Photo of Annette S. Kim,  MD, PhD

Annette S. Kim, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-3172
Fax: (617) 264-5169


akim@partners.org

Annette S. Kim, MD, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Pathology, Harvard Medical School
  • Associate Pathologist, Pathology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research program is currently focused on the study of normal and aberrant hematopoiesis, particularly in the study of hematolymphoid malignancies. I have prior training in synthetic organic chemistry, structural biology. I spent several years in the pharmaceutical industry prior to my return to academia where I both conducted drug discovery medicinal chemistry and led a target validation program within Cancer Biology. Since returning to clinical practice in hematopathology and molecular pathology, my research has identified diagnostic and prognostic miRNAs in MDS and has defined the role of hypermethylation in the regulation of miRNA in MDS. We have also developed miRNA-based models of the MDS phenotype in which we can demonstrate the activity of therapeutic compound. Using next generation sequencing methods we have optimized for small RNAs, we have identified both miRNAs and tRNA-derived fragments that are found in untreated samples that correlate with response to DNA methyltransferase inhibitors. My research also extends to other proposed therapies for hematolymphoid malignancies and in using flow and mass cytometry to better understand their mechanisms of action and therapeutic potential. In addition, I have conducted studies on cost effective practice of hematopathology as well as numerous clinical publications, with an emphasis on hemophagocytic lymphohistiocytosis and lymphoma.

