Photo of Barbara L. Smith,  MD, PhD

Barbara L. Smith, MD, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-6500
Fax: (617) 724-1079

Barbara L. Smith, MD, PhD

Massachusetts General Hospital


  • Associate Professor, Surgery, Harvard Medical School
  • Director, Comprehensive Breast Health Center, Massachusetts General Hospital


Research Abstract

1. Diagnosis of breast cancer in women under 40 and high risk women

2. Hormones and breast cancer: Fertility, pregnancy and menopause issues

3. Biological basis of local recurrence of breast cancer

4. Maintenance and expansion of breast clinical and research database

5. Patient perception of breast cancer risk and patients attitudes toward genetic testing for breast cancer risk and management of a positive test.


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  • Coopey SB, Smith BL. The Nipple is Just Another Margin. Ann Surg Oncol 2015. PubMed
  • Frederick MJ, Lin AM, Neuman R, Smith BL, Austen WG, Colwell AS. Nipple-sparing mastectomy in patients with previous breast surgery: comparative analysis of 775 immediate breast reconstructions. Plast Reconstr Surg 2015; 135:954e-62e. PubMed
  • Reish RG, Lin A, Phillips NA, Winograd J, Liao EC, Cetrulo CL, Smith BL, Austen WG, Colwell AS. Breast reconstruction outcomes after nipple-sparing mastectomy and radiation therapy. Plast Reconstr Surg 2015; 135:959-66. PubMed
  • McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W, Pu AT, Kerlin K, White J. RTOG 9804: A Prospective Randomized Trial for Good-Risk Ductal Carcinoma In Situ Comparing Radiotherapy With Observation. J Clin Oncol 2015; 33:709-15. PubMed
  • Miller CL, Colwell AS, Horick N, Skolny MN, Jammallo LS, O╩╝Toole JA, Shenouda MN, Sadek BT, Swaroop MN, Ferguson CM, Smith BL, Specht MC, Taghian AG. Immediate Implant Reconstruction Is Associated With a Reduced Risk of Lymphedema Compared to Mastectomy Alone: A Prospective Cohort Study. Ann Surg 2015. PubMed
  • Tang R, Coopey SB, Specht MC, Lei L, Gadd MA, Hughes KS, Brachtel EF, Smith BL. Lumpectomy specimen margins are not reliable┬áin predicting residual disease in breast conserving surgery. Am J Surg 2015. PubMed
  • Yao K, Liederbach E, Tang R, Lei L, Czechura T, Sisco M, Howard M, Hulick PJ, Winchester DJ, Coopey SB, Smith BL. Nipple-Sparing Mastectomy in BRCA1/2 Mutation Carriers: An Interim Analysis and Review of the Literature. Ann Surg Oncol 2014. PubMed
  • Woodward WA, Sneige N, Winter K, Kuerer HM, Hudis C, Rakovitch E, Smith BL, Pierce LJ, Germano I, Pu AT, Walker EM, Grisell DL, White JR, McCormick B, . Web based pathology assessment in RTOG 98-04. J Clin Pathol 2014. PubMed
  • Keruakous AR, Sadek BT, Shenouda MN, Niemierko A, Abi Raad RF, Specht M, Smith BL, Taghian AG. The impact of isolated tumor cells on loco-regional recurrence in breast cancer patients treated with breast-conserving treatment or mastectomy without post-mastectomy radiation therapy. Breast Cancer Res Treat 2014; 146:365-70. PubMed
  • Camp MS, Coopey SB, Tang R, Colwell A, Specht M, Greenup RA, Gadd MA, Brachtel E, Austen WG, Smith BL. Management of Positive Sub-areolar/Nipple Duct Margins in Nipple-Sparing Mastectomies. Breast J 2014. PubMed
  • Galland-Girodet S, Pashtan I, MacDonald SM, Ancukiewicz M, Hirsch AE, Kachnic LA, Specht M, Gadd M, Smith BL, Powell SN, Recht A, Taghian AG. Long-Term Cosmetic Outcomes and Toxicities of Proton Beam Therapy Compared With Photon-Based 3-Dimensional Conformal Accelerated Partial-Breast Irradiation: A Phase 1 Trial. Int J Radiat Oncol Biol Phys 2014. PubMed
