Photo of Clifford J. Tabin,  PhD

Clifford J. Tabin, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 432-7618
Fax: (617) 432-7595


tabin@genetics.med.harvard.edu

Clifford J. Tabin, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • George Jacob and Jacqueline Hazel Leder Professor, Genetics, Harvard Medical School
  • Chair, Genetics, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Publications

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  • Gros J, Tabin CJ. Vertebrate limb bud formation is initiated by localized epithelial-to-mesenchymal transition. Science 2014; 343:1253-6. PubMed
  • Rohner N, Jarosz DF, Kowalko JE, Yoshizawa M, Jeffery WR, Borowsky RL, Lindquist S, Tabin CJ. Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish. Science 2013; 342:1372-5. PubMed
  • Shyer AE, Tallinen T, Nerurkar NL, Wei Z, Gil ES, Kaplan DL, Tabin CJ, Mahadevan L. Villification: how the gut gets its villi. Science 2013; 342:212-8. PubMed
  • Rodrigues AR, Tabin CJ. Developmental biology. Deserts and waves in gene expression. Science 2013; 340:1181-2. PubMed
  • Hu JK, McGlinn E, Harfe BD, Kardon G, Tabin CJ. Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Genes Dev 2012; 26:2088-102. PubMed
  • Whited JL, Lehoczky JA, Tabin CJ. Inducible genetic system for the axolotl. Proc Natl Acad Sci U S A 2012; 109:13662-7. PubMed
  • Kamei CN, Kempf H, Yelin R, Daoud G, James RG, Lassar AB, Tabin CJ, Schultheiss TM. Promotion of avian endothelial cell differentiation by GATA transcription factors. Dev Biol 2011. PubMed
  • Whited JL, Lehoczky JA, Austin CA, Tabin CJ. Dynamic expression of two thrombospondins during axolotl limb regeneration. Dev Dyn 2011. PubMed
  • Haramati S, Chapnik E, Sztainberg Y, Eilam R, Zwang R, Gershoni N, McGlinn E, Heiser PW, Wills AM, Wirguin I, Rubin LL, Misawa H, Tabin CJ, Brown R, Chen A, Hornstein E. miRNA malfunction causes spinal motor neuron disease. Proc Natl Acad Sci U S A 2010; 107:13111-6. PubMed
  • Whited JL, Tabin CJ. Regeneration review reprise. J Biol 2010; 9:15. PubMed
  • Saxena A, Tabin CJ. miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation. Proc Natl Acad Sci U S A 2010; 107:87-91. PubMed
  • Blitz E, Viukov S, Sharir A, Shwartz Y, Galloway JL, Pryce BA, Johnson RL, Tabin CJ, Schweitzer R, Zelzer E. Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell 2010; 17:861-73. PubMed
  • McGlinn E, Yekta S, Mansfield JH, Soutschek J, Bartel DP, Tabin CJ. In ovo application of antagomiRs indicates a role for miR-196 in patterning the chick axial skeleton through Hox gene regulation. Proc Natl Acad Sci U S A 2009; 106:18610-5. PubMed
  • Purcell P, Joo BW, Hu JK, Tran PV, Calicchio ML, O'Connell DJ, Maas RL, Tabin CJ. Temporomandibular joint formation requires two distinct hedgehog-dependent steps. Proc Natl Acad Sci U S A 2009; 106:18297-302. PubMed
  • Galloway JL, Delgado I, Ros MA, Tabin CJ. A reevaluation of X-irradiation-induced phocomelia and proximodistal limb patterning. Nature 2009; 460:400-4. PubMed
  • Allard P,Tabin CJ. Achieving bilateral symmetry during vertebrate limb development. Semin Cell Dev Biol 2009; 20:479-84. PubMed
  • Gros J,Feistel K,Viebahn C,Blum M,Tabin CJ. Cell movements at Hensen's node establish left/right asymmetric gene expression in the chick. Science 2009; 324:941-4. PubMed
  • Mao J,McGlinn E,Huang P,Tabin CJ,McMahon AP. Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell 2009; 16:600-6. PubMed
  • Whited JL,Tabin CJ. Limb regeneration revisited. J Biol 2009; 8:5. PubMed
  • Yekta S,Tabin CJ,Bartel DP. MicroRNAs in the Hox network: an apparent link to posterior prevalence. Nat Rev Genet 2008; 9:789-96. PubMed
  • Bandyopadhyay A,Kubilus JK,Crochiere ML,Linsenmayer TF,Tabin CJ. Identification of unique molecular subdomains in the perichondrium and periosteum and their role in regulating gene expression in the underlying chondrocytes. Dev Biol 2008; 321:162-74. PubMed
  • Tabin CJ,McMahon AP. Developmental biology. Grasping limb patterning. Science 2008; 321:350-2. PubMed
  • Kurpios NA,Ibanes M,Davis NM,Lui W,Katz T,Martin JF,Belmonte JC,Tabin CJ. The direction of gut looping is established by changes in the extracellular matrix and in cell:cell adhesion. Proc Natl Acad Sci U S A 2008; 105:8499-506. PubMed
  • Protas M, Tabansky I, Conrad M, Gross JB, Vidal O, Tabin CJ, Borowsky R. Multi-trait evolution in a cave fish, Astyanax mexicanus. Evol Dev 2008; 10:196-209. PubMed
  • Tsuji K, Cox K, Bandyopadhyay A, Harfe BD, Tabin CJ, Rosen V. BMP4 is dispensable for skeletogenesis and fracture-healing in the limb. J Bone Joint Surg Am 2008; 90 Suppl 1:14-8. PubMed
