, Powell SN, Recht A, Taghian AG. Long-Term Cosmetic Outcomes and Toxicities of Proton Beam Therapy Compared With Photon-Based 3-Dimensional Conformal Accelerated Partial-Breast Irradiation: A Phase 1 Trial. Int J Radiat Oncol Biol Phys 2014. PubMed
  • Peterson DJ, Truong PT, Sadek BT, Alexander CS, Wiksyk B, Shenouda M, Raad RA, Taghian AG. Locoregional Recurrence and Survival Outcomes by Type of Local Therapy and Trastuzumab Use Among Women with Node-Negative, HER2-Positive Breast Cancer. Ann Surg Oncol 2014. PubMed
  • Warren LE, Miller CL, Horick N, Skolny MN, Jammallo LS, Sadek BT, Shenouda MN, O'Toole JA, MacDonald SM, Specht MC, Taghian AG. The impact of radiation therapy on the risk of lymphedema after treatment for breast cancer: a prospective cohort study. Int J Radiat Oncol Biol Phys 2014; 88:565-71. PubMed
  • Miller CL, Specht MC, Skolny MN, Horick N, Jammallo LS, O'Toole J, Shenouda MN, Sadek BT, Smith BL, Taghian AG. Risk of lymphedema after mastectomy: potential benefit of applying ACOSOG Z0011 protocol to mastectomy patients. Breast Cancer Res Treat 2014; 144:71-7. PubMed
  • Truong PT, Sadek BT, Lesperance MF, Alexander CS, Shenouda M, Raad RA, Taghian AG. Is biological subtype prognostic of locoregional recurrence risk in women with pT1-2N0 breast cancer treated with mastectomy? Int J Radiat Oncol Biol Phys 2013; 88:57-64. PubMed
  • Shenouda MN, Sadek BT, Goldberg SI, Keruakous AR, Croft BJ, Abi Raad RF, Taghian AG. Clinical Outcome of Isolated Locoregional Recurrence in Patients With Breast Cancer According to Their Primary Local Treatment. Clin Breast Cancer 2014. PubMed
  • Sadek BT, Shenouda MN, Abi Raad RF, Niemierko A, Keruakous AR, Goldberg SI, Taghian AG. Risk of local failure in breast cancer patients with lobular carcinoma in situ at the final surgical margins: is re-excision necessary? Int J Radiat Oncol Biol Phys 2013; 87:726-30. PubMed
  • O'Toole J, Jammallo LS, Skolny MN, Miller CL, Elliott K, Specht MC, Taghian AG. Lymphedema following treatment for breast cancer: a new approach to an old problem. Crit Rev Oncol Hematol 2013; 88:437-46. PubMed
  • Jammallo LS, Miller CL, Singer M, Horick NK, Skolny MN, Specht MC, O'Toole J, Taghian AG. Impact of body mass index and weight fluctuation on lymphedema risk in patients treated for breast cancer. Breast Cancer Res Treat 2013; 142:59-67. PubMed
  • Fogh S, Kachnic LA, Goldberg SI, Taghian AG, Powell SN, Hirsch AE. Localized therapy for male breast cancer: functional advantages with comparable outcomes using breast conservation. Clin Breast Cancer 2013; 13:344-9. PubMed
  • Specht MC, Miller CL, Skolny MN, Jammallo LS, O'Toole J, Horick N, Isakoff SJ, Smith BL, Taghian AG. Residual lymph node disease after neoadjuvant chemotherapy predicts an increased risk of lymphedema in node-positive breast cancer patients. Ann Surg Oncol 2013; 20:2835-41. PubMed
  • Specht MC, Miller CL, Russell TA, Horick N, Skolny MN, O'Toole JA, Jammallo LS, Niemierko A, Sadek BT, Shenouda MN, Finkelstein DM, Smith BL, Taghian AG. Defining a threshold for intervention in breast cancer-related lymphedema: what level of arm volume increase predicts progression? Breast Cancer Res Treat 2013; 140:485-94. PubMed
  • Corben AD, Abi-Raad R, Popa I, Teo CH, Macklin EA, Koerner FC, Taghian AG, Brachtel EF. Pathologic response and long-term follow-up in breast cancer patients treated with neoadjuvant chemotherapy: a comparison between classifications and their practical application. Arch Pathol Lab Med 2013; 137:1074-82. PubMed
  • O'Toole J, Miller CL, Specht MC, Skolny MN, Jammallo LS, Horick N, Elliott K, Niemierko A, Taghian AG. Cording following treatment for breast cancer. Breast Cancer Res Treat 2013; 140:105-11. PubMed
  • Russo AL, Taghian AG. Fat necrosis of the breast in the accelerated partial breast irradiation era: the need for a universal grading system. Breast Cancer Res Treat 2013; 140:1-11. PubMed
  • Jimenez RB, Goma C, Nyamwanda J, Kooy HM, Halabi T, Napolitano BN, McBride SM, Taghian AG, Lu HM, Macdonald SM. Intensity modulated proton therapy for postmastectomy radiation of bilateral implant reconstructed breasts: A treatment planning study. Radiother Oncol 2013. PubMed
