Photo of Clare M. Tempany-Afdhal,  MB, BCh

Clare M. Tempany-Afdhal, MB, BCh

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-7858
Fax: (617) 732-6033


ctempany@bwh.harvard.edu

Clare M. Tempany-Afdhal, MB, BCh

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Radiology, Harvard Medical School
  • Ferenc Jolesz Chair of Research, Radiology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My major areas of research interest are MR imaging of the pelvis (specifically Prostate cancer) and image-guided therapy. As co-PI of the NCIGT I along with Ferenc Jolesz lead this team and direct the AMIGO facility. My lab is dedicated to prostate cancer imaging as it relates to diagnosis, staging, treatment monitoring and Image-guided Therapy (IGT). We have program in MR guided prostate biopsies for diagnosis and treatment monitoring. I lead several prospective trials involving clinical prostate multi-parametric prostate MR at 3.0T with an endorectal coil. Our lab works in all aspects from acquisition and optimization of multi-parametric 3T imaging, image processing, registration, and segmentation, navigation and image display. We are also working on many engineering challenges associated with guidance and access to the prostate. We have a program in enabling technologies, including robotics for MR guided interventions and MR guided Focused Ultrasound surgery(FUS). The latter is a major interest of our program at NCIGT and specifically in prostate cancer. We established MR guided in bore prostate biopsies for cancer diagnosis in 1997, sicne then have migrated this program to our wide-bore 3T MR and perform MR targeted and guided prostate biopsies in large cohorts of patients. Our research also involves MR image-guided focal therapyfor localized prostate cancer- MR guided cryotherapy or MR guided FUS, radiation delivery-namely EBRT and brachytherapy. We are involved in multi-disciplinary trials with colleagues in Oncology, Urology and Radiation Oncology and also national multi-center groups such as ACRIN.

