Photo of Clare M. Tempany-Afdhal,  MB, BCh

Clare M. Tempany-Afdhal, MB, BCh

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-7858
Fax: (617) 732-6033


ctempany@bwh.harvard.edu

Clare M. Tempany-Afdhal, MB, BCh

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Radiology, Harvard Medical School
  • Ferenc Jolesz Chair of Research, Radiology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My major areas of research interest are MR imaging of the pelvis (specifically Prostate cancer) and image-guided therapy. As co-PI of the NCIGT I along with Ferenc Jolesz lead this team and direct the AMIGO facility. My lab is dedicated to prostate cancer imaging as it relates to diagnosis, staging, treatment monitoring and Image-guided Therapy (IGT). We have program in MR guided prostate biopsies for diagnosis and treatment monitoring. I lead several prospective trials involving clinical prostate multi-parametric prostate MR at 3.0T with an endorectal coil. Our lab works in all aspects from acquisition and optimization of multi-parametric 3T imaging, image processing, registration, and segmentation, navigation and image display. We are also working on many engineering challenges associated with guidance and access to the prostate. We have a program in enabling technologies, including robotics for MR guided interventions and MR guided Focused Ultrasound surgery(FUS). The latter is a major interest of our program at NCIGT and specifically in prostate cancer. We established MR guided in bore prostate biopsies for cancer diagnosis in 1997, sicne then have migrated this program to our wide-bore 3T MR and perform MR targeted and guided prostate biopsies in large cohorts of patients. Our research also involves MR image-guided focal therapyfor localized prostate cancer- MR guided cryotherapy or MR guided FUS, radiation delivery-namely EBRT and brachytherapy. We are involved in multi-disciplinary trials with colleagues in Oncology, Urology and Radiation Oncology and also national multi-center groups such as ACRIN.

Publications

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  • Fedorov A, Khallaghi S, S├ínchez CA, Lasso A, Fels S, Tuncali K, Sugar EN, Kapur T, Zhang C, Wells W, Nguyen PL, Abolmaesumi P, Tempany C. Open-source image registration for MRI-TRUS fusion-guided prostate interventions. 2015. PubMed
  • Yamauchi FI, Penzkofer T, Fedorov A, Fennessy FM, Chu R, Maier SE, Tempany CM, Mulkern RV, Panych LP. Prostate cancer discrimination in the peripheral zone with a reduced field-of-view T2-mapping MRI sequence. Magn Reson Imaging 2015. PubMed
  • Fedorov A, Penzkofer T, Hirsch MS, Flood TA, Vangel MG, Masry P, Tempany CM, Mulkern RV, Fennessy FM. The Role of Pathology Correlation Approach in Prostate Cancer Index Lesion Detection and Quantitative Analysis with Multiparametric MRI. Acad Radiol 2015. PubMed
  • Fennessy FM, Fedorov A, Penzkofer T, Kim KW, Hirsch MS, Vangel MG, Masry P, Flood TA, Chang MC, Tempany CM, Mulkern RV, Gupta SN. Quantitative pharmacokinetic analysis of prostate cancer DCE-MRI at 3T: Comparison of two arterial input functions on cancer detection with digitized whole mount histopathological validation. Magn Reson Imaging 2015. PubMed
  • Fedorov A, Wells W, Kikinis R, Tempany C, Vangel M. Application of Tolerance Limits to the Characterization of Image Registration Performance. IEEE Trans Med Imaging 2014. PubMed
  • Penzkofer T, Tempany-Afdhal CM. Prostate cancer detection and diagnosis: the role of MR and its comparison with other diagnostic modalities--a radiologist's perspective. NMR Biomed 2013; 27:3-15. PubMed
  • Fennessy FM, Fedorov A, Gupta SN, Schmidt EJ, Tempany CM, Mulkern RV. Practical considerations in T1 mapping of prostate for dynamic contrast enhancement pharmacokinetic analyses. Magn Reson Imaging 2012; 30:1224-33. PubMed
