Photo of Bruce A. Yankner,  MD, PhD

Bruce A. Yankner, MD, PhD

Harvard Medical School

Harvard Medical School


bruce_yankner@hms.harvard.edu

Bruce A. Yankner, MD, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • Professor, Neurology, Harvard Medical School
  • Professor, Genetics, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Publications

Powered by Harvard Catalyst
  • Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B, Shi Y. The histone demethylase LSD1/KDM1A promotes the DNA damage response. J Cell Biol 2013; 203:457-70. PubMed
  • Gabuzda D, Yankner BA. Physiology: Inflammation links ageing to the brain. Nature 2013; 497:197-8. PubMed
  • Lee PC, Dodart JC, Aron L, Finley LW, Bronson RT, Haigis MC, Yankner BA, Harper JW. Altered Social Behavior and Neuronal Development in Mice Lacking the Uba6-Use1 Ubiquitin Transfer System. Mol Cell 2013. PubMed
  • Haigis MC, Yankner BA. The aging stress response. Mol Cell 2010; 40:333-44. PubMed
  • Oberdoerffer P,Michan S,McVay M,Mostoslavsky R,Vann J,Park SK,Hartlerode A,Stegmuller J,Hafner A,Loerch P,Wright SM,Mills KD,Bonni A,Yankner BA,Scully R,Prolla TA,Alt FW,Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 2008; 135:907-18. PubMed
  • Papadia S, Soriano FX, Leveille F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, Hardingham GE. Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci 2008; 11:476-87. PubMed
  • Yankner BA, Lu T, Loerch P. The aging brain. Annu Rev Pathol 2007; 3:41-66. PubMed
  • Loerch PM,Lu T,Dakin KA,Vann JM,Isaacs A,Geula C,Wang J,Pan Y,Gabuzda DH,Li C,Prolla TA,Yankner BA. Evolution of the aging brain transcriptome and synaptic regulation. PLoS ONE 2008; 3:e3329. PubMed
  • Isaacs AM, Senn DB, Yuan M, Shine JP, Yankner BA. Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium. J Biol Chem 2006; 281:27916-23. PubMed
  • Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem 2006; 281:14474-85. PubMed
  • Hass MR, Yankner BA. A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J Biol Chem 2005; 280:36895-904. PubMed
  • Xu J, Zhong N, Wang H, Elias JE, Kim CY, Woldman I, Pifl C, Gygi SP, Geula C, Yankner BA. The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum Mol Genet 2005; 14:1231-41. PubMed
  • Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA. Gene regulation and DNA damage in the ageing human brain. Nature 2004; 429:883-91. PubMed
  • Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, St George-Hyslop P. Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. J Biol Chem 2003; 278:19974-9. PubMed
  • Xu J, Kao SY, Lee FJ, Song W, Jin LW, Yankner BA. Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med 2002; 8:600-6. PubMed
  • Ebinu JO, Yankner BA. A RIP tide in neuronal signal transduction. Neuron 2002; 34:499-502. PubMed
  • Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA. Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron 2002; 33:677-88. PubMed
  • Weninger SC, Yankner BA. Inflammation and Alzheimer disease: the good, the bad, and the ugly. Nat Med 2001; 7:527-8. PubMed
  • Yuan J, Yankner BA. Apoptosis in the nervous system. Nature 2000; 407:802-9. PubMed
  • Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A, Yankner BA. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat Cell Biol 2000; 2:463-5. PubMed
  • Lorenzo A, Yuan M, Zhang Z, Paganetti PA, Sturchler-Pierrat C, Staufenbiel M, Mautino J, Vigo FS, Sommer B, Yankner BA. Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. Nat Neurosci 2000; 3:460-4. PubMed
  • Yankner BA. A century of cognitive decline. Nature 2000; 404:125. PubMed
  • Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000; 403:98-103. PubMed
  • Yankner BA. The pathogenesis of Alzheimer's disease. Is amyloid beta-protein the beginning or the end? Ann N Y Acad Sci 2001; 924:26-8. PubMed
  • Song W, Nadeau P, Yuan M, Yang X, Shen J, Yankner BA. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci U S A 1999; 96:6959-63. PubMed
  • Yuan J, Yankner BA. Caspase activity sows the seeds of neuronal death. Nat Cell Biol 1999; 1:E44-5. PubMed
  • Liu C, Kato Y, Zhang Z, Do VM, Yankner BA, He X. beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci U S A 1999; 96:6273-8. PubMed
  • Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 1998; 395:698-702. PubMed
  • Geula C, Wu CK, Saroff D, Lorenzo A, Yuan M, Yankner BA. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med 1998; 4:827-31. PubMed
  • Yankner BA. Monster plaques: what they tell us about Alzheimer's disease. Nat Med 1998; 4:394-5. PubMed
  • Busciglio J, Hartmann H, Lorenzo A, Wong C, Baumann K, Sommer B, Staufenbiel M, Yankner BA. Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease. J Neurosci 1997; 17:5101-7. PubMed
