Photo of David Pepin,  PhD

David Pepin, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 838-3810


dpepin@partners.org

David Pepin, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Surgery, Harvard Medical School
  • Assistant Molecular Biologist, Surgery, Massachusetts General Hospital

Research Abstract

My laboratory is focused on developing translational approaches to the study of ovarian cancer, particularly for the treatment and prevention of chemoresistant recurrences. We have previously shown that the use of gene therapy vectors based on adeno-associated virus serotype 9 (AAV9) can be effective in delivering biologics for long term treatment of chemoresistant recurrences using patient-derived xenograft models developed in the laboratory. Those PDX models mimic the current standard of care by considering surgical debulking and chemotherapy, and allow us to infer the variability of patient responsiveness by personalizing to individual patient's tumors. One of the biologics we are evaluating, Mullerian Inhibiting Substance (MIS), was shown to be effective in inhibiting ovarian cancer growth. Additionally, we have shown that co-treatment with MIS during chemotherapy suppresses ovarian folliculogenesis, thus also preserving fertility during treatment. These applications are being pursued pre-clinically.

Publications

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  • Kano M, Sosulski AE, Zhang L, Saatcioglu HD, Wang D, Nagykery N, Sabatini ME, Gao G, Donahoe PK, Pépin D. AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy. Proc Natl Acad Sci U S A 2017. PubMed
  • Sosulski A, Horn H, Zhang L, Coletti C, Vathipadiekal V, Castro CM, Birrer MJ, Nagano O, Saya H, Lage K, Donahoe PK, Pépin D. CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis. PLoS ONE 2016; 11:e0156595. PubMed
  • Pépin D, Sosulski A, Zhang L, Wang D, Vathipadiekal V, Hendren K, Coletti CM, Yu A, Castro CM, Birrer MJ, Gao G, Donahoe PK. AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer. Proc Natl Acad Sci U S A 2015; 112:E4418-27. PubMed