  • Tokuda J, Song SE, Fischer GS, Iordachita II, Seifabadi R, Cho NB, Tuncali K, Fichtinger G, Tempany CM, Hata N. Preclinical evaluation of an MRI-compatible pneumatic robot for angulated needle placement in transperineal prostate interventions. 2012; 7:949-57. PubMed
  • Pursley J, Risholm P, Fedorov A, Tuncali K, Fennessy FM, Wells WM, Tempany CM, Cormack RA. A Bayesian nonrigid registration method to enhance intraoperative target definition in image-guided prostate procedures through uncertainty characterization. Med Phys 2012; 39:6858-67. PubMed
  • Hegde JV, Chen MH, Mulkern RV, Fennessy FM, D'Amico AV, Tempany CM. Preoperative 3-Tesla Multiparametric Endorectal Magnetic Resonance Imaging Findings and the Odds of Upgrading and Upstaging at Radical Prostatectomy in Men With Clinically Localized Prostate Cancer. Int J Radiat Oncol Biol Phys 2012. PubMed
  • Nguyen PL, Chen MH, Zhang Y, Tempany CM, Cormack RA, Beard CJ, Hurwitz MD, Suh WW, D'Amico AV. Updated results of magnetic resonance imaging guided partial prostate brachytherapy for favorable risk prostate cancer: implications for focal therapy. J Urol 2012; 188:1151-6. PubMed
  • Fedorov A, Tuncali K, Fennessy FM, Tokuda J, Hata N, Wells WM, Kikinis R, Tempany CM. Image registration for targeted MRI-guided transperineal prostate biopsy. J Magn Reson Imaging 2012; 36:987-92. PubMed
  • Tokuda J, Tuncali K, Iordachita I, Song SE, Fedorov A, Oguro S, Lasso A, Fennessy FM, Tempany CM, Hata N. In-bore setup and software for 3T MRI-guided transperineal prostate biopsy. Phys Med Biol 2012; 57:5823-40. PubMed
  • Seifabadi R, Cho NB, Song SE, Tokuda J, Hata N, Tempany CM, Fichtinger G, Iordachita I. Accuracy study of a robotic system for MRI-guided prostate needle placement. Int J Med Robot 2012. PubMed
  • Tempany CM, McDannold NJ, Hynynen K, Jolesz FA. Focused ultrasound surgery in oncology: overview and principles. Radiology 2011; 259:39-56. PubMed
  • Fennessy FM, Kong CY, Tempany CM, Swan JS. Quality-of-Life Assessment of Fibroid Treatment Options and Outcomes. Radiology 2011. PubMed
  • Su H, Camilo A, Cole GA, Hata N, Tempany CM, Fischer GS. High-Field MRI-Compatible Needle Placement Robot for Prostate Interventions. Stud Health Technol Inform 2011; 163:623-9. PubMed
  • Song SE, Cho N, Tokuda J, Hata N, Tempany C, Fichtinger G, Iordachita I. Preliminary Evaluation of a MRI-compatible Modular Robotic System for MRI-guided Prostate Interventions. Proc IEEE RAS EMBS Int Conf Biomed Robot Biomechatron 2010; 2010:796-801. PubMed
  • Song SE, Cho NB, Fischer G, Hata N, Tempany C, Fichtinger G, Iordachita I. Development of a Pneumatic Robot for MRI-guided Transperineal Prostate Biopsy and Brachytherapy: New Approaches. 2011; 2010:2580-2585. PubMed
  • Fennessy FM, Tuncali K, Morrison PR, Tempany CM. MR imaging-guided interventions in the genitourinary tract: an evolving concept. Magn Reson Imaging Clin N Am 2009; 18:11-28. PubMed
  • Afnan J, Tempany CM. Update on prostate imaging. Urol Clin North Am 2010; 37:23-5, Table of Contents. PubMed
  • Tokuda J, Fischer GS, DiMaio SP, Gobbi DG, Csoma C, Mewes PW, Fichtinger G, Tempany CM, Hata N. Integrated navigation and control software system for MRI-guided robotic prostate interventions. Comput Med Imaging Graph 2010; 34:3-8. PubMed
  • Tokuda J, Fischer GS, Papademetris X, Yaniv Z, Ibanez L, Cheng P, Liu H, Blevins J, Arata J, Golby AJ, Kapur T, Pieper S, Burdette EC, Fichtinger G, Tempany CM, Hata N. OpenIGTLink: an open network protocol for image-guided therapy environment. Int J Med Robot 2009; 5:423-34. PubMed
  • Taran FA, Tempany CM, Regan L, Inbar Y, Revel A, Stewart EA, . Magnetic resonance-guided focused ultrasound (MRgFUS) compared with abdominal hysterectomy for treatment of uterine leiomyomas. Ultrasound Obstet Gynecol 2009; 34:572-8. PubMed