  • Miller CL, West JA, Bettini AC, Koerner FC, Gudewicz TM, Freer PE, Coopey SB, Gadd MA, Hughes KS, Smith BL, Rafferty E, Specht MC. Surgical excision of radial scars diagnosed by core biopsy may help predict future risk of breast cancer. Breast Cancer Res Treat 2014. PubMed
  • Reish RG, Lin AM, Austen WG, Winograd J, Liao EC, Cetrulo CL, Smith BL, Colwell AS. Abstract 25: breast reconstruction outcomes after nipple-sparing mastectomy and radiation therapy. Plast Reconstr Surg 2014; 133:991. PubMed
  • Colwell AS, Tessler O, Lin AM, Liao E, Winograd J, Cetrulo CL, Tang R, Smith BL, Austen WG. Breast reconstruction following nipple-sparing mastectomy: predictors of complications, reconstruction outcomes, and 5-year trends. Plast Reconstr Surg 2014; 133:496-506. PubMed
  • Miller CL, Specht MC, Skolny MN, Horick N, Jammallo LS, O'Toole J, Shenouda MN, Sadek BT, Smith BL, Taghian AG. Risk of lymphedema after mastectomy: potential benefit of applying ACOSOG Z0011 protocol to mastectomy patients. Breast Cancer Res Treat 2014; 144:71-7. PubMed
  • Brachtel EF, Smith BL, Tearney GJ, Kang D. Spectrally encoded confocal microscopy for guiding lumpectomy. 2015; 2014:573851. PubMed
  • Wong JS, Chen YH, Gadd MA, Gelman R, Lester SC, Schnitt SJ, Sgroi DC, Silver BJ, Smith BL, Troyan SL, Harris JR. Eight-year update of a prospective study of wide excision alone for small low- or intermediate-grade ductal carcinoma in situ (DCIS). Breast Cancer Res Treat 2014; 143:343-50. PubMed
  • Coopey SB, Tang R, Lei L, Freer PE, Kansal K, Colwell AS, Gadd MA, Specht MC, Austen WG, Smith BL. Increasing eligibility for nipple-sparing mastectomy. Ann Surg Oncol 2013; 20:3218-22. PubMed
  • Webb ML, Cady B, Michaelson JS, Bush DM, Calvillo KZ, Kopans DB, Smith BL. A failure analysis of invasive breast cancer: Most deaths from disease occur in women not regularly screened. Cancer 2013. PubMed
  • Specht MC, Miller CL, Skolny MN, Jammallo LS, O'Toole J, Horick N, Isakoff SJ, Smith BL, Taghian AG. Residual lymph node disease after neoadjuvant chemotherapy predicts an increased risk of lymphedema in node-positive breast cancer patients. Ann Surg Oncol 2013; 20:2835-41. PubMed
  • Kansal KJ, Dominici LS, Tolaney SM, Isakoff SJ, Smith BL, Jiang W, Brock JE, Winer EP, Krop IE, Golshan M. Neoadjuvant bevacizumab: surgical complications of mastectomy with and without reconstruction. Breast Cancer Res Treat 2013; 141:255-9. PubMed
  • Specht MC, Miller CL, Russell TA, Horick N, Skolny MN, O'Toole JA, Jammallo LS, Niemierko A, Sadek BT, Shenouda MN, Finkelstein DM, Smith BL, Taghian AG. Defining a threshold for intervention in breast cancer-related lymphedema: what level of arm volume increase predicts progression? Breast Cancer Res Treat 2013; 140:485-94. PubMed
  • Hughes KS, Schnaper LA, Bellon JR, Cirrincione CT, Berry DA, McCormick B, Muss HB, Smith BL, Hudis CA, Winer EP, Wood WC. Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343. J Clin Oncol 2013; 31:2382-7. PubMed
  • Macdonald SM, Patel SA, Hickey S, Specht M, Isakoff SJ, Gadd M, Smith BL, Yeap BY, Adams J, Delaney TF, Kooy H, Lu HM, Taghian AG. Proton Therapy for Breast Cancer After Mastectomy: Early Outcomes of a Prospective Clinical Trial. Int J Radiat Oncol Biol Phys 2013. PubMed
