Photo of David C. Alsop,  PhD

David C. Alsop, PhD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center


dalsop@bidmc.harvard.edu

David C. Alsop, PhD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Professor, Radiology, Harvard Medical School
  • Staff Ph.D., Radiology, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research focuses on the development and application of new MRI methods for noninvasive measurement of tissue function and pathology. A particular focus is the development of blood flow imaging methods. One technique of MRI blood flow imaging, arterial spin labeling, has shown particular promise for characterizing tumor vascular supply and its changes with tumor progression or antiangiogenic therapy. With recent NIH funding in this area, we will pursue the use of ASL blood flow MRI for tumor characterization and monitoring of renal cell carcinoma and glioma.

Publications

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  • Zhang L, Wang X, Bullock AJ, Callea M, Shah H, Song J, Moreno K, Visentin B, Deutschman D, Alsop DC, Atkins MB, Mier JW, Signoretti S, Bhasin M, Sabbadini RA, Bhatt RS. Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer. Clin Cancer Res 2015. PubMed
  • Scheidegger R, Wong ET, Alsop DC. Contributors to contrast between glioma and brain tissue in chemical exchange saturation transfer sensitive imaging at 3Tesla. Neuroimage 2014. PubMed
  • Wang X, Bullock AJ, Zhang L, Wei L, Yu D, Mahagaokar K, Alsop DC, Mier JW, Atkins MB, Coxon A, Oliner J, Bhatt RS. The Role of Angiopoietins as Potential Therapeutic Targets in Renal Cell Carcinoma. Transl Oncol 2014. PubMed
  • Lennerz BS, Alsop DC, Holsen LM, Stern E, Rojas R, Ebbeling CB, Goldstein JM, Ludwig DS. Effects of dietary glycemic index on brain regions related to reward and craving in men. Am J Clin Nutr 2013; 98:641-7. PubMed
  • Wang X, Zhang L, O'Neill A, Bahamon B, Alsop DC, Mier JW, Goldberg SN, Signoretti S, Atkins MB, Wood CG, Bhatt RS. Cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts. Br J Cancer 2013; 108:319-26. PubMed
  • Grant AK, Vinogradov E, Wang X, Lenkinski RE, Alsop DC. Perfusion imaging with a freely diffusible hyperpolarized contrast agent. Magn Reson Med 2011. PubMed
  • Bhatt RS, Wang X, Zhang L, Collins MP, Signoretti S, Alsop DC, Goldberg SN, Atkins MB, Mier JW. Renal cancer resistance to antiangiogenic therapy is delayed by restoration of angiostatic signaling. Mol Cancer Ther 2010; 9:2793-802. PubMed
  • Alsop DC, Dai W, Grossman M, Detre JA. Arterial spin labeling blood flow MRI: its role in the early characterization of Alzheimer's disease. J. Alzheimers Dis. 2010; 20:871-80. PubMed
  • Dixon WT, Hancu I, Ratnakar SJ, Sherry AD, Lenkinski RE, Alsop DC. A multislice gradient echo pulse sequence for CEST imaging. Magn Reson Med 2009; 63:253-6. PubMed
  • Zaharchuk G, Bammer R, Straka M, Shankaranarayan A, Alsop DC, Fischbein NJ, Atlas SW, Moseley ME. Arterial spin-label imaging in patients with normal bolus perfusion-weighted MR imaging findings: pilot identification of the borderzone sign. Radiology 2009; 252:797-807. PubMed
  • Schor-Bardach R,Alsop DC,Pedrosa I,Solazzo SA,Wang X,Marquis RP,Atkins MB,Regan M,Signoretti S,Lenkinski RE,Goldberg SN. Does arterial spin-labeling MR imaging-measured tumor perfusion correlate with renal cell cancer response to antiangiogenic therapy in a mouse model? Radiology 2009; 251:731-42. PubMed
