Photo of Christian Rask-Madsen,  MD, PhD

Christian Rask-Madsen, MD, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 519-3769


christian.rask-madsen@joslin.harvard.edu

Christian Rask-Madsen, MD, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • Assistant Professor, Medicine, Harvard Medical School
  • Assistant Investigator, Vascular Biology and Complications, Joslin Diabetes Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

My main research interest is to describe how insulin resistance in vascular endothelial cells contributes to endothelial dysfunction and, in turn, complications to metabolic diseases like obesity and type 2 diabetes. We have previously found that endothelial cell insulin resistance contributes to atherosclerosis by promoting an activated, proadhesive endothelium with upregulation of vascular cell adhesion molecule-1 and increased adhesion of leukocytes to endothelial cells. Our current focus is how this type of endothelial dysfunction may promote colorectal cancer by producing a chronic, low-grade inflammation in intestinal mucosa. We study these mechanisms in cell culture models and genetically modified mice subjected to diet-induced obesity.

Publications

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  • Wang X, Häring MF, Rathjen T, Lockhart SM, Sørensen D, Ussar S, Rasmussen LM, Bertagnolli MM, Kahn CR, Rask-Madsen C. Insulin resistance in vascular endothelial cells promotes intestinal tumour formation. Oncogene 2017. PubMed
  • Wang X, Lockhart SM, Rathjen T, Albadawi H, Sørensen D, O'Neill BT, Dwivedi N, Preil SR, Beck HC, Dunwoodie SL, Watkins MT, Rasmussen LM, Rask-Madsen C. Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells. Diabetes 2016. PubMed