  • Oguro S, Tokuda J, Elhawary H, Haker S, Kikinis R, Tempany CM, Hata N. MRI signal intensity based B-spline nonrigid registration for pre- and intraoperative imaging during prostate brachytherapy. J Magn Reson Imaging 2009; 30:1052-8. PubMed
  • Weinreb JC,Blume JD,Coakley FV,Wheeler TM,Cormack JB,Sotto CK,Cho H,Kawashima A,Tempany-Afdhal CM,Macura KJ,Rosen M,Gerst SR,Kurhanewicz J. Prostate cancer: sextant localization at MR imaging and MR spectroscopic imaging before prostatectomy--results of ACRIN prospective multi-institutional clinicopathologic study. Radiology 2009; 251:122-33. PubMed
  • Viswanathan AN, Cormack R, Holloway CL, Tanaka C, O'farrell D, Devlin PM, Tempany C. Magnetic resonance-guided interstitial therapy for vaginal recurrence of endometrial cancer. Int J Radiat Oncol Biol Phys 2006; 66:91-9. PubMed
  • Mulkern RV, Barnes AS, Haker SJ, Hung YP, Rybicki FJ, Maier SE, Tempany CM. Biexponential characterization of prostate tissue water diffusion decay curves over an extended b-factor range. Magn Reson Imaging 2006; 24:563-8. PubMed
  • Barnes AS, Haker SJ, Mulkern RV, So M, D'Amico AV, Tempany CM. Magnetic resonance spectroscopy-guided transperineal prostate biopsy and brachytherapy for recurrent prostate cancer. Urology 2005; 66:1319. PubMed
  • Haker SJ, Mulkern RV, Roebuck JR, Barnes AS, Dimaio S, Hata N, Tempany CM. Magnetic resonance-guided prostate interventions. Top Magn Reson Imaging 2006; 16:355-68. PubMed
  • Febbo PG, Richie JP, George DJ, Loda M, Manola J, Shankar S, Barnes AS, Tempany C, Catalona W, Kantoff PW, Oh WK. Neoadjuvant docetaxel before radical prostatectomy in patients with high-risk localized prostate cancer. Clin Cancer Res 2005; 11:5233-40. PubMed
  • Landis DM, Schultz D, Cormack R, Tempany C, Beard C, Hurwitz M, O'Leary M, Albert M, Valentine K, D'Amico AV. Acute urinary retention after magnetic resonance image-guided prostate brachytherapy with and without neoadjuvant external beam radiotherapy. Urology 2005; 65:750-4. PubMed
  • D'amico AV, Tempany CM, Schultz D, Cormack RA, Hurwitz M, Beard C, Albert M, Kooy H, Jolesz F, Richie JP. Comparing PSA outcome after radical prostatectomy or magnetic resonance imaging-guided partial prostatic irradiation in select patients with clinically localized adenocarcinoma of the prostate. Urology 2003; 62:1063-7. PubMed
  • Zou KH, Warfield SK, Fielding JR, Tempany CM, William MW, Kaus MR, Jolesz FA, Kikinis R. Statistical validation based on parametric receiver operating characteristic analysis of continuous classification data. Acad Radiol 2003; 10:1359-68. PubMed
  • Chan I, Wells W, Mulkern RV, Haker S, Zhang J, Zou KH, Maier SE, Tempany CM. Detection of prostate cancer by integration of line-scan diffusion, T2-mapping and T2-weighted magnetic resonance imaging; a multichannel statistical classifier. Med Phys 2003; 30:2390-8. PubMed
  • Anzai Y, Piccoli CW, Outwater EK, Stanford W, Bluemke DA, Nurenberg P, Saini S, Maravilla KR, Feldman DE, Schmiedl UP, Brunberg JA, Francis IR, Harms SE, Som PM, Tempany CM,. Evaluation of neck and body metastases to nodes with ferumoxtran 10-enhanced MR imaging: phase III safety and efficacy study. Radiology 2003; 228:777-88. PubMed
  • Albert M, Tempany CM, Schultz D, Chen MH, Cormack RA, Kumar S, Hurwitz MD, Beard C, Tuncali K, O'Leary M, Topulos GP, Valentine K, Lopes L, Kanan A, Kacher D, Rosato J, Kooy H, Jolesz F, Carr-Locke DL, Richie JP, D'Amico AV. Late genitourinary and gastrointestinal toxicity after magnetic resonance image-guided prostate brachytherapy with or without neoadjuvant external beam radiation therapy. Cancer 2003; 98:949-54. PubMed
  • Sanghani MV, Schultz D, Tempany CM, Titelbaum D, Renshaw AA, Loffredo M, Cote K, McMahon B, D'Amico AV. Quantifying the change in endorectal magnetic resonance imaging-defined tumor volume during neoadjuvant androgen suppression therapy in patients with prostate cancer. Urology 2003; 62:487-91. PubMed
