Photo of Carlos Rodriguez-Galindo,  MD

Carlos Rodriguez-Galindo, MD

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute
Phone: (617) 632-4580


carlos_rodriguez-galindo@dfci.harvard.edu

Carlos Rodriguez-Galindo, MD

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Associate Professor, Pediatrics, Harvard Medical School
  • Director, Solid Tumor Program, Pediatric Oncology, Dana-Farber Cancer Institute
  • Medical Director, Pediatric Oncology Clinical Trials, Pediatric Oncology, Dana-Farber Cancer Institute

DF/HCC PROGRAM AFFILIATION

Research Abstract

My clinical research has focused on the development of innovative therapies for pediatric solid tumors, in particular retinoblastoma, sarcomas, and rare cancers. In the field of retinoblastoma, I lead a multidisciplinary team that integrates clinical and research initiatives focused on the development of a state of the art treatment center and advancement of science. In the RET5 protocol, I developed a comprehensive preclinical and clinical research program for the development of new agents and identification of molecular targets. Because retinoblastoma occurs at such early age, when the visual pathways are still developing, we are investigating changes in visual pathways occurring in those children. The information provided by this research will be very relevant to our understanding of brain development during infancy. In adrenocortical tumors, our group at St Jude identified a novel germline TP53 mutation in Brazilian children that results in a novel model of tumorigenesis. I continued to build on those findings and developed an international study through the Children’s Oncology Group (ARAR0332) that investigates biology and treatment of this malignancy. As part of those studies, we have identified a unique pattern of gene expression that will help characterize those tumors with malignant behavior. I have also developed a national research study for pediatric nasopharyngeal carcinoma (ARAR0331) that incorporates new concepts in the treatment of this malignancy and explores the role of EBV in its pathogenesis. Additional research initiatives in pediatric malignancies include my extensive work on the Ewing sarcoma, osteosarcoma and soft tissue sarcomas. My research in histiocytic disorders has centered in the use of nucleoside analogues in the treatment of Langerhans cell histiocytosis. My work on those fields has led to me assuming leadership roles in cooperative groups. I am the Chair of the Retinoblastoma and Rare Tumor Committee at the Children’s Oncology Group, and the Secretary of the Board and PI of the LCH-IV study of the Histiocyte Society.

Publications

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  • Minkov M, Rodriguez-Galindo C. Treatment of Langerhans cell histiocytosis: it is time to learn from the past. British Journal of Haematology 2015. PubMed
  • Rescorla FJ, Ross JH, Billmire DF, Dicken BJ, Villaluna D, Davis MM, Krailo M, Cullen JW, Olson TA, Egler RA, Amatruda JF, Rodrigues-Galindo C, Frazier AL. Surveillance after initial surgery for Stage I pediatric and adolescent boys with malignant testicular germ cell tumors: Report from the Children's Oncology Group. J Pediatr Surg 2015. PubMed
  • Wasserman JD, Novokmet A, Eichler-Jonsson C, Ribeiro RC, Rodriguez-Galindo C, Zambetti GP, Malkin D. Prevalence and functional consequence of TP53 mutations in pediatric adrenocortical carcinoma: a children's oncology group study. J Clin Oncol 2015; 33:602-9. PubMed
  • Ribeiro KB, Degar B, Antoneli CB, Rollins B, Rodriguez-Galindo C. Ethnicity, race, and socioeconomic status influence incidence of langerhans cell histiocytosis. Pediatr Blood Cancer 2015. PubMed
  • Frazier AL, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray MJ, Amatruda JF, Thornton C, Arul GS, Billmire D, Shaikh F, Pashankar F, Stoneham S, Krailo M, Nicholson JC. Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United Kingdom and United States. J Clin Oncol 2015; 33:195-201. PubMed
