Photo of Bob Carter,  MD, PhD

Bob Carter, MD, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-8583

Bob Carter, MD, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Neurosurgery, Harvard Medical School
  • Chief of Neurosurgery, Neurosurgery, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Carter's research is focused on the analysis of extracellular vesicles (EVs) as potential biomarkers for glioma. Dr. Carter is Professor and Chief of Neurosurgery at the Massachusetts General Hospital.  I specialize in intracranial surgery including benign and malignant brain tumors and metastatic brain lesions. My laboratory leads a multi-institutional collaborative effort to clinically validate exRNA biomarkers, including those present in EVs. We also study the role of chimeric T-cell receptors as therapeutics for glioma.

Publications

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  • Treiber JM, Steed TC, Brandel MG, Patel KS, Dale AM, Carter BS, Chen CC. Molecular physiology of contrast enhancement in glioblastomas: An analysis of The Cancer Imaging Archive (TCIA). J Clin Neurosci 2018. PubMed
  • Choi BD, Curry WT, Carter BS, Maus MV. Chimeric antigen receptor T-cell immunotherapy for glioblastoma: practical insights for neurosurgeons. Neurosurg Focus 2018; 44:E13. PubMed
  • Zachariah M, Oliveira-Costa JP, Carter B, Stott SL, Nahed BV. Blood-Based Biomarkers for the Diagnosis and Monitoring of Gliomas. 2018. PubMed
  • Patel KS, Dhawan S, Wang R, Carter BS, Chen JY, Chen CC. Post-operative imaging assessment of non-functioning pituitary adenomas. Acta Neurochir (Wien) 2018; 160:1029-1039. PubMed
  • Koga T, Li B, Figueroa JM, Ren B, Chen CC, Carter BS, Furnari FB. Mapping of genomic EGFRvIII deletions in glioblastoma: insight into rearrangement mechanisms and biomarker development. 2018. PubMed
  • Carroll KT, Lochte BC, Chen JY, Snyder VS, Carter BS, Chen CC. Intraoperative Magnetic Resonance Imaging-Guided Biopsy in the Diagnosis of Suprasellar Langerhans Cell Histiocytosis. World Neurosurg 2018; 112:6-13. PubMed
  • Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA. Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Sci Adv 2018; 4:eaar2766. PubMed
  • Carroll KT, Bryant AK, Hirshman B, Alattar AA, Joshi R, Gabel B, Carter BS, Harismendy O, Vaida F, Chen CC. Interaction Between the Contributions of Tumor Location, Tumor Grade, and Patient Age to the Survival Benefit Associated with Gross Total Resection. World Neurosurg 2018; 111:e790-e798. PubMed
  • Kang KH, Schapira E, Niemierko A, Martinez-Lage M, Bussière MR, Yock TI, Loeffler JS, Butler WE, Carter BS, Shih HA. The role of proton beam therapy in central neurocytoma: A single-institution experience. 2018. PubMed
  • Steed TC, Treiber JM, Brandel MG, Patel KS, Dale AM, Carter BS, Chen CC. Quantification of glioblastoma mass effect by lateral ventricle displacement. Sci Rep 2018; 8:2827. PubMed
  • Sahin A, Sanchez C, Bullain S, Waterman P, Weissleder R, Carter BS. Development of third generation anti-EGFRvIII chimeric T cells and EGFRvIII-expressing artificial antigen presenting cells for adoptive cell therapy for glioma. PLoS ONE 2018; 13:e0199414. PubMed
  • Patel KS, Carter BS, Chen CC. Role of Biopsies in the Management of Intracranial Gliomas. Prog Neurol Surg 2017; 30:232-243. PubMed
