Daniel B. Kopans, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-3093
Fax: (617) 726-1074


kopans.daniel@mgh.harvard.edu

Daniel B. Kopans, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Radiology, Harvard Medical School
  • Director, Breast Imaging, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our research interests involve all aspects of breast cancer detection and diagnosis. We are presently working with digital mammography to develop digital tomosynthesis. We also have active research in magnetic resonance imaging of the breast as well as developing models of tumor growth and spread as this applies to early detection using screening.

Publications

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  • Kopans DB, Webb ML, Cady B. The 20-year effort to reduce access to mammography screening: Historical facts dispute a commentary in Cancer. Cancer 2014. PubMed
  • Kopans DB. A new era in mammography screening. Radiology 2014; 271:629-31. PubMed
  • Kopans DB. Arguments against mammography screening continue to be based on faulty science. Oncologist 2014; 19:107-12. PubMed
  • Webb ML, Cady B, Michaelson JS, Bush DM, Calvillo KZ, Kopans DB, Smith BL. A failure analysis of invasive breast cancer: Most deaths from disease occur in women not regularly screened. Cancer 2013. PubMed
  • Kopans DB. Response to Dr Seidenwurm's Comments. J Am Coll Radiol 2013. PubMed
  • Kopans DB. Point: The New England Journal of Medicine Article Suggesting Overdiagnosis From Mammography Screening Is Scientifically Incorrect and Should Be Withdrawn. J Am Coll Radiol 2013. PubMed
  • Gupta S, Vij A, Cafiero E, Bloom D, Agarwal S, Donelan K, Kopans D, Saini S. Retail venue based screening mammography: assessment of women's preferences. Acad Radiol 2012; 19:1268-72. PubMed
  • Kopans DB. Do not jump too quickly to conclusions. Breast Cancer Res 2012; 14:108. PubMed
  • Fang Q, Selb J, Carp SA, Boverman G, Miller EL, Brooks DH, Moore RH, Kopans DB, Boas DA. Combined optical and X-ray tomosynthesis breast imaging. Radiology 2010; 258:89-97. PubMed
  • Kopans DB. Screening for breast cancer among women in their 40s. Lancet Oncol 2010; 11:1108-9. PubMed
  • Kopans DB. The U.S. Preventive Services Task Force guidelines are not supported by the scientific evidence. Radiology 2010; 257:294-5; author reply 295. PubMed
  • Kopans DB. The 2009 US Preventive Services Task Force (USPSTF) guidelines are not supported by science: the scientific support for mammography screening. Radiol Clin North Am 2010; 48:843-57. PubMed
  • Kopans DB. The 2009 U.S. Preventive Services Task Force guidelines ignore important scientific evidence and should be revised or withdrawn. Radiology 2010; 256:15-20. PubMed
  • Kopans DB. Re: "Saving lives: mammograms, breast cancer, and health insurance reform". J Am Coll Radiol 2010; 7:545; author reply 545-6. PubMed
  • Kopans DB. Re: "Quality of life and diagnostic imaging outcomes". J Am Coll Radiol 2010; 7:546; author reply 546-7. PubMed
  • Chan HP, Wu YT, Sahiner B, Wei J, Helvie MA, Zhang Y, Moore RH, Kopans DB, Hadjiiski L, Way T. Characterization of masses in digital breast tomosynthesis: comparison of machine learning in projection views and reconstructed slices. Med Phys 2010; 37:3576-86. PubMed
  • Kopans DB. The recent US preventive services task force guidelines are not supported by the scientific evidence and should be rescinded. J Am Coll Radiol 2010; 7:260-4. PubMed
