Photo of Annie W. Chan,  MD

Annie W. Chan, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-1159
Fax: (617) 726-3603


awchan@partners.org

Annie W. Chan, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Radiation Oncology, Harvard Medical School
  • Radiation Oncologist, Radiation Oncology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My clinical research has exploited the superior dose distribution of proton beam to improve clinical outcome and decrease the treatment-related morbidity in patients with nervous system and head and neck cancers. My basic science/translational research is to investigate the molecular mechanism of Schwann cell development and tumorigenesis.

Publications

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  • McBride SM, Busse PM, Clark JR, Wirth LJ, Ancukiewicz M, Chan AW. Long-term survival after distant metastasis in patients with oropharyngeal cancer. Oral Oncol 2014; 50:208-12. PubMed
  • McBride SM, Rothenberg SM, Faquin WC, Chan AW, Clark JR, Ellisen LW, Wirth LJ. Mutation frequency in 15 common cancer genes in high-risk head and neck squamous cell carcinoma. Head Neck 2014. PubMed
  • McBride SM, Parambi RJ, Jang JW, Goldsmith T, Busse PM, Chan AW. Intensity-modulated versus conventional radiation therapy for oropharyngeal carcinoma: Long-term dysphagia and tumor control outcomes. Head Neck 2013. PubMed
  • Jang JW, Parambi RJ, McBride SM, Goldsmith TA, Holman AS, Chan AW. Clinical factors predicting for prolonged enteral supplementation in patients with oropharyngeal cancer treated with chemoradiation. Oral Oncol 2013; 49:438-42. PubMed
  • Jang JW, Chan AW. Prevention and management of complications after radiotherapy for skull base tumors: a multidisciplinary approach. Adv. Otorhinolaryngol. 2012; 74:163-73. PubMed
  • Aizer AA, Chan AW. A tale of two tumors: pediatric and adult medulloblastoma. Oncology (Huntingt) 2013; 26:1095-7. PubMed
  • Wong HK, Lahdenranta J, Kamoun WS, Chan AW, McClatchey AI, Plotkin SR, Jain RK, di Tomaso E. Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors. Cancer Res 2010; 70:3483-93. PubMed
  • Truong MT, Kamat UR, Liebsch NJ, Curry WT, Lin DT, Barker FG, Loeffler JS, Chan AW. Proton radiation therapy for primary sphenoid sinus malignancies: treatment outcome and prognostic factors. Head Neck 2009; 31:1297-308. PubMed
  • Nichols AC,Chan AW,Curry WT,Barker FG,Deschler DG,Lin DT. Esthesioneuroblastoma: the massachusetts eye and ear infirmary and massachusetts general hospital experience with craniofacial resection, proton beam radiation, and chemotherapy. Skull Base 2009; 18:327-37. PubMed
  • Wong GL, Wong VW, Choi PC, Chan AW, Chum RH, Chan HK, Lau KK, Chim AM, Yiu KK, Chan FK, Sung JJ, Chan HL. Assessment of Fibrosis by Transient Elastography Compared With Liver Biopsy and Morphometry in Chronic Liver Diseases. Clin Gastroenterol Hepatol 2008; 6:1027-35. PubMed
  • Chan AW,Liebsch NJ. Proton radiation therapy for head and neck cancer. J Surg Oncol 2008; 97:697-700. PubMed
  • Qian X, Huang C, Cho CH, Hui WM, Rashid A, Chan AO. E-cadherin promoter hypermethylation induced by interleukin-1beta treatment or H. pylori infection in human gastric cancer cell lines. Cancer Lett 2008; 263:107-13. PubMed
