Photo of Andrew D. Luster,  MD, PhD

Andrew D. Luster, MD, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-5710
Fax: (617) 726-5651


aluster@mgh.harvard.edu

Andrew D. Luster, MD, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Persis, Cyrus and Marlow B. Harrison Professor of Medicine, Medicine, Harvard Medical School
  • Chief, Rheumatology, Allergy & Immunology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Luster’s laboratory focuses on understanding the role of chemokines and lipid chemoattractants in controlling the trafficking of leukocytes in vivo. Gene-targeted and transgenic reporter mouse strains have been developed to study the role of chemokines and chemoattractant receptors in the development and delivery of organ-specific innate and adaptive immune and inflammatory responses in mouse models of autoimmune, allergic and infectious diseases as well as in models of cancer. His laboratory is particularly interested in understanding the mechanistic role of chemokines in cancer immunotherapy and if chemokines can be used as biomarkers of effective immunotherapy. System biology approaches are being utilized to understand how multiple chemoattractant pathways are integrated in vivo for the fine control of leukocyte trafficking. Chemokines and chemoattractant receptors are also interrogated in human diseases to determine chemokine systems relevant for disease pathogenesis. Finally, his laboratory utilizes humanized mice with a human immune system to study mechanistic aspects of the human immune response in vivo, and to study the interaction of strictly human tropic pathogens (e.g., HIV) with the human immune system.

Publications

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  • Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, Means TK. The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Nat Immunol 2015. PubMed
  • Sokol CL, Luster AD. The Chemokine System in Innate Immunity. Cold Spring Harb Perspect Biol 2015. PubMed
  • Rashighi M, Agarwal P, Richmond JM, Harris TH, Dresser K, Su MW, Zhou Y, Deng A, Hunter CA, Luster AD, Harris JE. CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo. Sci Transl Med 2014; 6:223ra23. PubMed
  • Griffith JW, Sokol CL, Luster AD. Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol 2014; 32:659-702. PubMed
  • Islam SA, Ling MF, Leung J, Shreffler WG, Luster AD. Identification of human CCR8 as a CCL18 receptor. J Exp Med 2013; 210:1889-98. PubMed
  • Mikhak Z, Strassner JP, Luster AD. Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4. J Exp Med 2013; 210:1855-69. PubMed
  • Griffith JW, Luster AD. Targeting cells in motion: migrating toward improved therapies. Eur J Immunol 2013; 43:1430-5. PubMed
  • Afshar R, Strassner JP, Seung E, Causton B, Cho JL, Harris RS, Hamilos DL, Medoff BD, Luster AD. Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation. J Allergy Clin Immunol 2013. PubMed
  • Bromley SK, Yan S, Tomura M, Kanagawa O, Luster AD. Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern. J Immunol 2013; 190:970-6. PubMed
  • Groom JR, Richmond J, Murooka TT, Sorensen EW, Sung JH, Bankert K, von Andrian UH, Moon JJ, Mempel TR, Luster AD. CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation. Immunity 2012; 37:1091-103. PubMed
  • Sadik CD, Kim ND, Iwakura Y, Luster AD. Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and Fc粒R signaling. Proc Natl Acad Sci U S A 2012; 109:E3177-85. PubMed
  • Murooka TT, Deruaz M, Marangoni F, Vrbanac VD, Seung E, von Andrian UH, Tager AM, Luster AD, Mempel TR. HIV-infected T cells are migratory vehicles for viral dissemination. Nature 2012; 490:283-7. PubMed
  • Sung JH, Zhang H, Moseman EA, Alvarez D, Iannacone M, Henrickson SE, de la Torre JC, Groom JR, Luster AD, von Andrian UH. Chemokine guidance of central memory T cells is critical for antiviral recall responses in lymph nodes. Cell 2012; 150:1249-63. PubMed
  • Harris TH, Banigan EJ, Christian DA, Konradt C, Tait Wojno ED, Norose K, Wilson EH, John B, Weninger W, Luster AD, Liu AJ, Hunter CA. Generalized L辿vy walks and the role of chemokines in migration of effector CD8+ T cells. Nature 2012; 486:545-8. PubMed
  • Islam SA, Luster AD. T cell homing to epithelial barriers in allergic disease. Nat Med 2012; 18:705-15. PubMed
  • Sadik CD, Luster AD. Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation. J Leukoc Biol 2012; 91:207-15. PubMed
  • Seung E, Cho JL, Sparwasser T, Medoff BD, Luster AD. Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection. J Immunol 2011; 186:6830-8. PubMed
  • Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD. Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Nat Immunol 2011; 12:167-77. PubMed
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