Photo of Clifford J. Tabin,  PhD

Clifford J. Tabin, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 432-7618
Fax: (617) 432-7595


tabin@genetics.med.harvard.edu

Clifford J. Tabin, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • George Jacob and Jacqueline Hazel Leder Professor, Genetics, Harvard Medical School
  • Chair, Genetics, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Publications

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  • Lehoczky JA, Tabin CJ. Lgr6 marks nail stem cells and is required for digit tip regeneration. Proc Natl Acad Sci U S A 2015; 112:13249-54. PubMed
  • Wong SF, Agarwal V, Mansfield JH, Denans N, Schwartz MG, Prosser HM, Pourquié O, Bartel DP, Tabin CJ, McGlinn E. Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs. Proc Natl Acad Sci U S A 2015; 112:E4884-93. PubMed
  • Kamberov YG, Karlsson EK, Kamberova GL, Lieberman DE, Sabeti PC, Morgan BA, Tabin CJ. A genetic basis of variation in eccrine sweat gland and hair follicle density. Proc Natl Acad Sci U S A 2015; 112:9932-7. PubMed
  • Shyer AE, Huycke TR, Lee C, Mahadevan L, Tabin CJ. Bending gradients: how the intestinal stem cell gets its home. Cell 2015; 161:569-80. PubMed
  • Gros J, Tabin CJ. Vertebrate limb bud formation is initiated by localized epithelial-to-mesenchymal transition. Science 2014; 343:1253-6. PubMed
  • Rohner N, Jarosz DF, Kowalko JE, Yoshizawa M, Jeffery WR, Borowsky RL, Lindquist S, Tabin CJ. Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish. Science 2013; 342:1372-5. PubMed
  • Shyer AE, Tallinen T, Nerurkar NL, Wei Z, Gil ES, Kaplan DL, Tabin CJ, Mahadevan L. Villification: how the gut gets its villi. Science 2013; 342:212-8. PubMed
  • Rodrigues AR, Tabin CJ. Developmental biology. Deserts and waves in gene expression. Science 2013; 340:1181-2. PubMed
  • Hu JK, McGlinn E, Harfe BD, Kardon G, Tabin CJ. Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Genes Dev 2012; 26:2088-102. PubMed
  • Whited JL, Lehoczky JA, Tabin CJ. Inducible genetic system for the axolotl. Proc Natl Acad Sci U S A 2012; 109:13662-7. PubMed
  • Whited JL, Lehoczky JA, Austin CA, Tabin CJ. Dynamic expression of two thrombospondins during axolotl limb regeneration. Dev Dyn 2011. PubMed
  • Kamei CN, Kempf H, Yelin R, Daoud G, James RG, Lassar AB, Tabin CJ, Schultheiss TM. Promotion of avian endothelial cell differentiation by GATA transcription factors. Dev Biol 2011. PubMed
  • Haramati S, Chapnik E, Sztainberg Y, Eilam R, Zwang R, Gershoni N, McGlinn E, Heiser PW, Wills AM, Wirguin I, Rubin LL, Misawa H, Tabin CJ, Brown R, Chen A, Hornstein E. miRNA malfunction causes spinal motor neuron disease. Proc Natl Acad Sci U S A 2010; 107:13111-6. PubMed
  • Whited JL, Tabin CJ. Regeneration review reprise. J Biol 2010; 9:15. PubMed
  • Saxena A, Tabin CJ. miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation. Proc Natl Acad Sci U S A 2010; 107:87-91. PubMed
  • Blitz E, Viukov S, Sharir A, Shwartz Y, Galloway JL, Pryce BA, Johnson RL, Tabin CJ, Schweitzer R, Zelzer E. Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell 2010; 17:861-73. PubMed
  • McGlinn E, Yekta S, Mansfield JH, Soutschek J, Bartel DP, Tabin CJ. In ovo application of antagomiRs indicates a role for miR-196 in patterning the chick axial skeleton through Hox gene regulation. Proc Natl Acad Sci U S A 2009; 106:18610-5. PubMed
