David A. Boas, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-0130
Fax: (617) 726-7422


dboas@nmr.mgh.harvard.edu

David A. Boas, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Radiology, Harvard Medical School
  • Assistant Physicist, NMR Center, Massachusetts General Hospital

Research Abstract

Our current research interests are in bio-optics where various light scattering techniques and spectroscopies are used to probe biological systems. We are currently developing static and dynamic light scattering methods to look inside materials that multiply scatter light. Examples of such materials include tissue, colloids, emulsions, and foams. We are developing algorithms to reconstruct images of the optical and dynamical properties of these opaque materials on different lenght scales. This imaging modality, known as diffuse optical tomography (DOT ), may be used in medicine for optical mammography, hopital bedsidd monitoring of brain heamtomas, diagnosis of ischemic versus bleeding strokes, imaging of tissue blood oxygen saturation and flow, and identification of cancerous lesions. An exciting new application of DOT is the study of brain function.

Publications

Powered by Harvard Catalyst
  • Carp SA, Sajjadi AY, Wanyo CM, Fang Q, Specht MC, Schapira L, Moy B, Bardia A, Boas DA, Isakoff SJ. Hemodynamic signature of breast cancer under fractional mammographic compression using a dynamic diffuse optical tomography system. Biomed Opt Express 2014; 4:2911-24. PubMed
  • Fang Q, Selb J, Carp SA, Boverman G, Miller EL, Brooks DH, Moore RH, Kopans DB, Boas DA. Combined optical and X-ray tomosynthesis breast imaging. Radiology 2010; 258:89-97. PubMed
  • Sakadzić S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Devor A, Lo EH, Vinogradov SA, Boas DA. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods 2010; 7:755-9. PubMed
  • Tian P, Teng IC, May LD, Kurz R, Lu K, Scadeng M, Hillman EM, De Crespigny AJ, D'Arceuil HE, Mandeville JB, Marota JJ, Rosen BR, Liu TT, Boas DA, Buxton RB, Dale AM, Devor A. Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal. Proc Natl Acad Sci U S A 2010; 107:15246-51. PubMed
  • Fang Q, Boas DA. Monte Carlo simulation of photon migration in 3D turbid media accelerated by graphics processing units. Opt Express 2009; 17:20178-90. PubMed
  • Kumar AT, Chung E, Raymond SB, van de Water JA, Shah K, Fukumura D, Jain RK, Bacskai BJ, Boas DA. Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast. Opt Lett 2009; 34:2066-8. PubMed
  • Fang Q,Carp SA,Selb J,Boverman G,Zhang Q,Kopans DB,Moore RH,Miller EL,Brooks DH,Boas DA. Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression. IEEE Trans Med Imaging 2009; 28:30-42. PubMed
  • Devor A,Hillman EM,Tian P,Waeber C,Teng IC,Ruvinskaya L,Shalinsky MH,Zhu H,Haslinger RH,Narayanan SN,Ulbert I,Dunn AK,Lo EH,Rosen BR,Dale AM,Kleinfeld D,Boas DA. Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex. J Neurosci 2009; 28:14347-57. PubMed
  • Becerra L, Harris W, Joseph D, Huppert T, Boas DA, Borsook D. Diffuse optical tomography of pain and tactile stimulation: Activation in cortical sensory and emotional systems. Neuroimage 2008; 41:252-9. PubMed
  • Franceschini MA, Nissila I, Wu W, Diamond SG, Bonmassar G, Boas DA. Coupling between somatosensory evoked potentials and hemodynamic response in the rat. Neuroimage 2008; 41:189-203. PubMed
  • Wilcox T, Bortfeld H, Woods R, Wruck E, Boas DA. Hemodynamic response to featural changes in the occipital and inferior temporal cortex in infants: a preliminary methodological exploration. Dev Sci 2008; 11:361-70. PubMed
  • Shin HK, Nishimura M, Jones PB, Ay H, Boas DA, Moskowitz MA, Ayata C. Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemia. Stroke 2008; 39:1548-55. PubMed
  • Boas DA, Jones SR, Devor A, Huppert TJ, Dale AM. A vascular anatomical network model of the spatio-temporal response to brain activation. Neuroimage 2008; 40:1116-29. PubMed
  • Kumar AT, Raymond SB, Bacskai BJ, Boas DA. Comparison of frequency-domain and time-domain fluorescence lifetime tomography. Opt Lett 2008; 33:470-2. PubMed
  • Chen HC, Vaid J, Bortfeld H, Boas DA. Optical imaging of phonological processing in two distinct orthographies. Exp Brain Res 2007; 184:427-33. PubMed
  • Boverman G, Fang Q, Carp SA, Miller EL, Brooks DH, Selb J, Moore RH, Kopans DB, Boas DA. Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography. Phys Med Biol 2007; 52:3619-41. PubMed
  • Shin HK, Dunn AK, Jones PB, Boas DA, Lo EH, Moskowitz MA, Ayata C. Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia. Brain 2007; 130:1631-42. PubMed
  • Huppert TJ, Allen MS, Benav H, Jones PB, Boas DA. A multicompartment vascular model for inferring baseline and functional changes in cerebral oxygen metabolism and arterial dilation. J Cereb Blood Flow Metab 2007; 27:1262-79. PubMed
  • Raymond SB, Boas DA, Bacskai BJ, Kumar AT. Lifetime-based tomographic multiplexing. J Biomed Opt 2010; 15:046011. PubMed
  • Boas DA, Dunn AK. Laser speckle contrast imaging in biomedical optics. J Biomed Opt 2010; 15:011109. PubMed
  • Liu H, Boas DA, Zhang Y, Yodh AG, Chance B. Determination of optical properties and blood oxygenation in tissue using continuous NIR light. Phys Med Biol 1995; 40:1983-93. PubMed
  • Boas DA, O'Leary MA, Chance B, Yodh AG. Scattering of diffuse photon density waves by spherical inhomogeneities within turbid media: analytic solution and applications. Proc Natl Acad Sci U S A 1994; 91:4887-91. PubMed
Hide