  • Coopey SB, Mazzola E, Buckley JM, Sharko J, Belli AK, Kim EM, Polubriaginof F, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi AJ, Roche CA, Hughes KS. The role of chemoprevention in modifying the risk of breast cancer in women with atypical breast lesions. Breast Cancer Res Treat 2012. PubMed
  • Pashtan IM, Recht A, Ancukiewicz M, Brachtel E, Abi-Raad RF, D'Alessandro HA, Levy A, Wo JY, Hirsch AE, Kachnic LA, Goldberg S, Specht M, Gadd M, Smith BL, Powell SN, Taghian AG. External beam accelerated partial-breast irradiation using 32 gy in 8 twice-daily fractions: 5-year results of a prospective study. Int J Radiat Oncol Biol Phys 2012; 84:e271-7. PubMed
  • Coopey SB, Specht MC, Warren L, Smith BL, Winograd JM, Fleischmann K. Use of Preoperative Paravertebral Block Decreases Length of Stay in Patients Undergoing Mastectomy Plus Immediate Reconstruction. Ann Surg Oncol 2012. PubMed
  • Miller CL, Specht MC, Skolny MN, Jammallo LS, Horick N, O'Toole J, Coopey SB, Hughes K, Gadd M, Smith BL, Taghian AG. Sentinel lymph node biopsy at the time of mastectomy does not increase the risk of lymphedema: implications for prophylactic surgery. Breast Cancer Res Treat 2012; 135:781-9. PubMed
  • Greenup RA, Camp MS, Taghian AG, Buckley J, Coopey SB, Gadd M, Hughes K, Specht M, Smith BL. Cost comparison of radiation treatment options after lumpectomy for breast cancer. Ann Surg Oncol 2012; 19:3275-81. PubMed
  • Camp MS, Greenup RA, Taghian A, Coopey SB, Specht M, Gadd M, Hughes K, Smith BL. Application of ACOSOG Z0011 Criteria Reduces Perioperative Costs. Ann Surg Oncol 2012. PubMed
  • Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proc Natl Acad Sci U S A 2012; 109:15101-8. PubMed
  • Boutrus RR, Abi Raad RF, Kuter I, Ancukiewicz M, Roberts L, Solomon N, Ngo T, Borick H, Ryan P, Moy B, Gadd M, Chien J, Younger J, Smith B, Taghian AG, Harris L. Circulating tumor cells as predictors of response and failure in breast cancer patients treated with preoperative chemotherapy. Int J Biol Markers 2012. PubMed
  • Buckley JM, Coopey SB, Sharko J, Polubriaginof F, Drohan B, Belli AK, Kim EM, Garber JE, Smith BL, Gadd MA, Specht MC, Roche CA, Gudewicz TM, Hughes KS. The feasibility of using natural language processing to extract clinical information from breast pathology reports. J Pathol Inform 2012; 3:23. PubMed
  • Abi-Raad R, Boutrus R, Wang R, Niemierko A, Macdonald S, Smith B, Taghian AG. Patterns and Risk Factors of Locoregional Recurrence in T1-T2 Node Negative Breast Cancer Patients Treated with Mastectomy: Implications for Postmastectomy Radiotherapy. Int J Radiat Oncol Biol Phys 2011. PubMed
  • Michaelson JS, Chen LL, Bush D, Fong A, Smith B, Younger J. Improved web-based calculators for predicting breast carcinoma outcomes. Breast Cancer Res Treat 2011. PubMed
  • Bush D, Smith B, Younger J, Michaelson JS. The non-breast-cancer death rate among breast cancer patients. Breast Cancer Res Treat 2010. PubMed
  • Colwell AS, Gadd M, Smith BL, Austen WG. An inferolateral approach to nipple-sparing mastectomy: optimizing mastectomy and reconstruction. Ann Plast Surg 2010; 65:140-3. PubMed
  • Ancukiewicz M, Russell TA, Otoole J, Specht M, Singer M, Kelada A, Murphy CD, Pogachar J, Gioioso V, Patel M, Skolny M, Smith BL, Taghian AG. Standardized Method for Quantification of Developing Lymphedema in Patients Treated for Breast Cancer. Int J Radiat Oncol Biol Phys 2010. PubMed