Publications

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  • Adams CM, Kim AS, Mitra R, Choi JK, Gong JZ, Eischen CM. BCL-W has a fundamental role in B cell survival and lymphomagenesis. J Clin Invest 2017; 127:635-650. PubMed
  • Guo Y, Strickland SA, Mohan S, Li S, Bosompem A, Vickers KC, Zhao S, Sheng Q, Kim AS. MicroRNAs and tRNA-derived fragments predict the transformation of myelodysplastic syndromes to acute myeloid leukemia. Leuk Lymphoma 2017. PubMed
  • Rosado FG, Rinker EB, Plummer WD, Dupont WD, Spradlin NM, Reichard KK, Kim AS. The diagnosis of adult-onset haemophagocytic lymphohistiocytosis: lessons learned from a review of 29 cases of bone marrow haemophagocytosis in two large academic institutions. J Clin Pathol 2016; 69:805-9. PubMed
  • Andl CD, Le Bras GF, Loomans H, Kim AS, Zhou L, Zhang Y, Andl T. Association of TGFβ signaling with the maintenance of a quiescent stem cell niche in human oral mucosa. Histochem Cell Biol 2016. PubMed
  • Shaver AC, Zimmerman D, Liu M, Vnencak-Jones C, Kim AS. Concurrent and Clonally Related Pediatric Follicular Lymphoma and Burkitt Lymphoma in a 5-Year-Old Boy. Lab Med 2016; 47:43-7. PubMed
  • Rinker EB, Dueber JC, Qualtieri J, Tedesco J, Erdogan B, Bosompem A, Kim AS. Differential expression of ribosomal proteins in myelodysplastic syndromes. J Clin Pathol 2015. PubMed
  • Wynn JL, Scumpia PO, Stocks BT, Romano-Keeler J, Alrifai MW, Liu JH, Kim AS, Alford CE, Matta P, Weitkamp JH, Moore DJ. Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality. J Immunol 2015; 195:1064-70. PubMed
  • Guo Y, Bosompem A, Mohan S, Erdogan B, Ye F, Vickers KC, Sheng Q, Zhao S, Li CI, Su PF, Jagasia M, Strickland SA, Griffiths EA, Kim AS. Transfer RNA detection by small RNA deep sequencing and disease association with myelodysplastic syndromes. BMC Genomics 2015; 16:727. PubMed
  • Smith MC, Kressin MK, Crawford E, Wang XJ, Kim AS. B Lymphoblastic Leukemia With a Novel t(11;15) (q23;q15) and Unique Burkittoid Morphologic and Immunophenotypic Findings in a 9-Year-Old Boy. Lab Med 2015; 46:320-6. PubMed
  • Ondrejka SL, Jegalian AG, Kim AS, Chabot-Richards DS, Giltnane J, Czuchlewski DR, Shetty S, Sekeres MA, Yenamandra A, Head D, Jagasia M, Hsi ED. PDGFRB-rearranged T-lymphoblastic leukemia/lymphoma occurring with myeloid neoplasms: the missing link supporting a stem cell origin. Haematologica 2014; 99:e148-51. PubMed
  • Douds JJ, Long DJ, Kim AS, Li S. Diagnostic and prognostic significance of CD200 expression and its stability in plasma cell myeloma. J Clin Pathol 2014; 67:792-6. PubMed
  • Shaver AC, Ma L, Vnencak-Jones C, Schwarting RS, Fasig KJ, Kim AS. Transformation of small B-cell lymphoma into large cell CD30⁺, CD4⁺, Epstein-Barr virus-negative lymphoma. Arch Pathol Lab Med 2014; 138:1101-5. PubMed
  • Seegmiller AC, Wasserman A, Kim AS, Kressin MK, Marx ER, Zutter MM, Mosse CA. Limited utility of fluorescence in situ hybridization for common abnormalities of myelodysplastic syndrome at first presentation and follow-up of myeloid neoplasms. Leuk Lymphoma 2014; 55:601-5. PubMed
  • Ning MS, Kim AS, Prasad N, Levy SE, Zhang H, Andl T. Characterization of the Merkel Cell Carcinoma miRNome. J Skin Cancer 2014; 2014:289548. PubMed
  • Smith MC, Cohen DN, Greig B, Yenamandra A, Vnencak-Jones C, Thompson MA, Kim AS. The ambiguous boundary between EBV-related hemophagocytic lymphohistiocytosis and systemic EBV-driven T cell lymphoproliferative disorder. Int J Clin Exp Pathol 2014; 7:5738-49. PubMed
  • Guo Y, Bosompem A, Zhong X, Clark T, Shyr Y, Kim AS. A comparison of microRNA sequencing reproducibility and noise reduction using mirVana and TRIzol isolation methods. Int J Comput Biol Drug Des 2014; 7:102-12. PubMed
  • Erdogan B, Bosompem A, Peng D, Han L, Smith E, Kennedy ME, Alford CE, Wu H, Zhao Z, Mosse CA, El-Rifai W, Kim AS. Methylation of promoters of microRNAs and their host genes in myelodysplastic syndromes. Leuk Lymphoma 2013; 54:2720-7. PubMed
  • Seegmiller AC, Kim AS, Mosse CA, Levy MA, Thompson MA, Kressin MK, Jagasia MH, Strickland SA, Reddy NM, Marx ER, Sinkfield KJ, Pollard HN, Plummer WD, Dupont WD, Shultz EK, Dittus RS, Stead WW, Santoro SA, Zutter MM. Optimizing personalized bone marrow testing using an evidence-based, interdisciplinary team approach. Am J Clin Pathol 2013; 140:643-50. PubMed
  • Rosado FG, Kim AS. Hemophagocytic lymphohistiocytosis: an update on diagnosis and pathogenesis. Am J Clin Pathol 2013; 139:713-27. PubMed
  • Hart AJ, Jagasia MH, Kim AS, Mosse CA, Savani BN, Kassim A. Minimal residual disease in myeloma: are we there yet? Biol Blood Marrow Transplant 2012; 18:1790-9. PubMed
  • Kressin MK, Kim AS. Incidence of transient single metaphase chromosomal abnormalities identified by routine metaphase cytogenetics in bone marrow specimens. Leuk Lymphoma 2012; 53:2080-2. PubMed
  • Erickson JJ, Gilchuk P, Hastings AK, Tollefson SJ, Johnson M, Downing MB, Boyd KL, Johnson JE, Kim AS, Joyce S, Williams JV. Viral acute lower respiratory infections impair CD8+ T cells through PD-1. J Clin Invest 2012; 122:2967-82. PubMed
  • Kressin MK, Kim AS. Metastatic Merkel cell carcinoma in the bone marrow of a patient with plasma cell myeloma and therapy-related myelodysplastic syndrome. Int J Clin Exp Pathol 2012; 5:1007-12. PubMed
  • Chmielecki J, Peifer M, Viale A, Hutchinson K, Giltnane J, Socci ND, Hollis CJ, Dean RS, Yenamandra A, Jagasia M, Kim AS, Davé UP, Thomas RK, Pao W. Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm. Genes Chromosomes Cancer 2011; 51:54-65. PubMed
  • Erdogan B, Facey C, Qualtieri J, Tedesco J, Rinker E, Isett RB, Tobias J, Baldwin DA, Thompson JE, Carroll M, Kim AS. Diagnostic microRNAs in myelodysplastic syndrome. Exp Hematol 2011; 39:915-926.e2. PubMed
  • Simons CM, Stratton CW, Kim AS. Peripheral blood eosinophilia as a clue to the diagnosis of an occult Coccidioides infection. Hum Pathol 2011; 42:449-53. PubMed
  • Ma L, Katz Y, Sharan KP, Schwarting R, Kim AS. Epstein-Barr virus positive anaplastic large cell lymphoma: myth or reality? Int J Clin Exp Pathol 2011; 4:100-10. PubMed
  • Kim AS, Goldstein SC, Luger S, Van Deerlin VM, Bagg A. Sudden extramedullary T-lymphoblastic blast crisis in chronic myelogenous leukemia: a nonrandom event associated with imatinib? Am J Clin Pathol 2008; 129:639-48. PubMed
  • Bell IM, Stirdivant SM, Ahern J, Culberson JC, Darke PL, Dinsmore CJ, Drakas RA, Gallicchio SN, Graham SL, Heimbrook DC, Hall DL, Hua J, Kett NR, Kim AS, Kornienko M, Kuo LC, Munshi SK, Quigley AG, Reid JC, Trotter BW, Waxman LH, Williams TM, Zartman CB. Biochemical and structural characterization of a novel class of inhibitors of the type 1 insulin-like growth factor and insulin receptor kinases. Biochemistry 2005; 44:9430-40. PubMed
  • Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol 2004; 11:747-55. PubMed
  • Kim AS. Clinical impact of gene expression profiling on oncology diagnosis, prognosis, and treatment. Comb. Chem. High Throughput Screen. 2004; 7:183-206. PubMed
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