  • Stewart EA, Gedroyc WM, Tempany CM, Quade BJ, Inbar Y, Ehrenstein T, Shushan A, Hindley JT, Goldin RD, David M, Sklair M, Rabinovici J. Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative technique. Am J Obstet Gynecol 2003; 189:48-54. PubMed
  • Tempany CM, Stewart EA, McDannold N, Quade BJ, Jolesz FA, Hynynen K. MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study. Radiology 2003; 226:897-905. PubMed
  • Zou KH, Fielding JR, Silverman SG, Tempany CM. Hypothesis testing I: proportions. Radiology 2003; 226:609-13. PubMed
  • D'Amico AV, Toupless G, Lopes L, Valentine KJ, Cormack RA, Tempany CM, Kumar S, Marks PJ. Self-administration of untested medical therapy for treatment of prostate cancer can lead to clinically significant adverse events. Int J Radiat Oncol Biol Phys 2002; 54:1311-3. PubMed
  • Das P, Chen MH, Valentine K, Lopes L, Cormack RA, Renshaw AA, Tempany CM, Kumar S, D'Amico AV. Using the magnitude of PSA bounce after MRI-guided prostate brachytherapy to distinguish recurrence, benign precipitating factors, and idiopathic bounce. Int J Radiat Oncol Biol Phys 2002; 54:698-702. PubMed
  • Hirose M, Bharatha A, Hata N, Zou KH, Warfield SK, Cormack RA, D'Amico A, Kikinis R, Jolesz FA, Tempany CM. Quantitative MR imaging assessment of prostate gland deformation before and during MR imaging-guided brachytherapy. Acad Radiol 2002; 9:906-12. PubMed
  • Robinson JN, Norwitz ER, Mulkern R, Brown SA, Rybicki F, Tempany CM. Prenatal diagnosis of pyruvate dehydrogenase deficiency using magnetic resonance imaging. Prenat Diagn 2001; 21:1053-6. PubMed
  • Bharatha A, Hirose M, Hata N, Warfield SK, Ferrant M, Zou KH, Suarez-Santana E, Ruiz-Alzola J, D'Amico A, Cormack RA, Kikinis R, Jolesz FA, Tempany CM. Evaluation of three-dimensional finite element-based deformable registration of pre- and intraoperative prostate imaging. Med Phys 2002; 28:2551-60. PubMed
  • D'Amico AV, Manola J, Loffredo M, Lopes L, Nissen K, O'Farrell DA, Gordon L, Tempany CM, Cormack RA. A practical method to achieve prostate gland immobilization and target verification for daily treatment. Int J Radiat Oncol Biol Phys 2001; 51:1431-6. PubMed
  • Sica GT, Pugach ME, Koniaris LS, Goldhaber SZ, Polak JF, Mukerjee A, Tempany CM. Isolated calf vein thrombosis: comparison of MR venography and conventional venography after initial sonography in symptomatic patients. Acad Radiol 2001; 8:856-63. PubMed
  • Omalley AJ, Zou KH, Fielding JR, Tempany CM. Bayesian regression methodology for estimating a receiver operating characteristic curve with two radiologic applications: prostate biopsy and spiral CT of ureteral stones. Acad Radiol 2001; 8:713-25. PubMed
  • Hata N, Jinzaki M, Kacher D, Cormak R, Gering D, Nabavi A, Silverman SG, D'Amico AV, Kikinis R, Jolesz FA, Tempany CM. MR imaging-guided prostate biopsy with surgical navigation software: device validation and feasibility. Radiology 2001; 220:263-8. PubMed
  • Schierlitz L, Dumanli H, Robinson JN, Burrows PE, Schreyer AG, Kikinis R, Jolesz FA, Tempany CM. Three-dimensional magnetic resonance imaging of fetal brains. Lancet 2001; 357:1177-8. PubMed
  • Brown DL, Zou KH, Tempany CM, Frates MC, Silverman SG, McNeil BJ, Kurtz AB. Primary versus secondary ovarian malignancy: imaging findings of adnexal masses in the Radiology Diagnostic Oncology Group Study. Radiology 2001; 219:213-8. PubMed
  • D'Amico AV, Cormack RA, Tempany CM. MRI-guided diagnosis and treatment of prostate cancer. N Engl J Med 2001; 344:776-7. PubMed
  • Tempany CM, McNeil BJ. Advances in biomedical imaging. JAMA 2001; 285:562-7. PubMed