  • Smith BL. Clinical applications of breast pathology: management of in situ breast carcinomas and sentinel node biopsy issues. Mod Pathol 2010; 23 Suppl 2:S33-5. PubMed
  • Wo JY, Taghian AG, Nguyen PL, Raad RA, Sreedhara M, Bellon JR, Wong JS, Gadd MA, Smith BL, Harris JR. The Association Between Biological Subtype and Isolated Regional Nodal Failure After Breast-Conserving Therapy. Int J Radiat Oncol Biol Phys 2010; 77:188-96. PubMed
  • Michaelson JS, Chen LL, Silverstein MJ, Mihm MC, Sober AJ, Tanabe KK, Smith BL, Younger J. How cancer at the primary site and in the lymph nodes contributes to the risk of cancer death. Cancer 2009; 115:5095-107. PubMed
  • Michaelson JS, Chen LL, Silverstein MJ, Cheongsiatmoy JA, Mihm MC, Sober AJ, Tanabe KK, Smith BL, Younger J. Why cancer at the primary site and in the lymph nodes contributes to the risk of cancer death. Cancer 2009; 115:5084-94. PubMed
  • Chen LL, Nolan ME, Silverstein MJ, Mihm MC, Sober AJ, Tanabe KK, Smith BL, Younger J, Michaelson JS. The impact of primary tumor size, lymph node status, and other prognostic factors on the risk of cancer death. Cancer 2009; 115:5071-83. PubMed
  • Brachtel EF, Rusby JE, Michaelson JS, Chen LL, Muzikansky A, Smith BL, Koerner FC. Occult nipple involvement in breast cancer: clinicopathologic findings in 316 consecutive mastectomy specimens. J Clin Oncol 2009; 27:4948-54. PubMed
  • Samphao S, Wheeler AJ, Rafferty E, Michaelson JS, Specht MC, Gadd MA, Hughes KS, Smith BL. Diagnosis of breast cancer in women age 40 and younger: delays in diagnosis result from underuse of genetic testing and breast imaging. Am J Surg 2009; 198:538-43. PubMed
  • Lester SC, Bose S, Chen YY, Connolly JL, de Baca ME, Fitzgibbons PL, Hayes DF, Kleer C, O'Malley FP, Page DL, Smith BL, Tan LK, Weaver DL, Winer E, . Protocol for the examination of specimens from patients with invasive carcinoma of the breast. Arch Pathol Lab Med 2009; 133:1515-38. PubMed
  • Javid SH, Kirstein LJ, Rafferty E, Lipsitz S, Moore R, Rusby JE, Murphy CD, Hughes KS, Specht MC, Taghian AG, Smith BL. Outcome of multiple-wire localization for larger breast cancers: do multiple wires translate into additional imaging, biopsies, and recurrences? Am J Surg 2009; 198:368-72. PubMed
  • Javid SH,Smith BL,Mayer E,Bellon J,Murphy CD,Lipsitz S,Golshan M. Tubular carcinoma of the breast: results of a large contemporary series. Am J Surg 2008; 197:674-7. PubMed
  • Bafford AC,Burstein HJ,Barkley CR,Smith BL,Lipsitz S,Iglehart JD,Winer EP,Golshan M. Breast surgery in stage IV breast cancer: impact of staging and patient selection on overall survival. Breast Cancer Res Treat 2008; 115:7-12. PubMed
  • Lester SC,Bose S,Chen YY,Connolly JL,de Baca ME,Fitzgibbons PL,Hayes DF,Kleer C,O'Malley FP,Page DL,Smith BL,Weaver DL,Winer E. Protocol for the examination of specimens from patients with ductal carcinoma in situ of the breast. Arch Pathol Lab Med 2009; 133:15-25. PubMed
  • Murphy CD,Lee JM,Drohan B,Euhus DM,Kopans DB,Gadd MA,Rafferty EA,Specht MC,Smith BL,Hughes KS. The American Cancer Society guidelines for breast screening with magnetic resonance imaging: an argument for genetic testing. Cancer 2008; 113:3116-20. PubMed
  • Rusby JE,Smith BL. Unanswered questions in nipple-sparing mastectomy. Surg Oncol 2008; 17:259-60. PubMed
  • Wong JS, Taghian AG, Bellon JR, Keshaviah A, Smith BL, Winer EP, Silver B, Harris JR. Tangential Radiotherapy Without Axillary Surgery in Early-Stage Breast Cancer: Results of a Prospective Trial. Int J Radiat Oncol Biol Phys 2008; 72:866-70. PubMed