  • Purcell P, Joo BW, Hu JK, Tran PV, Calicchio ML, O'Connell DJ, Maas RL, Tabin CJ. Temporomandibular joint formation requires two distinct hedgehog-dependent steps. Proc Natl Acad Sci U S A 2009; 106:18297-302. PubMed
  • Galloway JL, Delgado I, Ros MA, Tabin CJ. A reevaluation of X-irradiation-induced phocomelia and proximodistal limb patterning. Nature 2009; 460:400-4. PubMed
  • Allard P,Tabin CJ. Achieving bilateral symmetry during vertebrate limb development. Semin Cell Dev Biol 2009; 20:479-84. PubMed
  • Gros J,Feistel K,Viebahn C,Blum M,Tabin CJ. Cell movements at Hensen's node establish left/right asymmetric gene expression in the chick. Science 2009; 324:941-4. PubMed
  • Mao J,McGlinn E,Huang P,Tabin CJ,McMahon AP. Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell 2009; 16:600-6. PubMed
  • Whited JL,Tabin CJ. Limb regeneration revisited. J Biol 2009; 8:5. PubMed
  • Yekta S,Tabin CJ,Bartel DP. MicroRNAs in the Hox network: an apparent link to posterior prevalence. Nat Rev Genet 2008; 9:789-96. PubMed
  • Bandyopadhyay A,Kubilus JK,Crochiere ML,Linsenmayer TF,Tabin CJ. Identification of unique molecular subdomains in the perichondrium and periosteum and their role in regulating gene expression in the underlying chondrocytes. Dev Biol 2008; 321:162-74. PubMed
  • Tabin CJ,McMahon AP. Developmental biology. Grasping limb patterning. Science 2008; 321:350-2. PubMed
  • Kurpios NA,Ibanes M,Davis NM,Lui W,Katz T,Martin JF,Belmonte JC,Tabin CJ. The direction of gut looping is established by changes in the extracellular matrix and in cell:cell adhesion. Proc Natl Acad Sci U S A 2008; 105:8499-506. PubMed
  • Protas M, Tabansky I, Conrad M, Gross JB, Vidal O, Tabin CJ, Borowsky R. Multi-trait evolution in a cave fish, Astyanax mexicanus. Evol Dev 2008; 10:196-209. PubMed
  • Tsuji K, Cox K, Bandyopadhyay A, Harfe BD, Tabin CJ, Rosen V. BMP4 is dispensable for skeletogenesis and fracture-healing in the limb. J Bone Joint Surg Am 2008; 90 Suppl 1:14-8. PubMed
  • Abzhanov A, Cordero DR, Sen J, Tabin CJ, Helms JA. Cross-regulatory interactions between Fgf8 and Shh in the avian frontonasal prominence. Congenit Anom (Kyoto) 2007; 47:136-48. PubMed
  • Pearse RV 2nd, Scherz PJ, Campbell JK, Tabin CJ. A cellular lineage analysis of the chick limb bud. Dev Biol 2007; 310:388-400. PubMed
  • Abzhanov A, Rodda SJ, McMahon AP, Tabin CJ. Regulation of skeletogenic differentiation in cranial dermal bone. Development 2007; 134:3133-44. PubMed
  • Scherz PJ, McGlinn E, Nissim S, Tabin CJ. Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb. Dev Biol 2007; 308:343-54. PubMed
  • Murchison ND, Price BA, Conner DA, Keene DR, Olson EN, Tabin CJ, Schweitzer R. Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development 2007; 134:2697-708. PubMed
  • Pryce BA, Brent AE, Murchison ND, Tabin CJ, Schweitzer R. Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene. Dev Dyn 2007; 236:1677-82. PubMed
  • Tabin CJ. The key to left-right asymmetry. Cell 2006; 127:27-32. PubMed
  • Rivera-Feliciano J, Lee KH, Kong SW, Rajagopal S, Ma Q, Springer Z, Izumo S, Tabin CJ, Pu WT. Development of heart valves requires Gata4 expression in endothelial-derived cells. Development 2006; 133:3607-18. PubMed
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