  • Lee JM, McMahon PM, Kong CY, Kopans DB, Ryan PD, Ozanne EM, Halpern EF, Gazelle GS. Cost-effectiveness of breast MR imaging and screen-film mammography for screening BRCA1 gene mutation carriers. Radiology 2010; 254:793-800. PubMed
  • Kopans DB. Mammography: yet another challenge. Radiology 2009; 253:587-9. PubMed
  • Sidky EY, Pan X, Reiser IS, Nishikawa RM, Moore RH, Kopans DB. Enhanced imaging of microcalcifications in digital breast tomosynthesis through improved image-reconstruction algorithms. Med Phys 2009; 36:4920-32. PubMed
  • Fang Q,Carp SA,Selb J,Boverman G,Zhang Q,Kopans DB,Moore RH,Miller EL,Brooks DH,Boas DA. Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression. IEEE Trans Med Imaging 2009; 28:30-42. PubMed
  • Schwartz GF,Hughes KS,Lynch HT,Fabian CJ,Fentiman IS,Robson ME,Domchek SM,Hartmann LC,Holland R,Winchester DJ,Anderson BO,Arun BK,Bartelink H,Bernard P,Bonanni B,Cady B,Clough KB,Feig SA,Heywang-Kobrunner SH,Howell A,Isaacs C,Kopans DB,Mansel RE,Masood S,Palazzo JP,Pressman PI,Solin LJ,Untch M. Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007. Breast J 2009; 15:4-16. PubMed
  • Murphy CD,Lee JM,Drohan B,Euhus DM,Kopans DB,Gadd MA,Rafferty EA,Specht MC,Smith BL,Hughes KS. The American Cancer Society guidelines for breast screening with magnetic resonance imaging: an argument for genetic testing. Cancer 2008; 113:3116-20. PubMed
  • Kao TJ,Boverman G,Kim BS,Isaacson D,Saulnier GJ,Newell JC,Choi MH,Moore RH,Kopans DB. Regional admittivity spectra with tomosynthesis images for breast cancer detection: preliminary patient study. IEEE Trans Med Imaging 2008; 27:1762-8. PubMed
  • Kopans DB,Rusby JE. Cutaneous caves and subcutaneous adipose columns in the breast: radiologic-pathologic correlation. Radiology 2008; 249:779-84. PubMed
  • Kopans DB. The science is needed. Radiology 2008; 249:719; author reply 719-20. PubMed
  • Kopans DB. LCIS found at core needle biopsy may not need surgical excision. AJR Am J Roentgenol 2008; 191:W152; author reply W153. PubMed
  • Chan HP,Wei J,Zhang Y,Helvie MA,Moore RH,Sahiner B,Hadjiiski L,Kopans DB. Computer-aided detection of masses in digital tomosynthesis mammography: comparison of three approaches. Med Phys 2008; 35:4087-95. PubMed
  • Kopans DB,Pisano ED,Acharyya S,Hendrick RE,Yaffe MJ,Conant EF,Fajardo LL,Bassett LW,Baum JK,Gatsonis CA. DMIST results: technologic or observer variability? Radiology 2008; 248:703; author reply 703. PubMed
  • Lee JM,Georgian-Smith D,Gazelle GS,Halpern EF,Rafferty EA,Moore RH,Yeh ED,D'Alessandro HA,Hitt RA,Kopans DB. Detecting nonpalpable recurrent breast cancer: the role of routine mammographic screening of transverse rectus abdominis myocutaneous flap reconstructions. Radiology 2008; 248:398-405. PubMed
  • Lee JM, Kopans DB, McMahon PM, Halpern EF, Ryan PD, Weinstein MC, Gazelle GS. Breast cancer screening in BRCA1 mutation carriers: effectiveness of MR imaging--Markov Monte Carlo decision analysis. Radiology 2008; 246:763-71. PubMed
  • Kopans DB. Basic physics and doubts about relationship between mammographically determined tissue density and breast cancer risk. Radiology 2008; 246:348-53. PubMed
  • Kopans DB. History repeats. Radiology 2008; 246:645; author reply 645-6. PubMed
  • Kopans DB. Screening mammography for women age 40 to 49 years. Ann Intern Med 2007; 147:740-1; author reply 741. PubMed
  • Georgian-Smith D, Moore RH, Halpern E, Yeh ED, Rafferty EA, D'Alessandro HA, Staffa M, Hall DA, McCarthy KA, Kopans DB. Blinded comparison of computer-aided detection with human second reading in screening mammography. AJR Am J Roentgenol 2007; 189:1135-41. PubMed
