Photo of Charles P. Lin,  PhD

Charles P. Lin, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-3957


charles_lin@hms.harvard.edu

Charles P. Lin, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Dermatology, Harvard Medical School
  • Associate Biophysicist, Dermatology, Massachusetts General Hospital

Research Abstract

Dr. Lin leads an Advanced Microscopy Group in the MGH Center for Systems Biology and Wellman Center for Photomedicine, where cutting-edge optical imaging techniques are being developed for in vivo cell tracking and molecular imaging studies. The research group is composed of a multidisciplinary team of optical engineers, physicists, biologist and chemist all working together to advance our understanding of the in vivo behavior of immune cells, cancer cells, and stem cells in disease models and in transplantation settings. There are several custom-built confocal and two photon hybrid microscopes in Dr. Lin's laboratory, each one tailored for a specific live animal imaging applications. A new system is currently being developed for image-guided laser microsurgery. Dr. Lin has also developed an in vivo flow cytometer for real-time detection and quantification of fluorescent cells in the circulation without the need to draw blood samples.

Publications

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  • Levy O, Mortensen LJ, Boquet G, Tong Z, Perrault C, Benhamou B, Zhang J, Stratton T, Han E, Safaee H, Musabeyezu J, Yang Z, Multon MC, Rothblatt J, Deleuze JF, Lin CP, Karp JM. A small-molecule screen for enhanced homing of systemically infused cells. Cell Rep 2015; 10:1261-8. PubMed
  • Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, Runnels JM, Zaher W, Mortensen LJ, Alt C, Turcotte R, Yusuf R, Côté D, Vinogradov SA, Scadden DT, Lin CP. Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature 2014; 508:269-73. PubMed
  • Ramsey H, Zhang Q, Brown DE, Steensma DP, Lin CP, Wu MX. Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3). Haematologica 2014; 99:282-91. PubMed
  • Park D, Spencer JA, Lin CP, Scadden DT. Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair. 2014. PubMed
  • Silberstein LE, Lin CP. A new image of the hematopoietic stem cell vascular niche. Cell Stem Cell 2013; 13:514-6. PubMed
  • Levy O, Zhao W, Mortensen LJ, Leblanc S, Tsang K, Fu M, Phillips JA, Sagar V, Anandakumaran P, Ngai J, Cui CH, Eimon P, Angel M, Lin CP, Yanik MF, Karp JM. mRNA-engineered mesenchymal stem cells for targeted delivery of interleukin-10 to sites of inflammation. Blood 2013; 122:e23-32. PubMed
  • Carlson AL, Fujisaki J, Wu J, Runnels JM, Turcotte R, Celso CL, Scadden DT, Strom TB, Lin CP. Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label. PLoS ONE 2013; 8:e69257. PubMed
  • Mortensen LJ, Levy O, Phillips JP, Stratton T, Triana B, Ruiz JP, Gu F, Karp JM, Lin CP. Quantification of Mesenchymal Stem Cell (MSC) delivery to a target site using in vivo confocal microscopy. PLoS ONE 2013; 8:e78145. PubMed
  • Phillips JA, Mortensen LJ, Ruiz JP, Sridharan R, Kumar S, Torres M, Sharma P, Lin CP, Karp JM, Hauschka PV. Advances in Single-cell Tracking of Mesenchymal Stem Cells (MSCs) During Musculoskeletal Regeneration. Orthop J Harv Med Sch 2013; 14:22-28. PubMed
  • Zettergren E, Swamy T, Runnels J, Lin CP, Niedre M. Tomographic sensing and localization of fluorescently labeled circulating cells in mice in vivo. Phys Med Biol 2012; 57:4627-41. PubMed
  • Fujisaki J, Wu J, Carlson AL, Silberstein L, Putheti P, Larocca R, Gao W, Saito TI, Lo Celso C, Tsuyuzaki H, Sato T, Côté D, Sykes M, Strom TB, Scadden DT, Lin CP. In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature 2011; 474:216-9. PubMed