Daniel B. Kopans, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-3093
Fax: (617) 726-1074


kopans.daniel@mgh.harvard.edu

Daniel B. Kopans, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Radiology, Harvard Medical School
  • Professor of Radiology and Senior Radiologist Breast Imaging Division, Radiology - Breast Imaging, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our research interests involve all aspects of breast cancer detection and diagnosis. We are presently working with digital mammography to develop digital tomosynthesis. We also have active research in magnetic resonance imaging of the breast as well as developing models of tumor growth and spread as this applies to early detection using screening.

Publications

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  • Vedantham S, Karellas A, Vijayaraghavan GR, Kopans DB. Digital Breast Tomosynthesis: State of the Art. Radiology 2015; 277:663-84. PubMed
  • Kopans DB. The Faulty Analysis of Breast Cancer Screening Data. Acad Radiol 2015. PubMed
  • Kopans DB. "Off Label" Use of FDA-Approved Devices and Digital Breast Tomosynthesis. AJR Am J Roentgenol 2015; 205:1149-51. PubMed
  • Kopans DB. The UK Age Trial: screening women in their forties. Lancet Oncol. 2015; 16:1012-3. PubMed
  • Kopans DB. An open letter to panels that are deciding guidelines for breast cancer screening. Breast Cancer Res Treat 2015; 151:19-25. PubMed
  • Kopans DB. Reply to "Tomosynthesis assisting in localization of breast lesions for ultrasound targeting seen on one mammographic view only". AJR Am J Roentgenol 2014; 203:W556. PubMed
  • Kopans DB, Webb ML, Cady B. The 20-year effort to reduce access to mammography screening: historical facts dispute a commentary in Cancer. Cancer 2014. PubMed
  • Webb ML, Cady B, Michaelson JS, Bush DM, Calvillo KZ, Kopans DB, Smith BL. A failure analysis of invasive breast cancer: most deaths from disease occur in women not regularly screened. Cancer 2014. PubMed
  • Kopans DB. A new era in mammography screening. Radiology 2014; 271:629-31. PubMed
  • Kopans DB. Arguments against mammography screening continue to be based on faulty science. Oncologist 2014; 19:107-12. PubMed
  • Kopans DB. Study "guesstimated" how many cancers would have occurred without mammography screening. BMJ 2014; 349:g6824. PubMed
  • Kopans DB. Point: The New England Journal of Medicine article suggesting overdiagnosis from mammography screening is scientifically incorrect and should be withdrawn. J Am Coll Radiol 2013. PubMed
  • Kopans DB. Response to Dr Seidenwurm's Comments. J Am Coll Radiol 2013. PubMed
  • Gupta S, Vij A, Cafiero E, Bloom D, Agarwal S, Donelan K, Kopans D, Saini S. Retail venue based screening mammography: assessment of women's preferences. Acad Radiol 2012; 19:1268-72. PubMed
  • Kopans DB. Do not jump too quickly to conclusions. Breast Cancer Res 2014; 14:108. PubMed
  • Fang Q, Selb J, Carp SA, Boverman G, Miller EL, Brooks DH, Moore RH, Kopans DB, Boas DA. Combined optical and X-ray tomosynthesis breast imaging. Radiology 2010; 258:89-97. PubMed
  • Kopans DB. Screening for breast cancer among women in their 40s. Lancet Oncol 2010; 11:1108-9. PubMed
  • Kopans DB. The U.S. Preventive Services Task Force guidelines are not supported by the scientific evidence. Radiology 2010; 257:294-5; author reply 295. PubMed
  • Kopans DB. The 2009 US Preventive Services Task Force (USPSTF) guidelines are not supported by science: the scientific support for mammography screening. Radiol Clin North Am 2010; 48:843-57. PubMed
  • Kopans DB. The 2009 U.S. Preventive Services Task Force guidelines ignore important scientific evidence and should be revised or withdrawn. Radiology 2010; 256:15-20. PubMed
  • Kopans DB. Re: "Quality of life and diagnostic imaging outcomes". J Am Coll Radiol 2010; 7:546; author reply 546-7. PubMed
  • Chan HP, Wu YT, Sahiner B, Wei J, Helvie MA, Zhang Y, Moore RH, Kopans DB, Hadjiiski L, Way T. Characterization of masses in digital breast tomosynthesis: comparison of machine learning in projection views and reconstructed slices. Med Phys 2010; 37:3576-86. PubMed
  • Kopans DB. Re: "Saving lives: mammograms, breast cancer, and health insurance reform". J Am Coll Radiol 2010; 7:545; author reply 545-6. PubMed
  • Kopans DB. The recent US preventive services task force guidelines are not supported by the scientific evidence and should be rescinded. J Am Coll Radiol 2010; 7:260-4. PubMed
  • Lee JM, McMahon PM, Kong CY, Kopans DB, Ryan PD, Ozanne EM, Halpern EF, Gazelle GS. Cost-effectiveness of breast MR imaging and screen-film mammography for screening BRCA1 gene mutation carriers. Radiology 2010; 254:793-800. PubMed
  • Kopans DB. Mammography: yet another challenge. Radiology 2009; 253:587-9. PubMed