  • Boverman G, Fang Q, Carp SA, Miller EL, Brooks DH, Selb J, Moore RH, Kopans DB, Boas DA. Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography. Phys Med Biol 2007; 52:3619-41. PubMed
  • Dominguez FJ, Lawrence C, Halpern EF, Drohan B, Grinstein G, Black DM, Smith BL, Gadd MA, Specht M, Kopans DB, Moore RH, Hughes SS, Roche CA, Hughes KS. Accuracy of Self-Reported Personal History of Cancer in an Outpatient Breast Center. J Genet Couns 2007; 16:341-5. PubMed
  • Kopans DB. Mammographic breast density. N Engl J Med 2007; 356:1885-7; author reply 1885. PubMed
  • del Carmen MG, Halpern EF, Kopans DB, Moy B, Moore RH, Goss PE, Hughes KS. Mammographic breast density and race. AJR Am J Roentgenol 2007; 188:1147-50. PubMed
  • Blanchard K, Colbert JA, Kopans DB, Moore R, Halpern EF, Hughes KS, Smith BL, Tanabe KK, Michaelson JS. Long-term risk of false-positive screening results and subsequent biopsy as a function of mammography use. Radiology 2006; 240:335-42. PubMed
  • Wu T, Moore RH, Kopans DB. Voting strategy for artifact reduction in digital breast tomosynthesis. Med Phys 2006; 33:2461-71. PubMed
  • Kopans DB. The effect of changes in tumor size on breast carcinoma survival in the U.S.: 1975-1999. Cancer 2006; 106:1863; author reply 1864. PubMed
  • Reiser I, Nishikawa RM, Giger ML, Wu T, Rafferty EA, Moore R, Kopans DB. Computerized mass detection for digital breast tomosynthesis directly from the projection images. Med Phys 2006; 33:482-91. PubMed
  • Kopans DB. Mammography screening is saving thousands of lives, but will it survive medical malpractice? Radiology 2003; 230:20-4. PubMed
  • Kopans DB. What is wrong with this picture? Screening mammography. AJR Am J Roentgenol 2003; 181:1429. PubMed
  • Kopans DB. Breast imaging and the symptomatic patient: enough with the "diagnostic" mammography. AJR Am J Roentgenol 2003; 181:1423; author reply 1423-4. PubMed
  • Kopans DB. Breast sonographic screening is not ready for prime time. AJR Am J Roentgenol 2003; 181:1426-7; author reply 1427. PubMed
  • Kopans DB, Monsees B, Feig SA. Screening for cancer: when is it valid?--Lessons from the mammography experience. Radiology 2003; 229:319-27. PubMed
  • Cheng X, Mao JM, Bush R, Kopans DB, Moore RH, Chorlton M. Breast cancer detection by mapping hemoglobin concentration and oxygen saturation. Appl Opt 2003; 42:6412-21. PubMed
  • Li A, Miller EL, Kilmer ME, Brukilacchio TJ, Chaves T, Stott J, Zhang Q, Wu T, Chorlton M, Moore RH, Kopans DB, Boas DA. Tomographic optical breast imaging guided by three-dimensional mammography. Appl Opt 2003; 42:5181-90. PubMed
  • Kopans DB. Mammographic screening for breast cancer. N Engl J Med 2003; 349:610-2; author reply 610-2. PubMed
  • Kopans DB. Older is better. AJR Am J Roentgenol 2003; 181:593; author reply 593-4. PubMed
  • Delille JP, Slanetz PJ, Yeh ED, Halpern EF, Kopans DB, Garrido L. Invasive ductal breast carcinoma response to neoadjuvant chemotherapy: noninvasive monitoring with functional MR imaging pilot study. Radiology 2003; 228:63-9. PubMed
  • Kopans DB, Rafferty E, Georgian-Smith D, Yeh E, D'Alessandro H, Moore R, Hughes K, Halpern E. A simple model of breast carcinoma growth may provide explanations for observations of apparently complex phenomena. Cancer 2003; 97:2951-9. PubMed
  • Kopans DB. Re: Association of volume and volume-independent factors with accuracy in screening mammogram interpretation. J Natl Cancer Inst 2003; 95:758-9. PubMed