  • O'Toole J, Jammallo LS, Miller CL, Skolny MN, Specht MC, Taghian AG. Screening for Breast Cancer-Related Lymphedema: The Need for Standardization. Oncologist 2013. PubMed
  • Macdonald SM, Patel SA, Hickey S, Specht M, Isakoff SJ, Gadd M, Smith BL, Yeap BY, Adams J, Delaney TF, Kooy H, Lu HM, Taghian AG. Proton Therapy for Breast Cancer After Mastectomy: Early Outcomes of a Prospective Clinical Trial. Int J Radiat Oncol Biol Phys 2013. PubMed
  • Macdonald SM, Jimenez R, Paetzold P, Adams J, Beatty J, Delaney TF, Kooy H, Taghian AG, Lu HM. Proton radiotherapy for chest wall and regional lymphatic radiation; dose comparisons and treatment delivery. Radiat Oncol 2013; 8:71. PubMed
  • Gierga DP, Turcotte JC, Sharp GC, Sedlacek DE, Cotter CR, Taghian AG. A voluntary breath-hold treatment technique for the left breast with unfavorable cardiac anatomy using surface imaging. Int J Radiat Oncol Biol Phys 2012; 84:e663-8. PubMed
  • Pashtan IM, Recht A, Ancukiewicz M, Brachtel E, Abi-Raad RF, D'Alessandro HA, Levy A, Wo JY, Hirsch AE, Kachnic LA, Goldberg S, Specht M, Gadd M, Smith BL, Powell SN, Taghian AG. External beam accelerated partial-breast irradiation using 32 gy in 8 twice-daily fractions: 5-year results of a prospective study. Int J Radiat Oncol Biol Phys 2012; 84:e271-7. PubMed
  • Ancukiewicz M, Miller CL, Skolny MN, O'Toole J, Warren LE, Jammallo LS, Specht MC, Taghian AG. Erratum to: Comparison of relative versus absolute arm size change as criteria for quantifying breast cancer-related lymphedema: the flaws in current studies and need for universal methodology. Breast Cancer Res Treat 2012; 136:623. PubMed
  • Arvold ND, Oh KS, Niemierko A, Taghian AG, Lin NU, Abi-Raad RF, Sreedhara M, Harris JR, Alexander BM. Brain metastases after breast-conserving therapy and systemic therapy: incidence and characteristics by biologic subtype. Breast Cancer Res Treat 2012; 136:153-60. PubMed
  • Miller CL, Specht MC, Skolny MN, Jammallo LS, Horick N, O'Toole J, Coopey SB, Hughes K, Gadd M, Smith BL, Taghian AG. Sentinel lymph node biopsy at the time of mastectomy does not increase the risk of lymphedema: implications for prophylactic surgery. Breast Cancer Res Treat 2012; 135:781-9. PubMed
  • Greenup RA, Camp MS, Taghian AG, Buckley J, Coopey SB, Gadd M, Hughes K, Specht M, Smith BL. Cost comparison of radiation treatment options after lumpectomy for breast cancer. Ann Surg Oncol 2012; 19:3275-81. PubMed
  • Hattangadi JA, Powell SN, Mauceri T, Taghian AG. In reply to Hannoun-Levi et al. Int J Radiat Oncol Biol Phys 2012; 84:306-7. PubMed
  • Camp MS, Greenup RA, Taghian A, Coopey SB, Specht M, Gadd M, Hughes K, Smith BL. Application of ACOSOG Z0011 Criteria Reduces Perioperative Costs. Ann Surg Oncol 2012. PubMed
  • Boutrus RR, Abi Raad RF, Kuter I, Ancukiewicz M, Roberts L, Solomon N, Ngo T, Borick H, Ryan P, Moy B, Gadd M, Chien J, Younger J, Smith B, Taghian AG, Harris L. Circulating tumor cells as predictors of response and failure in breast cancer patients treated with preoperative chemotherapy. Int J Biol Markers 2012. PubMed
  • Ancukiewicz M, Miller CL, Skolny MN, O'Toole J, Warren LE, Jammallo LS, Specht MC, Taghian AG. Comparison of relative versus absolute arm size change as criteria for quantifying breast cancer-related lymphedema: the flaws in current studies and need for universal methodology. Breast Cancer Res Treat 2012; 135:145-52. PubMed
  • Azoury F, Heymann S, Acevedo C, Spielmann M, Vielh P, Garbay JR, Taghian AG, Marsiglia H, Bourgier C. Phase II trial of 3D-conformal accelerated partial breast irradiation: lessons learned from patients and physicians' evaluation. Radiother Oncol 2012; 103:193-8. PubMed
  • Hattangadi JA, Powell SN, Macdonald SM, Mauceri T, Ancukiewicz M, Freer P, Lawenda B, Alm El-Din MA, Gadd MA, Smith BL, Taghian AG. Accelerated Partial Breast Irradiation with Low-Dose-Rate Interstitial Implant Brachytherapy After Wide Local Excision: 12-Year Outcomes from a Prospective Trial. Int J Radiat Oncol Biol Phys 2011. PubMed