  • Robson PM,Madhuranthakam AJ,Dai W,Pedrosa I,Rofsky NM,Alsop DC. Strategies for reducing respiratory motion artifacts in renal perfusion imaging with arterial spin labeling. Magn Reson Med 2009; 61:1374-87. PubMed
  • Pedrosa I, Alsop DC, Rofsky NM. Magnetic resonance imaging as a biomarker in renal cell carcinoma. Cancer 2009; 115:2334-45. PubMed
  • de Bazelaire C,Alsop DC,George D,Pedrosa I,Wang Y,Michaelson MD,Rofsky NM. Magnetic resonance imaging-measured blood flow change after antiangiogenic therapy with PTK787/ZK 222584 correlates with clinical outcome in metastatic renal cell carcinoma. Clin Cancer Res 2008; 14:5548-54. PubMed
  • Wang Z, Fernandez-Seara M, Alsop DC, Liu WC, Flax JF, Benasich AA, Detre JA. Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI. Neuroimage 2007; 39:973-8. PubMed
  • Wong ET, Alsop D, Lee D, Tam A, Barron L, Bloom J, Gautam S, Wu JK. Cerebrospinal fluid matrix metalloproteinase-9 increases during treatment of recurrent malignant gliomas. Cerebrospinal Fluid Res 2008; 5:1. PubMed
  • de Bazelaire C, Rofsky NM, Duhamel G, Zhang J, Michaelson MD, George D, Alsop DC. Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement. Eur Radiol 2006; 16:2083-91. PubMed
  • Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D, Schlaug G, Northoff G. Attentional modulation of emotional stimulus processing: An fMRI study using emotional expectancy. Hum Brain Mapp 2006; 27:662-77. PubMed
  • O'gorman RL, Kumari V, Williams SC, Zelaya FO, Connor SE, Alsop DC, Gray JA. Personality factors correlate with regional cerebral perfusion. Neuroimage 2006; 31:489-95. PubMed
  • O'gorman RL, Summers PE, Zelaya FO, Williams SC, Alsop DC, Lythgoe DJ. In vivo estimation of the flow-driven adiabatic inversion efficiency for continuous arterial spin labeling: A method using phase contrast magnetic resonance angiography. Magn Reson Med 2006; 55:1291-1297. PubMed
  • Bermpohl F, Pascual-Leone A, Amedi A, Merabet LB, Fregni F, Gaab N, Alsop D, Schlaug G, Northoff G. Dissociable networks for the expectancy and perception of emotional stimuli in the human brain. Neuroimage 2005; 30:588-600. PubMed
  • Duhamel G, Schlaug G, Alsop DC. Measurement of arterial input functions for dynamic susceptibility contrast magnetic resonance imaging using echoplanar images: comparison of physical simulations with in vivo results. Magn Reson Med 2006; 55:514-23. PubMed
  • Garcia DM, Duhamel G, Alsop DC. Efficiency of inversion pulses for background suppressed arterial spin labeling. Magn Reson Med 2005; 54:366-72. PubMed
  • Koelsch S, Fritz T, Schulze K, Alsop D, Schlaug G. Adults and children processing music: an fMRI study. Neuroimage 2005; 25:1068-76. PubMed
  • Wang J, Zhang Y, Wolf RL, Roc AC, Alsop DC, Detre JA. Amplitude-modulated continuous arterial spin-labeling 3.0-T perfusion MR imaging with a single coil: feasibility study. Radiology 2005; 235:218-28. PubMed
  • De Bazelaire C, Rofsky NM, Duhamel G, Michaelson MD, George D, Alsop DC. Arterial spin labeling blood flow magnetic resonance imaging for the characterization of metastatic renal cell carcinoma(1). Acad Radiol 2005; 12:347-57. PubMed
  • Walker MP, Stickgold R, Alsop D, Gaab N, Schlaug G. Sleep-dependent motor memory plasticity in the human brain. Neuroscience 2005; 133:911-7. PubMed
