Andrew H. Lichtman, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-6532
Fax: (617) 732-5795


alichtman@rics.bwh.harvard.edu

Andrew H. Lichtman, MD, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Pathology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our laboratory investigates the regulation of T cell mediated immune responses. One project focuses on functional interactions between endothelium and T lymphocytes. We study how vascular endothelial cells support selective recruitment and activation of different T cell subsets. Recent work focuses on the differential expression among T cell subsets of functional ligands for endothelial selectins. In vivo approaches include studies of peripheral recruitment of adoptively transferred mouse T cells in normal mice and adoptively transferred human T cells in human skin grafted onto SCID mice. A second major project in the laboratory concerns cytokine gene regulation in helper T cell subsets: The aim of this project is to determine the molecular basis for differential cytokine gene expression in helper T cell subsets. Studies are focused on the transcriptional regulation of IL-4 and interferon-gamma gene expression during and after mouse T cell subset differentation.

Publications

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  • Griffin GK, Lichtman AH. Two Sides to Every Pro-Inflammatory Coin: New Insights into the Role of Dendritic Cells in the Regulation of T-Cell Driven Autoimmune Myocarditis. Circulation 2013. PubMed
  • Shah SM, Drage MG, Lichtman AH, Haddad RI. Metastatic human papillomavirus-positive nasopharyngeal carcinoma with an unusual pattern of aggressive hematogenous spread. J Clin Oncol 2012; 30:e321-3. PubMed
  • Griffin GK, Newton G, Tarrio ML, Bu DX, Maganto-Garcia E, Azcutia V, Alcaide P, Grabie N, Luscinskas FW, Croce KJ, Lichtman AH. IL-17 and TNF-留 sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation. J Immunol 2012; 188:6287-99. PubMed
  • Bu DX, Tarrio M, Maganto-Garcia E, Stavrakis G, Tajima G, Lederer J, Jarolim P, Freeman GJ, Sharpe AH, Lichtman AH. Impairment of the Programmed Cell Death-1 Pathway Increases Atherosclerotic Lesion Development and Inflammation. Arterioscler Thromb Vasc Biol 2011. PubMed
  • Bu DX, Tarrio M, Grabie N, Zhang Y, Yamazaki H, Stavrakis G, Maganto-Garcia E, Pepper-Cunningham Z, Jarolim P, Aikawa M, García-Cardeña G, Lichtman AH. Statin-induced kruppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses. J Clin Invest 2010; 120:1961-70. PubMed
  • Packard RR,Lichtman AH,Libby P. Innate and adaptive immunity in atherosclerosis. Semin Immunopathol 2009; 31:5-22. PubMed
  • Gotsman I,Sharpe AH,Lichtman AH. T-cell costimulation and coinhibition in atherosclerosis. Circ Res 2008; 103:1220-31. PubMed
  • Packard RR,Maganto-Garcia E,Gotsman I,Tabas I,Libby P,Lichtman AH. CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis. Circ Res 2008; 103:965-73. PubMed
  • Gotsman I, Grabie N, Dacosta R, Sukhova G, Sharpe A, Lichtman AH. Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice. J Clin Invest 2007; 117:2974-82. PubMed
  • Love VA, Grabie N, Duramad P, Stavrakis G, Sharpe A, Lichtman A. CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes. Circ Res 2007; 101:248-57. PubMed
  • Taqueti VR, Grabie N, Colvin R, Pang H, Jarolim P, Luster AD, Glimcher LH, Lichtman AH. T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity. J Immunol 2006; 177:5890-901. PubMed
  • Buono C, Binder CJ, Stavrakis G, Witztum JL, Glimcher LH, Lichtman AH. T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proc Natl Acad Sci U S A 2005; 102:1596-601. PubMed
  • Rodig N, Ryan T, Allen JA, Pang H, Grabie N, Chernova T, Greenfield EA, Liang SC, Sharpe AH, Lichtman AH, Freeman GJ. Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. Eur J Immunol 2003; 33:3117-26. PubMed
  • Buono C, Come CE, Stavrakis G, Maguire GF, Connelly PW, Lichtman AH. Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse. Arterioscler Thromb Vasc Biol 2003; 23:454-60. PubMed
  • Buono C, Come CE, Witztum JL, Maguire GF, Connelly PW, Carroll M, Lichtman AH. Influence of C3 deficiency on atherosclerosis. Circulation 2002; 105:3025-31. PubMed
  • Cybulsky MI, Lichtman AH, Hajra L, Iiyama K. Leukocyte adhesion molecules in atherogenesis. Clin Chim Acta 1999; 286:207-18. PubMed
  • Lichtman AH, Clinton SK, Iiyama K, Connelly PW, Libby P, Cybulsky MI. Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate. Arterioscler Thromb Vasc Biol 1999; 19:1938-44. PubMed