  • Pinto EM, Chen X, Easton J, Finkelstein D, Liu Z, Pounds S, Rodriguez-Galindo C, Lund TC, Mardis ER, Wilson RK, Boggs K, Yergeau D, Cheng J, Mulder HL, Manne J, Jenkins J, Mastellaro MJ, Figueiredo BC, Dyer MA, Pappo A, Zhang J, Downing JR, Ribeiro RC, Zambetti GP. Genomic landscape of paediatric adrenocortical tumours. Nat Commun 2015; 6:6302. PubMed
  • Perry JA, Kiezun A, Tonzi P, Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E, Pedamallu CS, Helman E, Taylor-Weiner A, McKenna A, DeLuca DS, Lawrence MS, Ambrogio L, Sougnez C, Sivachenko A, Walensky LD, Wagle N, Mora J, de Torres C, Lavarino C, Dos Santos Aguiar S, Yunes JA, Brandalise SR, Mercado-Celis GE, Melendez-Zajgla J, Cárdenas-Cardós R, Velasco-Hidalgo L, Roberts CW, Garraway LA, Rodriguez-Galindo C, Gabriel SB, Lander ES, Golub TR, Orkin SH, Getz G, Janeway KA. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc Natl Acad Sci U S A 2014; 111:E5564-73. PubMed
  • Billmire DF, Rescorla FJ, Ross JH, Schlatter MG, Dicken BJ, Krailo MD, Rodriguez-Galindo C, Olson TA, Cullen JW, Frazier AL. Impact of central surgical review in a study of malignant germ cell tumors. J Pediatr Surg 2015. PubMed
  • Stoneham SJ, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray M, Amatruda JF, Thornton C, Arul GS, Billmire D, Krailo M, Stark D, Covens A, Hurteau J, Stenning S, Nicholson JC, Gershenson D, Frazier AL. Adolescents and Young Adults With a "Rare" Cancer: Getting Past Semantics to Optimal Care for Patients With Germ Cell Tumors. Oncologist 2014. PubMed
  • Green AL, Srivatsa A, Rodriguez-Galindo C. Delayed diagnosis and false relapse due to paternal testosterone use in adrenocortical carcinoma. Pediatrics 2014; 133:e1772-6. PubMed
  • Orbach DB, Vanderveen DK, Shah AS, Rodriguez-Galindo C. Blue Toe Syndrome: A Complication of Intra-arterial Technique, Not Intra-arterial Chemotherapy for Retinoblastoma. JAMA Ophthalmol 2014; 132:654. PubMed
  • Hettmer S, Archer NM, Somers GR, Novokmet A, Wagers AJ, Diller L, Rodriguez-Galindo C, Teot LA, Malkin D. Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers. Cancer 2014; 120:1068-75. PubMed
  • Vergamini LB, Frazier AL, Abrantes FL, Ribeiro KB, Rodriguez-Galindo C. Increase in the Incidence of Differentiated Thyroid Carcinoma in Children, Adolescents, and Young Adults: A Population-Based Study. J Pediatr 2014. PubMed
  • Sullivan EM, Wilson MW, Billups CA, Wu J, Merchant TE, Brennan RC, Haik BG, Shulkin B, Free TM, Given V, Rodriguez-Galindo C, Qaddoumi I. Pathologic Risk-based Adjuvant Chemotherapy for Unilateral Retinoblastoma Following Enucleation. J. Pediatr. Hematol. Oncol. 2014. PubMed
  • Billmire DF, Cullen JW, Rescorla FJ, Davis M, Schlatter MG, Olson TA, Malogolowkin MH, Pashankar F, Villaluna D, Krailo M, Egler RA, Rodriguez-Galindo C, Frazier AL. Surveillance after initial surgery for pediatric and adolescent girls with stage I ovarian germ cell tumors: report from the Children's Oncology Group. J Clin Oncol 2014; 32:465-70. PubMed
  • Hettmer S, Teot LA, Kozakewich H, Werger AM, Davies KJ, Fletcher CD, Grier HE, Rodriguez-Galindo C, Wagers AJ. Myogenic Tumors in Nevoid Basal Cell Carcinoma Syndrome. J. Pediatr. Hematol. Oncol. 2014. PubMed
  • Senerchia AA, Ribeiro KB, Rodriguez-Galindo C. Trends in incidence of primary cutaneous malignancies in children, adolescents, and young adults: a population-based study. Pediatr Blood Cancer 2013; 61:211-6. PubMed
  • Friedrich P, Ortiz R, Fuentes S, Gamboa Y, Ah Chu-Sanchez MS, Arambú IC, Montero M, Báez F, Rodríguez-Galindo C, Antillón-Klussmann F, . Barriers to effective treatment of pediatric solid tumors in middle-income countries: can we make sense of the spectrum of nonbiologic factors that influence outcomes? Cancer 2013; 120:112-25. PubMed
  • Sethi RV, Shih HA, Yeap BY, Mouw KW, Petersen R, Kim DY, Munzenrider JE, Grabowski E, Rodriguez-Galindo C, Yock TI, Tarbell NJ, Marcus KJ, Mukai S, MacDonald SM. Second nonocular tumors among survivors of retinoblastoma treated with contemporary photon and proton radiotherapy. Cancer 2013; 120:126-33. PubMed
  • Rodriguez-Galindo C. Langerhans cell histiocytosis: what's at the heart of the matter? Pediatr Blood Cancer 2013; 60:1732-3. PubMed