  • Overy K, Norton AC, Cronin KT, Gaab N, Alsop DC, Winner E, Schlaug G. Imaging melody and rhythm processing in young children. Neuroreport 2004; 15:1723-6. PubMed
  • Ances BM, McGarvey ML, Abrahams JM, Maldjian JA, Alsop DC, Zager EL, Detre JA. Continuous arterial spin labeled perfusion magnetic resonance imaging in patients before and after carotid endarterectomy. J Neuroimaging 2004; 14:133-8. PubMed
  • de Bazelaire CM, Duhamel GD, Rofsky NM, Alsop DC. MR imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0 T: preliminary results. Radiology 2004; 230:652-9. PubMed
  • Wang J, Li L, Roc AC, Alsop DC, Tang K, Butler NS, Schnall MD, Detre JA. Reduced susceptibility effects in perfusion fMRI with single-shot spin-echo EPI acquisitions at 1.5 Tesla. Magn Reson Imaging 2004; 22:1-7. PubMed
  • Grossman M, Koenig P, DeVita C, Glosser G, Moore P, Gee J, Detre J, Alsop D. Neural basis for verb processing in Alzheimer's disease: an fMRI study. Neuropsychology 2003; 17:658-74. PubMed
  • Wang J, Alsop DC, Song HK, Maldjian JA, Tang K, Salvucci AE, Detre JA. Arterial transit time imaging with flow encoding arterial spin tagging (FEAST). Magn Reson Med 2003; 50:599-607. PubMed
  • Duhamel G, de Bazelaire C, Alsop DC. Evaluation of systematic quantification errors in velocity-selective arterial spin labeling of the brain. Magn Reson Med 2003; 50:145-53. PubMed
  • Cooke A, DeVita C, Gee J, Alsop D, Detre J, Chen W, Grossman M. Neural basis for sentence comprehension deficits in frontotemporal dementia. Brain Lang 2003; 85:211-21. PubMed
  • Takahashi M, Uematsu H, Alsop DC. [Diffusion imaging] Nippon Igaku Hoshasen Gakkai Zasshi 2003; 63:2-7. PubMed
  • Grossman M, Cooke A, DeVita C, Lee C, Alsop D, Detre J, Gee J, Chen W, Stern MB, Hurtig HI. Grammatical and resource components of sentence processing in Parkinson's disease: an fMRI study. Neurology 2003; 60:775-81. PubMed
  • Gunning-Dixon FM, Gur RC, Perkins AC, Schroeder L, Turner T, Turetsky BI, Chan RM, Loughead JW, Alsop DC, Maldjian J, Gur RE. Age-related differences in brain activation during emotional face processing. Neurobiol Aging 2002; 24:285-95. PubMed
  • Grossman M, Koenig P, Glosser G, DeVita C, Moore P, Rhee J, Detre J, Alsop D, Gee J,. Neural basis for semantic memory difficulty in Alzheimer's disease: an fMRI study. Brain 2003; 126:292-311. PubMed
  • Wolf RL, Alsop DC, McGarvey ML, Maldjian JA, Wang J, Detre JA. Susceptibility contrast and arterial spin labeled perfusion MRI in cerebrovascular disease. J Neuroimaging 2003; 13:17-27. PubMed
  • Gur RE, McGrath C, Chan RM, Schroeder L, Turner T, Turetsky BI, Kohler C, Alsop D, Maldjian J, Ragland JD, Gur RC. An fMRI study of facial emotion processing in patients with schizophrenia. Am J Psychiatry 2002; 159:1992-9. PubMed
  • Wang J, Alsop DC, Li L, Listerud J, Gonzalez-At JB, Schnall MD, Detre JA. Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla. Magn Reson Med 2002; 48:242-54. PubMed
  • Gur RC, Schroeder L, Turner T, McGrath C, Chan RM, Turetsky BI, Alsop D, Maldjian J, Gur RE. Brain activation during facial emotion processing. Neuroimage 2002; 16:651-62. PubMed
  • Grossman M, Koenig P, DeVita C, Glosser G, Alsop D, Detre J, Gee J. The neural basis for category-specific knowledge: an fMRI study. Neuroimage 2002; 15:936-48. PubMed
  • Casasanto DJ, Killgore WD, Maldjian JA, Glosser G, Alsop DC, Cooke AM, Grossman M, Detre JA. Neural correlates of successful and unsuccessful verbal memory encoding. Brain Lang 2002; 80:287-95. PubMed