  • Arvold ND, Taghian AG, Niemierko A, Abi Raad RF, Sreedhara M, Nguyen PL, Bellon JR, Wong JS, Smith BL, Harris JR. Age, breast cancer subtype approximation, and local recurrence after breast-conserving therapy. J Clin Oncol 2011; 29:3885-91. PubMed
  • Hattangadi-Gluth JA, Wo JY, Nguyen PL, Abi Raad RF, Sreedhara M, Niemierko A, Freer PE, Georgian-Smith D, Bellon JR, Wong JS, Smith BL, Harris JR, Taghian AG. Basal Subtype of Invasive Breast Cancer is Associated with a Higher Risk of True Recurrence After Conventional Breast-Conserving Therapy. Int J Radiat Oncol Biol Phys 2011. PubMed
  • Khanfir K, Kallel A, Villette S, Belkacémi Y, Vautravers C, Nguyen T, Miller R, Li YX, Taghian AG, Boersma L, Poortmans P, Goldberg H, Vees H, Senkus E, Igdem S, Ozsahin M, Jeanneret Sozzi W. Management of Adenoid Cystic Carcinoma of the Breast: A Rare Cancer Network Study. Int J Radiat Oncol Biol Phys 2011. PubMed
  • Abi-Raad R, Boutrus R, Wang R, Niemierko A, Macdonald S, Smith B, Taghian AG. Patterns and Risk Factors of Locoregional Recurrence in T1-T2 Node Negative Breast Cancer Patients Treated with Mastectomy: Implications for Postmastectomy Radiotherapy. Int J Radiat Oncol Biol Phys 2011. PubMed
  • Fogh S, Hirsch AE, Langmead JP, Goldberg SI, Rosenberg CL, Taghian AG, Powell SN, Kachnic LA. Use of tamoxifen with postsurgical irradiation may improve survival in estrogen and progesterone receptor-positive male breast cancer. Clin Breast Cancer 2011; 11:39-45. PubMed
  • Mancias JD, Taghian AG. Accelerated partial breast irradiation using TARGIT: the pros, cons and the need for long-term results. Expert Rev Anticancer Ther 2010; 10:1869-75. PubMed
  • Boutrus R, Taghian AG, . Post mastectomy radiation for large node negative breast cancer: Time for a second look. Crit Rev Oncol Hematol 2011. PubMed
  • Boutrus R, Abi-Raad R, Niemierko A, Brachtel EF, Rizk L, Kelada A, Taghian AG. Does Lymphovascular Invasion Predict Regional Nodal Failure in Breast Cancer Patients with zero to three positive lymph nodes Treated with Conserving Surgery and Radiotherapy? Implications for Regional Radiation. Int J Radiat Oncol Biol Phys 2010; 78:793-8. PubMed
  • Bourgier C, Pichenot C, Verstraet R, El Nemr M, Heymann S, Biron B, Delaloge S, Mathieu MC, Garbay JR, Bourhis J, Taghian AG, Marsiglia H. Early Side Effects of Three-Dimensional Conformal External Beam Accelerated Partial Breast Irradiation to a Total Dose of 40 Gy in One Week (a Phase II Trial). Int J Radiat Oncol Biol Phys 2010. PubMed
  • Smith BD, Bentzen SM, Correa CR, Hahn CA, Hardenbergh PH, Ibbott GS, McCormick B, McQueen JR, Pierce LJ, Powell SN, Recht A, Taghian AG, Vicini FA, White JR, Haffty BG. Fractionation for Whole Breast Irradiation: An American Society for Radiation Oncology (ASTRO) Evidence-Based Guideline. Int J Radiat Oncol Biol Phys 2010. PubMed
  • Macdonald SM, Harisinghani MG, Katkar A, Napolitano B, Wolfgang J, Taghian AG. Nanoparticle-Enhanced MRI to Evaluate Radiation Delivery to the Regional Lymphatics for Patients With Breast Cancer. Int J Radiat Oncol Biol Phys 2010; 77:1098-104. PubMed
  • Ancukiewicz M, Russell TA, Otoole J, Specht M, Singer M, Kelada A, Murphy CD, Pogachar J, Gioioso V, Patel M, Skolny M, Smith BL, Taghian AG. Standardized Method for Quantification of Developing Lymphedema in Patients Treated for Breast Cancer. Int J Radiat Oncol Biol Phys 2010. PubMed
  • Wo JY, Taghian AG, Nguyen PL, Raad RA, Sreedhara M, Bellon JR, Wong JS, Gadd MA, Smith BL, Harris JR. The Association Between Biological Subtype and Isolated Regional Nodal Failure After Breast-Conserving Therapy. Int J Radiat Oncol Biol Phys 2010; 77:188-96. PubMed
  • Sanghani M, Truong PT, Raad RA, Niemierko A, Lesperance M, Olivotto IA, Wazer DE, Taghian AG. Validation of a web-based predictive nomogram for ipsilateral breast tumor recurrence after breast conserving therapy. J Clin Oncol 2010; 28:718-22. PubMed