  • Raciborska A, Bilska K, Drabko K, Chaber R, Pogorzala M, Wyrobek E, Polczyńska K, Rogowska E, Rodriguez-Galindo C, Wozniak W. Vincristine, irinotecan, and temozolomide in patients with relapsed and refractory Ewing sarcoma. Pediatr Blood Cancer 2013; 60:1621-5. PubMed
  • Hettmer S, Teot LA, van Hummelen P, MacConaill L, Bronson RT, Dall'Osso C, Mao J, McMahon AP, Gruber PJ, Grier HE, Rodriguez-Galindo C, Fletcher CD, Wagers AJ. Mutations in Hedgehog pathway genes in fetal rhabdomyomas. J Pathol 2013; 231:44-52. PubMed
  • Abraham A, Alsultan A, Jeng M, Rodriguez-Galindo C, Campbell PK. Clofarabine salvage therapy for refractory high-risk langerhans cell histiocytosis. Pediatr Blood Cancer 2013; 60:E19-22. PubMed
  • Rodriguez-Galindo C, Krailo M, Frazier L, Chintagumpala M, Amatruda J, Katzenstein H, Malogolowkin M, Spector L, Pashankar F, Meyers R, Tomlinson G, . Children's Oncology Group's 2013 blueprint for research: Rare tumors. Pediatr Blood Cancer 2013; 60:1016-21. PubMed
  • Benoit MM, Vargas SO, Bhattacharyya N, McGill TA, Robson CD, Ferraro N, Didas AE, Labow BI, Upton J, Taghinia A, Meara JG, Marcus KJ, Mack J, Rodriguez-Galindo C, Rahbar R. The presentation and management of mandibular tumors in the pediatric population. Laryngoscope 2013. PubMed
  • Wong JR, Harris JK, Rodriguez-Galindo C, Johnson KJ. Incidence of Childhood and Adolescent Melanoma in the United States: 1973-2009. Pediatrics 2013. PubMed
  • Pinto EM, Morton C, Rodriguez-Galindo C, McGregor L, Davidoff AM, Mercer K, Debelenko LV, Billups C, Ribeiro RC, Zambetti GP. Establishment and characterization of the first pediatric adrenocortical carcinoma xenograft model identifies topotecan as a potential chemotherapeutic agent. Clin Cancer Res 2013; 19:1740-7. PubMed
  • Kirzhner M, Shildkrot Y, Haik BG, Qaddoumi I, Rodriguez-Galindo C, Wilson MW. Pediatric Anophthalmic Sockets and Orbital Implants: Outcomes with Polymer-Coated Implants. Ophthalmology 2013. PubMed
  • Rodriguez-Galindo C, Friedrich P, Morrissey L, Frazier L. Global challenges in pediatric oncology. Curr Opin Pediatr 2013; 25:3-15. PubMed
  • Abdolvahabi A, Taylor BW, Holden RL, Shaw EV, Kentsis A, Rodriguez-Galindo C, Mukai S, Shaw BF. Colorimetric and longitudinal analysis of leukocoria in recreational photographs of children with retinoblastoma. PLoS ONE 2013; 8:e76677. PubMed
  • Qaddoumi I, Billups CA, Tagen M, Stewart CF, Wu J, Helton K, McCarville MB, Merchant TE, Brennan R, Free TM, Given V, Haik BG, Rodriguez-Galindo C, Wilson MW. Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity. Cancer 2012; 118:5663-70. PubMed
  • Haupt R, Minkov M, Astigarraga I, Schäfer E, Nanduri V, Jubran R, Egeler RM, Janka G, Micic D, Rodriguez-Galindo C, Van Gool S, Visser J, Weitzman S, Donadieu J, . Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years. Pediatr Blood Cancer 2012. PubMed
  • Bauer DE, Mitchell CM, Strait KM, Lathan CS, Stelow EB, Lüer SC, Muhammed S, Evans AG, Sholl LM, Rosai J, Giraldi E, Oakley RP, Rodriguez-Galindo C, London WB, Sallan SE, Bradner JE, French CA. Clinicopathologic Features and Long-term Outcomes of NUT Midline Carcinoma. Clin Cancer Res 2012; 18:5773-5779. PubMed
  • Friedrich P, Ortiz R, Strait K, Fuentes S, Gamboa Y, Arambú I, Ah-Chu-Sanchez M, London W, Rodríguez-Galindo C, Antillón-Klussmann F, Báez F, . Pediatric sarcoma in Central America: Outcomes, challenges, and plans for improvement. Cancer 2012. PubMed
  • Pérez-Cuevas R, Doubova SV, Zapata-Tarres M, Flores-Hernández S, Frazier L, Rodríguez-Galindo C, Cortes-Gallo G, Chertorivski-Woldenberg S, Muñoz-Hernández O. Scaling up cancer care for children without medical insurance in developing countries: The case of Mexico. Pediatr Blood Cancer 2012. PubMed
  • Terry J, Calicchio ML, Rodriguez-Galindo C, Perez-Atayde AR. Immunohistochemical expression of CRX in extracranial malignant small round cell tumors. Am J Surg Pathol 2012; 36:1165-9. PubMed
  • Cheuk DK, Sabin ND, Hossain M, Wozniak A, Naik M, Rodriguez-Galindo C, Krasin MJ, Shulkin BL. PET/CT for staging and follow-up of pediatric nasopharyngeal carcinoma. Eur J Nucl Med Mol Imaging 2012; 39:1097-106. PubMed