  • Grossman M, Cooke A, DeVita C, Chen W, Moore P, Detre J, Alsop D, Gee J. Sentence processing strategies in healthy seniors with poor comprehension: an fMRI study. Brain Lang 2002; 80:296-313. PubMed
  • Aguirre GK, Detre JA, Zarahn E, Alsop DC. Experimental design and the relative sensitivity of BOLD and perfusion fMRI. Neuroimage 2002; 15:488-500. PubMed
  • Polk TA, Stallcup M, Aguirre GK, Alsop DC, D'Esposito M, Detre JA, Farah MJ. Neural specialization for letter recognition. J Cogn Neurosci 2002; 14:145-59. PubMed
  • Grossman M, Cooke A, DeVita C, Alsop D, Detre J, Chen W, Gee J. Age-related changes in working memory during sentence comprehension: an fMRI study. Neuroimage 2002; 15:302-17. PubMed
  • Cooke A, Zurif EB, DeVita C, Alsop D, Koenig P, Detre J, Gee J, Pin. Neural basis for sentence comprehension: grammatical and short-term memory components. Hum Brain Mapp 2002; 15:80-94. PubMed
  • Grossman M, Koenig P, DeVita C, Glosser G, Alsop D, Detre J, Gee J. Neural representation of verb meaning: an fMRI study. Hum Brain Mapp 2002; 15:124-34. PubMed
  • Alsop D. Brain activity mapping with functional MR imaging. Acad Radiol 2002; 8:1195-7. PubMed
  • De Boeck G, Alsop D, Wood C. Cortisol effects on aerobic and anaerobic metabolism, nitrogen excretion, and whole-body composition in juvenile rainbow trout. Physiol Biochem Zool 2001; 74:858-68. PubMed
  • Chalela JA, Kasner SE, McGarvey M, Alsop DC, Detre JA. Continuous arterial spin labeling perfusion magnetic resonance imaging findings in postpartum vasculopathy. J Neuroimaging 2001; 11:444-6. PubMed
  • Wolf RL, Alsop DC, Levy-Reis I, Meyer PT, Maldjian JA, Gonzalez-Atavales J, French JA, Alavi A, Detre JA. Detection of mesial temporal lobe hypoperfusion in patients with temporal lobe epilepsy by use of arterial spin labeled perfusion MR imaging. AJNR Am J Neuroradiol 2001; 22:1334-41. PubMed
  • Maldjian JA, Detre JA, Killgore WD, Judy K, Alsop D, Grossman M, Glosser G. Neuropsychologic performance after resection of an activation cluster involved in cognitive memory function. AJR Am J Roentgenol 2001; 176:541-4. PubMed
  • Levy-Reis I, Casasanto DJ, Gonzalez JB, Alsop DC, Glosser G, Maldjan JA, French J, Detre JA. Cortical reorganization in linear nevus sebaceous syndrome: a multimodality neuroimaging study. J Neuroimaging 2001; 10:225-8. PubMed
  • Gur RC, Alsop D, Glahn D, Petty R, Swanson CL, Maldjian JA, Turetsky BI, Detre JA, Gee J, Gur RE. An fMRI study of sex differences in regional activation to a verbal and a spatial task. Brain Lang 2000; 74:157-70. PubMed
  • Smith DH, Nonaka M, Miller R, Leoni M, Chen XH, Alsop D, Meaney DF. Immediate coma following inertial brain injury dependent on axonal damage in the brainstem. J Neurosurg 2000; 93:315-22. PubMed
  • Gonzalez-At JB, Alsop DC, Detre JA. Cerebral perfusion and arterial transit time changes during task activation determined with continuous arterial spin labeling. Magn Reson Med 2000; 43:739-46. PubMed
  • Rizi RR, Ahn S, Alsop DC, Garrett-Roe S, Mescher M, Richter W, Schnall MD, Leigh JS, Warren WS. Intermolecular zero-quantum coherence imaging of the human brain. Magn Reson Med 2000; 43:627-32. PubMed
  • Alsop DC, Detre JA, Grossman M. Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging. Ann Neurol 2000; 47:93-100. PubMed
