Photo of Bradley J. Quade,  MD, PhD

Bradley J. Quade, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-7980
Fax: (617) 738-6996


bquade@partners.org

Bradley J. Quade, MD, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Pathology, Harvard Medical School
  • Clinical Co-Director, Center for Uterine Fibroids, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Quade's research interests focus primarily on mesenchymal tumors of the female genital tract. Benign uterine leiomyomas and endometrial polyps are among the most common neoplasms and pose a major public health problem for women of reproductive age. Although less common, malignant leiomyosarcomas can be difficult to distinguish from atypical or quasi-malignant leimoyoma variants. Dr. Quade's laboratory has ongoing projects to identify and characterize genes important in uterine leiomyoma pathobiology, and to understand the molecular genetic distinctions bewteen benign and malignant mesenchymal tumors of the uterus. In several recent publications, he has accessed aberrant expression of the DNA architectrural factors HMGIY and HMGIC in leiomyomas with chromosomal rearrangements involving their respective genes on chromosomes 6 and 12. His laboratory has shown that uterine leiomyosarcomas are characterized by frequent loss of heterozygosity for chromosome 10 compared to leiomyomas. He has shown in an earlier work that disseminated peritoneal leiomyomatosis, a clinical benign condition once regarded as metaplastic, has the molecular features of a metastasizing neoplasm and cytogenetic features similar to benign leiomyomas. Dr. Quade also is a co-investigator and project leader for the Developmental Genome Anatomy Project. This program project seeks to identify developmentally important genes by mapping balanced chromosome rearrangements associated with multiple congenital anomalies.

Publications

Powered by Harvard Catalyst
  • Parra-Herran C, Quick CM, Howitt BE, Dal Cin P, Quade BJ, Nucci MR. Inflammatory myofibroblastic tumor of the uterus: clinical and pathologic review of 10 cases including a subset with aggressive clinical course. Am J Surg Pathol 2015. PubMed
  • Howitt BE, Quade BJ, Nucci MR. Uterine polyps with features overlapping with those of Müllerian adenosarcoma: a clinicopathologic analysis of 29 cases emphasizing their likely benign nature. Am J Surg Pathol 2014. PubMed
  • Howitt BE, Sholl LM, Dal Cin P, Jia Y, Yuan L, MacConaill L, Lindeman N, Kuo F, Garcia E, Nucci MR, Quade BJ. Targeted genomic analysis of Müllerian adenosarcoma. J Pathol 2014. PubMed
  • Parra-Herran CE, Yuan L, Nucci MR, Quade BJ. Targeted development of specific biomarkers of endometrial stromal cell differentiation using bioinformatics: the IFITM1 model. Mod Pathol 2014; 27:569-79. PubMed
  • Conner JR, Meserve E, Pizer E, Garber J, Roh M, Urban N, Drescher C, Quade BJ, Muto M, Howitt BE, Pearlman MD, Berkowitz RS, Horowitz N, Crum CP, Feltmate C. Outcome of unexpected adnexal neoplasia discovered during risk reduction salpingo-oophorectomy in women with germ-line BRCA1 or BRCA2 mutations. Gynecol Oncol 2014; 132:280-6. PubMed
  • Schoolmeester JK, Howitt BE, Hirsch MS, Dal Cin P, Quade BJ, Nucci MR. Perivascular epithelioid cell neoplasm (PEComa) of the gynecologic tract: clinicopathologic and immunohistochemical characterization of 16 cases. Am J Surg Pathol 2014; 38:176-88. PubMed
  • Shoni M, Nagymanyoki Z, Vitonis AF, Jimenez C, Ng SW, Quade BJ, Berkowitz RS. p-21-Activated kinase-1, -4 and -6 and estrogen receptor expression pattern in normal placenta and gestational trophoblastic diseases. Gynecol Oncol 2013; 131:759-63. PubMed
  • Fadare O, Parkash V, Dupont WD, Acs G, Atkins KA, Irving JA, Pirog EC, Quade BJ, Quddus MR, Rabban JT, Vang R, Hecht JL. The diagnosis of endometrial carcinomas with clear cells by gynecologic pathologists: an assessment of interobserver variability and associated morphologic features. Am J Surg Pathol 2012; 36:1107-18. PubMed
  • Kim HG, Kim HT, Leach NT, Lan F, Ullmann R, Silahtaroglu A, Kurth I, Nowka A, Seong IS, Shen Y, Talkowski ME, Ruderfer D, Lee JH, Glotzbach C, Ha K, Kjaergaard S, Levin AV, Romeike BF, Kleefstra T, Bartsch O, Elsea SH, Jabs EW, MacDonald ME, Harris DJ, Quade BJ, Ropers HH, Shaffer LG, Kutsche K, Layman LC, Tommerup N, Kalscheuer VM, Shi Y, Morton CC, Kim CH, Gusella JF. Translocations disrupting PHF21A in the Potocki-Shaffer-syndrome region are associated with intellectual disability and craniofacial anomalies. Am J Hum Genet 2012; 91:56-72. PubMed
  • Seidman MA, Oduyebo T, Muto MG, Crum CP, Nucci MR, Quade BJ. Peritoneal dissemination complicating morcellation of uterine mesenchymal neoplasms. PLoS ONE 2012; 7:e50058. PubMed
  • Ordulu Z, Dal Cin P, Chong WW, Choy KW, Lee C, Muto MG, Quade BJ, Morton CC. Disseminated peritoneal leiomyomatosis after laparoscopic supracervical hysterectomy with characteristic molecular cytogenetic findings of uterine leiomyoma. Genes Chromosomes Cancer 2010; 49:1152-60. PubMed
  • Chen EY, Mehra K, Mehrad M, Ning G, Miron A, Mutter GL, Monte N, Quade BJ, McKeon FD, Yassin Y, Xian W, Crum CP. Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tube. J Pathol 2010; 222:110-6. PubMed
  • Xian W, Miron A, Roh M, Semmel DR, Yassin Y, Garber J, Oliva E, Goodman A, Mehra K, Berkowitz RS, Crum CP, Quade BJ. The Li-Fraumeni syndrome (LFS): a model for the initiation of p53 signatures in the distal Fallopian tube. J Pathol 2009; 220:17-23. PubMed
  • Hodge JC, Park PJ, Dreyfuss JM, Assil-Kishawi I, Somasundaram P, Semere LG, Quade BJ, Lynch AM, Stewart EA, Morton CC. Identifying the molecular signature of the interstitial deletion 7q subgroup of uterine leiomyomata using a paired analysis. Genes Chromosomes Cancer 2009; 48:865-85. PubMed
  • Hodge JC, Quade BJ, Rubin MA, Stewart EA, Dal Cin P, Morton CC. Molecular and cytogenetic characterization of plexiform leiomyomata provide further evidence for genetic heterogeneity underlying uterine fibroids. Am J Pathol 2008; 172:1403-10. PubMed
  • Medeiros F, Callahan MJ, Elvin JA, Dorfman DM, Berkowitz RS, Quade BJ. Intraplacental choriocarcinoma arising in a second trimester placenta with partial hydatidiform mole. Int J Gynecol Pathol 2008; 27:247-51. PubMed
  • Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med 2007; 13:992-7. PubMed
  • Leach NT, Sun Y, Michaud S, Zheng Y, Ligon KL, Ligon AH, Sander T, Korf BR, Lu W, Harris DJ, Gusella JF, Maas RL, Quade BJ, Cole AJ, Kelz MB, Morton CC. Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice. Am J Hum Genet 2007; 80:792-9. PubMed
Hide