I am interested in the molecular basis of cell migration in vivo. In particular, my lab focuses on how chemokines direct the movement of leukocytes and cancer cells to specific locations, and how chemokines contribute to tumor progression. My primary research model is genetically modified mice, and my group uses this model to investigate other aspects of chemokine physiology, such as their direct effects on innate and acquired immune responses and their effects on tumor biology. Much of our work involves examining the functions of the chemokine MCP-1, which plays a central role in polarizing T helper cell responses and is involved in diseases that have monocytic infiltrates such as atherosclerosis. However, we are also interested in Langerhans cell histiocytosis and the effects of chemokine receptor expression on patterns of organ involvement in this disease. My specific clinical interest is lung cancer, and when possible, our laboratory models address problems in this disease.