  • Killgore WD, Glosser G, Casasanto DJ, French JA, Alsop DC, Detre JA. Functional MRI and the Wada test provide complementary information for predicting post-operative seizure control. Seizure 2000; 8:450-5. PubMed
  • Detre JA, Samuels OB, Alsop DC, Gonzalez-At JB, Kasner SE, Raps EC. Noninvasive magnetic resonance imaging evaluation of cerebral blood flow with acetazolamide challenge in patients with cerebrovascular stenosis. J Magn Reson Imaging 1999; 10:870-5. PubMed
  • Maldjian JA, Gottschalk A, Patel RS, Detre JA, Alsop DC. The sensory somatotopic map of the human hand demonstrated at 4 Tesla. Neuroimage 1999; 10:55-62. PubMed
  • Detre JA, Alsop DC. Perfusion magnetic resonance imaging with continuous arterial spin labeling: methods and clinical applications in the central nervous system. Eur J Radiol 1999; 30:115-24. PubMed
  • Maldjian JA, Gottschalk A, Patel RS, Pincus D, Detre JA, Alsop DC. Mapping of secondary somatosensory cortex activation induced by vibrational stimulation: an fMRI study. Brain Res 1999; 824:291-5. PubMed
  • Yousem DM, Maldjian JA, Hummel T, Alsop DC, Geckle RJ, Kraut MA, Doty RL. The effect of age on odor-stimulated functional MR imaging. AJNR Am J Neuroradiol 1999; 20:600-8. PubMed
  • Hatabu H, Alsop DC, Listerud J, Bonnet M, Gefter WB. T2* and proton density measurement of normal human lung parenchyma using submillisecond echo time gradient echo magnetic resonance imaging. Eur J Radiol 1999; 29:245-52. PubMed
  • Yousem DM, Maldjian JA, Siddiqi F, Hummel T, Alsop DC, Geckle RJ, Bilker WB, Doty RL. Gender effects on odor-stimulated functional magnetic resonance imaging. Brain Res 1999; 818:480-7. PubMed
  • Alsop DC, Detre JA. Multisection cerebral blood flow MR imaging with continuous arterial spin labeling. Radiology 1998; 208:410-6. PubMed
  • Alsop DC, Connick TJ, Mizsei G. A spiral volume coil for improved RF field homogeneity at high static magnetic field strength. Magn Reson Med 1998; 40:49-54. PubMed
  • Detre JA, Maccotta L, King D, Alsop DC, Glosser G, D'Esposito M, Zarahn E, Aguirre GK, French JA. Functional MRI lateralization of memory in temporal lobe epilepsy. Neurology 1998; 50:926-32. PubMed
  • Detre JA, Alsop DC, Vives LR, Maccotta L, Teener JW, Raps EC. Noninvasive MRI evaluation of cerebral blood flow in cerebrovascular disease. Neurology 1998; 50:633-41. PubMed
  • Alsop DC. Phase insensitive preparation of single-shot RARE: application to diffusion imaging in humans. Magn Reson Med 1997; 38:527-33. PubMed
  • Chance B, Luo Q, Nioka S, Alsop DC, Detre JA. Optical investigations of physiology: a study of intrinsic and extrinsic biomedical contrast. Philos Trans R Soc Lond B Biol Sci 1997; 352:707-16. PubMed
  • Maccotta L, Detre JA, Alsop DC. The efficiency of adiabatic inversion for perfusion imaging by arterial spin labeling. NMR Biomed 1997; 10:216-21. PubMed
  • Detre JA, Zager EL, Alsop DC, Harris VA, Welsh FA. Correlation of diffusion MRI and heat shock protein in a rat embolic stroke model. J Neurol Sci 1997; 148:163-9. PubMed
  • D'Esposito M, Detre JA, Aguirre GK, Stallcup M, Alsop DC, Tippet LJ, Farah MJ. A functional MRI study of mental image generation. Neuropsychologia 1997; 35:725-30. PubMed
  • Alsop DC. The sensitivity of low flip angle RARE imaging. Magn Reson Med 1997; 37:176-84. PubMed