  • Gierga DP, Taghian AG, Chen GT. Clinical experience with image-guided radiotherapy in an accelerated partial breast intensity-modulated radiotherapy protocol: in regard to Leonard CE et al. (Int J Radiat Oncol Biol Phys Epub May 19, 2009). Int J Radiat Oncol Biol Phys 2009; 76:315; author reply 315. PubMed
  • Macdonald SM,Abi-Raad RF,Alm El-Din MA,Niemierko A,Kobayashi W,McGrath JJ,Goldberg SI,Powell S,Smith B,Taghian AG. Chest Wall Radiotherapy: Middle Ground for Treatment of Patients with One to Three Positive Lymph Nodes After Mastectomy. Int J Radiat Oncol Biol Phys 2009; 75:1297-303. PubMed
  • MacDonald S, Taghian AG. Prognostic factors for local control after breast conservation: does margin status still matter? J Clin Oncol 2009; 27:4929-30. PubMed
  • Alm El-Din MA, Taghian AG. Breast conservation therapy for patients with locally advanced breast cancer. Semin Radiat Oncol 2009; 19:229-35. PubMed
  • Javid SH, Kirstein LJ, Rafferty E, Lipsitz S, Moore R, Rusby JE, Murphy CD, Hughes KS, Specht MC, Taghian AG, Smith BL. Outcome of multiple-wire localization for larger breast cancers: do multiple wires translate into additional imaging, biopsies, and recurrences? Am J Surg 2009; 198:368-72. PubMed
  • Recht A, Ancukiewicz M, Alm El-Din MA, Lu XQ, Martin C, Berman SM, Hirsch AE, Kachnic LA, Katz A, MacDonald S, Nedea EA, Stevenson MA, Powell SN, Taghian AG. Lung dose-volume parameters and the risk of pneumonitis for patients treated with accelerated partial-breast irradiation using three-dimensional conformal radiotherapy. J Clin Oncol 2009; 27:3887-93. PubMed
  • Willers H, Taghian AG, Luo CM, Treszezamsky A, Sgroi DC, Powell SN. Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies. Mol Cancer Res 2009; 7:1304-9. PubMed
  • Sher DJ,Wittenberg E,Suh WW,Taghian AG,Punglia RS. Partial-breast irradiation versus whole-breast irradiation for early-stage breast cancer: a cost-effectiveness analysis. Int J Radiat Oncol Biol Phys 2008; 74:440-6. PubMed
  • Taghian AG,Bourgier C. Counterpoint: Conformal external beam for accelerated partial breast irradiation. Brachytherapy 2009; 8:184-8. PubMed
  • Floyd SR,Taghian AG. Post-mastectomy radiation in large node-negative breast tumors: does size really matter? Radiother Oncol 2009; 91:33-7. PubMed
  • Alm El-Din MA, Hughes KS, Raad RA, Goldberg SI, Aisenberg AC, Niemierko A, Taghian AG. Clinical outcome of breast cancer occurring after treatment for Hodgkin's lymphoma: case-control analysis. Radiat Oncol 2009; 4:19. PubMed
  • Alm El-Din MA,Hughes KS,Finkelstein DM,Betts KA,Yock TI,Tarbell NJ,Aisenberg AC,Taghian AG. Breast cancer after treatment of Hodgkin's lymphoma: risk factors that really matter. Int J Radiat Oncol Biol Phys 2008; 73:69-74. PubMed
  • Alm El-Din MA,El-Badawy SA,Taghian AG. Breast cancer after treatment of Hodgkin's lymphoma: general review. Int J Radiat Oncol Biol Phys 2008; 72:1291-7. PubMed
  • Wong JS, Taghian AG, Bellon JR, Keshaviah A, Smith BL, Winer EP, Silver B, Harris JR. Tangential Radiotherapy Without Axillary Surgery in Early-Stage Breast Cancer: Results of a Prospective Trial. Int J Radiat Oncol Biol Phys 2008; 72:866-70. PubMed
  • Kirstein LJ,Rafferty E,Specht MC,Moore RH,Taghian AG,Hughes KS,Gadd MA,Smith BL. Outcomes of multiple wire localization for larger breast cancers: when can mastectomy be avoided? J Am Coll Surg 2008; 207:342-6. PubMed
  • Alm El-Din MA,Feng JK,Taghian AG. Lumpectomy and partial breast irradiation for early-stage breast cancer following mantle irradiation for Hodgkin's lymphoma. Nat Clin Pract Oncol 2008; 5:426-9. PubMed
  • Nguyen PL, Taghian AG, Katz MS, Niemierko A, Abi Raad RF, Boon WL, Bellon JR, Wong JS, Smith BL, Harris JR. Breast cancer subtype approximated by estrogen receptor, progesterone receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy. J Clin Oncol 2008; 26:2373-8. PubMed
  • Katz A, Smith BL, Golshan M, Niemierko A, Kobayashi W, Raad RA, Kelada A, Rizk L, Wong JS, Bellon JR, Gadd M, Specht M, Taghian AG. Nomogram for the prediction of having four or more involved nodes for sentinel lymph node-positive breast cancer. J Clin Oncol 2008; 26:2093-8. PubMed
