Development of synthetic methods for biologically active compounds.
The first major focus area is the synthesis of heterocyclic compounds such as: benzo[N,N]-heterocycles (benzodiazepines, benzimidazoles, quinoxalines, quinoxalinones), phthalazinones, iso-benzofuranones. We have developed one step domino syntheses for the preparation of pyrazolines, pyrazoles, Hantzsch esters, and pyridines.
The second major area is the synthesis of organofluorine compounds. This topic includes a broad variety of molecules such as: trifluoromethyl-benzimidazoles, trifluoromethyl-Schiff-bases, trifluoromethyl-alpha-hydroxy-gamma-ketoesters, unnatural trifluormethyl-amino acids, 3,3,3-trifluoropropenes, alpha-fluoro-beta-trifluoromethyl-alpha, beta-unsaturated esters and indolyl-hydroxyl-trifluoromethyl-propionic acid esters.
Many in these groups of compounds have been earlier identified as potent anticancer agents.