  • Suehiro Y, Wong CW, Chirieac LR, Kondo Y, Shen L, Webb CR, Chan YW, Chan AS, Chan TL, Wu TT, Rashid A, Hamanaka Y, Hinoda Y, Shannon RL, Wang X, Morris J, Issa JP, Yuen ST, Leung SY, Hamilton SR. Epigenetic-Genetic Interactions in the APC/WNT, RAS/RAF, and P53 Pathways in Colorectal Carcinoma. Clin Cancer Res 2008; 14:2560-9. PubMed
  • Sun Y, Qiao L, Xia HH, Lin MC, Zou B, Yuan Y, Zhu S, Gu Q, Cheung TK, Kung HF, Yuen MF, Chan AO, Wong BC. Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1. Cancer Lett 2007; 260:62-71. PubMed
  • Cole BK, Curto M, Chan AW, McClatchey AI. Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing. Mol Cell Biol 2007; 28:1274-84. PubMed
  • Resto VA, Chan AW, Deschler DG, Lin DT. Extent of surgery in the management of locally advanced sinonasal malignancies. Head Neck 2007; 30:222-9. PubMed
  • Johannessen CM, Johnson BW, Williams SM, Chan AW, Reczek EE, Lynch RC, Rioth MJ, McClatchey A, Ryeom S, Cichowski K. TORC1 is essential for NF1-associated malignancies. Curr Biol 2008; 18:56-62. PubMed
  • Sekeres M, Gold JL, Chan AW, Lexchin J, Moher D, Van Laethem ML, Maskalyk J, Ferris L, Taback N, Rochon PA. Poor reporting of scientific leadership information in clinical trial registers. PLoS ONE 2008; 3:e1610. PubMed
  • Yee YK, Cheung TK, Chan AO, Yuen MF, Wong BC. Decreasing trend of esophageal adenocarcinoma in Hong Kong. Cancer Epidemiol Biomarkers Prev 2007; 16:2637-40. PubMed
  • Tse GM, Chan AW, Yu KH, King AD, Wong KT, Chen GG, Tsang RK, Chan AB. Strong immunohistochemical expression of vascular endothelial growth factor predicts overall survival in head and neck squamous cell carcinoma. Ann Surg Oncol 2007; 14:3558-65. PubMed
  • Houben CH, Tong JH, Chan AW, Chik KW, Lee KH, Sihoe JD, Tam YH, Yeung CK. Familial extrarenal Wilms tumor. J Pediatr Surg 2007; 42:1826-30. PubMed
  • Chan AO, Jim MH, Lam KF, Morris JS, Siu DC, Tong T, Ng FH, Wong SY, Hui WM, Chan CK, Lai KC, Cheung TK, Chan P, Wong G, Yuen MF, Lau YK, Lee S, Szeto ML, Wong BC, Lam SK. Prevalence of colorectal neoplasm among patients with newly diagnosed coronary artery disease. JAMA 2007; 298:1412-9. PubMed
  • Kosinski C, Li VS, Chan AS, Zhang J, Ho C, Tsui WY, Chan TL, Mifflin RC, Powell DW, Yuen ST, Leung SY, Chen X. Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Proc Natl Acad Sci U S A 2007; 104:15418-23. PubMed
  • Lam TJ, Wong BC, Mulder CJ, Pena AS, Hui WM, Lam SK, Chan AO. Increasing prevalence of advanced colonic polyps in young patients undergoing colonoscopy in a referral academic hospital in Hong Kong. World J Gastroenterol 2007; 13:3873-7. PubMed
  • Reveiz L, Krleza-Jeric K, Chan AW, De Aguiar S. Do trialists endorse clinical trial registration? Survey of a Pubmed sample. Trials 2007; 8:30. PubMed
  • Weber DC, Chan AW, Lessell S, McIntyre JF, Goldberg SI, Bussiere MR, Fitzek MM, Thornton AF, Delaney TF. Visual outcome of accelerated fractionated radiation for advanced sinonasal malignancies employing photons/protons. Radiother Oncol 2006; 81:243-9. PubMed
  • Pommier P, Liebsch NJ, Deschler DG, Lin DT, McIntyre JF, Barker FG, Adams JA, Lopes VV, Varvares M, Loeffler JS, Chan AW. Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg 2006; 132:1242-9. PubMed
  • Meyerhardt JA, Giovannucci EL, Holmes MD, Chan AT, Chan JA, Colditz GA, Fuchs CS. Physical activity and survival after colorectal cancer diagnosis. J Clin Oncol 2006; 24:3527-34. PubMed
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