  • Adhikari B, Li J, Brandel MG, Futalan D, Akers J, Deming T, Chen CC, Carter BS. The use of TMZ embedded hydrogels for the treatment of orthotopic human glioma xenografts. J Clin Neurosci 2018; 45:288-292. PubMed
  • Figueroa JM, Carter BS. Detection of glioblastoma in biofluids. J Neurosurg 2017. PubMed
  • Figueroa JM, Skog J, Akers J, Li H, Komotar R, Jensen R, Ringel F, Yang I, Kalkanis S, Thompson R, LoGuidice L, Berghoff E, Parsa A, Liau L, Curry W, Cahill D, Bettegowda C, Lang FF, Chiocca EA, Henson J, Kim R, Breakefield X, Chen C, Messer K, Hochberg F, Carter BS. Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients. 2018; 19:1494-1502. PubMed
  • Akers JC, Hua W, Li H, Ramakrishnan V, Yang Z, Quan K, Zhu W, Li J, Figueroa J, Hirshman BR, Miller B, Piccioni D, Ringel F, Komotar R, Messer K, Galasko DR, Hochberg F, Mao Y, Carter BS, Chen CC. A cerebrospinal fluid microRNA signature as biomarker for glioblastoma. 2018; 8:68769-68779. PubMed
  • Hirshman BR, Wilson BR, Ali MA, Schupper AJ, Proudfoot JA, Goetsch SJ, Carter BS, Sinclair G, Bartek J, Chiang V, Fogarty G, Hong A, Chen CC. Cumulative Intracranial Tumor Volume Augments the Prognostic Value of Diagnosis-Specific Graded Prognostic Assessment Model for Survival in Patients with Melanoma Cerebral Metastases. Neurosurgery 2018. PubMed
  • Brown JM, Mahan MA, Mandeville R, Carter BS. Establishing reconstructive neurosurgery as a subspecialty. Neurosurg Focus 2017; 43:E7. PubMed
  • Lau SK, Patel K, Kim T, Knipprath E, Kim GY, Cerviño LI, Lawson JD, Murphy KT, Sanghvi P, Carter BS, Chen CC. Clinical efficacy and safety of surface imaging guided radiosurgery (SIG-RS) in the treatment of benign skull base tumors. J. Neurooncol. 2017. PubMed
  • Tringale KR, Wilson BR, Hirshman B, Zhou T, Folsom D, Norman MA, Grant I, Chen CC, Carter BS. Psychiatric Disease Preceding Intracranial Tumor Diagnosis: Investigating the Association. Prim Care Companion CNS Disord 2016. PubMed
  • Hirshman BR, Jones LA, Carroll KT, Tang JA, Proudfoot JA, Carley KM, Carter BS, Chen CC. Coevolution of Peer-Reviewed Literature and Clinical Practice in High-Grade Glioma Resection. World Neurosurg 2016; 96:237-241. PubMed
  • Rennert RC, Santiago-Dieppa DR, Figueroa J, Sanai N, Carter BS. Future directions of operative neuro-oncology. J. Neurooncol. 2016; 130:377-382. PubMed
  • Chen CC, Carter BS, Wang R, Patel KS, Hess C, Bodach ME, Tumialan LM, Oyesiku NM, Patil CG, Litvack Z, Zada G, Aghi MK. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Preoperative Imaging Assessment of Patients With Suspected Nonfunctioning Pituitary Adenomas. Neurosurgery 2016; 79:E524-6. PubMed
  • Ziu M, Dunn IF, Hess C, Fleseriu M, Bodach ME, Tumialan LM, Oyesiku NM, Patel KS, Wang R, Carter BS, Chen JY, Chen CC, Patil CG, Litvack Z, Zada G, Aghi MK. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Posttreatment Follow-up Evaluation of Patients With Nonfunctioning Pituitary Adenomas. Neurosurgery 2016; 79:E541-3. PubMed
  • Skog J,Wurdinger T,van Rijn S,Meijer DH,Gainche L,Sena-Esteves M,Curry WT Jr,Carter BS,Krichevsky AM,Breakefield XO. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008; 10:1470-6. PubMed
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