  • Chang HL,Kish JB,Smith BL,Goldstein AM. A 16-year-old male with gynecomastia and ductal carcinoma in situ. Pediatr Surg Int 2008; 24:1251-3. PubMed
  • Barkley CR,Ligibel JA,Wong JS,Lipsitz S,Smith BL,Golshan M. Mucinous breast carcinoma: a large contemporary series. Am J Surg 2008; 196:549-51. PubMed
  • Murphy CD,Jones JL,Javid SH,Michaelson JS,Nolan ME,Lipsitz SR,Specht MC,Lesnikoski BA,Hughes KS,Gadd MA,Smith BL. Do sentinel node micrometastases predict recurrence risk in ductal carcinoma in situ and ductal carcinoma in situ with microinvasion? Am J Surg 2008; 196:566-8. PubMed
  • Rusby JE,Kirstein LJ,Brachtel EF,Michaelson JS,Koerner FC,Smith BL. Nipple-sparing mastectomy: lessons from ex vivo procedures. Breast J 2008; 14:464-70. PubMed
  • Kirstein LJ,Rafferty E,Specht MC,Moore RH,Taghian AG,Hughes KS,Gadd MA,Smith BL. Outcomes of multiple wire localization for larger breast cancers: when can mastectomy be avoided? J Am Coll Surg 2008; 207:342-6. PubMed
  • Patenaude AF,Orozco S,Li X,Kaelin CM,Gadd M,Matory Y,Mayzel K,Roche CA,Smith BL,Farkas W,Garber JE. Support needs and acceptability of psychological and peer consultation: attitudes of 108 women who had undergone or were considering prophylactic mastectomy. Psychooncology 2008; 17:831-43. PubMed
  • Sandkovsky U, Sandkovsky G, Suh J, Smith B, Sharp V, Polsky B. Legionella Pneumonia and HIV: Case Reports and Review of the Literature. AIDS Patient Care STDS 2008; 22:473-81. PubMed
  • Xu Y, Ravid K, Smith BD. Major histocompatibility class II transactivator (CIITA) expression in smooth muscle cells from A2b adenosine receptor knockout mice: crosstalk between the adenosine and IFN-gamma signaling. J Biol Chem 2008; 283:14213-20. PubMed
  • Nguyen PL, Taghian AG, Katz MS, Niemierko A, Abi Raad RF, Boon WL, Bellon JR, Wong JS, Smith BL, Harris JR. Breast cancer subtype approximated by estrogen receptor, progesterone receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy. J Clin Oncol 2008; 26:2373-8. PubMed
  • Katz A, Smith BL, Golshan M, Niemierko A, Kobayashi W, Raad RA, Kelada A, Rizk L, Wong JS, Bellon JR, Gadd M, Specht M, Taghian AG. Nomogram for the prediction of having four or more involved nodes for sentinel lymph node-positive breast cancer. J Clin Oncol 2008; 26:2093-8. PubMed
  • Buchholz TA, Lehman CD, Harris JR, Pockaj BA, Khouri N, Hylton NF, Miller MJ, Whelan T, Pierce LJ, Esserman LJ, Newman LA, Smith BL, Bear HD, Mamounas EP. Statement of the science concerning locoregional treatments after preoperative chemotherapy for breast cancer: a National Cancer Institute conference. J Clin Oncol 2008; 26:791-7. PubMed
  • Xu Y, Harton JA, Smith BD. CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation-dependent interactions with co-repressor molecules. J Biol Chem 2007; 283:1243-56. PubMed
  • Dominguez FJ, Golshan M, Black DM, Hughes KS, Gadd MA, Christian R, Lesnikoski BA, Specht M, Michaelson J, Smith BL. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ. Ann Surg Oncol 2007; 15:268-73. PubMed
  • Rusby JE, Brachtel EF, Michaelson JS, Koerner FC, Smith BL. Breast duct anatomy in the human nipple: three-dimensional patterns and clinical implications. Breast Cancer Res Treat 2007; 106:171-9. PubMed
  • Golshan M, Rusby J, Dominguez F, Smith BL. Breast conservation for male breast carcinoma. Breast 2007; 16:653-6. PubMed
