Photo of Benjamin D. Humphreys,  MD, PhD

Benjamin D. Humphreys, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-5971
Fax: (617) 525-5965


bhumphreys@partners.org

Benjamin D. Humphreys, MD, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Medicine, Harvard Medical School
  • Associate Physician, Medicine, Brigham And Women's Hospital
  • Director, Onco-Nephrology Program, Dana-Farber Cancer Institute

DF/HCC PROGRAM AFFILIATION

Research Abstract

In my translational research laboratory I investigate the mechanisms of kidney injury and repair. Our mission is to understand the cellular and molecular mechanisms of this process in order to identify new therapeutic strategies for humans suffering from kidney disease. One particular focus is the role of the hedgehog signaling pathway in kidney homeostasis and injury. In separate studies, we use genetic lineage analysis and RNA-sequencing approaches to define cellular hierarchies and catalog gene expression changes in individual cell types during kidney injury. We use in vitro approaches, mouse genetic models and human studies. My clinical specialty is Onco-Nephrology - kidney disease associated with cancer and its treatment, and I investigate the mechanisms of targeted therapy-induced kidney toxicity in humans, including hypertension and proteinuria.

Publications

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  • Grgic I, Hofmeister AF, Genovese G, Bernhardy AJ, Sun H, Maarouf OH, Bijol V, Pollak MR, Humphreys BD. Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo. Kidney Int 2014. PubMed
  • Chang-Panesso M, Humphreys BD. The Seen and the Unseen: Clinical Guidelines and Cost-Effective Care. J Am Soc Nephrol 2014. PubMed
  • Liu J, Krautzberger AM, Sui SH, Hofmann OM, Chen Y, Baetscher M, Grgic I, Kumar S, Humphreys BD, Hide WA, McMahon AP. Cell-specific translational profiling in acute kidney injury. J Clin Invest 2014; 124:2288. PubMed
  • Kusaba T, Humphreys BD. Controversies on the origin of proliferating epithelial cells after kidney injury. Pediatr Nephrol 2014; 29:673-9. PubMed
  • DiRocco DP, Bisi J, Roberts P, Strum J, Wong KK, Sharpless N, Humphreys BD. CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury. Am J Physiol Renal Physiol 2014; 306:F379-88. PubMed
  • Kusaba T, Lalli M, Kramann R, Kobayashi A, Humphreys BD. Differentiated kidney epithelial cells repair injured proximal tubule. Proc Natl Acad Sci U S A 2014; 111:1527-32. PubMed
  • Humphreys BD. Kidney injury, stem cells and regeneration. Curr Opin Nephrol Hypertens 2013; 23:25-31. PubMed
  • Humphreys BD. Kidney structures differentiated from stem cells. Nat Cell Biol 2013; 16:19-21. PubMed
  • Kramann R, Dirocco DP, Maarouf OH, Humphreys BD. Matrix Producing Cells in Chronic Kidney Disease: Origin, Regulation, and Activation. Curr Pathobiol Rep 2013. PubMed
  • Kramann R, DiRocco DP, Humphreys BD. Understanding the origin, activation and regulation of matrix-producing myofibroblasts for treatment of fibrotic disease. J Pathol 2013; 231:273-89. PubMed
  • Humphreys BD, Dirocco DP. Lineage-tracing methods and the kidney. Kidney Int 2013. PubMed
  • Humphreys BD, Xu F, Sabbisetti V, Grgic I, Naini SM, Wang N, Chen G, Xiao S, Patel D, Henderson JM, Ichimura T, Mou S, Soeung S, McMahon AP, Kuchroo VK, Bonventre JV. Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest 2013; 123:4023-35. PubMed
  • DiRocco DP, Kobayashi A, Taketo MM, McMahon AP, Humphreys BD. Wnt4/็กซ-catenin signaling in medullary kidney myofibroblasts. J Am Soc Nephrol 2013; 24:1399-412. PubMed
  • Balasubramanian S, Kota SK, Kuchroo VK, Humphreys BD, Strom TB. TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77. Sci Signal 2012; 5:ra90. PubMed
  • Lam AQ, Humphreys BD. Onco-Nephrology: AKI in the Cancer Patient. Clin J Am Soc Nephrol 2012; 7:1692-700. PubMed
  • de Jesus-Gonzalez N, Robinson E, Penchev R, von Mehren M, Heinrich MC, Tap W, Wang Q, Demetri G, George S, Humphreys BD. Regorafenib induces rapid and reversible changes in plasma nitric oxide and endothelin-1. Am J Hypertens 2012; 25:1118-23. PubMed
  • de Jesus-Gonzalez N, Robinson E, Moslehi J, Humphreys BD. Management of antiangiogenic therapy-induced hypertension. Hypertension 2012; 60:607-15. PubMed
  • Humphreys BD. Targeting pericyte differentiation as a strategy to modulate kidney fibrosis in diabetic nephropathy. Semin Nephrol 2012; 32:463-70. PubMed
  • Grgic I, Duffield JS, Humphreys BD. The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol 2011. PubMed
  • Robinson ES, Khankin EV, Choueiri TK, Dhawan MS, Rogers MJ, Karumanchi SA, Humphreys BD. Suppression of the Nitric Oxide Pathway in Metastatic Renal Cell Carcinoma Patients Receiving Vascular Endothelial Growth Factor-Signaling Inhibitors. Hypertension 2010; 56:1131-6. PubMed
  • Cohen LJ, Rennke HG, Laubach JP, Humphreys BD. The Spectrum of Kidney Involvement in Lymphoma: A Case Report and Review of the Literature. Am J Kidney Dis 2010; 56:1191-6. PubMed
  • Humphreys BD. Onco-nephrology: kidney disease in the cancer patient: introduction. Semin Nephrol 2010; 30:531-3. PubMed
  • Robinson ES, Khankin EV, Karumanchi SA, Humphreys BD. Hypertension induced by vascular endothelial growth factor signaling pathway inhibition: mechanisms and potential use as a biomarker. Semin Nephrol 2010; 30:591-601. PubMed
  • Heher EC, Goes NB, Spitzer TR, Raje NS, Humphreys BD, Anderson KC, Richardson PG. Kidney disease associated with plasma cell dyscrasias. Blood 2010; 116:1397-404. PubMed
  • Robinson ES, Matulonis UA, Ivy P, Berlin ST, Tyburski K, Penson RT, Humphreys BD. Rapid development of hypertension and proteinuria with cediranib, an oral vascular endothelial growth factor receptor inhibitor. Clin J Am Soc Nephrol 2010; 5:477-83. PubMed
  • Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, Valerius MT, McMahon AP, Duffield JS. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2009; 176:85-97. PubMed
  • Humphreys BD. Slow-cycling cells in renal papilla: stem cells awaken? J Am Soc Nephrol 2009; 20:2277-9. PubMed
  • Humphreys BD, Atkins MB. Rapid development of hypertension by sorafenib: toxicity or target? Clin Cancer Res 2009; 15:5947-9. PubMed
  • Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, McMahon AP, Bonventre JV. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2008; 2:284-91. PubMed
  • Patel TV, Morgan JA, Demetri GD, George S, Maki RG, Quigley M, Humphreys BD. A preeclampsia-like syndrome characterized by reversible hypertension and proteinuria induced by the multitargeted kinase inhibitors sunitinib and sorafenib. Journal of the National Cancer Institute 2008; 100:282-4. PubMed
  • Humphreys BD, Soiffer RJ, Magee CC. Renal failure associated with cancer and its treatment: an update. J Am Soc Nephrol 2004; 16:151-61. PubMed
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