Publications

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  • Tempany CM, Kapur T. Magnetic Resonance-Guided Interventions: The State of the Art. Magn Reson Imaging Clin N Am 2015; 23:xix. PubMed
  • Weinreb JC, Barentsz JO, Choyke PL, Cornud F, Haider MA, Macura KJ, Margolis D, Schnall MD, Shtern F, Tempany CM, Thoeny HC, Verma S. PI-RADS Prostate Imaging - Reporting and Data System: 2015, Version 2. Eur Urol 2015. PubMed
  • Barentsz JO, Weinreb JC, Verma S, Thoeny HC, Tempany CM, Shtern F, Padhani AR, Margolis D, Macura KJ, Haider MA, Cornud F, Choyke PL. Synopsis of the PI-RADS v2 Guidelines for Multiparametric Prostate Magnetic Resonance Imaging and Recommendations for Use. Eur Urol 2015. PubMed
  • Fennessy FM, Fedorov A, Penzkofer T, Kim KW, Hirsch MS, Vangel MG, Masry P, Flood TA, Chang MC, Tempany CM, Mulkern RV, Gupta SN. Quantitative pharmacokinetic analysis of prostate cancer DCE-MRI at 3T: comparison of two arterial input functions on cancer detection with digitized whole mount histopathological validation. Magn Reson Imaging 2015. PubMed
  • Su H, Shang W, Cole G, Li G, Harrington K, Camilo A, Tokuda J, Tempany CM, Hata N, Fischer GS. Piezoelectrically Actuated Robotic System for MRI-Guided Prostate Percutaneous Therapy. IEEE ASME Trans Mechatron 2015; 20:1920-1932. PubMed
  • Tilak G, Tuncali K, Song SE, Tokuda J, Olubiyi O, Fennessy F, Fedorov A, Penzkofer T, Tempany C, Hata N. 3T MR-guided in-bore transperineal prostate biopsy: A comparison of robotic and manual needle-guidance templates. J Magn Reson Imaging 2015. PubMed
  • Silveira PC, Dunne R, Sainani NI, Lacson R, Silverman SG, Tempany CM, Khorasani R. Impact of an Information Technology-Enabled Initiative on the Quality of Prostate Multiparametric MRI Reports. Acad Radiol 2015; 22:827-33. PubMed
  • Eslami S, Shang W, Li G, Patel N, Fischer GS, Tokuda J, Hata N, Tempany CM, Iordachita I. In-bore prostate transperineal interventions with an MRI-guided parallel manipulator: system development and preliminary evaluation. Int J Med Robot 2015. PubMed
  • Yamauchi FI, Penzkofer T, Fedorov A, Fennessy FM, Chu R, Maier SE, Tempany CM, Mulkern RV, Panych LP. Prostate cancer discrimination in the peripheral zone with a reduced field-of-view T(2)-mapping MRI sequence. Magn Reson Imaging 2015. PubMed
  • Fedorov A, Khallaghi S, S├ínchez CA, Lasso A, Fels S, Tuncali K, Sugar EN, Kapur T, Zhang C, Wells W, Nguyen PL, Abolmaesumi P, Tempany C. Open-source image registration for MRI-TRUS fusion-guided prostate interventions. 2015. PubMed
  • Xu H, Lasso A, Fedorov A, Tuncali K, Tempany C, Fichtinger G. Multi-slice-to-volume registration for MRI-guided transperineal prostate biopsy. 2015. PubMed
  • Fedorov A, Penzkofer T, Hirsch MS, Flood TA, Vangel MG, Masry P, Tempany CM, Mulkern RV, Fennessy FM. The role of pathology correlation approach in prostate cancer index lesion detection and quantitative analysis with multiparametric MRI. Acad Radiol 2015. PubMed
  • Tempany CM, Jayender J, Kapur T, Bueno R, Golby A, Agar N, Jolesz FA. Multimodal imaging for improved diagnosis and treatment of cancers. Cancer 2015. PubMed
  • Penzkofer T, Tuncali K, Fedorov A, Song SE, Tokuda J, Fennessy FM, Vangel MG, Kibel AS, Mulkern RV, Wells WM, Hata N, Tempany CM. Transperineal in-bore 3-T MR imaging-guided prostate biopsy: a prospective clinical observational study. Radiology 2014. PubMed
  • Phillips JG, Aizer AA, Chen MH, Zhang D, Hirsch MS, Richie JP, Tempany CM, Williams S, Hegde JV, Loffredo MJ, D'Amico AV. The effect of differing Gleason scores at biopsy on the odds of upgrading and the risk of death from prostate cancer. Clin Genitourin Cancer 2014. PubMed
  • Fedorov A, Wells WM, Kikinis R, Tempany CM, Vangel MG. Application of tolerance limits to the characterization of image registration performance. IEEE Trans Med Imaging 2014. PubMed
  • Penzkofer T, Tempany-Afdhal CM. Prostate cancer detection and diagnosis: the role of MR and its comparison with other diagnostic modalities--a radiologist's perspective. NMR Biomed 2013; 27:3-15. PubMed
  • Murciano-Goroff YR, Wolfsberger LD, Parekh A, Fennessy FM, Tuncali K, Orio PF, Niedermayr TR, Suh WW, Devlin PM, Tempany CM, Sugar EH, O'Farrell DA, Steele G, O'Leary M, Buzurovic I, Damato AL, Cormack RA, Fedorov AY, Nguyen PL. Variability in MRI vs. ultrasound measures of prostate volume and its impact on treatment recommendations for favorable-risk prostate cancer patients: a case series. Radiat Oncol 2014; 9:200. PubMed
  • Seifabadi R, Cho NB, Song SE, Tokuda J, Hata N, Tempany CM, Fichtinger G, Iordachita I. Accuracy study of a robotic system for MRI-guided prostate needle placement. Int J Med Robot 2013. PubMed
  • Hegde JV, Chen MH, Mulkern RV, Fennessy FM, D'Amico AV, Tempany CM. Preoperative 3-Tesla multiparametric endorectal magnetic resonance imaging findings and the odds of upgrading and upstaging at radical prostatectomy in men with clinically localized prostate cancer. Int J Radiat Oncol Biol Phys 2013. PubMed
  • Tokuda J, Song SE, Fischer GS, Iordachita II, Seifabadi R, Cho NB, Tuncali K, Fichtinger G, Tempany CM, Hata N. Preclinical evaluation of an MRI-compatible pneumatic robot for angulated needle placement in transperineal prostate interventions. 2012; 7:949-57. PubMed