  • Winer EP, Harris JR, Smith BL, D'Alessandro HA, Brachtel EF. Case records of the Massachusetts General Hospital. Case 32-2007. A 62-year-old woman with a second breast cancer. N Engl J Med 2007; 357:1640-8. PubMed
  • Rusby JE, Brachtel EF, Taghian A, Michaelson JS, Koerner FC, Smith BL. George Peters Award. Microscopic anatomy within the nipple: implications for nipple-sparing mastectomy. Am J Surg 2007; 194:433-7. PubMed
  • Smith BA. Strengthening the fabric of medicine. S D Med 2007; 60:389-90. PubMed
  • Price HP, Stark M, Smith B, Smith DF. TbARF1 influences lysosomal function but not endocytosis in procyclic stage Trypanosoma brucei. Mol Biochem Parasitol 2007; 155:123-7. PubMed
  • Xu Y, Farmer SR, Smith BD. Peroxisome proliferator-activated receptor gamma interacts with CIITA x RFX5 complex to repress type I collagen gene expression. J Biol Chem 2007; 282:26046-56. PubMed
  • Black D, Specht M, Lee JM, Dominguez F, Gadd M, Hughes K, Rafferty E, Smith B. Detecting occult malignancy in prophylactic mastectomy: preoperative MRI versus sentinel lymph node biopsy. Ann Surg Oncol 2007; 14:2477-84. PubMed
  • Dominguez FJ, Lawrence C, Halpern EF, Drohan B, Grinstein G, Black DM, Smith BL, Gadd MA, Specht M, Kopans DB, Moore RH, Hughes SS, Roche CA, Hughes KS. Accuracy of Self-Reported Personal History of Cancer in an Outpatient Breast Center. J Genet Couns 2007; 16:341-5. PubMed
  • Rusby JE, Smith BL, Dominguez FJ, Golshan M. Sentinel lymph node biopsy in men with breast cancer: a report of 31 consecutive procedures and review of the literature. Clin Breast Cancer 2007; 7:406-10. PubMed
  • Kozak KR, Smith BL, Adams J, Kornmehl E, Katz A, Gadd M, Specht M, Hughes K, Gioioso V, Lu HM, Braaten K, Recht A, Powell SN, DeLaney TF, Taghian AG. Accelerated partial-breast irradiation using proton beams: initial clinical experience. Int J Radiat Oncol Biol Phys 2006; 66:691-8. PubMed
  • Golshan M, Smith B. Prevention and management of arm lymphedema in the patient with breast cancer. J Support Oncol 2006; 4:381-6. PubMed
  • Blanchard K, Colbert JA, Kopans DB, Moore R, Halpern EF, Hughes KS, Smith BL, Tanabe KK, Michaelson JS. Long-term risk of false-positive screening results and subsequent biopsy as a function of mammography use. Radiology 2006; 240:335-42. PubMed
  • Zabicki K, Colbert JA, Dominguez FJ, Gadd MA, Hughes KS, Jones JL, Specht MC, Michaelson JS, Smith BL. Breast Cancer Diagnosis in Women PubMed
  • Taghian AG, Kozak KR, Doppke KP, Katz A, Smith BL, Gadd M, Specht M, Hughes K, Braaten K, Kachnic LA, Recht A, Powell SN. Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation. Int J Radiat Oncol Biol Phys 2006; 64:1092-9. PubMed
  • Wong JS, Kaelin CM, Troyan SL, Gadd MA, Gelman R, Lester SC, Schnitt SJ, Sgroi DC, Silver BJ, Harris JR, Smith BL. Prospective study of wide excision alone for ductal carcinoma in situ of the breast. J Clin Oncol 2006; 24:1031-6. PubMed
  • Ma XJ, Wang Z, Ryan PD, Isakoff SJ, Barmettler A, Fuller A, Muir B, Mohapatra G, Salunga R, Tuggle JT, Tran Y, Tran D, Tassin A, Amon P, Wang W, Wang W, Enright E, Stecker K, Estepa-Sabal E, Smith B, Younger J, Balis U, Michaelson J, Bhan A, Habin K, Baer TM, Brugge J, Haber DA, Erlander MG, Sgroi DC. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell 2004; 5:607-16. PubMed
  • Michaelson JS, Silverstein M, Sgroi D, Cheongsiatmoy JA, Taghian A, Powell S, Hughes K, Comegno A, Tanabe KK, Smith B. The effect of tumor size and lymph node status on breast carcinoma lethality. Cancer 2003; 98:2133-43. PubMed