  • Gierga DP, Riboldi M, Turcotte JC, Sharp GC, Jiang SB, Taghian AG, Chen GT. Comparison of target registration errors for multiple image-guided techniques in accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 2008; 70:1239-46. PubMed
  • Sher DJ, Wittenberg E, Taghian AG, Bellon JR, Punglia RS. Partial breast irradiation versus whole breast radiotherapy for early-stage breast cancer: a decision analysis. Int J Radiat Oncol Biol Phys 2007; 70:469-76. PubMed
  • Jeanneret-Sozzi W, Taghian A, Epelbaum R, Poortmans P, Zwahlen D, Amsler B, Villette S, Belkacemi Y, Nguyen T, Scalliet P, Maingon P, Gutierrez C, Gastelblum P, Krengli M, Raad RA, Ozsahin M, Mirimanoff RO. Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre Rare Cancer Network study. BMC Cancer 2008; 8:86. PubMed
  • Rusby JE, Brachtel EF, Taghian A, Michaelson JS, Koerner FC, Smith BL. George Peters Award. Microscopic anatomy within the nipple: implications for nipple-sparing mastectomy. Am J Surg 2007; 194:433-7. PubMed
  • MacDonald SM, Taghian AG. Is it time to use protons for breast cancer? Cancer J 2007; 13:84-6. PubMed
  • Macdonald SM, Taghian AG. Partial-breast irradiation: towards a replacement for whole-breast irradiation? Expert Rev Anticancer Ther 2007; 7:123-34. PubMed
  • Kozak KR, Smith BL, Adams J, Kornmehl E, Katz A, Gadd M, Specht M, Hughes K, Gioioso V, Lu HM, Braaten K, Recht A, Powell SN, DeLaney TF, Taghian AG. Accelerated partial-breast irradiation using proton beams: initial clinical experience. Int J Radiat Oncol Biol Phys 2006; 66:691-8. PubMed
  • Floyd SR, Buchholz TA, Haffty BG, Goldberg S, Niemierko A, Raad RA, Oswald MJ, Sullivan T, Strom EA, Powell SN, Katz A, Taghian AG. Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 CM and larger. Int J Radiat Oncol Biol Phys 2006; 66:358-64. PubMed
  • Taghian AG, Jeong JH, Mamounas EP, Parda DS, Deutsch M, Costantino JP, Wolmark N. Low locoregional recurrence rate among node-negative breast cancer patients with tumors 5 cm or larger treated by mastectomy, with or without adjuvant systemic therapy and without radiotherapy: results from five national surgical adjuvant breast and bowel J Clin Oncol 2006; 24:3927-32. PubMed
  • Taghian AG, Kozak KR, Katz A, Adams J, Lu HM, Powell SN, Delaney TF. Accelerated partial breast irradiation using proton beams: Initial dosimetric experience. Int J Radiat Oncol Biol Phys 2006; 65:1404-10. PubMed
  • Kozak KR, Katz A, Adams J, Crowley EM, Nyamwanda JA, Feng JK, Doppke KP, Delaney TF, Taghian AG. Dosimetric comparison of proton and photon three-dimensional, conformal, external beam accelerated partial breast irradiation techniques. Int J Radiat Oncol Biol Phys 2006; 65:1572-8. PubMed
  • Carlson RW, Moench SJ, Hammond ME, Perez EA, Burstein HJ, Allred DC, Vogel CL, Goldstein LJ, Somlo G, Gradishar WJ, Hudis CA, Jahanzeb M, Stark A, Wolff AC, Press MF, Winer EP, Paik S, Ljung BM,. HER2 testing in breast cancer: NCCN Task Force report and recommendations. J Natl Compr Canc Netw 2006; 4 Suppl 3:S1-22; quiz S23-4. PubMed
  • Kozak KR, Doppke KP, Katz A, Taghian AG. Dosimetric comparison of two different three-dimensional conformal external beam accelerated partial breast irradiation techniques. Int J Radiat Oncol Biol Phys 2006; 65:340-6. PubMed
  • Bert C, Metheany KG, Doppke KP, Taghian AG, Powell SN, Chen GT. Clinical experience with a 3D surface patient setup system for alignment of partial-breast irradiation patients. Int J Radiat Oncol Biol Phys 2006; 64:1265-74. PubMed
  • Taghian AG, Kozak KR, Doppke KP, Katz A, Smith BL, Gadd M, Specht M, Hughes K, Braaten K, Kachnic LA, Recht A, Powell SN. Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation. Int J Radiat Oncol Biol Phys 2006; 64:1092-9. PubMed
  • Burstein HJ, Bellon JR, Galper S, Lu HM, Kuter I, Taghian AG, Wong J, Gelman R, Bunnell CA, Parker LM, Garber JE, Winer EP, Harris JR, Powell SN. Prospective evaluation of concurrent paclitaxel and radiation therapy after adjuvant doxorubicin and cyclophosphamide chemotherapy for Stage II or III breast cancer. Int J Radiat Oncol Biol Phys 2006; 64:496-504. PubMed