  • Abzhanov A, Cordero DR, Sen J, Tabin CJ, Helms JA. Cross-regulatory interactions between Fgf8 and Shh in the avian frontonasal prominence. Congenit Anom (Kyoto) 2007; 47:136-48. PubMed
  • Pearse RV 2nd, Scherz PJ, Campbell JK, Tabin CJ. A cellular lineage analysis of the chick limb bud. Dev Biol 2007; 310:388-400. PubMed
  • Abzhanov A, Rodda SJ, McMahon AP, Tabin CJ. Regulation of skeletogenic differentiation in cranial dermal bone. Development 2007; 134:3133-44. PubMed
  • Scherz PJ, McGlinn E, Nissim S, Tabin CJ. Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb. Dev Biol 2007; 308:343-54. PubMed
  • Murchison ND, Price BA, Conner DA, Keene DR, Olson EN, Tabin CJ, Schweitzer R. Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development 2007; 134:2697-708. PubMed
  • Pryce BA, Brent AE, Murchison ND, Tabin CJ, Schweitzer R. Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene. Dev Dyn 2007; 236:1677-82. PubMed
  • Tabin CJ. The key to left-right asymmetry. Cell 2006; 127:27-32. PubMed
  • Rivera-Feliciano J, Lee KH, Kong SW, Rajagopal S, Ma Q, Springer Z, Izumo S, Tabin CJ, Pu WT. Development of heart valves requires Gata4 expression in endothelial-derived cells. Development 2006; 133:3607-18. PubMed
  • Hornstein E, Mansfield JH, Yekta S, Hu JK, Harfe BD, McManus MT, Baskerville S, Bartel DP, Tabin CJ. The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature 2005; 438:671-4. PubMed
  • Harfe BD, McManus MT, Mansfield JH, Hornstein E, Tabin CJ. The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A 2005; 102:10898-903. PubMed
  • Abzhanov A, Tzahor E, Lassar AB, Tabin CJ. Dissimilar regulation of cell differentiation in mesencephalic (cranial) and sacral (trunk) neural crest cells in vitro. Development 2003; 130:4567-79. PubMed
  • Dudley AT, Ros MA, Tabin CJ. A re-examination of proximodistal patterning during vertebrate limb development. Nature 2002; 418:539-44. PubMed
  • Heanue TA, Davis RJ, Rowitch DH, Kispert A, McMahon AP, Mardon G, Tabin CJ. Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes. Mech Dev 2002; 111:75-87. PubMed
  • Pearse RV, Vogan KJ, Tabin CJ. Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis. Dev Biol 2002; 239:15-29. PubMed
  • Tabin CJ, Johnson RL. Developmental biology: clocks and hox. Nature 2001; 412:780-1. PubMed
  • Pathi S, Pagan-Westphal S, Baker DP, Garber EA, Rayhorn P, Bumcrot D, Tabin CJ, Blake Pepinsky R, Williams KP. Comparative biological responses to human Sonic, Indian, and Desert hedgehog. Mech Dev 2001; 106:107-17. PubMed
  • Yokouchi Y, Vogan KJ, Pearse RV, Tabin CJ. Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression. Cell 1999; 98:573-83. PubMed
  • Pearse RV, Collier LS, Scott MP, Tabin CJ. Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators. Dev Biol 1999; 212:323-36. PubMed
  • Logan M, Tabin CJ. Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity. Science 1999; 283:1736-9. PubMed
  • Tabin CJ. A developmental model for thalidomide defects. Nature 1998; 396:322-3. PubMed
  • Logan M, Pag. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. Cell 1998; 94:307-17. PubMed
  • Roberts DJ, Smith DM, Goff DJ, Tabin CJ. Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development 1998; 125:2791-801. PubMed
  • Kengaku M, Capdevila J, Rodriguez-Esteban C, De La Pe. Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science 1998; 280:1274-7. PubMed
  • Pag. The transfer of left-right positional information during chick embryogenesis. Cell 1998; 93:25-35. PubMed
  • Vortkamp A, Pathi S, Peretti GM, Caruso EM, Zaleske DJ, Tabin CJ. Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair. Mech Dev 1998; 71:65-76. PubMed
  • Heanue TA, Johnson RL, Izpisua-Belmonte JC, Stern CD, De Robertis EM, Tabin CJ. Goosecoid misexpression alters the morphology and Hox gene expression of the developing chick limb bud. Mech Dev 1998; 69:31-7. PubMed
  • Levin M, Pagan S, Roberts DJ, Cooke J, Kuehn MR, Tabin CJ. Left/right patterning signals and the independent regulation of different aspects of situs in the chick embryo. Dev Biol 1997; 189:57-67. PubMed
  • Goff DJ, Tabin CJ. Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth. Development 1997; 124:627-36. PubMed
  • Marigo V, Johnson RL, Vortkamp A, Tabin CJ. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev Biol 1996; 180:273-83. PubMed
  • Marigo V, Davey RA, Zuo Y, Cunningham JM, Tabin CJ. Biochemical evidence that patched is the Hedgehog receptor. Nature 1996; 384:176-9. PubMed
  • Burke AC, Tabin CJ. Virally mediated misexpression of Hoxc-6 in the cervical mesoderm results in spinal nerve truncations. Dev Biol 1996; 178:192-7. PubMed
  • Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 1996; 273:613-22. PubMed
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