Photo of Bruce R. Rosen,  MD, PhD

Bruce R. Rosen, MD, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-3197
Fax: (617) 726-7422


bruce@nmr.mgh.harvard.edu

Bruce R. Rosen, MD, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Health Sciences and Technology, Harvard Medical School
  • Laurence Lamson Robbins Professor of Radiology, Radiology, Harvard Medical School
  • Director, MGH NMR Center, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Angiogenesis is a critical process for solid tumors to grow leading to the formation of a high density hyperpermeable network of microvessels with abnormal geometry. The chaotic proliferation of tumor vessels causes regional changes in blood volume and tissue perfusion that can be mapped with magnetic resonance (MR) imaging and other techniques. My research for the past thirty years has focused on the development and application of physiological and functional nuclear magnetic resonance techniques, as well as new approaches to combine functional MRI data with information from other modalities such as positron emission tomography (PET), magnetoencephalography (MEG) and noninvasive optical imaging. In addition to developmental work to advance these techniques, my research addresses how functional imaging tools can be applied to address specific biological and clinical problems. Among several areas of interest currently under investigation, my group is conducting quantitative MRI studies of hemodynamic and angiogenic parameters in cerebral neoplasms, to test the relationship between these physiological parameters and treatment effects for these cancers. My experience in this area includes the original description of dynamic susceptibility contrast methods for assessment of hemodynamics as a means to quantify cerebral and tumor blood flow and volume and microvessel size distribution, development of methods to quantify the cerebral rate of oxygen consumption, EPI-based methods to map molecular self-diffusion of water, and measurement and mapping of underlying eloquent cortical function using fMRI.

