Photo of Barbara Wegiel,  PhD

Barbara Wegiel, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 735-2846


bwegiel@bidmc.harvard.edu

Barbara Wegiel, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • Assistant Professor, Surgery, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

A major interest of our laboratory is the role of heme degradation enzymes: heme oxygenase-1 (HO-1) and biliverdin reductase (BVR) in inflammation and tumor biology. We have demonstrated that HO-1 and its product carbon monoxide (CO) are critical regulators of DNA repair pathway (PNAS, 2011) as well as myeloid cell maturation (CDD, 2014). CO at low non-toxic doses blocks tumor growth and accelerates responses to current chemotherapy (Can Res, 2013). Further, we have uncovered novel properties of BVR to act as a signaling molecule and mediate anti-inflammatory effects of biliverdin in myeloid cells (JBC, 2009; PNAS 2011). We continue to explore a role of BVR and HO-1 using our newly generated BVR and HO-1 conditional knockout mice as well as transgenic models of carcinogenesis.

Publications

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  • Eguchi T, Prince T, Wegiel B, Calderwood SK. Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer. J Cell Biochem 2015. PubMed
  • Bisht K, Wegiel B, Tampe J, Neubauer O, Wagner KH, Otterbein LE, Bulmer AC. Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling. Biochem Biophys Res Commun 2014; 449:94-9. PubMed
  • Wegiel B, Gallo D, Csizmadia E, Harris C, Belcher J, Vercellotti GM, Penacho N, Seth P, Sukhatme V, Ahmed A, Pandolfi PP, Helczynski L, Bjartell A, Persson JL, Otterbein LE. Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth. Cancer Res 2013; 73:7009-21. PubMed
  • Wegiel B, Hanto DW, Otterbein LE. The social network of carbon monoxide in medicine. Trends Mol Med 2013; 19:3-11. PubMed
  • Wegiel B, Gallo D, Csizmadia E, Roger T, Kaczmarek E, Harris C, Zuckerbraun BS, Otterbein LE. Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase. Proc Natl Acad Sci U S A 2011; 108:18849-54. PubMed
  • Otterbein LE, Hedblom A, Harris C, Csizmadia E, Gallo D, Wegiel B. Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein. Proc Natl Acad Sci U S A 2011; 108:14491-6. PubMed
  • Wegiel B, Bjartell A, Tuomela J, Dizeyi N, Tinzl M, Helczynski L, Nilsson E, Otterbein LE, Härkönen P, Persson JL. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. Journal of the National Cancer Institute 2008; 100:1022-36. PubMed
  • Wegiel B, Chin BY, Otterbein LE. Inhale to survive, cycle or die? Carbon monoxide and cellular proliferation. Cell Cycle 2008; 7:1379-84. PubMed