  • Alsop DC, Detre JA. Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow. J Cereb Blood Flow Metab 1996; 16:1236-49. PubMed
  • Aguirre GK, Detre JA, Alsop DC, D'Esposito M. The parahippocampus subserves topographical learning in man. Cereb Cortex 1996; 6:823-9. PubMed
  • Alsop DC, Murai H, Detre JA, McIntosh TK, Smith DH. Detection of acute pathologic changes following experimental traumatic brain injury using diffusion-weighted magnetic resonance imaging. J Neurotrauma 1996; 13:515-21. PubMed
  • Alsop DC, Detre JA, D'Esposito M, Howard RS, Maldjian JA, Grossman M, Listerud J, Flamm ES, Judy KD, Atlas SW. Functional activation during an auditory comprehension task in patients with temporal lobe lesions. Neuroimage 1996; 4:55-9. PubMed
  • Detre JA, Alsop DC, Aguirre GK, Sperling MR. Coupling of cortical and thalamic ictal activity in human partial epilepsy: demonstration by functional magnetic resonance imaging. Epilepsia 1996; 37:657-61. PubMed
  • Alsop DC, Connick TJ. Optimization of torque-balanced asymmetric head gradient coils. Magn Reson Med 1996; 35:875-86. PubMed
  • Maldjian J, Atlas SW, Howard RS, Greenstein E, Alsop D, Detre JA, Listerud J, D'Esposito M, Flamm ES. Functional magnetic resonance imaging of regional brain activity in patients with intracerebral arteriovenous malformations before surgical or endovascular therapy. J Neurosurg 1996; 84:477-83. PubMed
  • Atlas SW, Howard RS, Maldjian J, Alsop D, Detre JA, Listerud J, D'Esposito M, Judy KD, Zager E, Stecker M. Functional magnetic resonance imaging of regional brain activity in patients with intracerebral gliomas: findings and implications for clinical management. Neurosurgery 1996; 38:329-38. PubMed
  • D'Esposito M, Detre JA, Alsop DC, Shin RK, Atlas S, Grossman M. The neural basis of the central executive system of working memory. Nature 1995; 378:279-81. PubMed
  • Detre JA, Sirven JI, Alsop DC, O'Connor MJ, French JA. Localization of subclinical ictal activity by functional magnetic resonance imaging: correlation with invasive monitoring. Ann Neurol 1995; 38:618-24. PubMed
  • Smith DH, Meaney DF, Lenkinski RE, Alsop DC, Grossman R, Kimura H, McIntosh TK, Gennarelli TA. New magnetic resonance imaging techniques for the evaluation of traumatic brain injury. J Neurotrauma 1995; 12:573-7. PubMed
  • Randazzo BP, Kesari S, Gesser RM, Alsop D, Ford JC, Brown SM, Maclean A, Fraser NW. Treatment of experimental intracranial murine melanoma with a neuroattenuated herpes simplex virus 1 mutant. Virology 1995; 211:94-101. PubMed
  • Alsop DC, Hatabu H, Bonnet M, Listerud J, Gefter W. Multi-slice, breathhold imaging of the lung with submillisecond echo times. Magn Reson Med 1995; 33:678-82. PubMed
  • Ford JC, Hackney DB, Alsop DC, Jara H, Joseph PM, Hand CM, Black P. MRI characterization of diffusion coefficients in a rat spinal cord injury model. Magn Reson Med 1994; 31:488-94. PubMed
  • Ford JC, Hackney DB, Joseph PM, Phelan M, Alsop DC, Tabor SL, Hand CM, Markowitz RS, Black P. A method for in vivo high resolution MRI of rat spinal cord injury. Magn Reson Med 1994; 31:218-23. PubMed
  • Devlin M, Alsop D, Clapp A, Cottingham D, Fischer M, Gundersen J, Holmes W, Lange A, Lubin P, Meinhold P, Richards P, Smoot G. Preliminary results from the third flight of the Millimeter Anisotropy Experiment (MAX). Proc Natl Acad Sci U S A 1993; 90:4774-6. PubMed
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