  • Barb SM, Rodriguez-Galindo C, Wilson MW, Phillips NS, Zou P, Scoggins MA, Li Y, Qaddoumi I, Helton KJ, Bikhazi G, Haik BG, Ogg RJ. Functional Neuroimaging to Characterize Visual System Development in Children with Retinoblastoma. Invest Ophthalmol Vis Sci 2011. PubMed
  • Cheuk DK, Billups CA, Martin MG, Roland CR, Ribeiro RC, Krasin MJ, Rodriguez-Galindo C. Prognostic factors and long-term outcomes of childhood nasopharyngeal carcinoma. Cancer 2010; 117:197-206. PubMed
  • Pappo AS, Krailo M, Chen Z, Rodriguez-Galindo C, Reaman G. Infrequent Tumor Initiative of the Children's Oncology Group: Initial Lessons Learned and Their Impact on Future Plans. J Clin Oncol 2010; 28:5011-6. PubMed
  • Sultan I, Rodriguez-Galindo C, Al-Sharabati S, Guzzo M, Casanova M, Ferrari A. Salivary gland carcinomas in children and adolescents: A population-based study, with comparison to adult cases. Head Neck 2010. PubMed
  • Sáinz-Jaspeado M, Lagares-Tena L, Lasheras J, Navid F, Rodriguez-Galindo C, Mateo-Lozano S, Notario V, Sanjuan X, Garcia Del Muro X, Fabra A, Tirado OM. Caveolin-1 modulates the ability of Ewing's sarcoma to metastasize. Mol Cancer Res 2010; 8:1489-500. PubMed
  • Bhagat SP, Bass JK, White ST, Qaddoumi I, Wilson MW, Wu J, Rodriguez-Galindo C. Monitoring carboplatin ototoxicity with distortion-product otoacoustic emissions in children with retinoblastoma. Int. J. Pediatr. Otorhinolaryngol. 2010; 74:1156-63. PubMed
  • Wright KD, Qaddoumi I, Patay Z, Gajjar A, Wilson MW, Rodriguez-Galindo C. Successful treatment of early detected trilateral retinoblastoma using standard infant brain tumor therapy. Pediatr Blood Cancer 2010; 55:570-2. PubMed
  • Sultan I, Casanova M, Al-Jumaily U, Meazza C, Rodriguez-Galindo C, Ferrari A. Soft tissue sarcomas in the first year of life. Eur J Cancer 2010; 46:2449-56. PubMed
  • Wilson MW, Qaddoumi I, Billups C, Haik BG, Rodriguez-Galindo C. A clinicopathological correlation of 67 eyes primarily enucleated for advanced intraocular retinoblastoma. 2010. PubMed
  • Sultan I, Wilson MW, Nawaiseh I, Mehyar M, Kharma S, Al-Qudimat M, Hazin R, Alalami A, Jaradat I, Al-Husseini M, Abdeen G, Rodriguez-Galindo C, Qaddoumi I. Enucleation for retinoblastoma: the experience of a single center in Jordan. Int Ophthalmol 2010; 30:407-14. PubMed
  • Bunin GR, Felice MA, Davidson W, Friedman DL, Shields CL, Maidment A, O'Shea M, Nichols KE, Leahey A, Dunkel IJ, Jubran R, Rodriguez-Galindo C, Schmidt ML, Weinstein JL, Goldman S, Abramson DH, Wilson MW, Gallie BL, Chan HS, Shapiro M, Cnaan A, Ganguly A, Meadows AT. Medical radiation exposure and risk of retinoblastoma resulting from new germline RB1 mutation. Int J Cancer 2010. PubMed
  • Allen S, Wilson MW, Watkins A, Billups C, Qaddoumi I, Haik BH, Rodriguez-Galindo C. Comparison of two methods for carboplatin dosing in children with retinoblastoma. Pediatr Blood Cancer 2010; 55:47-54. PubMed
  • Sultan I, Casanova M, Ferrari A, Rihani R, Rodriguez-Galindo C. Differential features of nasopharyngeal carcinoma in children and adults: A SEER study. Pediatr Blood Cancer 2010; 55:279-284. PubMed
  • Dunkel IJ, Jubran RF, Gururangan S, Chantada GL, Finlay JL, Goldman S, Khakoo Y, O'Brien JM, Orjuela M, Rodriguez-Galindo C, Souweidane MM, Abramson DH. Trilateral retinoblastoma: potentially curable with intensive chemotherapy. Pediatr Blood Cancer 2010; 54:384-7. PubMed
  • Krasin MJ, Davidoff AM, Xiong X, Wu S, Hua CH, Navid F, Rodriguez-Galindo C, Rao BN, Hoth KA, Neel MD, Merchant TE, Kun LE, Spunt SL. Preliminary Results from a Prospective Study Using Limited Margin Radiotherapy in Pediatric and Young Adult Patients with High-Grade Nonrhabdomyosarcoma Soft-Tissue Sarcoma. Int J Radiat Oncol Biol Phys 2010; 76:874-8. PubMed
  • Aquilina K, Merchant TE, Rodriguez-Galindo C, Ellison DW, Sanford RA, Boop FA. Malignant transformation of irradiated craniopharyngioma in children: report of 2 cases. J Neurosurg Pediatrics 2010; 5:155-61. PubMed
  • Sultan I, Rodriguez-Galindo C, El-Taani H, Pastore G, Casanova M, Gallino G, Ferrari A. Distinct features of colorectal cancer in children and adolescents : a population-based study of 159 cases. Cancer 2010; 116:758-65. PubMed