  • Cormack RA, Tempany CM, D'Amico AV. Optimizing target coverage by dosimetric feedback during prostate brachytherapy. Int J Radiat Oncol Biol Phys 2000; 48:1245-9. PubMed
  • Cormack RA, D'Amico AV, Hata N, Silverman S, Weinstein M, Tempany CM. Feasibility of transperineal prostate biopsy under interventional magnetic resonance guidance. Urology 2000; 56:663-4. PubMed
  • Norwitz ER, Hoyte LP, Jenkins KJ, van der Velde ME, Ratiu P, Rodriguez-Thompson D, Wilkins-Haug L, Tempany CM, Fishman SJ. Separation of conjoined twins with the twin reversed-arterial-perfusion sequence after prenatal planning with three-dimensional modeling. N Engl J Med 2000; 343:399-402. PubMed
  • D'Amico AV, Tempany CM, Cormack R, Hata N, Jinzaki M, Tuncali K, Weinstein M, Richie JP. Transperineal magnetic resonance image guided prostate biopsy. J Urol 2000; 164:385-7. PubMed
  • Thomas MD, Cormack R, Tempany CM, Kumar S, Manola J, Schneider L, Hurwitz MD, D'Amico AV. Identifying the predictors of acute urinary retention following magnetic-resonance-guided prostate brachytherapy. Int J Radiat Oncol Biol Phys 2000; 47:905-8. PubMed
  • Tempany CM, Zou KH, Silverman SG, Brown DL, Kurtz AB, McNeil BJ. Staging of advanced ovarian cancer: comparison of imaging modalities--report from the Radiological Diagnostic Oncology Group. Radiology 2000; 215:761-7. PubMed
  • Hurwitz MD, Cormack R, Tempany CM, Kumar S, D'Amico AV. Three-dimensional real-time magnetic resonance-guided interstitial prostate brachytherapy optimizes radiation dose distribution resulting in a favorable acute side effect profile in patients with clinically localized prostate cancer. Tech Urol 2000; 6:89-94. PubMed
  • D'Amico A, Cormack R, Kumar S, Tempany CM. Real-time magnetic resonance imaging-guided brachytherapy in the treatment of selected patients with clinically localized prostate cancer. J Endourol 2000; 14:367-70. PubMed
  • Kooy HM, Cormack RA, Mathiowitz G, Tempany C, D'Amico AV. A software system for interventional magnetic resonance image-guided prostate brachytherapy. Comput Aided Surg 2001; 5:401-13. PubMed
  • Nguyen PL,Chen RC,Clark JA,Cormack RA,Loffredo M,McMahon E,Nguyen AU,Suh WW,Tempany CM,D'Amico AV. Patient-reported quality of life after salvage brachytherapy for radio-recurrent prostate cancer: A prospective Phase II study. Brachytherapy 2009; 8:345-52. PubMed
  • Kettenbach J, Kacher DF, Koskinen SK, Silverman SG, Nabavi A, Gering D, Tempany CM, Schwartz RB, Kikinis R, Black PM, Jolesz FA. Interventional and intraoperative magnetic resonance imaging. Annu Rev Biomed Eng 2001; 2:661-90. PubMed
  • Viswanathan AN, Szymonifka J, Tempany-Afdhal CM, O'Farrell DA, Cormack RA. A prospective trial of real-time magnetic resonance-guided catheter placement in interstitial gynecologic brachytherapy. Brachytherapy 2013; 12:240-7. PubMed
  • Cormack RA, Kooy H, Tempany CM, D'Amico AV. A clinical method for real-time dosimetric guidance of transperineal 125I prostate implants using interventional magnetic resonance imaging. Int J Radiat Oncol Biol Phys 2000; 46:207-14. PubMed
  • Kurtz AB, Tsimikas JV, Tempany CM, Hamper UM, Arger PH, Bree RL, Wechsler RJ, Francis IR, Kuhlman JE, Siegelman ES, Mitchell DG, Silverman SG, Brown DL, Sheth S, Coleman BG, Ellis JH, Kurman RJ, Caudry DJ, McNeil BJ. Diagnosis and staging of ovarian cancer: comparative values of Doppler and conventional US, CT, and MR imaging correlated with surgery and histopathologic analysis--report of the Radiology Diagnostic Oncology Group. Radiology 1999; 212:19-27. PubMed
  • D'Amico AV, Cormack R, Tempany CM, Kumar S, Topulos G, Kooy HM, Coleman CN. Real-time magnetic resonance image-guided interstitial brachytherapy in the treatment of select patients with clinically localized prostate cancer. Int J Radiat Oncol Biol Phys 1998; 42:507-15. PubMed
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