  • Fennessy FM, Fedorov A, Gupta SN, Schmidt EJ, Tempany CM, Mulkern RV. Practical considerations in T1 mapping of prostate for dynamic contrast enhancement pharmacokinetic analyses. Magn Reson Imaging 2012; 30:1224-33. PubMed
  • Pursley J, Risholm P, Fedorov A, Tuncali K, Fennessy FM, Wells WM, Tempany CM, Cormack RA. A Bayesian nonrigid registration method to enhance intraoperative target definition in image-guided prostate procedures through uncertainty characterization. Med Phys 2012; 39:6858-67. PubMed
  • Fedorov A, Tuncali K, Fennessy FM, Tokuda J, Hata N, Wells WM, Kikinis R, Tempany CM. Image registration for targeted MRI-guided transperineal prostate biopsy. J Magn Reson Imaging 2012; 36:987-92. PubMed
  • Nguyen PL, Chen MH, Zhang Y, Tempany CM, Cormack RA, Beard CJ, Hurwitz MD, Suh WW, D'Amico AV. Updated results of magnetic resonance imaging guided partial prostate brachytherapy for favorable risk prostate cancer: implications for focal therapy. J Urol 2012; 188:1151-6. PubMed
  • Tokuda J, Tuncali K, Iordachita I, Song SE, Fedorov A, Oguro S, Lasso A, Fennessy FM, Tempany CM, Hata N. In-bore setup and software for 3T MRI-guided transperineal prostate biopsy. Phys Med Biol 2012; 57:5823-40. PubMed
  • Fennessy FM, Kong CY, Tempany CM, Swan JS. Quality-of-life assessment of fibroid treatment options and outcomes. Radiology 2011. PubMed
  • Tempany CM, McDannold NJ, Hynynen K, Jolesz FA. Focused ultrasound surgery in oncology: overview and principles. Radiology 2011; 259:39-56. PubMed
  • Su H, Camilo A, Cole GA, Hata N, Tempany CM, Fischer GS. High-field MRI-compatible needle placement robot for prostate interventions. Stud Health Technol Inform 2011; 163:623-9. PubMed
  • Song SE, Cho N, Tokuda J, Hata N, Tempany C, Fichtinger G, Iordachita I. Preliminary Evaluation of a MRI-compatible Modular Robotic System for MRI-guided Prostate Interventions. Proc IEEE RAS EMBS Int Conf Biomed Robot Biomechatron 2010; 2010:796-801. PubMed
  • Song SE, Cho NB, Fischer G, Hata N, Tempany C, Fichtinger G, Iordachita I. Development of a Pneumatic Robot for MRI-guided Transperineal Prostate Biopsy and Brachytherapy: New Approaches. 2011; 2010:2580-2585. PubMed
  • Fennessy FM, Tuncali K, Morrison PR, Tempany CM. MR imaging-guided interventions in the genitourinary tract: an evolving concept. Magn Reson Imaging Clin N Am 2009; 18:11-28. PubMed
  • Afnan J, Tempany CM. Update on prostate imaging. Urol Clin North Am 2010; 37:23-5, Table of Contents. PubMed
  • Tokuda J, Fischer GS, DiMaio SP, Gobbi DG, Csoma C, Mewes PW, Fichtinger G, Tempany CM, Hata N. Integrated navigation and control software system for MRI-guided robotic prostate interventions. Comput Med Imaging Graph 2010; 34:3-8. PubMed
  • Tokuda J, Fischer GS, Papademetris X, Yaniv Z, Ibanez L, Cheng P, Liu H, Blevins J, Arata J, Golby AJ, Kapur T, Pieper S, Burdette EC, Fichtinger G, Tempany CM, Hata N. OpenIGTLink: an open network protocol for image-guided therapy environment. Int J Med Robot 2009; 5:423-34. PubMed
  • Oguro S, Tokuda J, Elhawary H, Haker S, Kikinis R, Tempany CM, Hata N. MRI signal intensity based B-spline nonrigid registration for pre- and intraoperative imaging during prostate brachytherapy. J Magn Reson Imaging 2009; 30:1052-8. PubMed
  • Taran FA, Tempany CM, Regan L, Inbar Y, Revel A, Stewart EA, . Magnetic resonance-guided focused ultrasound (MRgFUS) compared with abdominal hysterectomy for treatment of uterine leiomyomas. Ultrasound Obstet Gynecol 2009; 34:572-8. PubMed
  • Weinreb JC,Blume JD,Coakley FV,Wheeler TM,Cormack JB,Sotto CK,Cho H,Kawashima A,Tempany-Afdhal CM,Macura KJ,Rosen M,Gerst SR,Kurhanewicz J. Prostate cancer: sextant localization at MR imaging and MR spectroscopic imaging before prostatectomy--results of ACRIN prospective multi-institutional clinicopathologic study. Radiology 2009; 251:122-33. PubMed
  • Viswanathan AN, Cormack R, Holloway CL, Tanaka C, O'farrell D, Devlin PM, Tempany C. Magnetic resonance-guided interstitial therapy for vaginal recurrence of endometrial cancer. Int J Radiat Oncol Biol Phys 2006; 66:91-9. PubMed
  • Mulkern RV, Barnes AS, Haker SJ, Hung YP, Rybicki FJ, Maier SE, Tempany CM. Biexponential characterization of prostate tissue water diffusion decay curves over an extended b-factor range. Magn Reson Imaging 2006; 24:563-8. PubMed
  • Haker SJ, Mulkern RV, Roebuck JR, Barnes AS, Dimaio S, Hata N, Tempany CM. Magnetic resonance-guided prostate interventions. Top Magn Reson Imaging 2006; 16:355-68. PubMed
  • Zou KH, Fielding JR, Silverman SG, Tempany CM. Hypothesis testing I: proportions. Radiology 2003; 226:609-13. PubMed
  • Nguyen PL,Chen RC,Clark JA,Cormack RA,Loffredo M,McMahon E,Nguyen AU,Suh WW,Tempany CM,D'Amico AV. Patient-reported quality of life after salvage brachytherapy for radio-recurrent prostate cancer: A prospective Phase II study. Brachytherapy 2009; 8:345-52. PubMed
  • Viswanathan AN, Szymonifka J, Tempany-Afdhal CM, O'Farrell DA, Cormack RA. A prospective trial of real-time magnetic resonance-guided catheter placement in interstitial gynecologic brachytherapy. Brachytherapy 2013; 12:240-7. PubMed
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