  • Hartmann H, Busciglio J, Baumann KH, Staufenbiel M, Yankner BA. Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation. J Biol Chem 1997; 272:14505-8. PubMed
  • Baumann K, Paganetti PA, Sturchler-Pierrat C, Wong C, Hartmann H, Cescato R, Frey P, Yankner BA, Sommer B, Staufenbiel M. Distinct processing of endogenous and overexpressed recombinant presenilin 1. Neurobiol Aging 1997; 18:181-9. PubMed
  • Yankner BA. New clues to Alzheimer's disease: unraveling the roles of amyloid and tau. Nat Med 1996; 2:850-2. PubMed
  • Yankner BA. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 1996; 16:921-32. PubMed
  • Lorenzo A, Yankner BA. Amyloid fibril toxicity in Alzheimer's disease and diabetes. Ann N Y Acad Sci 1996; 777:89-95. PubMed
  • Busciglio J, Yankner BA. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 1995; 378:776-9. PubMed
  • Martin BL, Schrader-Fischer G, Busciglio J, Duke M, Paganetti P, Yankner BA. Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein. J Biol Chem 1995; 270:26727-30. PubMed
  • Busciglio J, Lorenzo A, Yeh J, Yankner BA. beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 1995; 14:879-88. PubMed
  • Lorenzo A, Yankner BA. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci U S A 1994; 91:12243-7. PubMed
  • Gabuzda D, Busciglio J, Chen LB, Matsudaira P, Yankner BA. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem 1994; 269:13623-8. PubMed
  • Lorenzo A, Razzaboni B, Weir GC, Yankner BA. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 1994; 368:756-60. PubMed
  • Gabuzda D, Busciglio J, Yankner BA. Inhibition of beta-amyloid production by activation of protein kinase C. J Neurochem 1993; 61:2326-9. PubMed
  • Busciglio J, Yeh J, Yankner BA. beta-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins. J Neurochem 1993; 61:1565-8. PubMed
  • Busciglio J, Gabuzda DH, Matsudaira P, Yankner BA. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc Natl Acad Sci U S A 1993; 90:2092-6. PubMed
  • Kowall NW, McKee AC, Yankner BA, Beal MF. In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment. Neurobiol Aging 1992; 13:537-42. PubMed
  • Busciglio J, Lorenzo A, Yankner BA. Methodological variables in the assessment of beta amyloid neurotoxicity. Neurobiol Aging 1992; 13:609-12. PubMed
  • Yankner BA. Commentary and perspective on studies of beta amyloid neurotoxicity. Neurobiol Aging 1992; 13:615-6. PubMed
  • Chen M, Tempst P, Yankner BA. Secretogranin I/chromogranin B is a heparin-binding adhesive protein. J Neurochem 1992; 58:1691-8. PubMed
  • Yankner BA, Mesulam MM. Seminars in medicine of the Beth Israel Hospital, Boston. beta-Amyloid and the pathogenesis of Alzheimer's disease. N Engl J Med 1991; 325:1849-57. PubMed
  • Kowall NW, Beal MF, Busciglio J, Duffy LK, Yankner BA. An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P. Proc Natl Acad Sci U S A 1991; 88:7247-51. PubMed
  • Chen M, Yankner BA. An antibody to beta amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types. Neurosci Lett 1991; 125:223-6. PubMed
  • Yankner BA, Caceres A, Duffy LK. Nerve growth factor potentiates the neurotoxicity of beta amyloid. Proc Natl Acad Sci U S A 1990; 87:9020-3. PubMed
  • Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 1990; 250:279-82. PubMed
  • Yankner BA, Benowitz LI, Villa-Komaroff L, Neve RL. Transfection of PC12 cells with the human GAP-43 gene: effects on neurite outgrowth and regeneration. Brain Res Mol Brain Res 1990; 7:39-44. PubMed
  • Neve RL, Dawes LR, Yankner BA, Benowitz LI, Rodriguez W, Higgins GA. Genetics and biology of the Alzheimer amyloid precursor. Prog Brain Res 1990; 86:257-67. PubMed
  • Yankner BA. Amyloid and Alzheimer's disease--cause or effect? Neurobiol Aging 1989; 10:470-1; discussion 477-8. PubMed
  • Yankner BA. NGF and Alzheimer's disease--considerations and caveats. Neurobiol Aging 1989; 10:546-7; discussion 552-3. PubMed
  • Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 1989; 245:417-20. PubMed
  • Yankner BA, Skolnik PR, Shoukimas GM, Gabuzda DH, Sobel RA, Ho DD. Cerebral granulomatous angiitis associated with isolation of human T-lymphotropic virus type III from the central nervous system. Ann Neurol 1986; 20:362-4. PubMed
  • Yankner BA, Shooter EM. The biology and mechanism of action of nerve growth factor. Annu Rev Biochem 1981; 51:845-68. PubMed
  • Shooter EM, Yankner BA, Landreth GE, Sutter A. Biosynthesis and mechanism of action of nerve growth factor. Recent Prog Horm Res 1980; 37:417-46. PubMed
  • Yankner BA, Shooter EM. Nerve growth factor in the nucleus: interaction with receptors on the nuclear membrane. Proc Natl Acad Sci U S A 1979; 76:1269-73. PubMed
Hide