  • Sultan I, Rihani R, Hazin R, Rodriguez-Galindo C. Second malignancies in patients with Ewing Sarcoma Family of Tumors: A population-based study. Acta Oncol 2010; 49:237-44. PubMed
  • Sultan I, Qaddoumi I, Rodríguez-Galindo C, Nassan AA, Ghandour K, Al-Hussaini M. Age, stage, and radiotherapy, but not primary tumor site, affects the outcome of patients with malignant rhabdoid tumors. Pediatr Blood Cancer 2009; 54:35-40. PubMed
  • Karplus G, Krasin MJ, Rodriguez-Galindo C, McCarville B, Jenkins J, Rao B, Spyridis G, Spunt SL. Retrospective study of the surgical management and outcome of nonrhabdomyosarcoma soft tissue sarcomas of the groin and axilla in children. J Pediatr Surg 2009; 44:1972-6. PubMed
  • Furman WL, Navid F, Daw NC, McCarville MB, McGregor LM, Spunt SL, Rodriguez-Galindo C, Panetta JC, Crews KR, Wu J, Gajjar AJ, Houghton PJ, Santana VM, Stewart CF. Tyrosine kinase inhibitor enhances the bioavailability of oral irinotecan in pediatric patients with refractory solid tumors. J Clin Oncol 2009; 27:4599-604. PubMed
  • Dardas M, Abboud M, Salti I, Sabri A, Shoucair M, Saleh M, Azar S, Rodriguez-Galindo C, Muwakkit S. Thyroid cancer in Lebanese children and adolescents: a 15-year experience at a single institution. Pediatr Hematol Oncol 2009; 26:439-47. PubMed
  • Lebensburger J, Katzenstein H, Jenkins JJ, Rodriguez-Galindo C. Bronchioloalveolar carcinoma as a second malignancy in osteosarcoma survivors. Pediatr Blood Cancer 2009; 53:499-501. PubMed
  • Wilson MW, Rodriguez-Galindo C, Billups C, Haik BG, Laningham F, Patay Z. Lack of correlation between the histologic and magnetic resonance imaging results of optic nerve involvement in eyes primarily enucleated for retinoblastoma. Ophthalmology 2009; 116:1558-63. PubMed
  • Sultan I, Rodriguez-Galindo C, Saab R, Yasir S, Casanova M, Ferrari A. Comparing children and adults with synovial sarcoma in the Surveillance, Epidemiology, and End Results program, 1983 to 2005: an analysis of 1268 patients. Cancer 2009; 115:3537-47. PubMed
  • Sastre X, Chantada GL, Doz F, Wilson MW, de Davila MT, Rodríguez-Galindo C, Chintagumpala M, Chévez-Barrios P, . Proceedings of the consensus meetings from the International Retinoblastoma Staging Working Group on the pathology guidelines for the examination of enucleated eyes and evaluation of prognostic risk factors in retinoblastoma. Arch Pathol Lab Med 2009; 133:1199-202. PubMed
  • Sultan I, Qaddoumi I, Yaser S, Rodriguez-Galindo C, Ferrari A. Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemiology and end results program, 1973 to 2005: an analysis of 2,600 patients. J Clin Oncol 2009; 27:3391-7. PubMed
  • Wilimas JA, Wilson MW, Haik BG, Barnoya M, Fu L, Castellanos M, Bonilla M, Phillips B, Helveston EM, Luna-Fineman S, Ribeiro R, Rodriguez-Galindo C. Development of retinoblastoma programs in Central America. Pediatr Blood Cancer 2009; 53:42-6. PubMed
  • Sultan I, Ghandour K, Al-Jumaily U, Hashem S, Rodriguez-Galindo C. Local control of the primary tumour in metastatic neuroblastoma. Eur J Cancer 2009; 45:1728-32. PubMed
  • Sultan I, Masarweh M, Ismael T, Al-Hussaini M, Almousa A, Ali HM, Rodriguez-Galindo C, Ghandour K. From upfront nephrectomy to preoperative chemotherapy and back: a single institution experience in the treatment of Wilms tumor. J Pediatr Hematol Oncol 2009; 31:333-8. PubMed
  • Wilson MW, Fraga CH, Rodriguez-Galindo C, Hagedorn N, Leggas ML, Stewart C. Expression of the multi-drug resistance proteins and the pregnane X receptor in treated and untreated retinoblastoma. Curr. Eye Res. 2009; 34:386-94. PubMed
  • Hoffer FA, Daw NC, Xiong X, Anghelescu D, Krasin M, Yan X, Davidoff AM, Furman WL, Rodriguez-Galindo C, Spunt SL. A phase 1/pilot study of radiofrequency ablation for the treatment of recurrent pediatric solid tumors. Cancer 2009; 115:1328-37. PubMed
  • Balaguer J, Wilson MW, Billups CA, Mancini J, Haik BG, Qaddoumi I, Khoury JD, Rodriguez-Galindo C. Predictive factors of invasion in eyes with retinoblastoma enucleated after eye salvage treatments. Pediatr Blood Cancer 2009; 52:351-6. PubMed