  • Talele AC, Slanetz PJ, Edmister WB, Yeh ED, Kopans DB. The lactating breast: MRI findings and literature review. Breast J 2003; 9:237-40. PubMed
  • Kopans DB. Effectiveness of US breast cancer screening remains to be demonstrated. Radiology 2003; 227:606; author reply 608-9. PubMed
  • Kopans DB. Gene-expression signatures in breast cancer. N Engl J Med 2003; 348:1715-7; author reply 1715. PubMed
  • Kopans DB. Breast cancer screening. Ann Intern Med 2003; 138:690; author reply 690. PubMed
  • Kopans DB. Re: Detection of ductal carcinoma in situ in women undergoing screening mammography. J Natl Cancer Inst 2003; 95:487; author reply 487-8. PubMed
  • Wu T, Stewart A, Stanton M, McCauley T, Phillips W, Kopans DB, Moore RH, Eberhard JW, Opsahl-Ong B, Niklason L, Williams MB. Tomographic mammography using a limited number of low-dose cone-beam projection images. Med Phys 2003; 30:365-80. PubMed
  • Kopans DB. Another view of mammography and beyond. AJR Am J Roentgenol 2003; 180:860; author reply 860. PubMed
  • Yeh ED, Slanetz PJ, Edmister WB, Talele A, Monticciolo D, Kopans DB. Invasive lobular carcinoma: spectrum of enhancement and morphology on magnetic resonance imaging. Breast J 2003; 9:13-8. PubMed
  • Kopans DB. The most recent breast cancer screening controversy about whether mammographic screening benefits women at any age: nonsense and nonscience. AJR Am J Roentgenol 2002; 180:21-6. PubMed
  • Moy L, Slanetz PJ, Moore R, Satija S, Yeh ED, McCarthy KA, Hall D, Staffa M, Rafferty EA, Halpern E, Kopans DB. Specificity of mammography and US in the evaluation of a palpable abnormality: retrospective review. Radiology 2002; 225:176-81. PubMed
  • Michaelson JS, Silverstein M, Wyatt J, Weber G, Moore R, Halpern E, Kopans DB, Hughes K. Predicting the survival of patients with breast carcinoma using tumor size. Cancer 2002; 95:713-23. PubMed
  • Kopans DB, Halpern E. Re: All-cause mortality in randomized trials of cancer screening. J Natl Cancer Inst 2002; 94:863; author reply 865-6. PubMed
  • Slanetz PJ, Edmister WB, Yeh ED, Talele AC, Kopans DB. Occult contralateral breast carcinoma incidentally detected by breast magnetic resonance imaging. Breast J 2002; 8:145-8. PubMed
  • Delille JP, Slanetz PJ, Yeh ED, Kopans DB, Garrido L. Breast cancer: regional blood flow and blood volume measured with magnetic susceptibility-based MR imaging--initial results. Radiology 2002; 223:558-65. PubMed
  • Kopans DB. Negative mammographic and US findings do not help exclude breast cancer. Radiology 2002; 222:857-8; author reply 858-9. PubMed
  • Kopans DB, Monsees B, Smith R, Feig S. Ten criteria for effective screening. AJR Am J Roentgenol 2002; 178:508-10. PubMed
  • Kopans DB. Beyond randomized controlled trials: organized mammographic screening substantially reduces breast carcinoma mortality. Cancer 2002; 94:580-1; author reply 581-3. PubMed
  • Michaelson J, Satija S, Moore R, Weber G, Halpern E, Garland A, Puri D, Kopans DB. The pattern of breast cancer screening utilization and its consequences. Cancer 2002; 94:37-43. PubMed
  • Slanetz PJ, Giardino AA, Oyama T, Koerner FC, Halpern EF, Moore RH, Kopans DB. Mammographic appearance of ductal carcinoma in situ does not reliably predict histologic subtype. Breast J 2002; 7:417-21. PubMed
  • Warren Burhenne LJ, Wood SA, D'Orsi CJ, Feig SA, Kopans DB, O'Shaughnessy KF, Sickles EA, Tabar L, Vyborny CJ, Castellino RA. Potential contribution of computer-aided detection to the sensitivity of screening mammography. Radiology 2000; 215:554-62. PubMed