  • Sidky EY, Pan X, Reiser IS, Nishikawa RM, Moore RH, Kopans DB. Enhanced imaging of microcalcifications in digital breast tomosynthesis through improved image-reconstruction algorithms. Med Phys 2009; 36:4920-32. PubMed
  • Fang Q,Carp SA,Selb J,Boverman G,Zhang Q,Kopans DB,Moore RH,Miller EL,Brooks DH,Boas DA. Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression. IEEE Trans Med Imaging 2009; 28:30-42. PubMed
  • Schwartz GF,Hughes KS,Lynch HT,Fabian CJ,Fentiman IS,Robson ME,Domchek SM,Hartmann LC,Holland R,Winchester DJ,Anderson BO,Arun BK,Bartelink H,Bernard P,Bonanni B,Cady B,Clough KB,Feig SA,Heywang-Kobrunner SH,Howell A,Isaacs C,Kopans DB,Mansel RE,Masood S,Palazzo JP,Pressman PI,Solin LJ,Untch M. Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007. Breast J 2009; 15:4-16. PubMed
  • Kao TJ,Boverman G,Kim BS,Isaacson D,Saulnier GJ,Newell JC,Choi MH,Moore RH,Kopans DB. Regional admittivity spectra with tomosynthesis images for breast cancer detection: preliminary patient study. IEEE Trans Med Imaging 2008; 27:1762-8. PubMed
  • Kopans DB,Rusby JE. Cutaneous caves and subcutaneous adipose columns in the breast: radiologic-pathologic correlation. Radiology 2008; 249:779-84. PubMed
  • Murphy CD,Lee JM,Drohan B,Euhus DM,Kopans DB,Gadd MA,Rafferty EA,Specht MC,Smith BL,Hughes KS. The American Cancer Society guidelines for breast screening with magnetic resonance imaging: an argument for genetic testing. Cancer 2008; 113:3116-20. PubMed
  • Kopans DB. The science is needed. Radiology 2008; 249:719; author reply 719-20. PubMed
  • Chan HP,Wei J,Zhang Y,Helvie MA,Moore RH,Sahiner B,Hadjiiski L,Kopans DB. Computer-aided detection of masses in digital tomosynthesis mammography: comparison of three approaches. Med Phys 2008; 35:4087-95. PubMed
  • Kopans DB. LCIS found at core needle biopsy may not need surgical excision. AJR Am J Roentgenol 2008; 191:W152; author reply W153. PubMed
  • Lee JM,Georgian-Smith D,Gazelle GS,Halpern EF,Rafferty EA,Moore RH,Yeh ED,D'Alessandro HA,Hitt RA,Kopans DB. Detecting nonpalpable recurrent breast cancer: the role of routine mammographic screening of transverse rectus abdominis myocutaneous flap reconstructions. Radiology 2008; 248:398-405. PubMed
  • Kopans DB,Pisano ED,Acharyya S,Hendrick RE,Yaffe MJ,Conant EF,Fajardo LL,Bassett LW,Baum JK,Gatsonis CA. DMIST results: technologic or observer variability? Radiology 2008; 248:703; author reply 703. PubMed
  • Lee JM, Kopans DB, McMahon PM, Halpern EF, Ryan PD, Weinstein MC, Gazelle GS. Breast cancer screening in BRCA1 mutation carriers: effectiveness of MR imaging--Markov Monte Carlo decision analysis. Radiology 2008; 246:763-71. PubMed
  • Kopans DB. Basic physics and doubts about relationship between mammographically determined tissue density and breast cancer risk. Radiology 2008; 246:348-53. PubMed
  • Kopans DB. History repeats. Radiology 2008; 246:645; author reply 645-6. PubMed
  • Kopans DB. Screening mammography for women age 40 to 49 years. Ann Intern Med 2007; 147:740-1; author reply 741. PubMed
  • Georgian-Smith D, Moore RH, Halpern E, Yeh ED, Rafferty EA, D'Alessandro HA, Staffa M, Hall DA, McCarthy KA, Kopans DB. Blinded comparison of computer-aided detection with human second reading in screening mammography. AJR Am J Roentgenol 2007; 189:1135-41. PubMed
  • Boverman G, Fang Q, Carp SA, Miller EL, Brooks DH, Selb J, Moore RH, Kopans DB, Boas DA. Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography. Phys Med Biol 2007; 52:3619-41. PubMed
  • Dominguez FJ, Lawrence C, Halpern EF, Drohan B, Grinstein G, Black DM, Smith BL, Gadd MA, Specht M, Kopans DB, Moore RH, Hughes SS, Roche CA, Hughes KS. Accuracy of Self-Reported Personal History of Cancer in an Outpatient Breast Center. J Genet Couns 2007; 16:341-5. PubMed
  • Kopans DB. Mammographic breast density. N Engl J Med 2007; 356:1885-7; author reply 1885. PubMed
  • del Carmen MG, Halpern EF, Kopans DB, Moy B, Moore RH, Goss PE, Hughes KS. Mammographic breast density and race. AJR Am J Roentgenol 2007; 188:1147-50. PubMed
  • Blanchard K, Colbert JA, Kopans DB, Moore R, Halpern EF, Hughes KS, Smith BL, Tanabe KK, Michaelson JS. Long-term risk of false-positive screening results and subsequent biopsy as a function of mammography use. Radiology 2006; 240:335-42. PubMed
  • Wu T, Moore RH, Kopans DB. Voting strategy for artifact reduction in digital breast tomosynthesis. Med Phys 2006; 33:2461-71. PubMed
  • Kopans DB. The effect of changes in tumor size on breast carcinoma survival in the U.S.: 1975-1999. Cancer 2006; 106:1863; author reply 1864. PubMed
  • Reiser I, Nishikawa RM, Giger ML, Wu T, Rafferty EA, Moore R, Kopans DB. Computerized mass detection for digital breast tomosynthesis directly from the projection images. Med Phys 2006; 33:482-91. PubMed
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