  • Saab R, Rodriguez-Galindo C, Matmati K, Rehg JE, Baumer SH, Khoury JD, Billups C, Neale G, Helton KJ, Skapek SX. p18Ink4c and p53 Act as tumor suppressors in cyclin D1-driven primitive neuroectodermal tumor. Cancer Res 2009; 69:440-8. PubMed
  • Antillon F, Castellanos M, Valverde P, Luna-Fineman S, Garrido C, Serrato T, Rodriguez-Galindo C, Casanova M, Ferrari A. Treating Pediatric soft tissue sarcomas in a country with limited resources: the experience of the Unidad Nacional de Oncologia Pediatrica in Guatemala. Pediatr Blood Cancer 2008; 51:760-4. PubMed
  • Rodriguez-Galindo C, Jeng M, Khuu P, McCarville MB, Jeha S. Clofarabine in refractory Langerhans cell histiocytosis. Pediatr Blood Cancer 2008; 51:703-6. PubMed
  • Rodriguez-Galindo C, Wilson MW, Chantada G, Fu L, Qaddoumi I, Antoneli C, Leal-Leal C, Sharma T, Barnoya M, Epelman S, Pizzarello L, Kane JR, Barfield R, Merchant TE, Robison LL, Murphree AL, Chevez-Barrios P, Dyer MA, O'Brien J, Ribeiro RC, Hungerford J, Helveston EM, Haik BG, Wilimas J. Retinoblastoma: one world, one vision. Pediatrics 2008; 122:e763-70. PubMed
  • Qaddoumi I, Nawaiseh I, Mehyar M, Razzouk B, Haik BG, Kharma S, Jaradat I, Rodriguez-Galindo C, Wilson MW. Team management, twinning, and telemedicine in retinoblastoma: a 3-tier approach implemented in the first eye salvage program in Jordan. Pediatr Blood Cancer 2008; 51:241-4. PubMed
  • Rivera GK, Quintana J, Villarroel M, Santana VM, Rodriguez-Galindo C, Neel MD, Velez G, Ribeiro RC, Daw NC. Transfer of complex frontline anticancer therapy to a developing country: the St. Jude osteosarcoma experience in Chile. Pediatr Blood Cancer 2008; 50:1143-6. PubMed
  • Navid F, Billups C, Liu T, Krasin MJ, Rodriguez-Galindo C. Second cancers in patients with the Ewing sarcoma family of tumours. Eur J Cancer 2008; 44:983-91. PubMed
  • Chantada GL, Doz F, Orjuela M, Qaddoumi I, Sitorus RS, Kepak T, Furmanchuk A, Castellanos M, Sharma T, Chevez-Barrios P, Rodriguez-Galindo C, . World disparities in risk definition and management of retinoblastoma: a report from the International Retinoblastoma Staging Working Group. Pediatr Blood Cancer 2008; 50:692-4. PubMed
  • Wagner LM, Crews KR, Stewart CF, Rodriguez-Galindo C, McNall-Knapp RY, Albritton K, Pappo AS, Furman WL. Reducing irinotecan-associated diarrhea in children. Pediatr Blood Cancer 2007; 50:201-7. PubMed
  • Wilson MW, Haik BG, Billups CA, Rodriguez-Galindo C. Incidence of new tumor formation in patients with hereditary retinoblastoma treated with primary systemic chemotherapy: is there a preventive effect? Ophthalmology 2007; 114:2077-82. PubMed
  • Leander C, Fu LC, Peña A, Howard SC, Rodriguez-Galindo C, Wilimas JA, Ribeiro RC, Haik B. Impact of an education program on late diagnosis of retinoblastoma in Honduras. Pediatr Blood Cancer 2007; 49:817-9. PubMed
  • Rodríguez-Galindo C, Liu T, Krasin MJ, Wu J, Billups CA, Daw NC, Spunt SL, Rao BN, Santana VM, Navid F. Analysis of prognostic factors in ewing sarcoma family of tumors: review of St. Jude Children's Research Hospital studies. Cancer 2007; 110:375-84. PubMed
  • Rodriguez-Galindo C, Chantada GL, Haik BG, Wilson MW. Treatment of Retinoblastoma: Current Status and Future Perspectives. Curr Treat Options Neurol 2007; 9:294-307. PubMed
  • Stewart CF, Panetta JC, O'Shaughnessy MA, Throm SL, Fraga CH, Owens T, Liu T, Billups C, Rodriguez-Galindo C, Gajjar A, Furman WL, McGregor LM. UGT1A1 promoter genotype correlates with SN-38 pharmacokinetics, but not severe toxicity in patients receiving low-dose irinotecan. J Clin Oncol 2007; 25:2594-600. PubMed
  • Hinds PS, Hockenberry M, Rai SN, Zhang L, Razzouk BI, Cremer L, McCarthy K, Rodriguez-Galindo C. Clinical field testing of an enhanced-activity intervention in hospitalized children with cancer. J Pain Symptom Manage 2007; 33:686-97. PubMed
  • Ribeiro RC, Rodriguez-Galindo C, Figueiredo BC, Mastellaro MJ, West AN, Kriwacki R, Zambetti GP. Germline TP53 R337H mutation is not sufficient to establish Li-Fraumeni or Li-Fraumeni-like syndrome. Cancer Lett 2007; 247:353-5; author reply 356-8. PubMed
