Photo of Bruce A. Yankner,  MD, PhD

Bruce A. Yankner, MD, PhD

Harvard Medical School

Harvard Medical School


bruce_yankner@hms.harvard.edu

Bruce A. Yankner, MD, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • Professor, Neurology, Harvard Medical School
  • Professor, Genetics, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Publications

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  • Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science 2015; 349:aaa5612. PubMed
  • Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B, Shi Y. The histone demethylase LSD1/KDM1A promotes the DNA damage response. J Cell Biol 2013; 203:457-70. PubMed
  • Gabuzda D, Yankner BA. Physiology: Inflammation links ageing to the brain. Nature 2013; 497:197-8. PubMed
  • Lee PC, Dodart JC, Aron L, Finley LW, Bronson RT, Haigis MC, Yankner BA, Harper JW. Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Mol Cell 2013. PubMed
  • Haigis MC, Yankner BA. The aging stress response. Mol Cell 2010; 40:333-44. PubMed
  • Oberdoerffer P,Michan S,McVay M,Mostoslavsky R,Vann J,Park SK,Hartlerode A,Stegmuller J,Hafner A,Loerch P,Wright SM,Mills KD,Bonni A,Yankner BA,Scully R,Prolla TA,Alt FW,Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 2008; 135:907-18. PubMed
  • Papadia S, Soriano FX, Leveille F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, Hardingham GE. Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci 2008; 11:476-87. PubMed
  • Loerch PM,Lu T,Dakin KA,Vann JM,Isaacs A,Geula C,Wang J,Pan Y,Gabuzda DH,Li C,Prolla TA,Yankner BA. Evolution of the aging brain transcriptome and synaptic regulation. PLoS ONE 2008; 3:e3329. PubMed
  • Yankner BA, Lu T, Loerch P. The aging brain. Annu Rev Pathol 2007; 3:41-66. PubMed
  • Isaacs AM, Senn DB, Yuan M, Shine JP, Yankner BA. Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium. J Biol Chem 2006; 281:27916-23. PubMed
  • Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem 2006; 281:14474-85. PubMed