  • Taghian AG, Recht A. Update on accelerated partial-breast irradiation. Curr Oncol Rep 2006; 8:35-41. PubMed
  • Sullivan T, Raad RA, Goldberg S, Assaad SI, Gadd M, Smith BL, Powell SN, Taghian AG. Tubular carcinoma of the breast: a retrospective analysis and review of the literature. Breast Cancer Res Treat 2005; 93:199-205. PubMed
  • Jagsi R, Raad RA, Goldberg S, Sullivan T, Michaelson J, Powell SN, Taghian AG. Locoregional recurrence rates and prognostic factors for failure in node-negative patients treated with mastectomy: implications for postmastectomy radiation. Int J Radiat Oncol Biol Phys 2005; 62:1035-9. PubMed
  • Taghian AG, Assaad SI, Niemierko A, Floyd SR, Powell SN. Is a reduction in radiation lung volume and dose necessary with paclitaxel chemotherapy for node-positive breast cancer? Int J Radiat Oncol Biol Phys 2005; 62:386-91. PubMed
  • Taghian A, Mohiuddin M, Jagsi R, Goldberg S, Ceilley E, Powell S. Current perceptions regarding surgical margin status after breast-conserving therapy: results of a survey. Ann Surg 2005; 241:629-39. PubMed
  • Taghian AG, Abi-Raad R, Assaad SI, Casty A, Ancukiewicz M, Yeh E, Molokhia P, Attia K, Sullivan T, Kuter I, Boucher Y, Powell SN. Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications. J Clin Oncol 2005; 23:1951-61. PubMed
  • Yeh E, Slanetz P, Kopans DB, Rafferty E, Georgian-Smith D, Moy L, Halpern E, Moore R, Kuter I, Taghian A. Prospective comparison of mammography, sonography, and MRI in patients undergoing neoadjuvant chemotherapy for palpable breast cancer. AJR Am J Roentgenol 2005; 184:868-77. PubMed
  • Ceilley E, Jagsi R, Goldberg S, Grignon L, Kachnic L, Powell S, Taghian A. Radiotherapy for invasive breast cancer in North America and Europe: results of a survey. Int J Radiat Oncol Biol Phys 2005; 61:365-73. PubMed
  • Taghian A, Jeong JH, Mamounas E, Anderson S, Bryant J, Deutsch M, Wolmark N. Patterns of locoregional failure in patients with operable breast cancer treated by mastectomy and adjuvant chemotherapy with or without tamoxifen and without radiotherapy: results from five National Surgical Adjuvant Breast and Bowel Project randomized c J Clin Oncol 2004; 22:4247-54. PubMed
  • Ceilley E, Jagsi R, Goldberg S, Kachnic L, Powell S, Taghian A. The management of ductal carcinoma in situ in North America and Europe. Results of a survey. Cancer 2004; 101:1958-67. PubMed
  • Taghian A, Jagsi R, Makris A, Goldberg S, Ceilley E, Grignon L, Powell S. Results of a survey regarding irradiation of internal mammary chain in patients with breast cancer: practice is culture driven rather than evidence based. Int J Radiat Oncol Biol Phys 2004; 60:706-14. PubMed
  • Yock TI, Taghian AG, Kachnic LA, Coen JJ, Assaad SI, Powell SN. The effect of delaying radiation therapy for systemic chemotherapy on local-regional control in breast cancer. Breast Cancer Res Treat 2004; 84:161-71. PubMed
  • Michaelson JS, Satija S, Kopans D, Moore R, Silverstein M, Comegno A, Hughes K, Taghian A, Powell S, Smith B. Gauging the impact of breast carcinoma screening in terms of tumor size and death rate. Cancer 2003; 98:2114-24. PubMed
  • Michaelson JS, Silverstein M, Sgroi D, Cheongsiatmoy JA, Taghian A, Powell S, Hughes K, Comegno A, Tanabe KK, Smith B. The effect of tumor size and lymph node status on breast carcinoma lethality. Cancer 2003; 98:2133-43. PubMed
  • Lawenda BD, Taghian AG, Kachnic LA, Hamdi H, Smith BL, Gadd MA, Mauceri T, Powell SN. Dose-volume analysis of radiotherapy for T1N0 invasive breast cancer treated by local excision and partial breast irradiation by low-dose-rate interstitial implant. Int J Radiat Oncol Biol Phys 2003; 56:671-80. PubMed
  • Coen JJ, Taghian AG, Kachnic LA, Assaad SI, Powell SN. Risk of lymphedema after regional nodal irradiation with breast conservation therapy. Int J Radiat Oncol Biol Phys 2003; 55:1209-15. PubMed
  • Chawla AK, Kachnic LA, Taghian AG, Niemierko A, Zapton DT, Powell SN. Radiotherapy and breast reconstruction: complications and cosmesis with TRAM versus tissue expander/implant. Int J Radiat Oncol Biol Phys 2002; 54:520-6. PubMed