  • Xie H, Lim YC, Luscinskas FW, Lichtman AH. Acquisition of selectin binding and peripheral homing properties by CD4(+) and CD8(+) T cells. J Exp Med 1999; 189:1765-76. PubMed
  • Aune TM, Mora AL, Kim S, Boothby M, Lichtman AH. Costimulation reverses the defect in IL-2 but not effector cytokine production by T cells with impaired IkappaBalpha degradation. J Immunol 1999; 162:5805-12. PubMed
  • Lim YC, Henault L, Wagers AJ, Kansas GS, Luscinskas FW, Lichtman AH. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J Immunol 1999; 162:3193-201. PubMed
  • Kol A, Bourcier T, Lichtman AH, Libby P. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. J Clin Invest 1999; 103:571-7. PubMed
  • Perez VL, Henault L, Lichtman AH. Endothelial antigen presentation: stimulation of previously activated but not nae TCR-transgenic mouse T cells. Cell Immunol 1998; 189:31-40. PubMed
  • Kol A, Sukhova GK, Lichtman AH, Libby P. Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation 1998; 98:300-7. PubMed
  • Kiani A, Viola JP, Lichtman AH, Rao A. Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1. Immunity 1998; 7:849-60. PubMed
  • Briscoe DM, Henault LE, Geehan C, Alexander SI, Lichtman AH. Human endothelial cell costimulation of T cell IFN-gamma production. J Immunol 1997; 159:3247-56. PubMed
  • Lichtman AH, Ding H, Henault L, Vachino G, Camphausen R, Cumming D, Luscinskas FW. CD45RA-RO+ (memory) but not CD45RA+RO- (naive) T cells roll efficiently on E- and P-selectin and vascular cell adhesion molecule-1 under flow. J Immunol 1997; 158:3640-50. PubMed
  • Lichtman AH, Abbas AK. T-cell subsets: recruiting the right kind of help. Curr Biol 1997; 7:R242-4. PubMed
  • Lederer JA, Perez VL, DesRoches L, Kim SM, Abbas AK, Lichtman AH. Cytokine transcriptional events during helper T cell subset differentiation. J Exp Med 1996; 184:397-406. PubMed
  • Lichtman AH, Cybulsky M, Luscinskas FW. Immunology of atherosclerosis: the promise of mouse models. Am J Pathol 1996; 149:351-7. PubMed
  • Briscoe DM, DesRoches LE, Kiely JM, Lederer JA, Lichtman AH. Antigen-dependent activation of T helper cell subsets by endothelium. Transplantation 1995; 59:1638-41. PubMed
  • Luscinskas FW, Ding H, Lichtman AH. P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor alpha-activated vascular endothelium under flow. J Exp Med 1995; 181:1179-86. PubMed
  • St Louis JD, Lederer JA, Lichtman AH. Costimulator deficient antigen presentation by an endothelial cell line induces a nonproliferative T cell activation response without anergy. J Exp Med 1993; 178:1597-605. PubMed
  • Todd MD, Grusby MJ, Lederer JA, Lacy E, Lichtman AH, Glimcher LH. Transcription of the interleukin 4 gene is regulated by multiple promoter elements. J Exp Med 1993; 177:1663-74. PubMed
  • Casey LS, Lichtman AH, Boothby M. IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes. J Immunol 1992; 148:3418-26. PubMed
  • Abbas AK, Williams ME, Burstein HJ, Chang TL, Bossu P, Lichtman AH. Activation and functions of CD4+ T-cell subsets. Immunol Rev 1991; 123:5-22. PubMed
  • Williams ME, Lichtman AH, Abbas AK. Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 clones but not in Th2 clones. J Immunol 1990; 144:1208-14. PubMed
  • Lichtman AH, Chin J, Schmidt JA, Abbas AK. Role of interleukin 1 in the activation of T lymphocytes. Proc Natl Acad Sci U S A 1988; 85:9699-703. PubMed
  • Lichtman AH, Williams ME, Ohara J, Paul WE, Faller DV, Abbas AK. Retrovirus infection alters growth factor responses of T lymphocytes. J Immunol 1987; 138:3276-83. PubMed
  • Lichtman AH, Tony HP, Parker DC, Abbas AK. Antigen presentation by hapten-specific B lymphocytes. IV. Comparative ability of B cells to present specific antigen and anti-immunoglobulin antibody. J Immunol 1987; 138:2822-5. PubMed
  • Lichtman AH, Kurt-Jones EA, Abbas AK. B-cell stimulatory factor 1 and not interleukin 2 is the autocrine growth factor for some helper T lymphocytes. Proc Natl Acad Sci U S A 1987; 84:824-7. PubMed
  • Lichtman AH, Segel GB, Lichtman MA. Effects of trifluoperazine and mitogenic lectins on calcium ATPase activity and calcium transport by human lymphocyte plasma membrane vesicles. J Cell Physiol 1982; 111:213-7. PubMed
  • Lichtman AH, Segel GB, Lichtman MA. Calcium transport and calcium-ATPase activity in human lymphocyte plasma membrane vesicles. J Biol Chem 1981; 256:6148-54. PubMed
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