Publications

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  • Attenberger U, Catana C, Chandarana H, Catalano OA, Friedman K, Schonberg SA, Thrall J, Salvatore M, Rosen BR, Guimaraes AR. Whole-body FDG PET-MR oncologic imaging: pitfalls in clinical interpretation related to inaccurate MR-based attenuation correction. Abdom Imaging 2015. PubMed
  • Jafari-Khouzani K, Emblem KE, Kalpathy-Cramer J, Bjørnerud A, Vangel MG, Gerstner ER, Schmainda KM, Paynabar K, Wu O, Wen PY, Batchelor T, Rosen B, Stufflebeam SM. Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients. Transl Oncol 2015; 8:137-46. PubMed
  • Emblem KE, Farrar CT, Gerstner ER, Batchelor TT, Borra RJ, Rosen BR, Sorensen AG, Jain RK. Vessel caliber--a potential MRI biomarker of tumour response in clinical trials. Nat Rev Clin Oncol 2014; 11:566-84. PubMed
  • Pinho MC, Polaskova P, Kalpathy-Cramer J, Jennings D, Emblem KE, Jain RK, Rosen BR, Wen PY, Sorensen AG, Batchelor TT, Gerstner ER. Low incidence of pseudoprogression by imaging in newly diagnosed glioblastoma patients treated with cediranib in combination with chemoradiation. Oncologist 2014; 19:75-81. PubMed
  • Catalano OA, Rosen BR, Sahani DV, Hahn PF, Guimaraes AR, Vangel MG, Nicolai E, Soricelli A, Salvatore M. Clinical impact of PET/MR imaging in patients with cancer undergoing same-day PET/CT: initial experience in 134 patients--a hypothesis-generating exploratory study. Radiology 2013; 269:857-69. PubMed
  • Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen BR, Loeffler JS, Wen PY, Sorensen AG, Jain RK. Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. Proc Natl Acad Sci U S A 2013; 110:19059-64. PubMed
  • Emblem KE, Mouridsen K, Bjornerud A, Farrar CT, Jennings D, Borra RJ, Wen PY, Ivy P, Batchelor TT, Rosen BR, Jain RK, Sorensen AG. Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy. Nat Med 2013; 19:1178-83. PubMed
  • Andronesi OC, Rapalino O, Gerstner E, Chi A, Batchelor TT, Cahill DP, Sorensen AG, Rosen BR. Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate. J Clin Invest 2013; 123:3659-63. PubMed
  • Farrar CT, Kamoun WS, Ley CD, Kim YR, Catana C, Kwon SJ, Rosen BR, Jain RK, Sorensen AG. Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model. PLoS ONE 2011; 6:e17228. PubMed
  • Tian P, Teng IC, May LD, Kurz R, Lu K, Scadeng M, Hillman EM, De Crespigny AJ, D'Arceuil HE, Mandeville JB, Marota JJ, Rosen BR, Liu TT, Boas DA, Buxton RB, Dale AM, Devor A. Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal. Proc Natl Acad Sci U S A 2010; 107:15246-51. PubMed
  • Farrar CT, Kamoun WS, Ley CD, Kim YR, Kwon SJ, Dai G, Rosen BR, di Tomaso E, Jain RK, Sorensen AG. In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model. 2010; 12:341-50. PubMed
  • Liu CH, Ren JQ, Yang J, Liu CM, Mandeville JB, Rosen BR, Bhide PG, Yanagawa Y, Liu PK. DNA-based MRI probes for specific detection of chronic exposure to amphetamine in living brains. J Neurosci 2009; 29:10663-70. PubMed
  • Huang S,Liu C,Dai G,Kim YR,Rosen BR. Manipulation of tissue contrast using contrast agents for enhanced MR microscopy in ex vivo mouse brain. Neuroimage 2009; 46:589-99. PubMed
  • Blackwell ML,Farrar CT,Fischl B,Rosen BR. Target-specific contrast agents for magnetic resonance microscopy. Neuroimage 2009; 46:382-93. PubMed
  • Liu CH,You Z,Liu CM,Kim YR,Whalen MJ,Rosen BR,Liu PK. Diffusion-weighted magnetic resonance imaging reversal by gene knockdown of matrix metalloproteinase-9 activities in live animal brains. J Neurosci 2009; 29:3508-17. PubMed
  • Devor A,Hillman EM,Tian P,Waeber C,Teng IC,Ruvinskaya L,Shalinsky MH,Zhu H,Haslinger RH,Narayanan SN,Ulbert I,Dunn AK,Lo EH,Rosen BR,Dale AM,Kleinfeld D,Boas DA. Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex. J Neurosci 2009; 28:14347-57. PubMed
  • Witzel T,Lin FH,Rosen BR,Wald LL. Stimulus-induced Rotary Saturation (SIRS): a potential method for the detection of neuronal currents with MRI. Neuroimage 2008; 42:1357-65. PubMed
  • Farrar CT,Dai G,Novikov M,Rosenzweig A,Weissleder R,Rosen BR,Sosnovik DE. Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging. NMR Biomed 2007; 21:453-63. PubMed
  • Huang S, Vader D, Wang Z, Stemmer-Rachamimov A, Weitz DA, Dai G, Rosen BR, Deisboeck TS. Using magnetic resonance microscopy to study the growth dynamics of a glioma spheroid in collagen I: A case study. BMC Med Imaging 2008; 8:3. PubMed
  • Liu CH, Kim YR, Ren JQ, Eichler F, Rosen BR, Liu PK. Imaging cerebral gene transcripts in live animals. J Neurosci 2007; 27:713-22. PubMed
  • Wu O, Sumii T, Asahi M, Sasamata M, Ostergaard L, Rosen BR, Lo EH, Dijkhuizen RM. Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models. J Cereb Blood Flow Metab 2006; 27:196-204. PubMed
  • Kim YR, van Meer MP, Mandeville JB, Tejima E, Dai G, Topalkara K, Qui J, Dijkhuizen RM, Moskowitz MA, Lo EH, Rosen BR. fMRI of delayed albumin treatment during stroke recovery in rats: implication for fast neuronal habituation in recovering brains. J Cereb Blood Flow Metab 2006; 27:142-53. PubMed
  • Knake S, Halgren E, Shiraishi H, Hara K, Hamer HM, Grant PE, Carr VA, Foxe D, Camposano S, Busa E, Witzel T, Hamalainen MS, Ahlfors SP, Bromfield EB, Black PM, Bourgeois BF, Cole AJ, Cosgrove GR, Dworetzky BA, Madsen JR, Larsson PG, Schomer DL, Thiele EA, Dale AM, Rosen BR, Stufflebeam SM. The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients. Epilepsy Res 2006; 69:80-6. PubMed
  • Zhao BQ, Wang S, Kim HY, Storrie H, Rosen BR, Mooney DJ, Wang X, Lo EH. Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med 2006; 12:441-5. PubMed
  • Bar M, Kassam KS, Ghuman AS, Boshyan J, Schmid AM, Schmidt AM, Dale AM, H. Top-down facilitation of visual recognition. Proc Natl Acad Sci U S A 2006; 103:449-54. PubMed
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