  • Ma XJ, Salunga R, Tuggle JT, Gaudet J, Enright E, McQuary P, Payette T, Pistone M, Stecker K, Zhang BM, Zhou YX, Varnholt H, Smith B, Gadd M, Chatfield E, Kessler J, Baer TM, Erlander MG, Sgroi DC. Gene expression profiles of human breast cancer progression. Proc Natl Acad Sci U S A 2003; 100:5974-9. PubMed
  • Citron ML, Berry DA, Cirrincione C, Hudis C, Winer EP, Gradishar WJ, Davidson NE, Martino S, Livingston R, Ingle JN, Perez EA, Carpenter J, Hurd D, Holland JF, Smith BL, Sartor CI, Leung EH, Abrams J, Schilsky RL, Muss HB, Norton L. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia J Clin Oncol 2003; 21:1431-9. PubMed
  • Burstein HJ, Harris LN, Gelman R, Lester SC, Nunes RA, Kaelin CM, Parker LM, Ellisen LW, Kuter I, Gadd MA, Christian RL, Kennedy PR, Borges VF, Bunnell CA, Younger J, Smith BL, Winer EP. Preoperative therapy with trastuzumab and paclitaxel followed by sequential adjuvant doxorubicin/cyclophosphamide for HER2 overexpressing stage II or III breast cancer: a pilot study. J Clin Oncol 2002; 21:46-53. PubMed
  • Zhao Y, Verselis SJ, Klar N, Sadowsky NL, Kaelin CM, Smith B, Foretova L, Li FP. Nipple fluid carcinoembryonic antigen and prostate-specific antigen in cancer-bearing and tumor-free breasts. J Clin Oncol 2001; 19:1462-7. PubMed
  • Humphrey KL, Saksena MA, Freer PE, Smith BL, Rafferty EA. To do or not to do: axillary nodal evaluation after ACOSOG Z0011 Trial. Radiographics 2014; 34:1807-16. PubMed
  • Tang R, Coopey SB, Buckley JM, Aftreth OP, Fernandez LJ, Brachtel EF, Michaelson JS, Gadd MA, Specht MC, Koerner FC, Smith BL. A pilot study evaluating shaved cavity margins with micro-computed tomography: a novel method for predicting lumpectomy margin status intraoperatively. Breast J 2013; 19:485-9. PubMed
  • Mangi AA, Smith BL, Gadd MA, Tanabe KK, Ott MJ, Souba WW. Surgical management of phyllodes tumors. Arch Surg 1999; 134:487-92; discussion 492-3. PubMed
  • Ott MJ, Tanabe KK, Gadd MA, Stark P, Smith BL, Finkelstein DM, Souba WW. Multimodality management of Merkel cell carcinoma. Arch Surg 1999; 134:388-92; discussion 392-3. PubMed
  • Cheng LL, Chang IW, Smith BL, Gonzalez RG. Evaluating human breast ductal carcinomas with high-resolution magic-angle spinning proton magnetic resonance spectroscopy. J Magn Reson 1998; 135:194-202. PubMed
  • Dees EC, Shulman LN, Souba WW, Smith BL. Does information from axillary dissection change treatment in clinically node-negative patients with breast cancer? An algorithm for assessment of impact of axillary dissection. Ann Surg 1997; 226:279-86; discussion 286-7. PubMed
  • Smith BL, Gadd MA, Lawler C, MacDonald DJ, Grudberg SC, Chi FS, Carlson K, Comegno A, Souba WW. Perception of breast cancer risk among women in breast center and primary care settings: correlation with age and family history of breast cancer. Surgery 1996; 120:297-303. PubMed
  • Souba WW, Tanabe KK, Gadd MA, Smith BL, Bushman MS. Attitudes and opinions toward surgical research. A survey of surgical residents and their chairpersons. Ann Surg 1996; 223:377-83. PubMed
  • FitzGerald MG, MacDonald DJ, Krainer M, Hoover I, O'Neil E, Unsal H, Silva-Arrieto S, Finkelstein DM, Beer-Romero P, Englert C, Sgroi DC, Smith BL, Younger JW, Garber JE, Duda RB, Mayzel KA, Isselbacher KJ, Friend SH, Haber DA. Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer. N Engl J Med 1996; 334:143-9. PubMed