Bela Torok, PhD

University Of Massachusetts - Boston

University Of Massachusetts - Boston
Phone: (617) 287-6159


bela.torok@umb.edu

Bela Torok, PhD

University Of Massachusetts - Boston

EDUCATIONAL TITLES

  • Associate Professor, Chemistry, University Of Massachusetts - Boston

DF/HCC PROGRAM AFFILIATION

Research Abstract

Development of synthetic methods for biologically active compounds.

The first major focus area is the synthesis of heterocyclic compounds such as: benzo[N,N]-heterocycles (benzodiazepines, benzimidazoles, quinoxalines, quinoxalinones), phthalazinones, iso-benzofuranones. We have developed one step domino syntheses for the preparation of pyrazolines, pyrazoles, Hantzsch esters, and pyridines.

The second major area is the synthesis of organofluorine compounds. This topic includes a broad variety of molecules such as: trifluoromethyl-benzimidazoles, trifluoromethyl-Schiff-bases, trifluoromethyl-alpha-hydroxy-gamma-ketoesters, unnatural trifluormethyl-amino acids, 3,3,3-trifluoropropenes, alpha-fluoro-beta-trifluoromethyl-alpha, beta-unsaturated esters and indolyl-hydroxyl-trifluoromethyl-propionic acid esters.

Many in these groups of compounds have been earlier identified as potent anticancer agents.

Publications

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  • Kulkarni A, Quang P, Curry V, Keyes R, Zhou W, Cho H, Baffoe J, Török B, Stieglitz K. 1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D. Chem Biol Drug Des 2014. PubMed
  • Rudnitskaya A, Borkin DA, Huynh K, Török B, Stieglitz K. Rational design, synthesis, and potency of N-substituted indoles, pyrroles, and triarylpyrazoles as potential fructose 1,6-bisphosphatase inhibitors. ChemMedChem 2010; 5:384-9. PubMed
  • Sood A, Abid M, Hailemichael S, Foster M, Török B, Török M. Effect of chirality of small molecule organofluorine inhibitors of amyloid self-assembly on inhibitor potency. Bioorg Med Chem Lett 2009; 19:6931-4. PubMed
  • Rudnitskaya A,Huynh K,Torok B,Stieglitz K. Novel heteroaromatic organofluorine inhibitors of fructose-1,6-bisphosphatase. J Med Chem 2009; 52:878-82. PubMed
  • Abid M, Teixeira L, T. Triflic acid-catalyzed highly stereoselective friedel-crafts aminoalkylation of indoles and pyrroles. Org Lett 2008; 10:933-5. PubMed
  • T. Organofluorine inhibitors of amyloid fibrillogenesis. Biochemistry 2006; 45:5377-83. PubMed