My research focuses on understanding the origin and progression of human cancers. This goal is driven from molecular target discovery and target validation approaches. I am currently investigating 1.) how immune cells respond to tumor-derived factors through carbohydrate-dependent mechanisms and 2.) how cell surface carbohydrates on tumor cells can be used to predict tumorigenicity and metastatic progression. We conduct structural and biochemical characterization of the critical carbohydrate determinants on immune/host cells or tumor cells. Results from these studies provide new insights on how tumors become malignant, grow and form distant metastases and how tumors evade host immune responses.