  • Chen Y, Taghian AG, Rosenberg AE, O'Connell J, Okunieff P, Suit HD. Predictive value of histologic tumor necrosis after radiation. Int J Cancer 2001; 96:334-40. PubMed
  • Taghian AG, Assaad SI, Niemierko A, Kuter I, Younger J, Schoenthaler R, Roche M, Powell SN. Risk of pneumonitis in breast cancer patients treated with radiation therapy and combination chemotherapy with paclitaxel. J Natl Cancer Inst 2001; 93:1806-11. PubMed
  • Xia F, Taghian DG, DeFrank JS, Zeng ZC, Willers H, Iliakis G, Powell SN. Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining. Proc Natl Acad Sci U S A 2001; 98:8644-9. PubMed
  • Chastagner P, Kozin SV, Taghian A. Topotecan selectively enhances the radioresponse of human small-cell lung carcinoma and glioblastoma multiforme xenografts in nude mice. Int J Radiat Oncol Biol Phys 2001; 50:777-82. PubMed
  • Taghian AG, Powell SN. The role of radiation therapy for primary breast cancer. Surg Clin North Am 1999; 79:1091-115. PubMed
  • Taghian AG, Suit HD. Animal systems for translational research in radiation oncology. Acta Oncol 1999; 38:829-38. PubMed
  • Taghian A. In vitro and in vivo radiation sensitivity of glioblastoma multiforme: correction. Int J Radiat Oncol Biol Phys 1998; 42:464. PubMed
  • Budach W, Gioioso D, Taghian A, Stuschke M, Suit HD. Repopulation capacity during fractionated irradiation of squamous cell carcinomas and glioblastomas in vitro. Int J Radiat Oncol Biol Phys 1997; 39:743-50. PubMed
  • Huang P, Taghian A, Hsu DW, Perez LA, Allam A, Duffy M, DaCosta A, Suit HD. Spontaneous metastasis, proliferation characteristics and radiation sensitivity of fractionated irradiation recurrent and unirradiated human xenografts. Radiother Oncol 1996; 41:73-81. PubMed
  • Taghian A, Gioioso D, Budach W, Suit H. Retraction of "In vitro split-dose recovery of glioblastoma multiforme" by Taghian et al. (Radiat. Res. 134, 16-21, 1993) Radiat Res 1996; 146:242. PubMed
  • Taghian A, Suit H, Baumann M. In vitro and in vivo radiation sensitivity of glioblastoma multiforme: correction. Int J Radiat Oncol Biol Phys 1996; 35:1124-5. PubMed
  • DeLaney TF, Afridi N, Taghian AG, Sanders DA, Fuleihan NS, Faller DV, Nogueira CP. 13-cis-retinoic acid with alpha-2a-interferon enhances radiation cytotoxicity in head and neck squamous cell carcinoma in vitro. Cancer Res 1996; 56:2277-80. PubMed
  • Ruka W, Taghian A, Gioioso D, Fletcher JA, Preffer F, Suit HD. Comparison between the in vitro intrinsic radiation sensitivity of human soft tissue sarcoma and breast cancer cell lines. J Surg Oncol 1996; 61:290-4. PubMed
  • Huang P, Taghian A, Allam A, Freeman J, Duffy M, Suit H. The effect of whole-body irradiation of nude mice on the tumor transplantability and control probability of a human soft tissue sarcoma xenograft. Radiat Res 1996; 145:337-42. PubMed
  • Huang P, Allam A, Taghian A, Freeman J, Duffy M, Suit HD. Growth and metastatic behavior of five human glioblastomas compared with nine other histological types of human tumor xenografts in SCID mice. J Neurosurg 1995; 83:308-15. PubMed
  • Allam A, Perez LA, Huang P, Taghian A, Azinovic I, Freeman J, Duffy M, Efird J, Suit HD. The effect of the overall treatment time of fractionated irradiation on the tumor control probability of a human soft tissue sarcoma xenograft in nude mice. Int J Radiat Oncol Biol Phys 1995; 32:105-11. PubMed
  • Huang P, Allam A, Perez LA, Taghian A, Freeman J, Suit HD. The effect of combining recombinant human tumor necrosis factor-alpha with local radiation on tumor control probability of a human glioblastoma multiforme xenograft in nude mice. Int J Radiat Oncol Biol Phys 1995; 32:93-8. PubMed
  • Taghian A, DuBois W, Budach W, Baumann M, Freeman J, Suit H. In vivo radiation sensitivity of glioblastoma multiforme. Int J Radiat Oncol Biol Phys 1995; 32:99-104. PubMed