  • Niklason LT, Christian BT, Niklason LE, Kopans DB, Castleberry DE, Opsahl-Ong BH, Landberg CE, Slanetz PJ, Giardino AA, Moore R, Albagli D, DeJule MC, Fitzgerald PF, Fobare DF, Giambattista BW, Kwasnick RF, Liu J, Lubowski SJ, Possin GE, Richotte JF, Wei CY, Wirth RF. Digital tomosynthesis in breast imaging. Radiology 1997; 205:399-406. PubMed
  • Kopans DB, Moore RH, McCarthy KA, Hall DA, Hulka CA, Whitman GJ, Slanetz PJ, Halpern EF. Should women with implants or a history of treatment for breast cancer be excluded from mammography screening programs? AJR Am J Roentgenol 1997; 168:29-31. PubMed
  • Kopans DB, Moore RH, McCarthy KA, Hall DA, Hulka CA, Whitman GJ, Slanetz PJ, Halpern EF. Positive predictive value of breast biopsy performed as a result of mammography: there is no abrupt change at age 50 years. Radiology 1996; 200:357-60. PubMed
  • Hulka CA, Smith BL, Sgroi DC, Tan L, Edmister WB, Semple JP, Campbell T, Kopans DB, Brady TJ, Weisskoff RM. Benign and malignant breast lesions: differentiation with echo-planar MR imaging. Radiology 1995; 197:33-8. PubMed
  • Kopans DB, Halpern E, Hulka CA. Statistical power in breast cancer screening trials and mortality reduction among women 40-49 years of age with particular emphasis on the National Breast Screening Study of Canada. Cancer 1994; 74:1196-203. PubMed
  • Kopans DB, Feig SA. The Canadian National Breast Screening Study: a critical review. AJR Am J Roentgenol 1993; 161:755-60. PubMed
  • Stacey-Clear A, McCarthy KA, Hall DA, Pile-Spellman E, White G, Hulka C, Whitman GJ, Mahoney E, Kopans DB. Breast cancer survival among women under age 50: is mammography detrimental? Lancet 1992; 340:991-4. PubMed
  • Kopans DB. The positive predictive value of mammography. AJR Am J Roentgenol 1992; 158:521-6. PubMed
  • Kopans DB. Standardized mammography reporting. Radiol Clin North Am 1992; 30:257-64. PubMed
  • Baines CJ, Miller AB, Kopans DB, Moskowitz M, Sanders DE, Sickles EA, To T, Wall C. Canadian National Breast Screening Study: assessment of technical quality by external review. AJR Am J Roentgenol 1990; 155:743-7; discussion 748-9. PubMed
  • Bright RA, Morrison AS, Brisson J, Burstein NA, Sadowsky NL, Kopans DB, Meyer JE. Histologic and mammographic specificity of risk factors for benign breast disease. Cancer 1989; 64:653-7. PubMed
  • Robertson CL, Kopans DB. Communication problems after mammographic screening. Radiology 1989; 172:443-4. PubMed
  • Kopans DB, Swann CA, White G, McCarthy KA, Hall DA, Belmonte SJ, Gallagher W. Asymmetric breast tissue. Radiology 1989; 171:639-43. PubMed
  • Kopans DB, Meyer JE, Lindfors KK. Whole-breast US imaging: four-year follow-up. Radiology 1985; 157:505-7. PubMed
  • Kopans DB, Lindfors K, McCarthy KA, Meyer JE. Spring hookwire breast lesion localizer: use with rigid-compression mammographic systems. Radiology 1985; 157:537-8. PubMed
  • Kopans DB, Meyer JE, Sadowsky N. Breast imaging. N Engl J Med 1984; 310:960-7. PubMed
  • Meyer JE, Kopans DB, Stomper PC, Lindfors KK. Occult breast abnormalities: percutaneous preoperative needle localization. Radiology 1984; 150:335-7. PubMed
  • Kopans DB, Meyer JE, Cohen AM, Wood WC. Palpable breast masses. The importance of preoperative mammography. JAMA 1981; 246:2819-22. PubMed
  • Kopans DB, DeLuca S. A modified needle-hookwire technique to simplify preoperative localization of occult breast lesions. Radiology 1980; 134:781. PubMed
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