  • Johnson DA, Zhang J, Frase S, Wilson M, Rodriguez-Galindo C, Dyer MA. Neuronal differentiation and synaptogenesis in retinoblastoma. Cancer Res 2007; 67:2701-11. PubMed
  • Hinds PS, Hockenberry M, Rai SN, Zhang L, Razzouk BI, McCarthy K, Cremer L, Rodriguez-Galindo C. Nocturnal awakenings, sleep environment interruptions, and fatigue in hospitalized children with cancer. Oncol Nurs Forum 2007; 34:393-402. PubMed
  • West AN, Neale GA, Pounds S, Figueredo BC, Rodriguez Galindo C, Pianovski MA, Oliveira Filho AG, Malkin D, Lalli E, Ribeiro R, Zambetti GP. Gene expression profiling of childhood adrenocortical tumors. Cancer Res 2007; 67:600-8. PubMed
  • Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA. Inactivation of the p53 pathway in retinoblastoma. Nature 2006; 444:61-6. PubMed
  • Chantada G, Doz F, Antoneli CB, Grundy R, Clare Stannard FF, Dunkel IJ, Grabowski E, Leal-Leal C, Rodríguez-Galindo C, Schvartzman E, Popovic MB, Kremens B, Meadows AT, Zucker JM. A proposal for an international retinoblastoma staging system. Pediatr Blood Cancer 2006; 47:801-5. PubMed
  • Wilson MW, Haik BG, Rodriguez-Galindo C. Socioeconomic impact of modern multidisciplinary management of retinoblastoma. Pediatrics 2006; 118:e331-6. PubMed
  • Spunt SL, Rodriguez-Galindo C, Fuller CE, Harper J, Krasin MJ, Billups CA, Khoury JD. Ewing sarcoma-family tumors that arise after treatment of primary childhood cancer. Cancer 2006; 107:201-6. PubMed
  • West AN, Ribeiro RC, Jenkins J, Rodriguez-Galindo C, Figueiredo BC, Kriwacki R, Zambetti GP. Identification of a novel germ line variant hotspot mutant p53-R175L in pediatric adrenal cortical carcinoma. Cancer Res 2006; 66:5056-62. PubMed
  • Wilson MW, Fraga CH, Fuller CE, Rodriguez-Galindo C, Mancini J, Hagedorn N, Leggas ML, Stewart CF. Immunohistochemical detection of multidrug-resistant protein expression in retinoblastoma treated by primary enucleation. Invest Ophthalmol Vis Sci 2006; 47:1269-73. PubMed
  • Furman WL, Crews KR, Billups C, Wu J, Gajjar AJ, Daw NC, Patrick CC, Rodriguez-Galindo C, Stewart CF, Dome JS, Panetta JC, Houghton PJ, Santana VM. Cefixime allows greater dose escalation of oral irinotecan: a phase I study in pediatric patients with refractory solid tumors. J Clin Oncol 2006; 24:563-70. PubMed
  • Daw NC, Billups CA, Rodriguez-Galindo C, McCarville MB, Rao BN, Cain AM, Jenkins JJ, Neel MD, Meyer WH. Metastatic osteosarcoma. Cancer 2006; 106:403-12. PubMed
  • Rodriguez-Galindo C, Crews KR, Stewart CF, Furman W, Panetta JC, Daw NC, Cain A, Tan M, Houghton PH, Santana VM. Phase I study of the combination of topotecan and irinotecan in children with refractory solid tumors. Cancer Chemother Pharmacol 2005; 57:15-24. PubMed
  • Dyer MA, Rodriguez-Galindo C, Wilson MW. Use of preclinical models to improve treatment of retinoblastoma. PLoS Med. 2005; 2:e332. PubMed
  • Wilson MW, Haik BG, Liu T, Merchant TE, Rodriguez-Galindo C. Effect on ocular survival of adding early intensive focal treatments to a two-drug chemotherapy regimen in patients with retinoblastoma. Am J Ophthalmol 2005; 140:397-406. PubMed
  • Rodriguez-Galindo C, Figueiredo BC, Zambetti GP, Ribeiro RC. Biology, clinical characteristics, and management of adrenocortical tumors in children. Pediatr Blood Cancer 2005; 45:265-73. PubMed
  • Krasin MJ, Davidoff AM, Rodriguez-Galindo C, Billups CA, Fuller CE, Neel MD, Merchant TE. Definitive surgery and multiagent systemic therapy for patients with localized Ewing sarcoma family of tumors: local outcome and prognostic factors. Cancer 2005; 104:367-73. PubMed
  • Saab R, Rao BN, Rodriguez-Galindo C, Billups CA, Fortenberry TN, Daw NC. Osteosarcoma of the pelvis in children and young adults: the St. Jude Children's Research Hospital experience. Cancer 2005; 103:1468-74. PubMed
  • Rodriguez-Galindo C, Wofford M, Castleberry RP, Swanson GP, London WB, Fontanesi J, Pappo AS, Douglass EC. Preradiation chemotherapy with methotrexate, cisplatin, 5-fluorouracil, and leucovorin for pediatric nasopharyngeal carcinoma. Cancer 2005; 103:850-7. PubMed
  • Crews KR, Stewart CF, Liu T, Rodriguez-Galindo C, Santana VM, Daw NC. Effect of fractionated ifosfamide on the pharmacokinetics of irinotecan in pediatric patients with osteosarcoma. J Pediatr Hematol Oncol 2004; 26:764-7. PubMed