  • Huang P, Allam A, Taghian A, Ruka W, Freeman J, Duffy M, Suit HD. Quantitative comparison of xenotransplantation of a human soft tissue sarcoma into the subcutaneous tissue of normal, postincision, and postincision plus indomethacin-treated nude mice. J Surg Oncol 1995; 58:257-62. PubMed
  • Allam A, Gioioso D, Taghian A, Duffy M, Fidler IJ, Suit HD. Intrinsic radiation sensitivity: no correlation with the metastatic potential of human and murine tumor cell lines. J Natl Cancer Inst 1993; 85:1954-7. PubMed
  • Taghian A, Budach W, Zietman A, Freeman J, Gioioso D, Suit HD. Quantitative comparison between the transplantability of human and murine tumors into the brain of NCr/Sed-nu/nu nude and severe combined immunodeficient mice. Cancer Res 1993; 53:5018-21. PubMed
  • Taghian A, Budach W, Zietman A, Freeman J, Gioioso D, Ruka W, Suit HD. Quantitative comparison between the transplantability of human and murine tumors into the subcutaneous tissue of NCr/Sed-nu/nu nude and severe combined immunodeficient mice. Cancer Res 1993; 53:5012-7. PubMed
  • Allam A, Taghian A, Gioioso D, Duffy M, Suit HD. Intratumoral heterogeneity of malignant gliomas measured in vitro. Int J Radiat Oncol Biol Phys 1993; 27:303-8. PubMed
  • Budach W, Taghian A, Freeman J, Gioioso D, Suit HD. Impact of stromal sensitivity on radiation response of tumors. J Natl Cancer Inst 1993; 85:988-93. PubMed
  • Taghian A, Gioioso D, Budach W, Suit H. In vitro split-dose recovery of glioblastoma multiforme. Radiat Res 1993; 134:16-21. PubMed
  • Taghian A, Ramsay J, Allalunis-Turner J, Budach W, Gioioso D, Pardo F, Okunieff P, Bleehen N, Urtasun R, Suit H. Intrinsic radiation sensitivity may not be the major determinant of the poor clinical outcome of glioblastoma multiforme. Int J Radiat Oncol Biol Phys 1993; 25:243-9. PubMed
  • Suit H, Skates S, Taghian A, Okunieff P, Efird JT. Clinical implications of heterogeneity of tumor response to radiation therapy. Radiother Oncol 1992; 25:251-60. PubMed
  • Budach W, Hartford A, Gioioso D, Freeman J, Taghian A, Suit HD. Tumors arising in SCID mice share enhanced radiation sensitivity of SCID normal tissues. Cancer Res 1992; 52:6292-6. PubMed
  • Taghian A, Suit H, Pardo F, Gioioso D, Tomkinson K, DuBois W, Gerweck L. In vitro intrinsic radiation sensitivity of glioblastoma multiforme. Int J Radiat Oncol Biol Phys 1992; 23:55-62. PubMed
  • Pernot M, Malissard L, Taghian A, Hoffstetter S, Luporsi E, For. Velotonsillar squamous cell carcinoma: 277 cases treated by combined external irradiation and brachytherapy--results according to extension, localization, and dose rate. Int J Radiat Oncol Biol Phys 1992; 23:715-23. PubMed
  • Pardo FS, Bristow RG, Taghian A, Ong A, Borek C. Role of transfection and clonal selection in mediating radioresistance. Proc Natl Acad Sci U S A 1991; 88:10652-6. PubMed
  • Taghian A, Lespinasse F, Guichard ME. Radiosensitization by the combination of etanidazole (SR-2508) and pimonidazole (Ro 03-8799) in human tumor xenografts. Int J Radiat Oncol Biol Phys 1991; 21:1535-40. PubMed
  • Taghian A, de Vathaire F, Terrier P, Le M, Auquier A, Mouriesse H, Grimaud E, Sarrazin D, Tubiana M. Long-term risk of sarcoma following radiation treatment for breast cancer. Int J Radiat Oncol Biol Phys 1991; 21:361-7. PubMed
  • Le Bourgeois JP, Geara F, Piedbois P, Haddad E, L. [Radiotherapy of epidemic Kaposi's sarcoma in patients with AIDS. Analysis of 149 cases treated by extended and/or localized cutaneous irradiation] Ann Dermatol Venereol 1990; 117:17-21. PubMed
  • Geara F, Le Bourgeois JP, Piedbois P, Haddad E, Levy E, Taghian A. [Radiotherapy of Kaposi's sarcoma in AIDS] Ann Radiol (Paris) 1988; 32:112-6. PubMed
  • Taghian A, Pernot M, Hoffstetter S, Luporsi E, Bey P. Radiation therapy alone for medically inoperable patients with adenocarcinoma of the endometrium. Int J Radiat Oncol Biol Phys 1988; 15:1135-40. PubMed
  • Langlois D, Hoffstetter S, Malissard L, Pernot M, Taghian A. Salvage irradiation of oropharynx and mobile tongue about 192 iridium brachytherapy in Centre Alexis Vautrin. Int J Radiat Oncol Biol Phys 1988; 14:849-53. PubMed
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