Dr. Luster’s laboratory focuses on understanding the role of chemokines and lipid chemoattractants in controlling the trafficking of leukocytes in vivo. Gene-targeted and transgenic reporter mouse strains have been developed to study the role of chemokines and chemoattractant receptors in the development and delivery of organ-specific innate and adaptive immune and inflammatory responses in mouse models of autoimmune, allergic and infectious diseases as well as in models of cancer. His laboratory is particularly interested in understanding the mechanistic role of chemokines in cancer immunotherapy and if chemokines can be used as biomarkers of effective immunotherapy. System biology approaches are being utilized to understand how multiple chemoattractant pathways are integrated in vivo for the fine control of leukocyte trafficking. Chemokines and chemoattractant receptors are also interrogated in human diseases to determine chemokine systems relevant for disease pathogenesis. Finally, his laboratory utilizes humanized mice with a human immune system to study mechanistic aspects of the human immune response in vivo, and to study the interaction of strictly human tropic pathogens (e.g., HIV) with the human immune system.