  • Krasin MJ, Rodriguez-Galindo C, Billups CA, Davidoff AM, Neel MD, Merchant TE, Kun LE. Definitive irradiation in multidisciplinary management of localized Ewing sarcoma family of tumors in pediatric patients: outcome and prognostic factors. Int J Radiat Oncol Biol Phys 2004; 60:830-8. PubMed
  • Schmidt JE, Morgan JI, Rodriguez-Galindo C, Webb DL, Liang H, Tamburro RF. Heme oxygenase-1 messenger RNA expression is induced in peripheral blood mononuclear cells of pediatric cancer patients with systemic inflammatory response syndrome. Pediatr Crit Care Med 2004; 5:554-60. PubMed
  • Krasin MJ, Rodriguez-Galindo C, Davidoff AM, Billups CA, Fuller CE, Neel MD, Kun LE, Merchant TE. Efficacy of combined surgery and irradiation for localized Ewings sarcoma family of tumors. Pediatr Blood Cancer 2004; 43:229-36. PubMed
  • Merchant TE, Gould CJ, Wilson MW, Hilton NE, Rodriguez-Galindo C, Haik BG. Episcleral plaque brachytherapy for retinoblastoma. Pediatr Blood Cancer 2004; 43:134-9. PubMed
  • Rodriguez-Galindo C. Pharmacological management of Ewing sarcoma family of tumours. Expert Opin Pharmacother 2004; 5:1257-70. PubMed
  • Rodriguez-Galindo C, Shah N, McCarville MB, Billups CA, Neel MN, Rao BN, Daw NC. Outcome after local recurrence of osteosarcoma: the St. Jude Children's Research Hospital experience (1970-2000). Cancer 2004; 100:1928-35. PubMed
  • Crews KR, Liu T, Rodriguez-Galindo C, Tan M, Meyer WH, Panetta JC, Link MP, Daw NC. High-dose methotrexate pharmacokinetics and outcome of children and young adults with osteosarcoma. Cancer 2004; 100:1724-33. PubMed
  • Hankins J, Naidu P, Rieman M, Wang W, Kaushansky K, Rodriguez-Galindo C. Thrombocytosis in an infant with high thrombopoietin concentrations. J Pediatr Hematol Oncol 2004; 26:142-5. PubMed
  • Rodriguez-Galindo C, Helton KJ, Sánchez ND, Rieman M, Jeng M, Wang W. Extranodal Rosai-Dorfman disease in children. J Pediatr Hematol Oncol 2004; 26:19-24. PubMed
  • Rao BN, Rodriguez-Galindo C. Local control in childhood extremity sarcomas: salvaging limbs and sparing function. Med Pediatr Oncol 2003; 41:584-7. PubMed
  • Rodriguez-Galindo C, Wilson MW, Haik BG, Lipson MJ, Cain A, Merchant TE, Kaste S, Pratt CB. Treatment of metastatic retinoblastoma. Ophthalmology 2003; 110:1237-40. PubMed
  • Rao BN, Rodriguez-Galindo C. Intra-arterial cisplatin in osteosarcoma: same question, different answer. Ann Surg Oncol 2003; 10:481-3. PubMed
  • Rodriguez-Galindo C, Wilson MW, Haik BG, Merchant TE, Billups CA, Shah N, Cain A, Langston J, Lipson M, Kun LE, Pratt CB. Treatment of intraocular retinoblastoma with vincristine and carboplatin. J Clin Oncol 2003; 21:2019-25. PubMed
  • Rodriguez-Galindo C, Spunt SL, Pappo AS. Treatment of Ewing sarcoma family of tumors: current status and outlook for the future. Med Pediatr Oncol 2003; 40:276-87. PubMed
  • Merchant TE, Gould CJ, Hilton NE, Kun LE, Rodríguez-Galindo C, Pratt CB, Wilson MW, Haik B. Ocular preservation after 36 Gy external beam radiation therapy for retinoblastoma. J Pediatr Hematol Oncol 2002; 24:246-9. PubMed
  • Rodríguez-Galindo C, Daw NC, Kaste SC, Meyer WH, Dome JS, Pappo AS, Rao BN, Pratt CB. Treatment of refractory osteosarcoma with fractionated cyclophosphamide and etoposide. J Pediatr Hematol Oncol 2002; 24:250-5. PubMed
  • Rodriguez-Galindo C, Kelly P, Jeng M, Presbury GG, Rieman M, Wang W. Treatment of children with Langerhans cell histiocytosis with 2-chlorodeoxyadenosine. Am J Hematol 2002; 69:179-84. PubMed
  • Rodriguez-Galindo C, Billups CA, Kun LE, Rao BN, Pratt CB, Merchant TE, Santana VM, Pappo AS. Survival after recurrence of Ewing tumors: the St Jude Children's Research Hospital experience, 1979-1999. Cancer 2002; 94:561-9. PubMed
  • Vosoghi H, Rodriguez-Galindo C, Wilson MW. Orbital involvement in langerhans cell histiocytosis. Ophthal Plast Reconstr Surg 2009; 25:430-3. PubMed
  • Rodriguez-Galindo C. Ewing sarcoma and its many faces: are we close to a cure? Med Wieku Rozwoj 2013; 17:113-6. PubMed
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