Photo of Christian Rask-Madsen,  MD, PhD

Christian Rask-Madsen, MD, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 519-3769

Christian Rask-Madsen, MD, PhD

Harvard Medical School


  • Assistant Professor, Medicine, Harvard Medical School
  • Assistant Investigator, Vascular Biology and Complications, Joslin Diabetes Center


Research Abstract

My main research interest is to describe how insulin resistance in vascular

endothelial cells contributes to endothelial dysfunction and, in turn, complications to

metabolic diseases like obesity and type 2 diabetes. We have previously found that

endothelial cell insulin resistance contributes to atherosclerosis by promoting an

activated, proadhesive endothelium with upregulation of vascular cell adhesion

molecule-1 and increased adhesion of leukocytes to endothelial cells. Our current

foucs is how this type of endothelial dysfunction may promote colorectal cancer by

producing a chronic, low-grade inflammation in intestinal mucosa. We study these

mechansims in cell culture models and genetically modified mice subjected to diet-

induced obesity.


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  • Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol 2013; 33:3227-41. PubMed
  • Rask-Madsen C, Li Q, Freund B, Feather D, Abramov R, Wu IH, Chen K, Yamamoto-Hiraoka J, Goldenbogen J, Sotiropoulos KB, Clermont A, Geraldes P, Dall'Osso C, Wagers AJ, Huang PL, Rekhter M, Scalia R, Kahn CR, King GL. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab 2010; 11:379-89. PubMed